In vivo real time monitoring of vasoconstriction and vasodilation by a combined diffuse reflectance spectroscopy and Doppler optical coherence tomography approach

A combined diffuse reflectance (DR) spectroscopy and doppler optical coherence tomography (DOCT) approach may offer a powerful means for assessment of tissue function, and potentially provide a way for earlier cancer detection through non‐invasive local blood supply measurements. The goal of the study was to compare a DR‐derived blood‐content‐related index to a measure of local blood supply flow as furnished by DOCT during manipulations with blood circulation (vasoconstriction and vasodilation), investigate similarities and differences, complementarity of techniques, and then applying these results to the underlying biology.

[1]  Maggie L. Gordon,et al.  High speed, wide velocity dynamic range Doppler optical coherence tomography (Part III): in vivo endoscopic imaging of blood flow in the rat and human gastrointestinal tracts. , 2003, Optics express.

[2]  Jun Li,et al.  Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy. , 2005, Journal of biomedical optics.

[3]  Naoki Muguruma,et al.  Usefulness of a hemoglobin index determined by electronic endoscopy in the diagnosis of helicobacter pylori gastritis , 2002 .

[4]  B. Fenton,et al.  Oxygenation and vascular perfusion in spontaneous and transplanted tumor models. , 2003, Advances in experimental medicine and biology.

[5]  H.J.C.M. Sterenborg,et al.  Skin optics , 1989, IEEE Transactions on Biomedical Engineering.

[6]  S. Dymling,et al.  Measurement of blood perfusion in tissue using Doppler ultrasound. , 1991, Ultrasound in medicine & biology.

[7]  L. Hafström,et al.  Influence of vasoactive drugs on blood flow in subcutaneous tumors – an experimental study in rats , 1980, Journal of surgical oncology.

[8]  G. Zonios,et al.  Diffuse reflectance spectroscopy of human adenomatous colon polyps in vivo. , 1999, Applied optics.

[9]  Victor X D Yang,et al.  Interstitial Doppler optical coherence tomography. , 2005, Optics letters.

[10]  Marcos Intaglietta,et al.  Oxygen gradients in the microcirculation. , 2003, Physiological reviews.

[11]  P. Carmeliet,et al.  Angiogenesis in cancer and other diseases , 2000, Nature.

[12]  Julius Pekar,et al.  High speed, wide velocity dynamic range Doppler optical coherence tomography (Part I): System design, signal processing, and performance. , 2003, Optics express.

[13]  Valery V Tuchin,et al.  Advances in small animal mesentery models for in vivo flow cytometry, dynamic microscopy, and drug screening. , 2007, World journal of gastroenterology.

[14]  V V Tuchin,et al.  Investigation of blood flow microcirculation by diffusing wave spectroscopy. , 2001, Critical reviews in biomedical engineering.

[15]  J. Alcázar,et al.  Tumor angiogenesis assessed by three‐dimensional power Doppler ultrasound in early, advanced and metastatic ovarian cancer: a preliminary study , 2006, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[16]  Victor X D Yang,et al.  Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience. , 2005, Gastrointestinal endoscopy.

[17]  S. Lo,et al.  Quantitative analysis of angiogenesis using confocal laser scanning microscopy , 2004, Angiogenesis.

[18]  A. A. Stratonnikov,et al.  Evaluation of blood oxygen saturation in vivo from diffuse reflectance spectra. , 2001, Journal of biomedical optics.

[19]  L. Svaasand,et al.  Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy. , 2000, Neoplasia.

[20]  Anita Mahadevan-Jansen,et al.  Experimental and simulated angular profiles of fluorescence and diffuse reflectance emission from turbid media. , 2005, Applied optics.

[21]  Victor X D Yang,et al.  Wide dynamic range detection of bidirectional flow in Doppler optical coherence tomography using a two-dimensional Kasai estimator. , 2007, Optics letters.

[22]  H. Friess,et al.  Evaluation of laser Doppler flowmetry for the study of benign and malignant gastric blood flow in vivo , 1999, Gut.

[23]  P. Vaupel,et al.  Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. , 2001, Journal of the National Cancer Institute.

[24]  C. Anderson.  GI magnetic resonance angiography. , 2002, Gastrointestinal endoscopy.

[25]  Francis A. Duck,et al.  Physical properties of tissue : a comprehensive reference book , 1990 .

[26]  Arjen Amelink,et al.  In vivo measurement of the local optical properties of tissue by use of differential path-length spectroscopy. , 2004, Optics letters.

[27]  I. Meglinski,et al.  Quantitative assessment of skin layers absorption and skin reflectance spectra simulation in the visible and near-infrared spectral regions. , 2002, Physiological measurement.

[28]  Džena Hidović-Rowe,et al.  Modelling and validation of spectral reflectance for the colon , 2005, Physics in medicine and biology.