Alpha lipoic acid protects heart against myocardial ischemia-reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation.

[1]  Z. Zuo,et al.  Mechanisms of the cerebral vasodilator actions of isoflavonoids of Gegen on rat isolated basilar artery. , 2012, Journal of ethnopharmacology.

[2]  A. Camara,et al.  Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts. , 2011, Pharmacological research.

[3]  R. Gottlieb.  Cell Death Pathways in Acute Ischemia/Reperfusion Injury , 2011, Journal of cardiovascular pharmacology and therapeutics.

[4]  F. Mach,et al.  Single Administration of the CXC Chemokine-Binding Protein Evasin-3 During Ischemia Prevents Myocardial Reperfusion Injury in Mice , 2010, Arteriosclerosis, thrombosis, and vascular biology.

[5]  M. Disatnik,et al.  Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice. , 2010, Journal of molecular and cellular cardiology.

[6]  Alexander M. Wolf,et al.  Metabolic Remodeling Induced by Mitochondrial Aldehyde Stress Stimulates Tolerance to Oxidative Stress in the Heart , 2009, Circulation research.

[7]  L. Rochette,et al.  Antioxidant Properties of an Endogenous Thiol: Alpha-lipoic Acid, Useful in the Prevention of Cardiovascular Diseases , 2009, Journal of cardiovascular pharmacology.

[8]  A. Jovanovic,et al.  M-LDH physically associated with sarcolemmal KATP channels mediates cytoprotection in heart embryonic H9C2 cells , 2009, The international journal of biochemistry & cell biology.

[9]  A. Jovanovic,et al.  A dual mechanism of cytoprotection afforded by M-LDH in embryonic heart H9C2 cells , 2009, Biochimica et biophysica acta.

[10]  M. Disatnik,et al.  Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target? , 2009, Trends in cardiovascular medicine.

[11]  Shufeng Zhou,et al.  Determinants and Prognostic Implications of Reperfusion Injury During Primary Percutaneous Coronary Intervention in Chinese Patients with Acute Myocardial Infarction , 2009, Clinical cardiology.

[12]  M. Disatnik,et al.  Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2. , 2009, Journal of molecular and cellular cardiology.

[13]  M. Disatnik,et al.  Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart , 2008, Science.

[14]  M. Bednarski,et al.  The role of lipoic acid in prevention of nitroglycerin tolerance. , 2008, European journal of pharmacology.

[15]  C. Tintori,et al.  Antiproliferative and proapoptotic activities of new pyrazolo[3,4‐d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[16]  R. Bolli,et al.  Stromal Cell–Derived Factor-1&agr; Confers Protection Against Myocardial Ischemia/Reperfusion Injury: Role of the Cardiac Stromal Cell–Derived Factor-1&agr;–CXCR4 Axis , 2007 .

[17]  V. Vasiliou,et al.  Neurotoxicity and Metabolism of the Catecholamine-Derived 3,4-Dihydroxyphenylacetaldehyde and 3,4-Dihydroxyphenylglycolaldehyde: The Role of Aldehyde Dehydrogenase , 2007, Pharmacological Reviews.

[18]  D. Conklin,et al.  Aldehyde metabolism in the cardiovascular system. , 2007, Molecular bioSystems.

[19]  T. Münzel,et al.  Role of Reduced Lipoic Acid in the Redox Regulation of Mitochondrial Aldehyde Dehydrogenase (ALDH-2) Activity , 2007, Journal of Biological Chemistry.

[20]  I. Stagljar,et al.  Glyceraldehyde 3‐phosphate dehydrogenase serves as an accessory protein of the cardiac sarcolemmal KATP channel , 2005 .

[21]  Vasilis Vasiliou,et al.  Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family , 2005, Human Genomics.

[22]  H. Harms,et al.  Formation of 4-hydroxy-2-nonenal protein adducts in the ischemic rat heart after transplantation. , 2005, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[23]  A. Jovanovic,et al.  High glucose regulates the activity of cardiac sarcolemmal ATP-sensitive K+ channels via 1,3-bisphosphoglycerate: a novel link between cardiac membrane excitability and glucose metabolism. , 2005, Diabetes.

[24]  P. Doevendans,et al.  Role of apoptosis in reperfusion injury. , 2004, Cardiovascular research.

[25]  S. Armstrong.  Protein kinase activation and myocardial ischemia/reperfusion injury. , 2004, Cardiovascular research.

[26]  Jun Peng,et al.  Inhibition of cardiac tumor necrosis factor-alpha production by calcitonin gene-related peptide-mediated ischemic preconditioning in isolated rat hearts. , 2000, European journal of pharmacology.

[27]  H. Freisleben.  Lipoic acid reduces ischemia-reperfusion injury in animal models. , 2000, Toxicology.

[28]  G. De Nucci,et al.  Modulation of coronary flow and cardiomyocyte size by sensory fibers. , 1999, Hypertension.

[29]  L. Gille,et al.  Effect of alpha-lipoic acid and dihydrolipoic acid on ischemia/reperfusion injury of the heart and heart mitochondria. , 1995, Biochimica et biophysica acta.

[30]  E. Stadtman,et al.  Modification of histidine residues in proteins by reaction with 4-hydroxynonenal. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[31]  V. Jaquet,et al.  Reactive oxygen species in myocardial reperfusion injury: from physiopathology to therapeutic approaches. , 2012, Current pharmaceutical biotechnology.

[32]  L. Rochette,et al.  Antioxidant properties of alpha-lipoic acid: effects on red blood membrane permeability and adaptation of isolated rat heart to reversible ischemia , 2008, Molecular and Cellular Biochemistry.

[33]  P. Hjemdahl,et al.  Pharmacological Prevention of Reperfusion Injury in Acute Myocardial Infarction , 2004, American journal of cardiovascular drugs : drugs, devices, and other interventions.