Preparation and evaluation of compressed coated tablets using polyelectrolyte complex for targeted delivery of anti-amoebic drug

An unwanted absorption of anti-amoebic drug at upper gastrointestinal tract (GIT) causes numerous side effects and requires higher doses to get therapeutic effect. The primary goal of this study was to develop a secnidazole colon targeted drug delivery system (CTDDS) employing compressed coated tablets (CCT) coated with polyelectrolyte complexes (PECs). The optimized PEC was formulated by using varying ratios of cationic and anionic polymers which have the ability to resist a wide range of pH environment from stomach to colon (acidic, neutral to basic). The in vitro release profile of drug was studied in various simulated physiological conditions i.e., gastric, intestinal and colonic environment. For in vivo evaluation, barium sulfate imaging x-ray technique was used to evaluate the transit behavior of formulation in GIT. The results obtained from physical evaluation have demonstrated uniform diameter, thickness, desired hardness (> 4 kg/cm 2 ), and friability (not more than 1.0%) . The Korsmeyer-Peppas model suggested the kinetics of drug release as ‘n> 0.89’ which indicates super case–II transport mechanism. In vivo images have confirmed that the tablet formulations were not disintegrated in the upper stomach and degraded in the colonic area.

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