Topical nanocrystalline silver cream suppresses inflammatory cytokines and induces apoptosis of inflammatory cells in a murine model of allergic contact dermatitis

Background  Nanocrystalline silver has both antimicrobial and anti‐inflammatory properties. However, the exact mechanisms underlying these activities are not known.

[1]  T Schwarz,et al.  Interleukin-12 and its role in cutaneous sensitization. , 1995, Research in immunology.

[2]  S. Kondo,et al.  Interleukin-1 receptor antagonist suppresses contact hypersensitivity. , 1995, The Journal of investigative dermatology.

[3]  H I Maibach,et al.  Epidermal cytokines in murine cutaneous irritant responses , 2000, Journal of applied toxicology : JAT.

[4]  H. Schuppe,et al.  Topical FK506 suppresses cytokine and costimulatory molecule expression in epidermal and local draining lymph node cells during primary skin immune responses. , 1998, Journal of immunology.

[5]  G. Piérard,et al.  Adverse effects of topical corticosteroids , 1989, Acta dermato-venereologica. Supplementum.

[6]  C. Neumann,et al.  Epidermal cytokines IL-1beta, TNF-alpha, and IL-12 in patients with atopic dermatitis: response to application of house dust mite antigens. , 1998, The Journal of investigative dermatology.

[7]  E. Letko,et al.  Tacrolimus (FK 506). , 1999, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[8]  L. Genestier,et al.  Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells. , 1998, The Journal of clinical investigation.

[9]  J. Alroy,et al.  Anti‐inflammatory effect of topical nanocrystalline silver cream on allergic contact dermatitis in a guinea pig model , 2004, Clinical and experimental dermatology.

[10]  S. Kondo,et al.  Epidermal cytokines in allergic contact dermatitis. , 1995, Journal of the American Academy of Dermatology.

[11]  Felix Treumer,et al.  Dimethylfumarate is a potent inducer of apoptosis in human T cells. , 2003, The Journal of investigative dermatology.

[12]  W. Pichler,et al.  Antigen‐presenting cells and keratinocytes express interleukin‐12 in allergic contact dermatitis , 2000, Contact dermatitis.

[13]  L. D. de Heide,et al.  Cushing's syndrome caused by topical steroid therapy for psoriasis. , 2002, The Netherlands journal of medicine.

[14]  H. Abken,et al.  Interleukin-12 Antagonists as New Therapeutic Agents in Inflammatory Bowel Disease , 2003, Pathobiology.

[15]  S. Kunkel,et al.  Modulation of leucocyte adhesion molecules, a T‐cell chemotaxin (IL‐8) and a regulatory cytokine (TNF‐α) in allergic contact dermatitis (rhus dermatitis) , 1991, The British journal of dermatology.

[16]  E. Tredget,et al.  A matched-pair, randomized study evaluating the efficacy and safety of Acticoat silver-coated dressing for the treatment of burn wounds. , 1998, The Journal of burn care & rehabilitation.

[17]  R. Burrell,et al.  Efficacy of topical silver against fungal burn wound pathogens. , 1999, American journal of infection control.

[18]  A. Remitz,et al.  Topical Noncorticosteroid Immunomodulation in the Treatment of Atopic Dermatitis , 2002, American journal of clinical dermatology.

[19]  G. Trinchieri,et al.  Neutralization of IL-12 in vivo prevents induction of contact hypersensitivity and induces hapten-specific tolerance. , 1996, Journal of immunology.

[20]  A. Buret,et al.  Early healing events in a porcine model of contaminated wounds: effects of nanocrystalline silver on matrix metalloproteinases, cell apoptosis, and healing , 2002, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[21]  Koichiro Nakamura,et al.  Interleukin-12 p40 gene (IL12B) 3'-untranslated region polymorphism is associated with susceptibility to atopic dermatitis and psoriasis vulgaris. , 2002, Journal of dermatological science.

[22]  M. Neurath,et al.  An interleukin 12 p40-IgG2b fusion protein abrogates T cell mediated inflammation: anti-inflammatory activity in Crohn’s disease and experimental colitis in vivo , 2004, Gut.

[23]  R. Kalish.  Recent developments in the pathogenesis of allergic contact dermatitis. , 1991, Archives of dermatology.

[24]  U. Merschdorf,et al.  High-dose methylprednisolone therapy in multiple sclerosis induces apoptosis in peripheral blood leukocytes. , 2001, Archives of neurology.

[25]  Maguire Hc.  Murine Recombinant lnterleukin-12 Increases the Acquisition of Allergic Contact Dermatitis in the Mouse , 1995 .

[26]  W. Pichler,et al.  Down-regulation of IL-12 by topical corticosteroids in chronic atopic dermatitis. , 2000, The Journal of allergy and clinical immunology.

[27]  H. Williams,et al.  Topical corticosteroid phobia in patients with atopic eczema , 2000, The British journal of dermatology.

[28]  R. Burrell,et al.  Wound management in an era of increasing bacterial antibiotic resistance: a role for topical silver treatment. , 1998, American journal of infection control.

[29]  S. Deventer,et al.  Contrasting roles of IL‐12p40 and IL‐12p35 in the development of hapten‐induced colitis , 2002, European journal of immunology.

[30]  N. Yawalkar,et al.  Expression of interleukin-12 is increased in psoriatic skin. , 1998, The Journal of investigative dermatology.

[31]  R. Burrell,et al.  Comparative evaluation of the antimicrobial activity of ACTICOAT antimicrobial barrier dressing. , 1999, The Journal of burn care & rehabilitation.

[32]  C. Neumann,et al.  Epidermal Cytokines IL-1β, TNF-α, and IL-12 in Patients with Atopic Dermatitis: Response to Application of House Dust Mite Antigens1 , 1998 .

[33]  Steven R. Cohen,et al.  The relationship between atopic dermatitis and contact dermatitis. , 2003, Clinics in dermatology.

[34]  I. Turpin.  Adverse effects of topical corticosteroid use. , 1997 .