THE ACTIONS OF DIHYDROXYPHENYLALANINE AND DIHYDROXYPHENYLSERINE ON THE SLEEP‐WAKEFULNESS CYCLE OF THE RAT AFTER PERIPHERAL DECARBOXYLASE INHIBITION

1 The actions of dihydroxyphenylalanine (DOPA) and dihydroxyphenylserine (DOPS) were assessed on the sleep‐wakefulness cycle of male Wistar rats. 2 In comparative studies the extracerebral decarboxylase was inhibited with serinetrihydroxybenzylhydrazide (RO 4‐4602) before injection of DOPA or DOPS. 3 DOPA (80‐160 mg/kg, i.p.) with or without previous inhibition of the peripheral decarboxylase gave rise to an initial significant increase of slow wave activity, which may be related to a release of 5‐hydroxytryptamine. 4 During the subsequent 8 h sessions, DOPA significantly decreased slow wave sleep and rapid eye movement sleep (REM) and increased wakefulness. 5 DOPS (80‐160 mg/kg, i.p.) did not significantly modify the sleep‐wakefulness cycle apart from a decrease of the latency for the first REM episode after 160 mg/kg in the RO 4‐4602 pretreated animals.

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