ErbB receptors: from oncogenes to targeted cancer therapies.
暂无分享,去创建一个
Qiang Wang | A. Berezov | Geng Zhang | Hongtao Zhang | R. Murali | M. Greene | Q. Wang | Qiang Wang | J. Drebin | Ramachandran Murali | Alan Berezov | Mark I Greene | Jeffrey Drebin | Hongtao Zhang | Geng Zhang
[1] Patricia L. Harris,et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. , 2004, The New England journal of medicine.
[2] J. Mendelsohn,et al. Augmentation of a humanized Anti-HER2 mAb 4D5 induced growth inhibition by a human-mouse chimeric anti-EGF receptor mAb C225 , 1999, Oncogene.
[3] Y. Yarden,et al. Untangling the ErbB signalling network , 2001, Nature Reviews Molecular Cell Biology.
[4] Hong Ma,et al. Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways , 2002, Oncogene.
[5] R. Weinberg,et al. Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin. , 1979, Proceedings of the National Academy of Sciences of the United States of America.
[6] C R King,et al. Amplification of a novel v-erbB-related gene in a human mammary carcinoma. , 1985, Science.
[7] S. Gabriel,et al. EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy , 2004, Science.
[8] A. Berezov,et al. Disabling erbB receptors with rationally designed exocyclic mimetics of antibodies: structure-function analysis. , 2001, Journal of medicinal chemistry.
[9] M. A. Hardwicke,et al. Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers. , 2006, Cancer research.
[10] J. Rowley. A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining , 1973, Nature.
[11] A. Berezov,et al. AHNP-streptavidin: a tetrameric bacterially produced antibody surrogate fusion protein against p185her2/neu , 2006, Oncogene.
[12] William Pao,et al. Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[13] W. Denny,et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[14] W. Muller,et al. Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors. , 1994, Molecular and Cellular Biology.
[15] Patricia L. Harris,et al. Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[16] T. Ried,et al. Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu , 2002, Oncogene.
[17] P. Jänne,et al. The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. , 2006, Cancer cell.
[18] Krystal J Alligood,et al. A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib) , 2004, Cancer Research.
[19] R. Kobayashi,et al. Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells (Cancer Research (2005) 65, (11118-11128)) , 2008 .
[20] Ming Tan,et al. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. , 2004, Cancer cell.
[21] R. Wilson,et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[22] Cori Bargmann,et al. Oncogenic activation of the neu‐encoded receptor protein by point mutation and deletion. , 1988, The EMBO journal.
[23] R. Weinberg,et al. Inhibition of tumor growth by a monoclonal antibody reactive with an oncogene-encoded tumor antigen. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[24] T. Fleming,et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. , 2001, The New England journal of medicine.
[25] M. Fukuoka,et al. EKB-569, a new irreversible epidermal growth factor receptor tyrosine kinase inhibitor, with clinical activity in patients with non-small cell lung cancer with acquired resistance to gefitinib. , 2006, Lung cancer.
[26] M. J. van de Vijver,et al. Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene , 1987, Molecular and cellular biology.
[27] W. J. Brammar,et al. Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis. , 1987, Oncogene.
[28] R. Weinberg,et al. Monoclonal antibodies identify a cell-surface antigen associated with an activated cellular oncogene , 1984, Nature.
[29] Jürg Zimmermann,et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells , 1996, Nature Medicine.
[30] K. Lackey,et al. The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer. , 2001, Cancer research.
[31] L. Cantley,et al. A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling , 1994, Cell.
[32] E. Vitetta,et al. A Comparison of the in Vitro and in Vivo Activities of IgG and F(ab′)2 Fragments of a Mixture of Three Monoclonal Anti-Her-2 Antibodies , 2004, Clinical Cancer Research.
[33] M. Saif,et al. Panitumumab the first fully human monoclonal antibody: from the bench to the clinic , 2007, Anti-cancer drugs.
[34] A. Bridges,et al. A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. , 1994, Science.
[35] M. Greene,et al. Intermolecular association of the p185 neu protein and EGF receptor modulates EGF receptor function , 1990, Cell.
[36] Samuel Bouyain,et al. The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[37] Jun Yao,et al. Selective inhibition of ErbB2-overexpressing breast cancer in vivo by a novel TAT-based ErbB2-targeting signal transducers and activators of transcription 3-blocking peptide. , 2006, Cancer research.
[38] John Mendelsohn,et al. The EGF receptor family as targets for cancer therapy , 2000, Oncogene.
[39] J. Willson,et al. A novel mechanism of resistance to epidermal growth factor receptor antagonism in vivo. , 2007, Cancer research.
[40] V. Brown,et al. Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts , 1989, Cell.
[41] Robert A. Weinberg,et al. Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies , 1985, Cell.
[42] Jae-Hoon Kim,et al. Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains , 2002, Cell.
[43] S. Stein,et al. Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers. , 2007, Cancer research.
[44] R. Baserga. Oncogenes and the strategy of growth factors , 1994, Cell.
[45] L. Weiner,et al. Antibody constructs in cancer therapy , 2007, Cancer.
[46] T. Oyama,et al. Resistance to gefitinib , 2006, International Journal of Clinical Oncology.
[47] F. Cappuzzo,et al. Combination of EGFR gene copy number and protein expression predicts outcome for advanced non-small-cell lung cancer patients treated with gefitinib. , 2006, Annals of oncology : official journal of the European Society for Medical Oncology.
[48] Ryuji Kobayashi,et al. Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. , 2005, Cancer research.
[49] Hongtao Zhang,et al. A sensitive and high-throughput assay to detect low-abundance proteins in serum , 2006, Nature Medicine.
[50] N. Spector,et al. Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells , 2005, Oncogene.
[51] W. L. McGuire,et al. Prognostic factors for recurrence and survival in human breast cancer , 1987, Breast Cancer Research and Treatment.
[52] Makoto Katsumata,et al. Prevention of breast tumour development in vivo by downregulation of the p185neureceptor , 1995, Nature Medicine.
[53] H. Stein,et al. Discordant results obtained for different methods of HER-2/neu testing in breast cancer--a question of standardization, automation and timing. , 2004, The International journal of biological markers.
[54] L. Presta,et al. Humanization of an anti-p185HER2 antibody for human cancer therapy. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[55] A. Oza,et al. Multicenter, randomized phase II trial of oral CI-1033 for previously treated advanced ovarian cancer. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[56] P. Jeffrey,et al. Structural basis for inhibition of the epidermal growth factor receptor by cetuximab. , 2005, Cancer cell.
[57] R. Murali,et al. Shared antigenic epitopes and pathobiological functions of anti-p185(her2/neu) monoclonal antibodies. , 1999, Experimental and molecular pathology.
[58] M. Kraus,et al. Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas. , 1995, Oncogene.
[59] S. Ross,et al. Imaging tumors with an albumin-binding Fab, a novel tumor-targeting agent. , 2007, Cancer research.
[60] S. Muchmore,et al. Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin. , 2000, Molecular cell.
[61] M. Sliwkowski,et al. Structure of the Epidermal Growth Factor Receptor Kinase Domain Alone and in Complex with a 4-Anilinoquinazoline Inhibitor* , 2002, The Journal of Biological Chemistry.
[62] J. Baselga,et al. Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. , 2007, Journal of the National Cancer Institute.
[63] T. Ohmura,et al. Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells. , 2005, Cancer research.
[64] P. Nowell,et al. A minute chromosome in human chronic granulocytic leukemia , 1960 .
[65] M. Daidone,et al. Radiosensitization of human melanoma cells by ribozyme-mediated inhibition of survivin expression. , 2003, The Journal of investigative dermatology.
[66] N. Goldstein,et al. Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. , 1995, Clinical cancer research : an official journal of the American Association for Cancer Research.
[67] R. Neve,et al. Biological effects of anti-ErbB2 single chain antibodies selected for internalizing function. , 2001, Biochemical and biophysical research communications.
[68] F. Waldman,et al. Characterization and chromosomal instability of novel derived cell lines from a wt-erbB-2 transgenic mouse model. , 2003, Carcinogenesis.
[69] A. Ullrich,et al. Heregulin‐dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3. , 1995, The EMBO journal.
[70] Joon-Oh Park,et al. MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling , 2007, Science.
[71] M. Kraus,et al. Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[72] A. Berezov,et al. Disabling Receptor Ensembles with Rationally Designed Interface Peptidomimetics* , 2002, The Journal of Biological Chemistry.
[73] M. Meyerson,et al. Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[74] J. Kuriyan,et al. Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. , 1999, Molecular cell.
[75] G. Plowman,et al. Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[76] W. Dougall,et al. Intermolecular association and trans-phosphorylation of different neu-kinase forms permit SH2-dependent signaling and oncogenic transformation. , 1995, Oncogene.
[77] K. Shokat,et al. Escape from HER family tyrosine kinase inhibitor therapy by the kinase inactive HER3 , 2007, Nature.
[78] Donald M. O'Rourke,et al. Rationally designed anti-HER2/neu peptide mimetic disables P185HER2/neu tyrosine kinases in vitro and in vivo , 2000, Nature Biotechnology.
[79] M. Greene,et al. EGFR enhances Survivin expression through the phosphoinositide 3 (PI-3) kinase signaling pathway. , 2005, Experimental and molecular pathology.
[80] Chaohong Sun,et al. Solution structure of human survivin and its binding interface with Smac/Diablo. , 2005, Biochemistry.
[81] J. Mendelsohn,et al. Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors. , 1983, Molecular biology & medicine.
[82] Gavin MacBeath,et al. A quantitative protein interaction network for the ErbB receptors using protein microarrays , 2006, Nature.
[83] A. M. Stanley,et al. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab , 2003, Nature.
[84] R. Weinberg,et al. The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen , 1984, Nature.
[85] Edith A Perez,et al. Advances in adjuvant therapy for breast cancer. , 2006, Clinical advances in hematology & oncology : H&O.
[86] R. Tsien,et al. Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor , 1987, Nature.
[87] M. Meyerson,et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. , 2005, The New England journal of medicine.
[88] A. Ullrich,et al. p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor , 1989, Molecular and cellular biology.
[89] V. Brown,et al. Anti-receptor antibodies reverse the phenotype of cells transformed by two interacting proto-oncogene encoded receptor proteins. , 1990, Oncogene.
[90] E. Shaw,et al. Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[91] M. Greene,et al. Monoclonal antibodies reactive with distinct domains of the neu oncogene-encoded p185 molecule exert synergistic anti-tumor effects in vivo. , 1988, Oncogene.
[92] M. Daidone,et al. Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer , 2002, Cellular and Molecular Life Sciences CMLS.
[93] P. Leder,et al. A bifunctional targeted peptide that blocks HER-2 tyrosine kinase and disables mitochondrial function in HER-2-positive carcinoma cells. , 2005, Cancer research.
[94] Greg Yothers,et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. , 2005, The New England journal of medicine.
[95] L. Pustilnik,et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. , 1997, Cancer research.
[96] C. Heldin,et al. Dimerization of cell surface receptors in signal transduction , 1995, Cell.
[97] D. Davies,et al. Epidermal growth factor receptor tyrosine kinase. Investigation of catalytic mechanism, structure-based searching and discovery of a potent inhibitor. , 1994, Biochemical pharmacology.
[98] J. Baselga,et al. Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts. , 1993, Cancer research.
[99] W. Earnshaw,et al. Chromosomal passengers: the four-dimensional regulation of mitotic events , 2004, Chromosoma.
[100] E. D. de Vries,et al. Phase 1 study with BIBW 2992, an irreversible dual tyrosine kinase inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) in a 2 week on 2 week off schedule. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[101] C. Davis,et al. Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. , 2001, Critical reviews in oncology/hematology.
[102] W. Dougall,et al. Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[103] S. Harrison,et al. Crystal structures of c-Src reveal features of its autoinhibitory mechanism. , 1999, Molecular cell.
[104] P. Carter,et al. Differential responses of human tumor cell lines to anti-p185HER2 monoclonal antibodies , 1993, Cancer Immunology, Immunotherapy.
[105] Ming Tan,et al. ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells. , 2006, Cancer research.
[106] W. McGuire,et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. , 1987, Science.
[107] D. O’Rourke,et al. Conversion of a radioresistant phenotype to a more sensitive one by disabling erbB receptor signaling in human cancer cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[108] Robert L. Margolis,et al. Crystal Structure of Human Survivin Reveals a Bow Tie?Shaped Dimer with Two Unusual ?-Helical Extensions , 2000 .
[109] Hyun-soo Cho,et al. Structure of the Extracellular Region of HER3 Reveals an Interdomain Tether , 2002, Science.
[110] N. Hynes,et al. ErbB‐2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling , 1997, The EMBO journal.
[111] M. Dowsett,et al. Current Status of HER2 Testing , 2002, Oncology.
[112] Michael Kofler,et al. The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors. , 2003, Molecular cell.
[113] P. Depowski,et al. Loss of Expression of the PTEN Gene Protein Product Is Associated with Poor Outcome in Breast Cancer , 2001, Modern Pathology.
[114] Edouard C. Nice,et al. Crystal Structure of a Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor α , 2002, Cell.
[115] D. Weiner,et al. A point mutation in the neu oncogene mimics ligand induction of receptor aggregation , 1989, Nature.
[116] W. Muller,et al. Mutations affecting conserved cysteine residues within the extracellular domain of Neu promote receptor dimerization and activation. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[117] Lyndsay N Harris,et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.