Ultraviolet radiation-induced erythema in human skin.

We have evaluated UVR-induced erythema in previously unexposed buttock skin of volunteers of skin types I, II, III, and IV. Studies were done with solar-simulated radiation (SSR), UVB, and UVAI and we determined the just perceptible minimal erythema dose (MED) and, in some cases, quantified erythema with a reflectance device. The results show that there is a trend for increased SSR MED with skin type, with the MED of skin type IV being approximately twice that of skin type I, a smaller difference than one might have expected. However, there is a very considerable overlap of MED between skin types which shows that MED is a very poor indictor of skin type. Quantitative dose-response and time course studies with SSR and UVAI showed broadly similar responses when comparable MED-based exposures were given. We used our data to test the new concept of the standard erythema dose (SED) with two different erythema action spectra, and confirmed that the SED approach works with the different UVR sources that we studied.

[1]  C. Potten,et al.  The similarity of action spectra for thymine dimers in human epidermis and erythema suggests that DNA is the chromophore for erythema. , 1998, The Journal of investigative dermatology.

[2]  B. Diffey,et al.  Quantitative studies on UVA‐induced erythema in human skin , 1987, The British journal of dermatology.

[3]  J. C. Leun,et al.  TRANSMISSION OF UV‐RADIATION THROUGH HUMAN EPIDERMAL LAYERS AS A FACTOR INFLUENCING THE MINIMAL ERYTHEMA DOSE , 1984, Photochemistry and photobiology.

[4]  M. Fimiani,et al.  Phenotypic characters related to skin type and minimal erythemal dose. , 1987, Photo-dermatology.

[5]  T. Fitzpatrick The validity and practicality of sun-reactive skin types I through VI. , 1988, Archives of dermatology.

[6]  B. Diffey OBSERVED AND PREDICTED MINIMAL ERYTHEMA DOSES: A COMPARATIVE STUDY , 1994, Photochemistry and photobiology.

[7]  S. González,et al.  Erythema and melanogenesis action spectra in heavily pigmented individuals as compared to fair‐skinned Caucasians , 1996, Photodermatology, photoimmunology & photomedicine.

[8]  C. Potten,et al.  Tanning in Human Skin Types II and III Offers Modest Photoprotection Against Erythema , 1998, Photochemistry and photobiology.

[9]  C. Potten,et al.  Repeated ultraviolet exposure affords the same protection against DNA photodamage and erythema in human skin types II and IV but is associated with faster DNA repair in skin type IV. , 2002, The Journal of investigative dermatology.

[10]  R. Anderson,et al.  ERYTHEMA AND MELANOGENESIS ACTION SPECTRA OF NORMAL HUMAN SKIN * , 1982, Photochemistry and photobiology.

[11]  J. Chung,et al.  Relationship between skin phototype and MED in Korean, brown skin , 1997, Photodermatology, photoimmunology & photomedicine.

[12]  L. Rhodes,et al.  A comparison of the ultraviolet B-induced erythemal response of back and buttock skin. , 1992, Photodermatology, photoimmunology & photomedicine.

[13]  H. Tronnier,et al.  ACTION SPECTRUM FOR ERYTHEMA IN HUMANS INVESTIGATED WITH DYE LASERS , 1995, Photochemistry and photobiology.

[14]  C. Potten,et al.  Sensitivity to Sunburn Is Associated with Susceptibility to Ultraviolet Radiation–Induced Suppression of Cutaneous Cell–Mediated Immunity , 2000, The Journal of experimental medicine.

[15]  B L Diffey,et al.  Quantitative aspects of ultraviolet erythema. , 1991, Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics.

[16]  H. Muller,et al.  Ultraviolet light induced injury: Immunological and inflammatory effects , 2001, Immunology and cell biology.

[17]  B. Diffey,et al.  The onset of ultraviolet erythema , 1987, The British journal of dermatology.

[18]  B L Diffey,et al.  The standard erythema dose: a new photobiological concept , 1997, Photodermatology, photoimmunology & photomedicine.

[19]  C. Potten,et al.  The in situ repair kinetics of epidermal thymine dimers and 6-4 photoproducts in human skin types I and II. , 1996, The Journal of investigative dermatology.

[20]  B. Diffey,et al.  A portable instrument for quantifying erythema induced by ultraviolet radiation , 1984, The British journal of dermatology.

[21]  A. Chardon,et al.  Collaborative development of a sun protection factor test method: a proposed European Standard. COLIPA Task Force ‘Sun Protection Measurement’, Europe , 1996, International journal of cosmetic science.