论文信息 - Alternative Splicing Regulation Impacts Heart Development

Alternative Splicing Regulation Impacts Heart Development

SR proteins serve multiple roles in the posttranscriptional control of gene expression, including as regulators of alternative splicing. In this issue of Cell, Xu et al. (2005) demonstrate that a heart-specific knockout of one SR protein, ASF/SF2, produces cardiomyopathy and misregulation of specific alternative splicing events during early postnatal development.

T. Cooper | Thomas A Cooper

[1] J. Ross,et al. Dilated cardiomyopathy caused by tissue‐specific ablation of SC35 in the heart , 2004, The EMBO journal.

[2] Xiang-Dong Fu,et al. ASF/SF2-Regulated CaMKIIδ Alternative Splicing Temporally Reprograms Excitation-Contraction Coupling in Cardiac Muscle , 2005, Cell.

[3] S. Brenner,et al. Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[4] Christopher J. Lee,et al. Genome-wide detection of alternative splicing in expressed sequences of human genes , 2001, Nucleic Acids Res..

[5] Robert B Darnell,et al. Nova-1 Regulates Neuron-Specific Alternative Splicing and Is Essential for Neuronal Viability , 2000, Neuron.

[6] N. Gray,et al. A novel role for shuttling SR proteins in mRNA translation. , 2004, Genes & development.

[7] B. Graveley. Sorting out the complexity of SR protein functions. , 2000, RNA.

[8] H. Schulman,et al. Regulation of signal transduction by protein targeting: the case for CaMKII. , 2001, Biochemical and biophysical research communications.

[9] W. Hauswirth,et al. A Muscleblind Knockout Model for Myotonic Dystrophy , 2003, Science.