Numerous adrenal chromaffin cell preparations fail to produce analgesic effects in the formalin test or in tests of acute pain even with nicotine stimulation

[1]  E. Buchser,et al.  Intrathecal implants of bovine chromaffin cells alleviate mechanical allodynia in a rat model of neuropathic pain , 1998, Pain.

[2]  J. Sagen,et al.  Attenuation of formalin pain responses in the rat by adrenal medullary transplants in the spinal subarachnoid space , 1997, Pain.

[3]  E. Doherty,et al.  Intraventricular encapsulated calf adrenal chromaffin cells: viable for at least 500 days in vivo without detectable adverse effects on behavioral/cognitive function or host immune sensitization in rats. , 1997, Restorative neurology and neuroscience.

[4]  A. Hama,et al.  Alterations in rat spinal cord cGMP by peripheral nerve injury and adrenal medullary transplantation , 1996, Neuroscience Letters.

[5]  K. Czech,et al.  Bovine Chromaffin Cells for CNS Transplantation do not Elicit Xenogeneic T Cell Proliferative Responses in Vitro , 1996 .

[6]  J. Sagen,et al.  Attenuation of pain-related hyperventilation in adjuvant arthritic rats with adrenal medullary transplants in the spinal subarachnoid space , 1995, Pain.

[7]  A. Hama,et al.  Alleviation of neuropathic pain symptoms by xenogeneic chromaffin cell grafts in the spinal subarachnoid space , 1994, Brain Research.

[8]  Hong Wang,et al.  Absence of appreciable tolerance and morphine cross-tolerance in rats with adrenal medullary transplants in the spinal cord , 1994, Neuropharmacology.

[9]  A. Hama,et al.  Induction of spinal NADPH-diaphorase by nerve injury is attenuated by adrenal medullary transplants , 1994, Brain Research.

[10]  J. Sagen,et al.  Neuropeptide and Catecholamine Delivery to Central Nervous System by Implanted Chromaffin Cells , 1994 .

[11]  P. Tresco,et al.  Transplants of immunologically isolated xenogeneic chromaffin cells provide a long-term source of pain-reducing neuroactive substances , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[12]  A. Hama,et al.  Reduced pain-related behavior by adrenal medullary transplants in rats with experimental painful peripheral neuropathy , 1993, Pain.

[13]  J. Sagen,et al.  Survival and integration of bovine chromaffin cells transplanted into rat central nervous system without exogenous trophic factors , 1992, The Journal of comparative neurology.

[14]  J. Sagen,et al.  Short-Term Immunosuppression Enhances Long-Term Survival of Bovine Chromaffin Cell Xenografts in Rat Cns , 1992, Cell transplantation.

[15]  J. Sagen.  Chromaffin cell transplants for alleviation of chronic pain. , 1992, ASAIO journal.

[16]  M. Zurita,et al.  Chromaffin allografts into arachnoid of spinal cord reduce basal pain responses in rats. , 1991, Neuroreport.

[17]  Hong Wang,et al.  Adrenal Medullary Transplants Increase Spinal Cord Cerebrospinal Fluid Catecholamine Levels and Reduce Pain Sensitivity , 1991, Journal of neurochemistry.

[18]  J. Sagen,et al.  Host-graft relationships of isolated bovine chromaffin cells in rat periaqueductal grey , 1990, Journal of neurocytology.

[19]  Z. Seltzer,et al.  Subarachnoid spinal cord transplantation of adrenal medulla suppresses chronic neuropathic pain behavior in rats , 1990, Brain Research.

[20]  J. Sagen,et al.  Adrenal medullary implants in the rat spinal cord reduce nociception in a chronic pain model , 1990, Pain.

[21]  Hong Wang,et al.  Prolonged analgesia by enkephalinase inhibition in rats with spinal cord adrenal medullary transplants. , 1990, European journal of pharmacology.

[22]  J. Sagen,et al.  Increased levels of Met-enkephalin-like immunoreactivity in the spinal cord CSF of rats with adrenal medullary transplants , 1989, Brain Research.

[23]  J. Sagen,et al.  Pharmacologic consequences of the vascular permeability of chromaffin cell transplants in CNS pain modulatory regions , 1988, Experimental Neurology.

[24]  G. Pappas,et al.  Fine structural correlates of vascular permeability of chromaffin cell transplants in CNS pain modulatory regions , 1988, Experimental Neurology.

[25]  J. Sagen,et al.  The fine structure of chromaffin cell implants in the pain modulatory regions of the rat periaqueductal gray and spinal cord. , 1988, Progress in brain research.

[26]  J. Sagen,et al.  Morphological and Functional Correlates of Chromaffin Cell Transplants in CNS Pain Modulatory Regions a , 1987, Annals of the New York Academy of Sciences.

[27]  E. Azmitia,et al.  Cell and tissue transplantation into the adult brain , 1987, Neurobiology of Aging.

[28]  J. Sagen,et al.  Adrenal medullary tissue transplants in the rat spinal cord reduce pain sensitivity , 1986, Brain Research.

[29]  H. Pollard,et al.  Analgesia induced by isolated bovine chromaffin cells implanted in rat spinal cord. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[30]  M. Zimmermann,et al.  Ethical guidelines for investigations of experimental pain in conscious animals , 1983, Pain.