Optical control of focal epilepsy in vivo with caged γ‐aminobutyric acid

There is enormous clinical potential in exploiting the spatial and temporal resolution of optical techniques to modulate pathophysiological neuronal activity, especially intractable focal epilepsy. We have recently utilized a new ruthenium‐based caged compound, ruthenium‐bipyridine‐triphenylphosphine–γ‐aminobutyric acid (RuBi‐GABA), which releases GABA when exposed to blue light, to rapidly terminate paroxysmal activity in vitro and in vivo.

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