Hyperthermia adds to chemotherapy.

[1]  F. Valeriote,et al.  Synergistic interaction of anticancer agents: a cellular perspective. , 1975, Cancer chemotherapy reports.

[2]  J W Gray,et al.  Effects of hyperthermia on survival and progression of Chinese hamster ovary cells. , 1978, Cancer research.

[3]  R Blumenthal,et al.  Design of liposomes for enhanced local release of drugs by hyperthermia. , 1978, Science.

[4]  D. Deen,et al.  Isobologram analysis of X-ray--BCNU interactions in vitro. , 1979, Radiation research.

[5]  G. Hahn.  Potential for therapy of drugs and hyperthermia. , 1979, Cancer research.

[6]  K. Henle,et al.  Arrhenius analysis of heat survival curves from normal and thermotolerant CHO cells. , 1979, Radiation research.

[7]  J. Marmor.  Interactions of hyperthermia and chemotherapy in animals. , 1979, Cancer research.

[8]  D. Kaufman,et al.  Cycle-related toxicity and transformation in 10T1/2 cells treated with N-methyl-N'-nitro-N-nitrosoguanidine. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[9]  J. Bertram,et al.  Differential cell cycle phase specificity for neoplastic transformation and mutation to ouabain resistance induced by N-methyl-N'-nitro-N-nitrosoguanidine in synchronized C3H10T 1/2 C18 cells. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[10]  J. Bull.  An update on the anticancer effects of a combination of chemotherapy and hyperthermia. , 1984, Cancer research.

[11]  R. Engelhardt.  Hyperthermia and drugs. , 1987, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[12]  J. Ellis.  Proteins as molecular chaperones , 1987, Nature.

[13]  O. Dahl.  Interaction of hyperthermia and chemotherapy. , 1988, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[14]  P. Okunieff,et al.  Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. , 1989, Cancer research.

[15]  E. Hall,et al.  Interaction of heat with X-rays and cis-platinum; cell lethality and oncogenic transformation. , 1989, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[16]  J. Kerr,et al.  Cell death induced in a murine mastocytoma by 42-47 degrees C heating in vitro: evidence that the form of death changes from apoptosis to necrosis above a critical heat load. , 1990, International journal of radiation biology.

[17]  M. Dewhirst,et al.  Relationships among tumor temperature, treatment time, and histopathological outcome using preoperative hyperthermia with radiation in soft tissue sarcomas. , 1992, International journal of radiation oncology, biology, physics.

[18]  R. Morimoto,et al.  Cells in stress: transcriptional activation of heat shock genes. , 1993, Science.

[19]  U. Göbel,et al.  Regionale Hyperthermie mit systemischer Chemotherapie bei Kindern und Jugendlichen: Durchführbarkeit und klinische Verläufe bei 34 intensiv vorbehandelten Patienten mit prognostisch ungünstigen Tumorerkrankungen , 1993 .

[20]  M. Dewhirst.  Future directions in hyperthermia biology. , 1994, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[21]  R. Hamazoe,et al.  Intraperitoneal thermochemotherapy for prevention of peritoneal recurrence of gastric cancer. Final results of a randomized controlled study , 1994, Cancer.

[22]  T. Soussi,et al.  Cancer and the heat shock response. , 1994, European journal of cancer.

[23]  M. Amichetti,et al.  Report of long-term follow-up in a randomized trial comparing radiation therapy and radiation therapy plus hyperthermia to metastatic lymph nodes in stage IV head and neck patients. , 1994, International journal of radiation oncology, biology, physics.

[24]  E. Hall,et al.  Interaction of hyperthermia and chemotherapy agents; cell lethality and oncogenic potential. , 1994, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[25]  J. Haveman,et al.  Effect of hyperthermia on the cytotoxicity of 2′,2′‐difluorodeoxycytidine (gemcitabine) in cultured SW1573 cells , 1995, International journal of cancer.

[26]  J. Overgaard,et al.  Randomised trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastatic malignant melanoma , 1995, The Lancet.

[27]  Gabriele Multhoff,et al.  A stress‐inducible 72‐kDa heat‐shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells , 1995, International journal of cancer.

[28]  E. White,et al.  Life, death, and the pursuit of apoptosis. , 1996, Genes & development.

[29]  T. Otsuka,et al.  Hyperthermia induces apoptosis in malignant fibrous histiocytoma cells in vitro , 1996, International journal of cancer.

[30]  D Machin,et al.  Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. International Collaborative Hyperthermia Group. , 1996, International journal of radiation oncology, biology, physics.

[31]  D. Alberts,et al.  Intraperitoneal cisplatin plus intravenous cyclophosphamide versus intravenous cisplatin plus intravenous cyclophosphamide for stage III ovarian cancer. , 1996, The New England journal of medicine.

[32]  R. Rietbroek,et al.  Phase II trial of weekly locoregional hyperthermia and cisplatin in patients with a previously irradiated recurrent carcinoma of the uterine cervix , 1997, Cancer.

[33]  R. Issels,et al.  Heat shock protein 72 on tumor cells: a recognition structure for natural killer cells. , 1997, Journal of immunology.

[34]  S. Fujimoto,et al.  Improved mortality rate of gastric carcinoma patients with peritoneal carcinomatosis treated with intraperitoneal hyperthermic chemoperfusion combined with surgery , 1997, Cancer.

[35]  R. Wessalowski,et al.  Treatment Results in Children and Adolescents with loco-regional Recurrences of abdominal Germ Cell Tumors (GCTs): A Pilot-Study with PEI Chemotherapy and regional deep Hyperthermia (RHT) in Comparison to a matched Cohort* , 1997, Klinische Padiatrie.

[36]  K Messmer,et al.  Non-invasive temperature mapping using MRI: comparison of two methods based on chemical shift and T1-relaxation. , 1998, Magnetic resonance imaging.

[37]  J. MacFall,et al.  Magnetic resonance thermometry during hyperthermia for human high-grade sarcoma. , 1998, International journal of radiation oncology, biology, physics.

[38]  A. Melcher,et al.  Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression , 1998, Nature Medicine.

[39]  M. Caligiuri,et al.  Tumor cell apoptosis, lymphocyte recruitment and tumor vascular changes are induced by low temperature, long duration (fever‐like) whole body hyperthermia , 1998, Journal of cellular physiology.

[40]  A. Eggermont,et al.  Prophylactic isolated limb perfusion for localized, high-risk limb melanoma: results of a multicenter randomized phase III trial. European Organization for Research and Treatment of Cancer Malignant Melanoma Cooperative Group Protocol 18832, the World Health Organization Melanoma Program Trial 15, a , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[41]  G. Mann,et al.  Adult soft tissue sarcoma. , 1999, The Australian and New Zealand journal of surgery.

[42]  P. Sugarbaker,et al.  Results of Treatment of 385 Patients With Peritoneal Surface Spread of Appendiceal Malignancy , 1999, Annals of Surgical Oncology.

[43]  R. Issels,et al.  Estimated number of children with cancer eligible for hyperthermia based on population- and treatment-related criteria. , 1999, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[44]  J. Haveman,et al.  Effectiveness of 2',2'difluorodeoxycytidine (Gemcitabine) combined with hyperthermia in rat R-1 rhabdomyosarcoma in vitro and in vivo. , 1999, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[45]  J. Verweij,et al.  A phase I/II study of combined weekly systemic cisplatin and locoregional hyperthermia in patients with previously irradiated recurrent carcinoma of the uterine cervix , 1999, British Journal of Cancer.

[46]  Y. Nishimura,et al.  For the clinical application of thermochemotherapy given at mild temperatures. , 1999, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[47]  M. Reiser,et al.  MRT-gesteuerte regionale Tiefenhyperthermie , 1999, Der Radiologe.

[48]  W. Earnshaw,et al.  Induction of apoptosis by cancer chemotherapy. , 2000, Experimental cell research.

[49]  P. Srivastava,et al.  Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway. , 2000, International immunology.

[50]  D Needham,et al.  A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model. , 2000, Cancer research.

[51]  Nina Bhardwaj,et al.  Consequences of cell death: exposure to necrotic tumor cells , 2000 .

[52]  A. Hart,et al.  Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial , 2000, The Lancet.

[53]  J W Oosterhuis,et al.  A randomised phase II study on neo-adjuvant chemotherapy for 'high-risk' adult soft-tissue sarcoma. , 2001, European journal of cancer.

[54]  H. Kampinga,et al.  Hyperthermic radiosensitization: mode of action and clinical relevance , 2001, International journal of radiation biology.

[55]  B N Bundy,et al.  Phase III trial of standard-dose intravenous cisplatin plus paclitaxel versus moderately high-dose carboplatin followed by intravenous paclitaxel and intraperitoneal cisplatin in small-volume stage III ovarian carcinoma: an intergroup study of the Gynecologic Oncology Group, Southwestern Oncology Gr , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[56]  R. Issels,et al.  Hyperthermia in oncology. , 2001 .

[57]  K. Geisinger,et al.  Prospective Trial for the Treatment of Malignant Peritoneal Mesothelioma , 2001, The American surgeon.

[58]  O. S. Nielsen,et al.  A future for hyperthermia in cancer treatment? , 2001, European journal of cancer.

[59]  Peter J. S. Hutzler,et al.  Tumor-Derived Heat Shock Protein 70 Peptide Complexes Are Cross-Presented by Human Dendritic Cells1 , 2002, The Journal of Immunology.

[60]  Johannes Buchner,et al.  Molecular chaperones--cellular machines for protein folding. , 2002, Angewandte Chemie.

[61]  P. Wust,et al.  Hyperthermia in combined treatment of cancer. , 2002, The Lancet Oncology.

[62]  P. Wust,et al.  The cellular and molecular basis of hyperthermia. , 2002, Critical reviews in oncology/hematology.

[63]  P. Srivastava,et al.  Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses. , 2002, Annual review of immunology.

[64]  J. Zee,et al.  Heating the patient: a promising approach? , 2002 .

[65]  R. Issels,et al.  Heat shock protein 70: role in antigen presentation and immune stimulation , 2002, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[66]  E. Repasky,et al.  A phase I study of fever-range whole body hyperthermia (FR-WBH) in patients with advanced solid tumours: correlation with mouse models , 2002, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[67]  K. Flaherty,et al.  Unusual hematologic malignancies. Case 1. Hematologic malignancy presenting with diarrhea and bony lesions: systemic mastocytosis. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[68]  A. Eggermont,et al.  Current uses of isolated limb perfusion in the clinic and a model system for new strategies. , 2003, The Lancet. Oncology.

[69]  M. Reiser,et al.  MR-imaging changes of musculoskeletal soft-tissue sarcomas associated with neoadjuvant chemotherapy and hyperthermia , 2003, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[70]  H. van Tinteren,et al.  Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[71]  A. Salonia,et al.  Multicentric study comparing intravesical chemotherapy alone and with local microwave hyperthermia for prophylaxis of recurrence of superficial transitional cell carcinoma. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[72]  R. Willers,et al.  An Approach for Cure: PEI-Chemotherapy and Regional Deep Hyperthermia in Children and Adolescents with Unresectable Malignant Tumors , 2003, Klinische Padiatrie.

[73]  D. Jäger,et al.  A Systemic Hyperthermia Oncologic Working Group Trial , 2003, Oncology.

[74]  F. Gilly,et al.  Peritoneal carcinomatosis from digestive tract cancer: new management by cytoreductive surgery and intraperitoneal chemohyperthermia. , 2004, The Lancet. Oncology.

[75]  C. Gross,et al.  Treatment of Colon and Lung Cancer Patients with ex Vivo Heat Shock Protein 70-Peptide-Activated, Autologous Natural Killer Cells , 2004, Clinical Cancer Research.

[76]  Peter Vaupel,et al.  Tumor microenvironmental physiology and its implications for radiation oncology. , 2004, Seminars in radiation oncology.

[77]  M. Fiegl,et al.  Ifosfamide, carboplatin and etoposide (ICE) as second-line regimen alone and in combination with regional hyperthermia is active in chemo-pre-treated advanced soft tissue sarcoma of adults , 2004, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[78]  M. Dellian,et al.  Novel Temperature-Sensitive Liposomes with Prolonged Circulation Time , 2004, Clinical Cancer Research.

[79]  D. Dix,et al.  Genomic Instability and Enhanced Radiosensitivity in Hsp70.1- and Hsp70.3-Deficient Mice , 2004, Molecular and Cellular Biology.

[80]  Chieko Azuma,et al.  Thermal Dose Is Related to Duration of Local Control in Canine Sarcomas Treated with Thermoradiotherapy , 2005, Clinical Cancer Research.

[81]  Zeljko Vujaskovic,et al.  Randomized trial of hyperthermia and radiation for superficial tumors. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[82]  P. Wust,et al.  Current status of radiant whole-body hyperthermia at temperatures >41.5°C and practical guidelines for the treatment of adults. The German ‘Interdisciplinary Working Group on Hyperthermia’ , 2005, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[83]  R. Jain.  Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy , 2005, Science.

[84]  Waldemar Wlodarczyk,et al.  Noninvasive magnetic resonance thermography of recurrent rectal carcinoma in a 1.5 Tesla hybrid system. , 2005, Cancer research.

[85]  H. Park,et al.  Implications of increased tumor blood flow and oxygenation caused by mild temperature hyperthermia in tumor treatment , 2005, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[86]  Daniel T. Fisher,et al.  Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism , 2006, Nature Immunology.

[87]  G. Multhoff,et al.  Control of Metastasized Pancreatic Carcinomas in SCID/Beige Mice with Human IL-2/TKD-Activated NK Cells1 , 2006, The Journal of Immunology.

[88]  M. Ogris,et al.  Temperature dependent gene expression induced by PNIPAM-based copolymers: potential of hyperthermia in gene transfer. , 2006, Bioconjugate chemistry.

[89]  Harm H. Kampinga,et al.  Cell biological effects of hyperthermia alone or combined with radiation or drugs: A short introduction to newcomers in the field , 2006, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[90]  W. Webb,et al.  Dynamics of heat shock factor association with native gene loci in living cells , 2006, Nature.

[91]  H. Rosing,et al.  Intraperitoneal chemotherapy with taxanes for ovarian cancer with peritoneal dissemination. , 2006, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[92]  Waldemar Wlodarczyk,et al.  Noninvasive magnetic resonance thermography of soft tissue sarcomas during regional hyperthermia , 2006, Cancer.

[93]  M. Löbrich,et al.  Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status. , 2007, Cancer research.

[94]  S. Kalnicki,et al.  Localized hyperthermia combined with intratumoral dendritic cells induces systemic antitumor immunity. , 2007, Cancer research.

[95]  J. Blay,et al.  Regional hyperthermia (RHT) improves response and survival when combined with systemic chemotherapy in the management of locally advanced, high grade soft tissue sarcomas (STS) of the extremities, the body wall and the abdomen: A phase III randomised pros , 2007 .

[96]  Ernst Wagner,et al.  Programmed drug delivery: nanosystems for tumor targeting , 2007, Expert opinion on biological therapy.

[97]  D. Metzinger,et al.  Hyperthermic intraperitoneal chemotherapy in conjunction with surgery for the treatment of recurrent ovarian carcinoma. , 2007, Gynecologic oncology.

[98]  J. Blay,et al.  Adjuvant chemotherapy (CT) with doxorubicin and ifosfamide in resected soft tissue sarcoma (STS): Interim analysis of a randomised phase III trial , 2007 .

[99]  Martine Franckena,et al.  Long-term improvement in treatment outcome after radiotherapy and hyperthermia in locoregionally advanced cervix cancer: an update of the Dutch Deep Hyperthermia Trial. , 2008, International journal of radiation oncology, biology, physics.

[100]  R. Issels.  Regional hyperthermia in high-risk soft tissue sarcomas , 2008, Current opinion in oncology.

[101]  Regional hyperthermia (RHT) combined with gemcitabine (GEM) + cisplatin (CIS) in patients with GEM-refractory advanced pancreatic cancer: Results of the ESHO phase II trial , 2008 .

[102]  W. Dewey,et al.  Arrhenius relationships from the molecule and cell to the clinic , 2009, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.