Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation.

[1]  K. Seibert,et al.  Differential inhibition of fracture healing by non‐selective and cyclooxygenase‐2 selective non‐steroidal anti‐inflammatory drugs , 2003, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[2]  A. M. Simon,et al.  Cyclo‐Oxygenase 2 Function Is Essential for Bone Fracture Healing , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[3]  B. Olsen,et al.  Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis. , 2002, Development.

[4]  D. Shoback,et al.  Extracellular Ca2+-Sensing Receptors Modulate Matrix Production and Mineralization in Chondrogenic RCJ3.1C5.18 Cells. , 2002, Endocrinology.

[5]  J. Puzas,et al.  A Role for the BMP Antagonist Chordin in Endochondral Ossification , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[6]  B. Boyan,et al.  Characterization of PGE2 receptors (EP) and their role as mediators of 1α,25-(OH)2D3 effects on growth zone chondrocytes , 2001, The Journal of Steroid Biochemistry and Molecular Biology.

[7]  R. Serra,et al.  The perichondrium plays an important role in mediating the effects of TGF‐β1 on endochondral bone formation , 2001, Developmental dynamics : an official publication of the American Association of Anatomists.

[8]  V. Goldberg,et al.  BMP‐2 induction and TGF‐β1 modulation of rat periosteal cell chondrogenesis , 2001 .

[9]  C. Deng,et al.  TGF-β/Smad3 Signals Repress Chondrocyte Hypertrophic Differentiation and Are Required for Maintaining Articular Cartilage , 2001, The Journal of cell biology.

[10]  E. Schwarz,et al.  Smad2 and 3 Mediate Transforming Growth Factor-β1-Induced Inhibition of Chondrocyte Maturation* *The work was supported by National Health Services Grant AR-38945 (to R.J.O.) and an Orthopaedic Research Education Foundation Award (to C.M.F.). , 2000, Endocrinology.

[11]  Thiennu H. Vu,et al.  Matrix Metalloproteinase 9 and Vascular Endothelial Growth Factor Are Essential for Osteoclast Recruitment into Developing Long Bones , 2000, The Journal of cell biology.

[12]  P. Billings,et al.  MMP‐13 is induced during chondrocyte hypertrophy , 2000, Journal of cellular biochemistry.

[13]  T. Underhill,et al.  Analysis of Nedd4 expression during skeletal development in the mouse limb , 2000, Mechanisms of Development.

[14]  Y. Kitamura,et al.  Cbfa1 Is a Positive Regulatory Factor in Chondrocyte Maturation* , 2000, The Journal of Biological Chemistry.

[15]  M. García-Ramírez,et al.  Vascular Endothelial Growth Factor Is Expressed in Human Fetal Growth Cartilage , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[16]  Vicki Rosen,et al.  Regulation of Skeletal Progenitor Differentiation by the Bmp and Retinoid Signaling Pathways , 2000, The Journal of cell biology.

[17]  H. Ito,et al.  Effects of transforming growth factor-β signaling on chondrogenesis in mouse chondrogenic EC cells, ATDC5 , 1999 .

[18]  Theodore Miclau,et al.  Does adult fracture repair recapitulate embryonic skeletal formation? , 1999, Mechanisms of Development.

[19]  Napoleone Ferrara,et al.  VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation , 1999, Nature Medicine.

[20]  R. Serra,et al.  Parathyroid Hormone–related Peptide (pthrp)-dependent and -independent Effects of Transforming Growth Factor ␤ (tgf-␤ ) on Endochondral Bone Formation , 1999 .

[21]  J. Compston,et al.  Immunolocalisation of vascular endothelial growth factor (VEGF) in human neonatal growth plate cartilage , 1999, Journal of anatomy.

[22]  Richard R. Behringer,et al.  Sox9 is required for cartilage formation , 1999, Nature Genetics.

[23]  T. Underhill,et al.  Retinoids and their receptors in skeletal development , 1998, Microscopy research and technique.

[24]  Susan W. Volk,et al.  A BMP Responsive Transcriptional Region in the Chicken Type X Collagen Gene , 1998 .

[25]  Gabriele Bergers,et al.  MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes , 1998, Cell.

[26]  Giuseppe M Peretti,et al.  Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair , 1998, Mechanisms of Development.

[27]  A I Caplan,et al.  In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. , 1998, Experimental cell research.

[28]  Mahlon D. Johnson,et al.  Expression of a Truncated, Kinase-Defective TGF-β Type II Receptor in Mouse Skeletal Tissue Promotes Terminal Chondrocyte Differentiation and Osteoarthritis , 1997, The Journal of cell biology.

[29]  Patrick P.L. Tam,et al.  SOX9 directly regulates the type-ll collagen gene , 1997, Nature Genetics.

[30]  A. Gutierrez-Hartmann,et al.  Combination of osteoinductive bone proteins differentiates mesenchymal C3H/10T1/2 cells specifically to the cartilage lineage , 1997, Journal of cellular biochemistry.

[31]  P N Goodfellow,et al.  SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene , 1997, Molecular and cellular biology.

[32]  J. Puzas,et al.  Differential regulation of type‐II and type‐X collagen synthesis by parathyroid hormone‐related protein in chick growth‐plate chondrocytes , 1997, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[33]  B. Lanske,et al.  PTH/PTHrP Receptor in Early Development and Indian Hedgehog--Regulated Bone Growth , 1996, Science.

[34]  L. Gerstenfeld,et al.  Expression of bone‐specific genes by hypertrophic chondrocytes: Implications of the complex functions of the hypertrophic chondrocyte during endochondral bone development , 1996, Journal of cellular biochemistry.

[35]  R. Tuan,et al.  Formation of cartilage-like spheroids by micromass cultures of murine C3H10T1/2 cells upon treatment with transforming growth factor-beta 1. , 1995, Differentiation; research in biological diversity.

[36]  A. Krasinskas,et al.  Shared phenotypic expression of osteoblasts and chondrocytes in fracture callus , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[37]  R. Derynck,et al.  Toward a molecular understanding of skeletal development , 1995, Cell.

[38]  S A Newman,et al.  Morphogenetic differences between fore and hind limb precartilage mesenchyme: relation to mechanisms of skeletal pattern formation. , 1994, Developmental biology.

[39]  M. Sporn,et al.  TGF-beta 1 prevents hypertrophy of epiphyseal chondrocytes: regulation of gene expression for cartilage matrix proteins and metalloproteases. , 1993, Developmental biology.

[40]  K. Ono,et al.  Transforming growth factor-beta 1 stimulates chondrogenesis and inhibits osteogenesis in high density culture of periosteum-derived cells. , 1993, Endocrinology.

[41]  M. Glimcher,et al.  High‐resolution immunolocalization of osteopontin and osteocalcin in bone and cartilage during endochondral ossification in the chicken tibia , 1992, The Anatomical record.

[42]  J. Puzas,et al.  Influence of prostaglandins on DNA and matrix synthesis in growth plate chondrocytes , 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[43]  Stuart A. Newman,et al.  Role of transforming growth factor-β in chondrogenic pattern formation in the embryonic limb: Stimulation of mesenchymal condensation and fibronectin gene expression by exogenenous TGF-β and evidence for endogenous TGF-β-like activity , 1991 .

[44]  W. Kulyk,et al.  Promotion of embryonic chick limb cartilage differentiation by transforming growth factor-beta. , 1989, Developmental biology.

[45]  M. Iwamoto,et al.  Terminal differentiation and calcification in rabbit chondrocyte cultures grown in centrifuge tubes: regulation by transforming growth factor beta and serum factors. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[46]  R. Reiter,et al.  Stage-related capacity for limb chondrogenesis in cell culture. , 1977, Developmental biology.

[47]  R. Cancedda,et al.  Vascular endothelial growth factor (VEGF) in cartilage neovascularization and chondrocyte differentiation: auto-paracrine role during endochondral bone formation. , 2000, Journal of cell science.

[48]  R. Cancedda,et al.  Vascular endothelial growth factor (VEGF) in cartilage neovascularization and chondrocyte differentiation: auto-paracrine role during endochondral bone formation. J Cell Sci 113(Pt 1):59-69 , 2000 .

[49]  W. Woodward,et al.  Embryonic limb mesenchyme micromass culture as an in vitro model for chondrogenesis and cartilage maturation. , 2000, Methods in molecular biology.

[50]  K. Winterhalter,et al.  Terminal differentiation of chondrocytes in culture is a spontaneous process and is arrested by transforming growth factor-beta 2 and basic fibroblast growth factor in synergy. , 1995, Experimental cell research.