Methyltransferase like 3 inhibition limits intrahepatic cholangiocarcinoma metabolic reprogramming and potentiates the efficacy of chemotherapy

[1]  Yufeng Shi,et al.  METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions , 2022, Nature Communications.

[2]  Wei Liu,et al.  METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis , 2022, Nature Cell Biology.

[3]  N. Pavlova,et al.  The hallmarks of cancer metabolism: Still emerging. , 2022, Cell metabolism.

[4]  D. Figeys,et al.  Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma. , 2021, Cancer cell.

[5]  Shinichi Nakagawa,et al.  NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis. , 2021, Cell metabolism.

[6]  Y. Zeng,et al.  DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis , 2021, Nature Communications.

[7]  B. Teh,et al.  Cholangiocarcinoma , 2021, Nature Reviews Disease Primers.

[8]  S. Yuan,et al.  Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma , 2021, Acta pharmaceutica Sinica. B.

[9]  N. Chandel,et al.  Cancer metabolism: looking forward , 2021, Nature Reviews. Cancer.

[10]  Chuan He,et al.  Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response , 2021, Nucleic acids research.

[11]  Andrew J. Bannister,et al.  Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia , 2021, Nature.

[12]  Q. Lan,et al.  The Emerging Roles of RNA m6A Methylation and Demethylation as Critical Regulators of Tumorigenesis, Drug Sensitivity, and Resistance , 2021, Cancer Research.

[13]  F. He,et al.  METTL3 restrains papillary thyroid cancer progression via m6A/c-Rel/IL-8 mediated neutrophils infiltration. , 2021, Molecular therapy : the journal of the American Society of Gene Therapy.

[14]  Lei Jiang,et al.  R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis. , 2021, Molecular cell.

[15]  C. Luo,et al.  Targeting p300/CBP Attenuates Hepatocellular Carcinoma Progression through Epigenetic Regulation of Metabolism , 2020, Cancer Research.

[16]  Jun Yu,et al.  RNA m6A methyltransferase METTL3 facilitates colorectal cancer by activating m6A-GLUT1-mTORC1 axis and is a therapeutic target. , 2020, Gastroenterology.

[17]  M. Matsuda,et al.  NFAT5 promotes oral squamous cell carcinoma progression in a hyperosmotic environment , 2020, Laboratory Investigation.

[18]  Juan Zhao,et al.  LncRNA TTN-AS1 promotes the progression of oral squamous cell carcinoma via miR-411-3p/NFAT5 axis , 2020, Cancer cell international.

[19]  Jionglong Su,et al.  m6A-Atlas: a comprehensive knowledgebase for unraveling the N6-methyladenosine (m6A) epitranscriptome , 2020, Nucleic Acids Res..

[20]  Raj Kumar,et al.  NFAT5, which protects against hypertonicity, is activated by that stress via structuring of its intrinsically disordered domain , 2020, Proceedings of the National Academy of Sciences.

[21]  Yingxuan Chen,et al.  Enterotoxigenic Bacteroides fragilis induces the stemness in colorectal cancer via upregulating histone demethylase JMJD2B , 2020, Gut microbes.

[22]  G. Gores,et al.  Cholangiocarcinoma 2020: the next horizon in mechanisms and management , 2020, Nature Reviews Gastroenterology & Hepatology.

[23]  Hongsheng Wang,et al.  N6-methyladenosine regulates glycolysis of cancer cells through PDK4 , 2020, Nature Communications.

[24]  T. Kouzarides,et al.  Role of RNA modifications in cancer , 2020, Nature Reviews Cancer.

[25]  G. Gores,et al.  Systemic therapies for intrahepatic cholangiocarcinoma. , 2020, Journal of hepatology.

[26]  Chuan He,et al.  N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription , 2020, Science.

[27]  Wei Liu,et al.  Transcription factor NFAT5 contributes to the glycolytic phenotype rewiring and pancreatic cancer progression via transcription of PGK1 , 2019, Cell Death & Disease.

[28]  R. Deberardinis,et al.  Mechanisms and Implications of Metabolic Heterogeneity in Cancer. , 2019, Cell metabolism.

[29]  Chuan He,et al.  Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers. , 2019, Molecular cell.

[30]  Hualiang Jiang,et al.  Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. , 2019, Cancer cell.

[31]  Xin Hu,et al.  Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer. , 2019, Cancer research.

[32]  C. Kanduri,et al.  FOXK1 and FOXK2 regulate aerobic glycolysis , 2019, Nature.

[33]  Hailing Shi,et al.  Transcriptome-wide reprogramming of N6-methyladenosine modification by the mouse microbiome , 2018, Cell Research.

[34]  S. Ramakrishna,et al.  NFAT5 promotes in vivo development of murine melanoma metastasis. , 2018, Biochemical and biophysical research communications.

[35]  Xinxiang Li,et al.  The FOXC1/FBP1 signaling axis promotes colorectal cancer proliferation by enhancing the Warburg effect , 2018, Oncogene.

[36]  Lai Wei,et al.  RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2 , 2018, Hepatology.

[37]  J. Steyaert,et al.  How the Warburg effect supports aggressiveness and drug resistance of cancer cells? , 2018, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

[38]  Jianjun Chen,et al.  RNA N6-methyladenosine modification in cancers: current status and perspectives , 2018, Cell Research.

[39]  G. Gores,et al.  Cholangiocarcinoma — evolving concepts and therapeutic strategies , 2018, Nature Reviews Clinical Oncology.

[40]  Stefan Hüttelmaier,et al.  Recognition of RNA N6-methyladenosine by IGF2BP Proteins Enhances mRNA Stability and Translation , 2018, Nature Cell Biology.

[41]  Francine E. Garrett-Bakelman,et al.  The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal and leukemia cells , 2017, Nature Medicine.

[42]  Quan P. Ly,et al.  MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. , 2017, Cancer cell.

[43]  Min Zhang,et al.  MICU1 drives glycolysis and chemoresistance in ovarian cancer , 2017, Nature Communications.

[44]  Chuan He,et al.  m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program. , 2017, Cancer cell.

[45]  Ran Elkon,et al.  Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation , 2017, Cell.

[46]  J. Qin,et al.  Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis , 2017, Hepatology.

[47]  Feng Liu,et al.  METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N6‐methyladenosine‐dependent primary MicroRNA processing , 2017, Hepatology.

[48]  Chuan He,et al.  Post-transcriptional gene regulation by mRNA modifications , 2016, Nature Reviews Molecular Cell Biology.

[49]  R. Gregory,et al.  The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. , 2016, Molecular cell.

[50]  Chuan He,et al.  N 6 -methyladenosine Modulates Messenger RNA Translation Efficiency , 2015, Cell.

[51]  W. Neuhofer,et al.  NFAT5-mediated expression of S100A4 contributes to proliferation and migration of renal carcinoma cells , 2014, Front. Physiol..

[52]  Gideon Rechavi,et al.  Gene expression regulation mediated through reversible m6A RNA methylation , 2014, Nature Reviews Genetics.

[53]  J. Geschwind,et al.  Tumor glycolysis as a target for cancer therapy: progress and prospects , 2013, Molecular Cancer.

[54]  Zhike Lu,et al.  m6A-dependent regulation of messenger RNA stability , 2013, Nature.

[55]  Mark Ravenhill Funding , 2013, The Practical Guide to Public Inquiries.

[56]  M. Kupiec,et al.  Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq , 2012, Nature.

[57]  Chi V. Dang,et al.  Otto Warburg's contributions to current concepts of cancer metabolism , 2011, Nature Reviews Cancer.