Ca2+-dependent regulation in neuronal gene expression

Ca2+ is an important signal-transduction molecule that plays a role in many intracellular signaling pathways. Recent advances have indicated that in neurons, Ca2+-controlled signaling mechanisms cooperate in order to discriminate amongst incoming cellular inputs. Ca2+-dependent transcriptional events can thereby be made selectively responsive to bursts of synaptic activity of specific intensity or duration.

[1]  R. Fields,et al.  Regulated Expression of the Neural Cell Adhesion Molecule L1 by Specific Patterns of Neural Impulses , 1995, Science.

[2]  D. Warner.  Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. , 1993 .

[3]  J. Darnell.  The JAK-STAT pathway: summary of initial studies and recent advances. , 1996, Recent progress in hormone research.

[4]  E. Nestler,et al.  Molecular mechanisms of drug reinforcement and addiction. , 1995, Annual review of neuroscience.

[5]  E R Kandel,et al.  A Molecular Switch for the Consolidation of Long‐Term Memory: cAMP‐Inducible Gene Expression , 1995, Annals of the New York Academy of Sciences.

[6]  E. Tekle,et al.  Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide , 1997, The Journal of Biological Chemistry.

[7]  Philip R. Cohen,et al.  FGF and stress regulate CREB and ATF‐1 via a pathway involving p38 MAP kinase and MAPKAP kinase‐2. , 1996, The EMBO journal.

[8]  E. Schuman,et al.  Dendrites , 1978, Journal of the Geological Society.

[9]  R. Buchsbaum,et al.  The N-terminal pleckstrin, coiled-coil, and IQ domains of the exchange factor Ras-GRF act cooperatively to facilitate activation by calcium , 1996, Molecular and cellular biology.

[10]  Richard Paylor,et al.  Behavioral assessment of c-fos mutant mice , 1994, Brain Research.

[11]  T. Soderling,et al.  Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation. , 1994, The Journal of biological chemistry.

[12]  E. Villacres,et al.  Induction of CRE-Mediated Gene Expression by Stimuli That Generate Long-Lasting LTP in Area CA1 of the Hippocampus , 1996, Neuron.

[13]  B. Howard,et al.  The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases , 1996, Cell.

[14]  M. Waxham,et al.  Neuronal Activity Increases the Phosphorylation of the Transcription Factor cAMP Response Element-binding Protein (CREB) in Rat Hippocampus and Cortex* , 1996, The Journal of Biological Chemistry.

[15]  T. Soderling,et al.  Characterization of a Ca2+/Calmodulin-dependent Protein Kinase Cascade , 1995, The Journal of Biological Chemistry.

[16]  A. Graybiel,et al.  Dopaminergic regulation of transcription factor expression in organotypic cultures of developing striatum , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[17]  D. Church,et al.  The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases , 1996, Molecular and cellular biology.

[18]  Anjana Rao,et al.  An Enhanced Immune Response in Mice Lacking the Transcription Factor NFAT1 , 1996, Science.

[19]  Thorsten Heinzel,et al.  A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors , 1996, Cell.

[20]  K. Rajewsky,et al.  Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning , 1994, Nature.

[21]  A. Edelman,et al.  Human calcium‐calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine‐177 by calcium‐calmodulin dependent protein kinase I kinase. , 1995, The EMBO journal.

[22]  E. Kandel,et al.  Modulation of an NCAM-related adhesion molecule with long-term synaptic plasticity in Aplysia. , 1992, Science.

[23]  D. Livingston,et al.  Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. , 1996, Genes & development.

[24]  D. Livingston,et al.  Association of p300 and CBP with simian virus 40 large T antigen , 1996, Molecular and cellular biology.

[25]  J. Milbrandt,et al.  Luteinizing Hormone Deficiency and Female Infertility in Mice Lacking the Transcription Factor NGFI-A (Egr-1) , 1996, Science.

[26]  R. Janknecht,et al.  Transcription. A growing coactivator network. , 1996, Nature.

[27]  G Leng,et al.  Induction of c-fos expression in hypothalamic magnocellular neurons requires synaptic activation and not simply increased spike activity , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[28]  A. Edelman,et al.  A protein activator of Ca(2+)-calmodulin-dependent protein kinase Ia. , 1994, The Journal of biological chemistry.

[29]  N. Toni,et al.  PSA–NCAM Is Required for Activity-Induced Synaptic Plasticity , 1996, Neuron.

[30]  T. Carew,et al.  Molecular Enhancement of Memory Formation , 1996, Neuron.

[31]  Eric R. Kandel,et al.  Cell Adhesion Molecules, CREB, and the Formation of New Synaptic Connections , 1996, Neuron.

[32]  D Cohen,et al.  Phosphorylation of DARPP-32, a Dopamine- and cAMP-regulated Phosphoprotein, by Casein Kinase I in Vitro and in Vivo(*) , 1995, The Journal of Biological Chemistry.

[33]  D. O'Connor,et al.  Stimulus-transcription Coupling in Pheochromocytoma Cells , 1996, The Journal of Biological Chemistry.

[34]  H. Shih,et al.  Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP , 1996, Nature.

[35]  A. Nordheim,et al.  Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP. , 1996, Oncogene.

[36]  W. Quinn,et al.  Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila , 1994, Cell.

[37]  S. Bhattacharya,et al.  Cooperation of Stat2 and p300/CBP in signalling induced by interferon-α , 1996, Nature.

[38]  G. Condorelli,et al.  Human p300 Protein Is a Coactivator for the Transcription Factor MyoD (*) , 1996, The Journal of Biological Chemistry.

[39]  G. Nabel,et al.  Regulation of NF-κB by Cyclin-Dependent Kinases Associated with the p300 Coactivator , 1997, Science.

[40]  R. Tjian,et al.  SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein. , 1996, Genes & development.

[41]  A. Edelman,et al.  Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation. , 1995, The Journal of biological chemistry.

[42]  Ralf Janknecht,et al.  Transcriptional control: Versatile molecular glue , 1996, Current Biology.

[43]  Darnell Je.  The JAK-STAT pathway: summary of initial studies and recent advances. , 1996 .

[44]  J. Blenis,et al.  Neurotransmitter- and Growth Factor-Induced cAMP Response Element Binding Protein Phosphorylation in Glial Cell Progenitors: Role of Calcium Ions, Protein Kinase C, and Mitogen-Activated Protein Kinase/Ribosomal S6 Kinase Pathway , 1997, The Journal of Neuroscience.

[45]  T. Bliss,et al.  Increase in extracellular NCAM and amyloid precursor protein following induction of long-term potentiation in the dentate gyrus of anaesthetized rats , 1994, Neuroscience Letters.

[46]  W. J. Wu,et al.  Identification of a Putative Effector for Cdc42Hs with High Sequence Similarity to the RasGAP-related Protein IQGAP1 and a Cdc42Hs Binding Partner with Similarity to IQGAP2* , 1996, The Journal of Biological Chemistry.

[47]  J. Darnell,et al.  Two contact regions between Stat1 and CBP/p300 in interferon γ signaling , 1996 .

[48]  R. Janknecht,et al.  Versatile molecular glue. Transcriptional control. , 1996, Current biology : CB.

[49]  R. Halaban,et al.  Identification of p90RSK as the probable CREB-Ser133 kinase in human melanocytes. , 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[50]  Michael E. Greenberg,et al.  Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase , 1996, Science.

[51]  A. Edelman,et al.  Multiple Ca-Calmodulin-dependent Protein Kinase Kinases from Rat Brain , 1996, The Journal of Biological Chemistry.

[52]  A. Nairn,et al.  Activation of a Calcium-Calmodulin-dependent Protein Kinase I Cascade in PC12 Cells* , 1996, The Journal of Biological Chemistry.

[53]  S. Ishii,et al.  CBP as a transcriptional coactivator of c-Myb. , 1996, Genes & development.

[54]  R. Munglani,et al.  Proto-oncogenes: basic concepts and stimulation induced changes in the spinal cord. , 1995, Progress in brain research.

[55]  K. Deisseroth,et al.  Signaling from Synapse to Nucleus: Postsynaptic CREB Phosphorylation during Multiple Forms of Hippocampal Synaptic Plasticity , 1996, Neuron.

[56]  T. Tully,et al.  CREB as a Memory Modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in drosophila , 1995, Cell.

[57]  H. Hidaka,et al.  Ca2+/calmodulin-dependent protein kinase kinase cascade. , 1994, Biochemical and biophysical research communications.

[58]  J. Darnell,et al.  Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[59]  P. Worley,et al.  Induction of β-A activin expression by synaptic activity and during neocortical development , 1995, Neuroscience.

[60]  J. McNamara,et al.  N-methyl-D-aspartate receptors activate transcription of c-fos and NGFI-A by distinct phospholipase A2-requiring intracellular signaling pathways. , 1995, Molecular pharmacology.

[61]  Hilmar Bading,et al.  Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression , 1997, Nature.

[62]  H. Fujisawa,et al.  Purification and characterization of Ca2+/calmodulin-dependent protein kinase IV kinase from rat brain. , 1994, Journal of biochemistry.

[63]  S. Bhattacharya,et al.  An essential role for p300/CBP in the cellular response to hypoxia. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[64]  T. Curran,et al.  Fos: an immediate-early transcription factor in neurons. , 1995, Journal of neurobiology.

[65]  Alcino J. Silva,et al.  Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein , 1994, Cell.

[66]  T. Hunter,et al.  A growing coactivator network , 1996, Nature.

[67]  M. Montminy,et al.  Adaptor-mediated Recruitment of RNA Polymerase II to a Signal-dependent Activator (*) , 1996, The Journal of Biological Chemistry.

[68]  A. Rao,et al.  Calcineurin Binds the Transcription Factor NFAT1 and Reversibly Regulates Its Activity (*) , 1996, The Journal of Biological Chemistry.

[69]  M. Dragunow.  A role for immediate-early transcription factors in learning and memory , 1996, Behavior genetics.

[70]  H. Hidaka,et al.  Phosphorylation of Ca2+/calmodulin-dependent protein kinase V and regulation of its activity. , 1993, Biochemical and biophysical research communications.

[71]  J. Chrivia,et al.  CREB-binding Protein Activates Transcription through Multiple Domains* , 1996, The Journal of Biological Chemistry.

[72]  E. Price,et al.  Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4 , 1996, Nature.

[73]  T. Soderling,et al.  Phosphorylation of CREB by CaM-kinase IV activated by CaM-kinase IV kinase. , 1995, Biochemical and biophysical research communications.

[74]  M. Greenberg,et al.  Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB , 1994, Cell.

[75]  A. Means,et al.  Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression , 1994, Molecular and cellular biology.

[76]  A. Nordheim,et al.  MAP kinase-dependent transcriptional coactivation by Elk-1 and its cofactor CBP. , 1996, Biochemical and biophysical research communications.

[77]  Jeng-Shin Lee,et al.  Differential Interactions of the CREB/ATF Family of Transcription Factors with p300 and Adenovirus E1A* , 1996, The Journal of Biological Chemistry.

[78]  P. Bickford,et al.  Tissue Plasminogen Activator Induction in Purkinje Neurons After Cerebellar Motor Learning , 1995, Science.

[79]  N. Nomura,et al.  Identification of IQGAP as a Putative Target for the Small GTPases, Cdc42 and Rac1* , 1996, The Journal of Biological Chemistry.

[80]  E. Kandel,et al.  Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[81]  K. Deisseroth,et al.  CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression , 1996, Cell.

[82]  Andrew J. Bannister,et al.  The CBP co-activator is a histone acetyltransferase , 1996, Nature.

[83]  M. Greenberg,et al.  L-type Voltage-sensitive Ca2+ Channel Activation Regulates c-fos Transcription at Multiple Levels (*) , 1995, The Journal of Biological Chemistry.

[84]  Scott T. Wong,et al.  Regulation of type I adenylyl cyclase by calmodulin kinase IV in vivo , 1996, Molecular and cellular biology.

[85]  M. Greenberg,et al.  Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channels. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[86]  H. Enslen,et al.  Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity. , 1994, Genes & development.

[87]  Andrew J. Cole,et al.  Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation , 1989, Nature.

[88]  K. Sakamoto,et al.  Transcriptional Activation of egr-1 by Granulocyte-Macrophage Colony-stimulating Factor but Not Interleukin 3 Requires Phosphorylation of cAMP Response Element-binding Protein (CREB) on Serine 133 (*) , 1995, The Journal of Biological Chemistry.

[89]  H. Fujisawa,et al.  Purification and characterization of Ca2+/calmodulin-dependent protein kinase kinase beta from rat cerebellum. , 1997, Journal of Biochemistry (Tokyo).

[90]  T. Tully,et al.  CREB and the formation of long-term memory , 1996, Current Opinion in Neurobiology.

[91]  C. Shatz.  Emergence of order in visual system development. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[92]  T. Soderling,et al.  Roles of calmodulin-dependent protein kinases and phosphatase in calcium-dependent transcription of immediate early genes. , 1994, The Journal of biological chemistry.

[93]  C. Klee,et al.  Superoxide dismutase protects calcineurin from inactivation , 1996, Nature.

[94]  T. Chatila,et al.  Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr , 1996, The Journal of experimental medicine.

[95]  E. Kandel,et al.  Toward a molecular definition of long-term memory storage. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[96]  S. Lev,et al.  Activation of Pyk2 by Stress Signals and Coupling with JNK Signaling Pathway , 1996, Science.

[97]  B. Howard,et al.  A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A , 1996, Nature.

[98]  Ted Abel,et al.  Transgenic approaches to cognition , 1995, Current Opinion in Neurobiology.

[99]  E R Kandel,et al.  Serotonin-mediated endocytosis of apCAM: an early step of learning-related synaptic growth in Aplysia. , 1992, Science.

[100]  M. Greenberg,et al.  Calcium activates serum response factor-dependent transcription by a Ras- and Elk-1-independent mechanism that involves a Ca2+/calmodulin-dependent kinase , 1995, Molecular and cellular biology.

[101]  M. Hagiwara,et al.  Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB , 1992, Cell.

[102]  H. Schulman,et al.  Decoding Ca2+ signals to the nucleus by multifunctional CaM kinase. , 1995, Progress in brain research.

[103]  J. Sikela,et al.  Activation mechanisms for Ca2+/calmodulin-dependent protein kinase IV. Identification of a brain CaM-kinase IV kinase. , 1994, The Journal of biological chemistry.

[104]  D. Saffen,et al.  Muscarinic Acetylcholine Receptor‐Mediated Induction of zif268 mRNA in PC12D Cells Requires Protein Kinase C and the Influx of Extracellular Calcium , 1997, Journal of neurochemistry.

[105]  M E Greenberg,et al.  Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock. , 1993, Science.

[106]  B. O’Malley,et al.  CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[107]  M. Greenberg,et al.  CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases. , 1991, Science.

[108]  P. Sassone-Corsi,et al.  Transcription factors responsive to cAMP. , 1995, Annual review of cell and developmental biology.

[109]  T. Bliss,et al.  Differential expression of immediate early genes in the hippocampus and spinal cord , 1990, Neuron.

[110]  T. Bliss,et al.  Spatial and temporal changes in signal transduction pathways during LTP , 1994, Neuron.

[111]  C. Klee,et al.  Factors responsible for the Ca2+‐dependent inactivation of calcineurin in brain , 1995, FEBS letters.

[112]  E. Peles,et al.  Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions , 1995, Nature.

[113]  E. Kandel,et al.  Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory , 1997, Cell.

[114]  M E Greenberg,et al.  Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. , 1993, Science.

[115]  Richard J Smeyne,et al.  Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements , 1995, Neuron.

[116]  H. Fujisawa,et al.  Requirement of brain extract for the activity of brain calmodulin-dependent protein kinase IV expressed in Escherichia coli. , 1993, Journal of biochemistry.

[117]  C. Barnes,et al.  Narp, a novel member of the pentraxin family, promotes neurite outgrowth and is dynamically regulated by neuronal activity , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[118]  T. Soderling,et al.  Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[119]  Michael E Greenberg,et al.  A Defect in Nurturing in Mice Lacking the Immediate Early Gene fosB , 1996, Cell.

[120]  F. Gage,et al.  The Signal-Dependent Coactivator CBP Is a Nuclear Target for pp90RSK , 1996, Cell.

[121]  H. Schulman,et al.  lnterleukin-2 transcriptional block by multifunctional Ca2+/ calmodulin kinase , 1994, Nature.

[122]  K. Shuai,et al.  Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1 , 1996, Molecular and cellular biology.

[123]  T. Hunter,et al.  Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus , 1995, Current Biology.

[124]  J. Darnell,et al.  The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase. , 1996, The EMBO journal.

[125]  P. Polakis,et al.  IQGAP1, a calmodulin‐binding protein with a rasGAP‐related domain, is a potential effector for cdc42Hs. , 1996, The EMBO journal.

[126]  M. Montminy,et al.  Role of CBP/P300 in nuclear receptor signalling , 1996, Nature.

[127]  K. Fukunaga,et al.  Purification and Characterization of a Ca2+‐ and Calmodulin‐Dependent Protein Kinase from Rat Brain , 1982, Journal of neurochemistry.

[128]  J. Loeffler,et al.  Fine tuning of calcium entry into neurons regulates adenosine 3′,5′-monophosphate-dependent transcription by several distinct mechanisms , 1996, Neuroscience.

[129]  G. Crabtree,et al.  Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression , 1996, Nature.

[130]  W. Abraham,et al.  Immediate early gene expression associated with the persistence of heterosynaptic long-term depression in the hippocampus. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[131]  Alcino J. Silva,et al.  Spaced training induces normal long-term memory in CREB mutant mice , 1997, Current Biology.

[132]  Mary Chen,et al.  Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change , 1995, Cell.

[133]  L. Squire,et al.  Retrograde amnesia and memory consolidation: a neurobiological perspective , 1995, Current Opinion in Neurobiology.

[134]  P. Worley,et al.  COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[135]  A. Routtenberg,et al.  Gene expression of the transcription factor NF-kappa B in hippocampus: regulation by synaptic activity. , 1996, Brain research. Molecular brain research.

[136]  Carol A Barnes,et al.  Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites , 1995, Neuron.

[137]  B. McNaughton,et al.  Thresholds for synaptic activation of transcription factors in hippocampus: correlation with long-term enhancement , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[138]  A. Edelman,et al.  Multiple Ca(2+)-calmodulin-dependent protein kinase kinases from rat brain. Purification, regulation by Ca(2+)-calmodulin, and partial amino acid sequence. , 1996, Journal of Biological Chemistry.

[139]  M. Montminy,et al.  Multiple protein kinase A-regulated events are required for transcriptional induction by cAMP. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[140]  U. Frey,et al.  Synaptic tagging and long-term potentiation , 1997, Nature.

[141]  A. Graybiel,et al.  Spatiotemporal Dynamics of CREB Phosphorylation: Transient versus Sustained Phosphorylation in the Developing Striatum , 1996, Neuron.

[142]  M. Montminy,et al.  Transcriptional regulation by cyclic AMP. , 1997, Annual review of biochemistry.

[143]  M. Greenberg,et al.  Calcium Influx via the NMDA Receptor Induces Immediate Early Gene Transcription by a MAP Kinase/ERK-Dependent Mechanism , 1996, The Journal of Neuroscience.