Role of Nrf2 in Fracture Healing: Clinical Aspects of Oxidative Stress

[1]  G. Filippatos,et al.  2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. , 2019, European heart journal.

[2]  C. Trautwein,et al.  Nrf2 Ameliorates DDC-Induced Sclerosing Cholangitis and Biliary Fibrosis and Improves the Regenerative Capacity of the Liver. , 2019, Toxicological sciences : an official journal of the Society of Toxicology.

[3]  A. Nussler,et al.  Nicotine and Cotinine Inhibit Catalase and Glutathione Reductase Activity Contributing to the Impaired Osteogenesis of SCP-1 Cells Exposed to Cigarette Smoke , 2018, Oxidative medicine and cellular longevity.

[4]  P. Machura,et al.  Premature ovarian insufficiency – hormone replacement therapy and management of long-term consequences , 2018, Przeglad menopauzalny = Menopause review.

[5]  Hongtao Li,et al.  Lutein Suppresses Oxidative Stress and Inflammation by Nrf2 Activation in an Osteoporosis Rat Model , 2018, Medical science monitor : international medical journal of experimental and clinical research.

[6]  K. Kharbanda,et al.  N‐Acetyl Cysteine Treatment Restores Early Phase Fracture Healing in Ethanol‐Fed Rats , 2018, Alcoholism, clinical and experimental research.

[7]  Takafumi Suzuki,et al.  Hyperactivation of Nrf2 leads to hypoplasia of bone in vivo , 2018, Genes to cells : devoted to molecular & cellular mechanisms.

[8]  S. Stock,et al.  Alcohol exposure decreases osteopontin expression during fracture healing and osteopontin-mediated mesenchymal stem cell migration in vitro , 2018, Journal of Orthopaedic Surgery and Research.

[9]  G. Kerckhofs,et al.  The Impact of Type 2 Diabetes on Bone Fracture Healing , 2018, Front. Endocrinol..

[10]  M. Granke,et al.  Chronic alcohol abuse in men alters bone mechanical properties by affecting both tissue mechanical properties and microarchitectural parameters. , 2017, Morphologie : bulletin de l'Association des anatomistes.

[11]  M. Brandi,et al.  Oxidative stress in bone remodeling: role of antioxidants. , 2017, Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases.

[12]  M. Fendt,et al.  Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease , 2017, Redox biology.

[13]  M. D. Sousa Neto,et al.  Exposure to Secondhand Smoke Impairs Fracture Healing in Rats , 2017, Clinical orthopaedics and related research.

[14]  G. McCabe,et al.  Nrf2 regulates mass accrual and the antioxidant endogenous response in bone differently depending on the sex and age , 2017, PloS one.

[15]  R. Natoli,et al.  Alcohol‐related deficient fracture healing is associated with activation of FoxO transcription factors in mice , 2016, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[16]  P. Aswath,et al.  Amorphous Silica: A New Antioxidant Role for Rapid Critical‐Sized Bone Defect Healing , 2016, Advanced healthcare materials.

[17]  Y. Şirin,et al.  The effects of supplemental melatonin administration on the healing of bone defects in streptozotocin-induced diabetic rats , 2016, Journal of applied oral science : revista FOB.

[18]  Y. Kan,et al.  Nrf2 in health and disease: current and future clinical implications. , 2015, Clinical science.

[19]  A. Bullock,et al.  Structural basis of Keap1 interactions with Nrf2 , 2015, Free radical biology & medicine.

[20]  Jiliang Li,et al.  Role of Nrf2 in bone metabolism , 2015, Journal of Biomedical Science.

[21]  Leijiao Li,et al.  Deletion of Nrf2 reduces skeletal mechanical properties and decreases load-driven bone formation. , 2015, Bone.

[22]  Jean X. Jiang,et al.  Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal aging and bone diseases , 2015, Journal of Bone and Mineral Metabolism.

[23]  F. Hölzle,et al.  Nrf2 augments skeletal muscle regeneration after ischaemia–reperfusion injury , 2014, The Journal of pathology.

[24]  S. Biswal,et al.  Nrf2 is required for normal postnatal bone acquisition in mice , 2014, Bone Research.

[25]  Y. Kan,et al.  Nrf2 Deficiency Impairs Fracture Healing in Mice , 2014, Calcified Tissue International.

[26]  A. Cuadrado,et al.  Effects of Nrf2 Deficiency on Bone Microarchitecture in an Experimental Model of Osteoporosis , 2014, Oxidative medicine and cellular longevity.

[27]  D. Chen,et al.  Delayed Fracture Healing and Increased Callus Adiposity in a C57BL/6J Murine Model of Obesity-Associated Type 2 Diabetes Mellitus , 2014, PloS one.

[28]  Hong-Hee Kim,et al.  Nrf2 is a novel regulator of bone acquisition. , 2014, Bone.

[29]  Y. Kan,et al.  Nrf2 Protects Against TWEAK-mediated Skeletal Muscle Wasting , 2014, Scientific Reports.

[30]  K. Alberti,et al.  Diagnosis and Classification of Diabetes Mellitus , 2013, Diabetes Care.

[31]  W. Jeong,et al.  Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation. , 2013, Free radical biology & medicine.

[32]  T. Kodama,et al.  The Keap1/Nrf2 Protein Axis Plays a Role in Osteoclast Differentiation by Regulating Intracellular Reactive Oxygen Species Signaling* , 2013, The Journal of Biological Chemistry.

[33]  R. Palmer,et al.  The effect of smoking on bone healing , 2013, Bone & joint research.

[34]  M. Freeman,et al.  Loss of Nrf2 accelerates ionizing radiation-induced bone loss by upregulating RANKL. , 2012, Free radical biology & medicine.

[35]  T. Pufe,et al.  Sulforaphane has opposing effects on TNF-alpha stimulated and unstimulated synoviocytes , 2012, Arthritis Research & Therapy.

[36]  Jiake Xu,et al.  An overview of the regulation of bone remodelling at the cellular level. , 2012, Clinical biochemistry.

[37]  A. Shuid,et al.  Effects of α‐tocopherol on the early phase of osteoporotic fracture healing , 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[38]  T. Pufe,et al.  Interplay between Vascular Endothelial Growth Factor (VEGF) and Nuclear Factor Erythroid 2-related Factor-2 (Nrf2) , 2011, The Journal of Biological Chemistry.

[39]  Rachel K Nauer,et al.  Antioxidant Therapy Attenuates Deficient Bone Fracture Repair Associated With Binge Alcohol Exposure , 2011, Journal of orthopaedic trauma.

[40]  C. Cooper,et al.  Osteoporosis: burden, health care provision and opportunities in the EU , 2011, Archives of osteoporosis.

[41]  Thomas A Einhorn,et al.  The biology of fracture healing. , 2011, Injury.

[42]  J. Okazaki,et al.  Characterization of Oxidative Stress Status during Diabetic Bone Healing , 2011, Cells Tissues Organs.

[43]  Masayuki Yamamoto,et al.  Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution , 2011, Genes to cells : devoted to molecular & cellular mechanisms.

[44]  P. O S I T I O N S T A T E M E N T,et al.  Diagnosis and Classification of Diabetes Mellitus , 2011, Diabetes Care.

[45]  Y. Kan,et al.  Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice , 2010, Annals of the rheumatic diseases.

[46]  I. Kim,et al.  Reactive Oxygen Species Generated by NADPH Oxidase 2 and 4 Are Required for Chondrogenic Differentiation* , 2010, The Journal of Biological Chemistry.

[47]  Won-Young Lee,et al.  Association of Oxidative Stress with Postmenopausal Osteoporosis and the Effects of Hydrogen Peroxide on Osteoclast Formation in Human Bone Marrow Cell Cultures , 2010, Calcified Tissue International.

[48]  A. Parfitt,et al.  What old means to bone , 2010, Trends in Endocrinology & Metabolism.

[49]  A. Mantalaris,et al.  Investigating the role of PDGF as a potential drug therapy in bone formation and fracture healing , 2009, Expert opinion on investigational drugs.

[50]  Y. Wittrant,et al.  Oxidative stress in bone remodelling and disease. , 2009, Trends in Molecular Medicine.

[51]  H. Fujii,et al.  Role of oxidative stress in diabetic bone disorder. , 2009, Bone.

[52]  Thomas Pufe,et al.  The systemic angiogenic response during bone healing , 2009, Archives of Orthopaedic and Trauma Surgery.

[53]  C. B. Pickett,et al.  The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress* , 2009, Journal of Biological Chemistry.

[54]  R. Eliakim,et al.  Nicotine modulates bone metabolism-associated gene expression in osteoblast cells , 2009, Journal of Bone and Mineral Metabolism.

[55]  D. Ornitz,et al.  Fibroblast growth factor expression during skeletal fracture healing in mice , 2009, Developmental dynamics : an official publication of the American Association of Anatomists.

[56]  Ayumi Kodama,et al.  Functional expression of β2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells , 2009, Journal of cellular physiology.

[57]  Patrick K. Strotman,et al.  Binge alcohol treatment of adolescent rats followed by alcohol abstinence is associated with site-specific differences in bone loss and incomplete recovery of bone mass and strength. , 2008, Alcohol.

[58]  E H Schemitsch,et al.  Fracture vascularity and bone healing: a systematic review of the role of VEGF. , 2008, Injury.

[59]  T. Pufe,et al.  Kavalactones Protect Neural Cells against Amyloid β Peptide-Induced Neurotoxicity via Extracellular Signal-Regulated Kinase 1/2-Dependent Nuclear Factor Erythroid 2-Related Factor 2 Activation , 2008, Molecular Pharmacology.

[60]  H. Fujii,et al.  Bone formation in spontaneously diabetic Torii-newly established model of non-obese type 2 diabetes rats. , 2008, Bone.

[61]  J. Cauley,et al.  Diabetes mellitus, bone mineral density, and fracture risk , 2007, Current opinion in endocrinology, diabetes, and obesity.

[62]  E. Ho,et al.  Impaired osteoinduction in a rat model for chronic alcohol abuse. , 2007, Bone.

[63]  Y. Toyama,et al.  Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification , 2007, The Journal of experimental medicine.

[64]  E. Hinoi,et al.  Nrf2 Negatively Regulates Osteoblast Differentiation via Interfering with Runx2-dependent Transcriptional Activation* , 2006, Journal of Biological Chemistry.

[65]  S. Giannini,et al.  Quantitative heel ultrasound in a population-based study in Italy and its relationship with fracture history: the ESOPO study , 2006, Osteoporosis International.

[66]  Donna D. Zhang.  Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway , 2006, Drug metabolism reviews.

[67]  D. Chakkalakal.  Alcohol-induced bone loss and deficient bone repair. , 2005, Alcoholism, clinical and experimental research.

[68]  M. Akhter,et al.  Bone Biomechanical Property Deterioration Due to Tobacco Smoke Exposure , 2005, Calcified Tissue International.

[69]  A. M. Phillips.  Overview of the fracture healing cascade. , 2005, Injury.

[70]  Ilangovan Ramachandran,et al.  Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats. , 2005, Clinica chimica acta; international journal of clinical chemistry.

[71]  M. Mcguire,et al.  Inhibition of bone repair in a rat model for chronic and excessive alcohol consumption. , 2005, Alcohol.

[72]  H. Yeler,et al.  Investigation of oxidative stress during fracture healing in the rats , 2005, Cell biochemistry and function.

[73]  H. Kroger,et al.  Smoking and fracture risk: a meta-analysis , 2005, Osteoporosis International.

[74]  Z. Werb,et al.  Matrix remodeling during endochondral ossification. , 2004, Trends in cell biology.

[75]  R. Carano,et al.  Angiogenesis and bone repair. , 2003, Drug discovery today.

[76]  Z. Urry,et al.  A crucial role for thiol antioxidants in estrogen-deficiency bone loss. , 2003, The Journal of clinical investigation.

[77]  Thomas A Einhorn,et al.  Fracture healing as a post‐natal developmental process: Molecular, spatial, and temporal aspects of its regulation , 2003, Journal of cellular biochemistry.

[78]  G. Schmidmaier,et al.  Quantitative measurement of the splice variants 120 and 164 of the angiogenic peptide vascular endothelial growth factor in the time flow of fracture healing: a study in the rat , 2002, Cell and Tissue Research.

[79]  H. Redmond,et al.  Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[80]  T. Baysal,et al.  Fracture healing and bone mass in rats fed on liquid diet containing ethanol. , 2002, Alcoholism, clinical and experimental research.

[81]  W. Puhl,et al.  Vascular endothelial growth factor stimulates chemotactic migration of primary human osteoblasts. , 2002, Bone.

[82]  J. Thompson,et al.  Acidic Fibroblast Growth Factor Signaling Inhibits Peroxynitrite‐Induced Death of Osteoblasts and Osteoblast Precursors , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[83]  F. Parhami,et al.  Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. , 2001, Free radical biology & medicine.

[84]  Susan R. Johnson,et al.  Osteoporosis prevention, diagnosis, and therapy. , 2001, JAMA.

[85]  H. Väänänen,et al.  The cell biology of osteoclast function. , 2000, Journal of cell science.

[86]  S. Seber,et al.  Oxidant status increased during fracture healing in rats. , 1999, Acta orthopaedica Scandinavica.

[87]  T A Einhorn,et al.  The cell and molecular biology of fracture healing. , 1998, Clinical orthopaedics and related research.

[88]  T. Einhorn,et al.  Programmed removal of chondrocytes during endochondral fracture healing , 1998, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[89]  H. Sies,et al.  Oxidative stress: oxidants and antioxidants , 1997, Experimental physiology.

[90]  D. Marsh,et al.  Inflammatory cells in normal human fracture healing. , 1994, Acta orthopaedica Scandinavica.

[91]  Mark E. Bolander,et al.  Regulation of Fracture Repair by Growth Factors , 1992, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[92]  D J Simmons,et al.  Fracture Healing Perspectives , 1985, Clinical orthopaedics and related research.

[93]  Louis C. Gerstenfeld,et al.  Fracture healing: mechanisms and interventions , 2015, Nature Reviews Rheumatology.

[94]  P. Ruzicka,et al.  The effect of chronic alcohol administration on bone mineral content and bone strength in male rats. , 2010, Physiological research.

[95]  Y. Hao,et al.  Quality of Healing Compared Between Osteoporotic Fracture and Normal Traumatic Fracture , 2007 .

[96]  G. Fuhrmann,et al.  Luteolin protects rat PC12 and C6 cells against MPP+ induced toxicity via an ERK dependent Keap1-Nrf2-ARE pathway. , 2007, Journal of neural transmission. Supplementum.

[97]  A A Siddiqui,et al.  Experimental analysis of screw hold as judged by operators v pullout strength. , 2005, Injury.

[98]  A. Patwardhan,et al.  The effects of binge alcohol exposure on bone resorption and biomechanical and structural properties are offset by concurrent bisphosphonate treatment. , 2004, Alcoholism, clinical and experimental research.

[99]  S. Ueng,et al.  Bone healing of tibial lengthening is delayed by cigarette smoking: study of bone mineral density and torsional strength on rabbits. , 1999, The Journal of trauma.