Machine learning-based approaches to analyse and improve the diagnosis of endothelial dysfunction

Endothelial Dysfunction is achieving increasing importance, because it is strictly related to cardiovascular risks and it provides important prognostic data in addition to the classical ones. This paper introduces a machine learning approach for predicting Endothelial Dysfunction. The approach was applied and tested on a newly collected dataset, “Endothelial Dysfunction Dataset (EDD)” and several machine learning algorithms are compared. This method comprises features related to the anthropometric or pathological characteristics of the analysed subjects. The experiments yield high accuracy, demonstrating the effectiveness and suitability of the proposed approach.

[1]  Nick C Fox,et al.  Automatic classification of MR scans in Alzheimer's disease. , 2008, Brain : a journal of neurology.

[2]  The endothelial cell. , 1966, British medical journal.

[3]  Paolo Sernani,et al.  Exploring the ambient assisted living domain: a systematic review , 2017, J. Ambient Intell. Humaniz. Comput..

[4]  Wei Yang,et al.  Neighborhood Component Feature Selection for High-Dimensional Data , 2012, J. Comput..

[5]  Ming Dong,et al.  A study of the effectiveness of machine learning methods for classification of clinical interview fragments into a large number of categories , 2016, J. Biomed. Informatics.

[6]  G. Sesti,et al.  Heart rate affects endothelial function in essential hypertension , 2013, Internal and Emergency Medicine.

[7]  J. Kai,et al.  Can machine-learning improve cardiovascular risk prediction using routine clinical data? , 2017, PloS one.

[8]  Corinna Cortes,et al.  Support-Vector Networks , 1995, Machine Learning.

[9]  Aldo Franco Dragoni,et al.  Event Calculus Agent Minds Applied to Diabetes Monitoring , 2017, AAMAS Workshops.

[10]  Yonghong Peng,et al.  A novel feature selection approach for biomedical data classification , 2010, J. Biomed. Informatics.

[11]  Nello Cristianini,et al.  An Introduction to Support Vector Machines and Other Kernel-based Learning Methods , 2000 .

[12]  C. Stefanadis,et al.  The role of nitric oxide on endothelial function. , 2012, Current vascular pharmacology.

[13]  Emre Çomak,et al.  A decision support system based on support vector machines for diagnosis of the heart valve diseases , 2007, Comput. Biol. Medicine.

[14]  Xuegong Zhang,et al.  Recursive SVM feature selection and sample classification for mass-spectrometry and microarray data , 2006, BMC Bioinformatics.

[15]  J. Al Suwaidi,et al.  Endothelial Dysfunction: Cardiovascular Risk Factors, Therapy, and Outcome , 2005, Vascular health and risk management.

[16]  Emanuele Frontoni,et al.  Robotic platform for deep change detection for rail safety and security , 2017, 2017 European Conference on Mobile Robots (ECMR).

[17]  Emanuele Frontoni,et al.  Security issues for data sharing and service interoperability in eHealth systems: The Nu.Sa. test bed , 2014, 2014 International Carnahan Conference on Security Technology (ICCST).

[18]  Geoffrey E. Hinton,et al.  Neighbourhood Components Analysis , 2004, NIPS.

[19]  Ron Kohavi,et al.  A Study of Cross-Validation and Bootstrap for Accuracy Estimation and Model Selection , 1995, IJCAI.

[20]  J. Ross Quinlan,et al.  Induction of Decision Trees , 1986, Machine Learning.

[21]  Mohammad Khubeb Siddiqui,et al.  Application of data mining: Diabetes health care in young and old patients , 2013, J. King Saud Univ. Comput. Inf. Sci..

[22]  R. Geetha Ramani,et al.  Parkinson Disease Classification using Data Mining Algorithms , 2011 .

[23]  P. Spritzer,et al.  Menopause, estrogens, and endothelial dysfunction: current concepts. , 2007, Clinics.

[24]  W. Park,et al.  Endothelial Dysfunction: Clinical Implications in Cardiovascular Disease and Therapeutic Approaches , 2015, Journal of Korean medical science.

[25]  Ramon Luengo-Fernandez,et al.  European Cardiovascular Disease Statistics 2017 , 2012 .

[26]  G. Dumont,et al.  Assessing the incremental value of blood oxygen saturation (SpO(2)) in the miniPIERS (Pre-eclampsia Integrated Estimate of RiSk) Risk Prediction Model. , 2015, Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC.

[27]  Thomas A. Darden,et al.  Gene selection for sample classification based on gene expression data: study of sensitivity to choice of parameters of the GA/KNN method , 2001, Bioinform..

[28]  Emanuele Frontoni,et al.  Visual and Textual Sentiment Analysis of Brand-Related Social Media Pictures Using Deep Convolutional Neural Networks , 2017, ICIAP.

[29]  A. Bachelor GLOSSARY OF TERMS GLOSSARY OF TERMS , 2010 .

[30]  Stan Szpakowicz,et al.  Beyond Accuracy, F-Score and ROC: A Family of Discriminant Measures for Performance Evaluation , 2006, Australian Conference on Artificial Intelligence.

[31]  D. Dvir,et al.  Pulse pressure is a predictor of vascular endothelial function in middle-aged subjects with no apparent heart disease , 2010, Vascular medicine.

[32]  Giorgio C. Buttazzo,et al.  Non-intrusive Patient Monitoring for Supporting General Practitioners in Following Diseases Evolution , 2015, IWBBIO.

[33]  Luca Romeo,et al.  A Hidden Semi-Markov Model based approach for rehabilitation exercise assessment , 2018, J. Biomed. Informatics.

[34]  Leo Breiman,et al.  Random Forests , 2001, Machine Learning.

[35]  Emanuele Frontoni,et al.  Mobile robot for retail surveying and inventory using visual and textual analysis of monocular pictures based on deep learning , 2017, 2017 European Conference on Mobile Robots (ECMR).

[36]  Xueguang Shao,et al.  Selecting significant genes by randomization test for cancer classification using gene expression data , 2013, J. Biomed. Informatics.

[37]  Arvind Kumar Tiwari,et al.  MACHINE LEARNING BASED APPROACHES FOR PREDICTION OF PARKINSON 'S DISEASE , 2016 .

[38]  Juan Carlos Kaski,et al.  Noninvasive Assessment of Endothelial Function in Clinical Practice , 2012 .

[39]  J. Keaney,et al.  The clinical implications of endothelial dysfunction. , 2003, Journal of the American College of Cardiology.

[40]  Lekha Bhambhu,et al.  DATA CLASSIFICATION USING SUPPORT VECTOR MACHINE , 2009 .

[41]  Reuben R. Shamir,et al.  Machine Learning Approach to Optimizing Combined Stimulation and Medication Therapies for Parkinson's Disease , 2015, Brain Stimulation.

[42]  Roberto Pierdicca,et al.  Automatic Classification for Anti Mixup Events in Advanced Manufacturing System , 2015 .

[43]  Dinggang Shen,et al.  Morphological classification of brains via high-dimensional shape transformations and machine learning methods , 2004, NeuroImage.

[44]  Richard O. Duda,et al.  Pattern classification and scene analysis , 1974, A Wiley-Interscience publication.