T 2 N 1 M 0 Non-Small Cell Lung Cancer : Surgery and Prognostic Factors

Stage II of the non-small cell lung cancer (NSCLC) classification system has undergone more change than any other stage during revisions. In the current system, stage IIb groups potentially resectable tumors that invade extrapulmonary structures and do not affect the lymph nodes (T3N0M0) together with tumors confined exclusively to the lung parenchyma, but with nonmediastinal lymph node involvement (T2N1MO).1 Several series of patients treated surgically for NSCLC classified as T2N1M0 showed the 5-year survival rate to be between 38% and 43.8%.2-6 Although studies on the impact of non-mediastinal lymph node involvement on survival do exist, they are few, and those focusing exclusively on tumors classified as T2N1M0 are even fewer.7 ORIGINAL ARTICLES

[1]  O. Solak,et al.  Prognostic significance of surgical-pathologic multiple-station N1 disease in non-small cell carcinoma of the lung. , 2004, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[2]  K. Yasumoto,et al.  Survival and characteristics of lymph node involvement in patients with N1 non-small cell lung cancer. , 2004, Lung cancer.

[3]  Bengt Bergman,et al.  Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. , 2004, The New England journal of medicine.

[4]  A. Marra,et al.  Pathologic N1 non-small cell lung cancer: correlation between pattern of lymphatic spread and prognosis. , 2003, The Journal of thoracic and cardiovascular surgery.

[5]  R. Tsuchiya,et al.  Prognosis and survival after resection for bronchogenic carcinoma based on the 1997 TNM-staging classification: the Japanese experience. , 2001, The Annals of thoracic surgery.

[6]  H. Asamura,et al.  Where is the boundary between N1 and N2 stations in lung cancer? , 2000, The Annals of thoracic surgery.

[7]  P. Goldstraw,et al.  Inter-observer variability in systematic nodal dissection: A comparison of European and Japanese nodal designation , 2000 .

[8]  J. Crowley,et al.  Induction chemotherapy before surgery for early-stage lung cancer: A novel approach. Bimodality Lung Oncology Team. , 2000, The Journal of thoracic and cardiovascular surgery.

[9]  A. Dujon,et al.  Prognostic significance of surgical-pathologic N1 disease in non-small cell carcinoma of the lung. , 1999, The Annals of thoracic surgery.

[10]  R. Porta,et al.  Normativa actualizada (1998) sobre diagnóstico y estadifícación del carcinoma broncogénico , 1998 .

[11]  A. Sakurada,et al.  Prognostic assessment of 1310 patients with non-small-cell lung cancer who underwent complete resection from 1980 to 1993. , 1998, The Journal of thoracic and cardiovascular surgery.

[12]  S. Burdett,et al.  Postoperative radiotherapy in non-small-cell lung cancer: systematic review and meta-analysis of individual patient data from nine randomised controlled trials , 1998, The Lancet.

[13]  R. Snijder,et al.  Lymph node type as a prognostic factor for survival in T2 N1 M0 non-small cell lung carcinoma. , 1997, The Annals of thoracic surgery.

[14]  Y. Ichinose,et al.  Surgical results and prognostic factors of pathologic N1 disease in non-small-cell carcinoma of the lung. Significance of N1 level: lobar or hilar nodes. , 1994, The Journal of thoracic and cardiovascular surgery.

[15]  V. Rusch,et al.  Survival after resection of stage II non-small cell lung cancer. , 1992, The Annals of thoracic surgery.

[16]  T. Naruke,et al.  Lymph node mapping and curability at various levels of metastasis in resected lung cancer. , 1978, The Journal of thoracic and cardiovascular surgery.

[17]  E. Lemarié,et al.  Preoperative chemotherapy followed by surgery compared with primary surgery in resectable stage I (except T1N0), II, and IIIa non-small-cell lung cancer. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[18]  P. Goldstraw,et al.  Inter-observer variability in systematic nodal dissection: comparison of European and Japanese nodal designation. , 2002, The Annals of thoracic surgery.

[19]  J. Alarcón,et al.  Supervivencia posquirúrgica en el estadio II del carcinoma broncogénico no anaplásico de células pequeñas , 2001 .