Autophagy, molecular chaperones, and unfolded protein response as promoters of tumor recurrence

[1]  K. Yonemori,et al.  Ocular toxicity of investigational anti-cancer drugs in early phase clinical trials , 2022, Investigational New Drugs.

[2]  Yuzhen Gao,et al.  Understanding the role of Cripto-1 in cancer progression and therapeutic strategies , 2022, Clinical and Translational Oncology.

[3]  Q. Zhan,et al.  Liver tumour immune microenvironment subtypes and neutrophil heterogeneity , 2022, Nature.

[4]  P. Papageorgis,et al.  Regulation of Metastatic Tumor Dormancy and Emerging Opportunities for Therapeutic Intervention , 2022, International journal of molecular sciences.

[5]  Hongxi Xu,et al.  Osteoblasts and osteoclasts: an important switch of tumour cell dormancy during bone metastasis , 2022, Journal of Experimental & Clinical Cancer Research.

[6]  A. Bruselles,et al.  Analysis of Dormancy-Associated Transcriptional Networks Reveals a Shared Quiescence Signature in Lung and Colorectal Cancer , 2022, International journal of molecular sciences.

[7]  C. Richardson,et al.  Inhibition of IRE1α RNase activity sensitizes patient‐derived acute myeloid leukaemia cells to proteasome inhibitors , 2022, Journal of cellular and molecular medicine.

[8]  Takeshi Imamura,et al.  Cell–matrix interface regulates dormancy in human colon cancer stem cells , 2022, Nature.

[9]  A. Bardelli,et al.  A modified fluctuation-test framework characterizes the population dynamics and mutation rate of colorectal cancer persister cells , 2022, Nature Genetics.

[10]  G. Minchiotti,et al.  CRIPTO Is a Marker of Chemotherapy-Induced Stem Cell Expansion in Non-Small Cell Lung Cancer , 2022, Frontiers in Oncology.

[11]  J. Mazières,et al.  Early Steps of Resistance to Targeted Therapies in Non-Small-Cell Lung Cancer , 2022, Cancers.

[12]  G. M. Di Guglielmo,et al.  Autophagy regulates transforming growth factor β signaling and receptor trafficking. , 2022, Biochimica et biophysica acta. Molecular cell research.

[13]  Y. Ong,et al.  Natural HSP90 inhibitors as a potential therapeutic intervention in treating cancers: A comprehensive review. , 2022, Pharmacological research.

[14]  R. Austin,et al.  Scratching the Surface—An Overview of the Roles of Cell Surface GRP78 in Cancer , 2022, Biomedicines.

[15]  Jorge Morales-Valencia,et al.  The origins of cancer cell dormancy. , 2022, Current opinion in genetics & development.

[16]  Andrea Esposito,et al.  Resveratrol Contrasts IL-6 Pro-Growth Effects and Promotes Autophagy-Mediated Cancer Cell Dormancy in 3D Ovarian Cancer: Role of miR-1305 and of Its Target ARH-I , 2022, Cancers.

[17]  Huiying Yu,et al.  Mesenchymal Stem Cells and their Derived Exosomes Promote Malignant Phenotype of Polyploid Non-Small-Cell Lung Cancer Cells through AMPK Signaling Pathway , 2022, Analytical cellular pathology.

[18]  R. Liddington,et al.  SRC plays a specific role in the cross-talk between apoptosis and autophagy via phosphorylation of a novel regulatory site on AMPK. , 2022, Autophagy reports.

[19]  M. Pfaffl,et al.  The Chaperone Protein GRP78 Promotes Survival and Migration of Head and Neck Cancer After Direct Radiation Exposure and Extracellular Vesicle-Transfer , 2022, Frontiers in Oncology.

[20]  S. Zada,et al.  Autophagy-mediated degradation of NOTCH1 intracellular domain controls the epithelial to mesenchymal transition and cancer metastasis , 2022, Cell & bioscience.

[21]  B. Han,et al.  ATF6α promotes prostate cancer progression by enhancing PLA2G4A‐mediated arachidonic acid metabolism and protecting tumor cells against ferroptosis , 2022, The Prostate.

[22]  B. Reynolds,et al.  Slow-Cycling Cells in Glioblastoma: A Specific Population in the Cellular Mosaic of Cancer Stem Cells , 2022, bioRxiv.

[23]  J. Gestwicki,et al.  Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells , 2022, International journal of molecular sciences.

[24]  Yan Zhong,et al.  Overexpression of Eukaryotic translation initiation factor 3D induces stem cell-like properties and metastasis in cervix cancer by activating FAK through inhibiting degradation of GRP78 , 2022, Bioengineered.

[25]  C. Brennan,et al.  Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy. , 2022, Developmental cell.

[26]  R. Zhao,et al.  Single-cell RNA sequencing reveals a pro-invasive cancer-associated fibroblast subgroup associated with poor clinical outcomes in patients with gastric cancer , 2022, Theranostics.

[27]  Hyun-Ju Park,et al.  A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effects , 2022, Theranostics.

[28]  Shannon E. McCarthy,et al.  Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche , 2021, Cell.

[29]  OUP accepted manuscript , 2022, Journal of the National Cancer Institute.

[30]  M. Prince,et al.  Advancement in Cancer Stem Cell Biology and Precision Medicine—Review Article Head and Neck Cancer Stem Cell Plasticity and the Tumor Microenvironment , 2022, Frontiers in Cell and Developmental Biology.

[31]  Huanbai Xu,et al.  GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure , 2021, Cell Death & Disease.

[32]  C. Sander,et al.  Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer , 2021, Communications Biology.

[33]  I. Guzhova,et al.  The mTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy , 2021, Membranes.

[34]  K. Nickel,et al.  Mitophagy Induction by ROS-PINK1 Signaling Protects Head and Neck Cancer From Radiotherapy. , 2021, International journal of radiation oncology, biology, physics.

[35]  A. Sood,et al.  The life cycle of polyploid giant cancer cell and dormancy in cancer: opportunities for novel therapeutic interventions. , 2021, Seminars in cancer biology.

[36]  Marie Cohen,et al.  Linking cell-surface GRP78 to cancer: From basic research to clinical value of GRP78 antibodies. , 2021, Cancer letters.

[37]  R. Liddington,et al.  Cell adhesion suppresses autophagy via Src/FAK-mediated phosphorylation and inhibition of AMPK. , 2021, Cellular signalling.

[38]  Deokhoon Kim,et al.  Integrin αvβ3 Induces HSP90 Inhibitor Resistance via FAK Activation in KRAS-Mutant Non–Small Cell Lung Cancer , 2021, Cancer research and treatment.

[39]  Yi Lu,et al.  Role of HSP90 in Cancer , 2021, International journal of molecular sciences.

[40]  S. Gibson,et al.  Three dimensions of autophagy in regulating tumor growth: Cell survival/death, cell proliferation, and tumor dormancy. , 2021, Biochimica et biophysica acta. Molecular basis of disease.

[41]  D. Panigrahy,et al.  Debris-stimulated tumor growth: a Pandora’s box? , 2021, Cancer and Metastasis Reviews.

[42]  M. Kandušer,et al.  Targeting Autophagy Triggers Apoptosis and Complements the Action of Venetoclax in Chronic Lymphocytic Leukemia Cells , 2021, Cancers.

[43]  Jianguo Wang,et al.  The metabolic flexibility of quiescent CSC: implications for chemotherapy resistance , 2021, Cell Death & Disease.

[44]  A. Ballabio,et al.  Autophagy in major human diseases , 2021, The EMBO journal.

[45]  A. Regev,et al.  Cycling cancer persister cells arise from lineages with distinct programs , 2021, Nature.

[46]  Xiangxuan Zhao,et al.  The HSP90 inhibitor, XL888, enhanced cell apoptosis via downregulating STAT3 after insufficient radiofrequency ablation in hepatocellular carcinoma. , 2021, Life sciences.

[47]  N. Djouder,et al.  When dormancy fuels tumour relapse , 2021, Communications biology.

[48]  K. Payne.  Cellular Stress Responses and Metabolic Reprogramming in Cancer Progression and Dormancy. , 2021, Seminars in cancer biology.

[49]  A. Wieczorek,et al.  Inhibition of the Heat Shock Protein A (HSPA) Family Potentiates the Anticancer Effects of Manumycin A , 2021, Cells.

[50]  Pei-Ming Yang,et al.  PERK/ATF4-Dependent ZFAS1 Upregulation Is Associated with Sorafenib Resistance in Hepatocellular Carcinoma Cells , 2021, International journal of molecular sciences.

[51]  E. Chapman,et al.  Function, Therapeutic Potential, and Inhibition of Hsp70 Chaperones. , 2021, Journal of medicinal chemistry.

[52]  Ce Li,et al.  Immune Landscape of Gastric Carcinoma Tumor Microenvironment Identifies a Peritoneal Relapse Relevant Immune Signature , 2021, Frontiers in Immunology.

[53]  Cyrus M. Ghajar,et al.  Thorny ground, rocky soil: tissue-specific mechanisms of tumor dormancy and relapse. , 2021, Seminars in cancer biology.

[54]  A. D. Panopoulos,et al.  Cell surface GRP78 and Dermcidin cooperate to regulate breast cancer cell migration through Wnt signaling , 2021, Oncogene.

[55]  Huan Wang,et al.  Identification of Heat Shock Protein 90 as a Recurrence Related Marker in Juvenile Nasopharyngeal Angiofibroma , 2021, American journal of rhinology & allergy.

[56]  C. Perou,et al.  ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer , 2021, Nature Cancer.

[57]  D. Salomon,et al.  Cripto-1 as a Potential Target of Cancer Stem Cells for Immunotherapy , 2021, Cancers.

[58]  R. Clarke,et al.  Inhibition of Antiestrogen-Promoted Pro-Survival Autophagy and Tamoxifen Resistance in Breast Cancer through Vitamin D Receptor , 2021, Nutrients.

[59]  Sukanya Basu,et al.  Slow-Cycling (Dormant) Cancer Cells in Therapy Resistance, Cancer Relapse and Metastasis. , 2021, Seminars in cancer biology.

[60]  Amy S. Lee,et al.  Endoplasmic reticulum chaperone GRP78/BiP is critical for mutant Kras-driven lung tumorigenesis , 2021, Oncogene.

[61]  J. Chiu,et al.  Pathophysiological roles of cell surface and extracellular protein disulfide isomerase and their molecular mechanisms , 2021, British journal of pharmacology.

[62]  M. Manjili,et al.  Multifaceted functions of chronic inflammation in regulating tumor dormancy and relapse. , 2021, Seminars in cancer biology.

[63]  Eleni Fitsiou,et al.  Biological functions of therapy-induced senescence in cancer. , 2021, Seminars in cancer biology.

[64]  Ezanee Azlina Mohamad Hanif,et al.  Is targeting autophagy mechanism in cancer a good approach? The possible double-edge sword effect , 2021, Cell & bioscience.

[65]  D. Gozuacik,et al.  Autophagy and Cancer Dormancy , 2021, Frontiers in Oncology.

[66]  Yang Jiang,et al.  YAP promotes autophagy and progression of gliomas via upregulating HMGB1 , 2021, Journal of experimental & clinical cancer research : CR.

[67]  H. Russnes,et al.  Bone marrow NG2+/Nestin+ mesenchymal stem cells drive DTC dormancy via TGF-β2 , 2021, Nature Cancer.

[68]  K. Jacobson,et al.  Biological Evaluation of 5'-(N-Ethylcarboxamido)adenosine Analogues as Grp94-Selective Inhibitors. , 2021, ACS medicinal chemistry letters.

[69]  Lei Jin,et al.  Towards a Framework for Better Understanding of Quiescent Cancer Cells , 2021, Cells.

[70]  R. Bernards,et al.  Fighting Drug Resistance through the Targeting of Drug-Tolerant Persister Cells , 2021, Cancers.

[71]  Chunyan Xu,et al.  Overexpression of heat shock protein 70 inhibits epithelial-mesenchymal transition and cell migration induced by transforming growth factor-β in A549 cells , 2021, Cell Stress and Chaperones.

[72]  Yong Ma,et al.  Unfolded protein response in colorectal cancer , 2021, Cell & bioscience.

[73]  Sang Yeon Cho,et al.  Targeting YAP‐p62 signaling axis suppresses the EGFR‐TKI‐resistant lung adenocarcinoma , 2021, Cancer medicine.

[74]  M. Zavolan,et al.  Transcriptional Enhancer Factor Domain Family member 4 Exerts an Oncogenic Role in Hepatocellular Carcinoma by Hippo‐Independent Regulation of Heat Shock Protein 70 Family Members , 2021, Hepatology communications.

[75]  L. Ramenghi,et al.  Potential biomarkers of childhood brain tumor identified by proteomics of cerebrospinal fluid from extraventricular drainage (EVD) , 2021, Scientific Reports.

[76]  Jordan G Bryan,et al.  An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence. , 2021, Cancer cell.

[77]  Weidong Zhou,et al.  Ubiquitin-conjugating enzyme E2T promotes tumor stem cell characteristics and migration of cervical cancer cells by regulating the GRP78/FAK pathway , 2021, Open life sciences.

[78]  Ho-Yyoung Lee,et al.  Evodiamine inhibits both stem cell and non-stem-cell populations in human cancer cells by targeting heat shock protein 70 , 2021, Theranostics.

[79]  Afshin Samali,et al.  An Emerging Role for the Unfolded Protein Response in Pancreatic Cancer , 2021, Cancers.

[80]  Trevor J Pugh,et al.  Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy , 2021, Cell.

[81]  Stephen T. C. Wong,et al.  A Phase II Study of the Efficacy and Safety of Chloroquine in Combination With Taxanes in the Treatment of Patients With Advanced or Metastatic Anthracycline-refractory Breast Cancer. , 2020, Clinical breast cancer.

[82]  J. LoPiccolo,et al.  Combining Nelfinavir With Chloroquine Inhibits In Vivo Growth of Human Lung Cancer Xenograft Tumors , 2021, In Vivo.

[83]  Qi Zhao,et al.  Melatonin inhibiting the survival of human gastric cancer cells under ER stress involving autophagy and Ras‐Raf‐MAPK signalling , 2020, Journal of cellular and molecular medicine.

[84]  P. Zawierucha,et al.  Insight into Cisplatin-Resistance Signaling of W1 Ovarian Cancer Cells Emerges mTOR and HSP27 as Targets for Sensitization Strategies , 2020, International journal of molecular sciences.

[85]  Kesang Li,et al.  Rapamycin inhibits lung squamous cell carcinoma growth by downregulating glypican-3/Wnt/β-catenin signaling and autophagy , 2020, Journal of Cancer Research and Clinical Oncology.

[86]  J. van Rheenen,et al.  Targeting dormant tumor cells to prevent cancer recurrence , 2020, The FEBS journal.

[87]  Luigi Ombrato,et al.  Technical Advancements for Studying Immune Regulation of Disseminated Dormant Cancer Cells , 2020, Frontiers in Oncology.

[88]  C. Galassi,et al.  Tuning Cancer Fate: Tumor Microenvironment's Role in Cancer Stem Cell Quiescence and Reawakening , 2020, Frontiers in Immunology.

[89]  J. López-González,et al.  The Double-Edge Sword of Autophagy in Cancer: From Tumor Suppression to Pro-tumor Activity , 2020, Frontiers in Oncology.

[90]  B. Durden,et al.  Therapy Resistance, Cancer Stem Cells and ECM in Cancer: The Matrix Reloaded , 2020, Cancers.

[91]  Yeul-Hong Kim,et al.  HSP90 Inhibitor, 17-DMAG, Alone and in Combination with Lapatinib Attenuates Acquired Lapatinib-Resistance in ER-positive, HER2-Overexpressing Breast Cancer Cell Line , 2020, Cancers.

[92]  F. Kuonen,et al.  Targeting the Extra-Cellular Matrix—Tumor Cell Crosstalk for Anti-Cancer Therapy: Emerging Alternatives to Integrin Inhibitors , 2020, Frontiers in Oncology.

[93]  E. Wagner,et al.  Wnt signaling and Loxl2 promote aggressive osteosarcoma , 2020, Cell Research.

[94]  S. Leung,et al.  Differential expression and prognostic relevance of autophagy-related markers ATG4B, GABARAP, and LC3B in breast cancer , 2020, Breast Cancer Research and Treatment.

[95]  Hui Wang,et al.  Inhibition of autophagy by chloroquine enhances the antitumor activity of gemcitabine for gallbladder cancer , 2020, Cancer Chemotherapy and Pharmacology.

[96]  J. Aguirre-Ghiso,et al.  The current paradigm and challenges ahead for the dormancy of disseminated tumor cells , 2020, Nature Cancer.

[97]  Y. Shin,et al.  The ATF6-EGF Pathway Mediates the Awakening of Slow-Cycling Chemoresistant Cells and Tumor Recurrence by Stimulating Tumor Angiogenesis , 2020, Cancers.

[98]  E. Lam,et al.  Reciprocal regulation between GCN2 (eIF2AK4) and PERK (eIF2AK3) through the JNK-FOXO3 axis to modulate cancer drug resistance and clonal survival , 2020, Molecular and Cellular Endocrinology.

[99]  Yan Zhao,et al.  CD13 Induces Autophagy to Promote Hepatocellular Carcinoma Cell Chemoresistance Through the P38/Hsp27/CREB/ATG7 Pathway , 2020, The Journal of Pharmacology and Experimental Therapeutics.

[100]  T. Phan,et al.  The dormant cancer cell life cycle , 2020, Nature Reviews Cancer.

[101]  J. Cheong,et al.  ULK1 inhibition as a targeted therapeutic strategy for FLT3-ITD-mutated acute myeloid leukemia , 2020, Journal of experimental & clinical cancer research : CR.

[102]  S. Zubova,et al.  Molecular Chaperones and Proteolytic Machineries Regulate Protein Homeostasis in Aging Cells , 2020, Cells.

[103]  G. Berchem,et al.  Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti–PD-1/PD-L1 immunotherapy , 2020, Science Advances.

[104]  Jeong-Seok Nam,et al.  The force awakens: metastatic dormant cancer cells , 2020, Experimental & Molecular Medicine.

[105]  D. Gewirtz,et al.  Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy , 2020, Cancers.

[106]  W. L. Ruzzo,et al.  Metabolic Control over mTOR-Dependent Diapause-like State. , 2020, Developmental cell.

[107]  A. Giuliani,et al.  A pre-existing population of ZEB2+ quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer , 2020, Journal of Experimental & Clinical Cancer Research.

[108]  M. Whiteway,et al.  RNA sequencing reveals an additional Crz1-binding motif in promoters of its target genes in the human fungal pathogen Candida albicans , 2020, Cell Communication and Signaling.

[109]  Henry W. Long,et al.  Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. , 2020, Cancer cell.

[110]  Li Li,et al.  Heat shock protein 90 (Hsp90) Inhibitors: An Update on Achievements, Challenges, and Future Directions. , 2020, Journal of medicinal chemistry.

[111]  D. Barkan,et al.  Dormant disseminated tumor cells and cancer stem/progenitor-like cells: similarities and opportunities. , 2020, Seminars in cancer biology.

[112]  Gan Zhou,et al.  Targeted inhibition of ULK1 enhances daunorubicin sensitivity in acute myeloid leukemia. , 2019, Life sciences.

[113]  Amy M. Hurwitz,et al.  DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters. , 2019, Cell reports.

[114]  Yong He,et al.  Metformin‐sensitized NSCLC cells to osimertinib via AMPK‐dependent autophagy inhibition , 2019, The clinical respiratory journal.

[115]  A. Tichý,et al.  A Potent Autophagy Inhibitor (Lys05) Enhances the Impact of Ionizing Radiation on Human Lung Cancer Cells H1299 , 2019, International journal of molecular sciences.

[116]  A. Shibata,et al.  Combination of Anti-Cancer Drugs with Molecular Chaperone Inhibitors , 2019, International journal of molecular sciences.

[117]  R. Sanz-Pamplona,et al.  GRP94 promotes brain metastasis by engaging pro-survival autophagy. , 2019, Neuro-oncology.

[118]  Yuxin Bai,et al.  Autophagy promotes triple negative breast cancer metastasis via YAP nuclear localization. , 2019, Biochemical and biophysical research communications.

[119]  F. Francescangeli,et al.  Breast Cancer Stem Cells as Drivers of Tumor Chemoresistance, Dormancy and Relapse: New Challenges and Therapeutic Opportunities , 2019, Cancers.

[120]  Dongxia Yang,et al.  GRP78 activates the Wnt/HOXB9 pathway to promote invasion and metastasis of hepatocellular carcinoma by chaperoning LRP6. , 2019, Experimental cell research.

[121]  Yanqing Ding,et al.  KNK437 restricts the growth and metastasis of colorectal cancer via targeting DNAJA1/CDC45 axis , 2019, Oncogene.

[122]  J. Buchner,et al.  Structure, Function, and Regulation of the Hsp90 Machinery. , 2019, Cold Spring Harbor perspectives in biology.

[123]  S. Piccolo,et al.  Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ mechanotransduction , 2019, Proceedings of the National Academy of Sciences.

[124]  Ke-Chih Lin,et al.  Polyploid giant cancer cells: Unrecognized actuators of tumorigenesis, metastasis, and resistance , 2019, The Prostate.

[125]  F. Pinaud,et al.  GRP78 regulates CD44v membrane homeostasis and cell spreading in tamoxifen-resistant breast cancer , 2019, Life Science Alliance.

[126]  Xin-hua Liang,et al.  NR2F1 contributes to cancer cell dormancy, invasion and metastasis of salivary adenoid cystic carcinoma by activating CXCL12/CXCR4 pathway , 2019, BMC Cancer.

[127]  R. Verma,et al.  Simulated microgravity increases polyploid giant cancer cells and nuclear localization of YAP , 2019, Scientific Reports.

[128]  Amy S. Lee,et al.  The COOH-Terminal Proline-Rich Region of GRP78 Is a Key Regulator of Its Cell Surface Expression and Viability of Tamoxifen-Resistant Breast Cancer Cells☆ , 2019, Neoplasia.

[129]  F. Francescangeli,et al.  Stem Cell Plasticity and Dormancy in the Development of Cancer Therapy Resistance , 2019, Front. Oncol..

[130]  Yongsheng Fan,et al.  The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis , 2019, Nature Communications.

[131]  Nadinath B. Nillegoda,et al.  The Hsp70 chaperone network , 2019, Nature Reviews Molecular Cell Biology.

[132]  C. Glorieux,et al.  Targeting hsp90 family members: A strategy to improve cancer cell death. , 2019, Biochemical pharmacology.

[133]  Jun Guo,et al.  Overexpression of Hsc70 promotes proliferation, migration, and invasion of human glioma cells , 2019, Journal of cellular biochemistry.

[134]  H. Dahms,et al.  Unfolded Protein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells , 2019, International journal of molecular sciences.

[135]  Jianbo He,et al.  Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells. , 2019, Cell stem cell.

[136]  R. Bast,et al.  The role of vascular endothelial growth factor, interleukin 8, and insulinlike growth factor in sustaining autophagic DIRAS3‐induced dormant ovarian cancer xenografts , 2019, Cancer.

[137]  Ji Young Kim,et al.  C-terminal HSP90 inhibitor L80 elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition. , 2019, Cancer letters.

[138]  Tony Taldone,et al.  A Chemical Biology Approach to the Chaperome in Cancer-HSP90 and Beyond. , 2019, Cold Spring Harbor perspectives in biology.

[139]  Alexandra G. Smith,et al.  Autophagy, cancer stem cells and drug resistance , 2019, The Journal of pathology.

[140]  P. Cartron,et al.  Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer , 2019, Biochemical pharmacology.

[141]  B. Durden,et al.  ER stress sensor, glucose regulatory protein 78 (GRP78) regulates redox status in pancreatic cancer thereby maintaining “stemness” , 2019, Cell Death & Disease.

[142]  Yicheng Zhao,et al.  Blockage of SLC31A1‐dependent copper absorption increases pancreatic cancer cell autophagy to resist cell death , 2019, Cell proliferation.

[143]  Fabian J Theis,et al.  IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling , 2019, Nature Communications.

[144]  Sandra Healy,et al.  The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance , 2018, Biology of the cell.

[145]  Feixiang Wu,et al.  Starvation‐induced autophagy promotes the invasion and migration of human bladder cancer cells via TGF‐β1/Smad3‐mediated epithelial‐mesenchymal transition activation , 2018, Journal of cellular biochemistry.

[146]  P. Agostinis,et al.  Endoplasmic reticulum stress signalling – from basic mechanisms to clinical applications , 2018, The FEBS journal.

[147]  Yaling Tang,et al.  Cellular Phenotype Plasticity in Cancer Dormancy and Metastasis , 2018, Front. Oncol..

[148]  C. Yun,et al.  The Roles of Autophagy in Cancer , 2018, International journal of molecular sciences.

[149]  P. Lønning,et al.  NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients , 2018, Breast Cancer Research.

[150]  Xiao Fu,et al.  Cytoplasmic liver kinase B1 promotes the growth of human lung adenocarcinoma by enhancing autophagy , 2018, Cancer science.

[151]  Michael S. Goldberg,et al.  Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice , 2018, Science.

[152]  Y. Tzeng,et al.  Ovatodiolide suppresses yes-associated protein 1-modulated cancer stem cell phenotypes in highly malignant hepatocellular carcinoma and sensitizes cancer cells to chemotherapy in vitro. , 2018, Toxicology in vitro : an international journal published in association with BIBRA.

[153]  Anup M Oommen,et al.  Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy , 2018, Nature Communications.

[154]  Jian-ming Tan,et al.  Overexpression of ULK1 Represents a Potential Diagnostic Marker for Clear Cell Renal Carcinoma and the Antitumor Effects of SBI-0206965 , 2018, EBioMedicine.

[155]  D. Rubinsztein,et al.  Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis , 2018, Nature Communications.

[156]  Yibin Kang,et al.  Metastatic niche functions and therapeutic opportunities , 2018, Nature Cell Biology.

[157]  K. Wennerberg,et al.  Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib. , 2018, Cancer letters.

[158]  H. K. Blomhoff,et al.  cAMP-mediated autophagy inhibits DNA damage-induced death of leukemia cells independent of p53 , 2018, Oncotarget.

[159]  Yong Yu,et al.  Tumor suppressor LKB1 inhibits the progression of gallbladder carcinoma and predicts the prognosis of patients with this malignancy. , 2018, International journal of oncology.

[160]  H. Verspaget,et al.  CRIPTO promotes an aggressive tumour phenotype and resistance to treatment in hepatocellular carcinoma , 2018, The Journal of pathology.

[161]  C. Iacobuzio-Donahue,et al.  Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases , 2017, Science.

[162]  N. Aksenov,et al.  Discovery and optimization of cardenolides inhibiting HSF1 activation in human colon HCT-116 cancer cells , 2018, Oncotarget.

[163]  K. Hunter,et al.  Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence , 2018, Nature Communications.

[164]  S. Ghavami,et al.  Autophagy modulates transforming growth factor beta 1 induced epithelial to mesenchymal transition in non-small cell lung cancer cells. , 2018, Biochimica et biophysica acta. Molecular cell research.

[165]  K. Macleod,et al.  Functions of autophagy in the tumor microenvironment and cancer metastasis , 2018, The FEBS journal.

[166]  H. Bear,et al.  Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy , 2018, Oncotarget.

[167]  R. Weinberg,et al.  The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy , 2018, Science Translational Medicine.

[168]  C. K. Das,et al.  Pro-survival autophagy and cancer cell resistance to therapy , 2018, Cancer and Metastasis Reviews.

[169]  J. Aguirre-Ghiso,et al.  Emerging Topics on Disseminated Cancer Cell Dormancy and the Paradigm of Metastasis , 2018 .

[170]  Rajdeep Chowdhury,et al.  TGF-β2-induced EMT is dampened by inhibition of autophagy and TNF-α treatment , 2018, Oncotarget.

[171]  Sui Huang,et al.  Resolvins suppress tumor growth and enhance cancer therapy , 2018, The Journal of experimental medicine.

[172]  C. Hetz,et al.  The Unfolded Protein Response and Cell Fate Control. , 2017, Molecular cell.

[173]  S. Yun,et al.  Cripto Enhances Proliferation and Survival of Mesenchymal Stem Cells by Up-Regulating JAK2/STAT3 Pathway in a GRP78-Dependent Manner , 2017, Biomolecules & therapeutics.

[174]  Q. Gao,et al.  MicroRNA-30a suppresses autophagy-mediated anoikis resistance and metastasis in hepatocellular carcinoma. , 2018, Cancer letters.

[175]  R. Gomis,et al.  MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer , 2018, Nature Cell Biology.

[176]  Fei-hu Ji,et al.  Cisplatin-induced autophagy protects breast cancer cells from apoptosis by regulating yes-associated protein. , 2017, Oncology reports.

[177]  Elena Butturini,et al.  Metastatic Breast Cancer Cells Enter Into Dormant State and Express Cancer Stem Cells Phenotype Under Chronic Hypoxia , 2017, Journal of cellular biochemistry.

[178]  S. Chandarlapaty,et al.  A phase I trial of ganetespib in combination with paclitaxel and trastuzumab in patients with human epidermal growth factor receptor-2 (HER2)-positive metastatic breast cancer , 2017, Breast Cancer Research.

[179]  S. Akimoto,et al.  Cetuximab promotes SN38 sensitivity via suppression of heat shock protein 27 in colorectal cancer cells with wild-type RAS. , 2017, Oncology reports.

[180]  K. Pantel,et al.  Cancer stem cells: The root of tumor recurrence and metastases. , 2017, Seminars in cancer biology.

[181]  Junhong Zhang,et al.  SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways. , 2017, Oncology reports.

[182]  Chiara Riganti,et al.  PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy , 2017, Molecular Cancer.

[183]  E. White,et al.  Autophagy and Tumor Metabolism. , 2017, Cell metabolism.

[184]  I. Mercado-uribe,et al.  Dedifferentiation into blastomere-like cancer stem cells via formation of polyploid giant cancer cells , 2017, Oncogene.

[185]  P. Kloen,et al.  CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer , 2017, Oncogene.

[186]  Y. Shiozawa,et al.  Mer Tyrosine Kinase Regulates Disseminated Prostate Cancer Cellular Dormancy , 2017, Journal of cellular biochemistry.

[187]  A. Edkins,et al.  Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model , 2017, BMC Cancer.

[188]  Michael R. Padgen,et al.  Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments , 2017, Nature Cell Biology.

[189]  S. Westerheide,et al.  The Heat Shock Transcription Factor HSF1 Induces Ovarian Cancer Epithelial-Mesenchymal Transition in a 3D Spheroid Growth Model , 2016, PloS one.

[190]  Rainer Spang,et al.  Early dissemination seeds metastasis in breast cancer , 2016, Nature.

[191]  Jun S. Song,et al.  Inhibition of mTor induces a paused pluripotent state , 2016, Nature.

[192]  C. Eberhart,et al.  Targeting Notch Signaling and Autophagy Increases Cytotoxicity in Glioblastoma Neurospheres , 2016, Brain pathology.

[193]  J. Lee,et al.  Autophagy negatively regulates tumor cell proliferation through phosphorylation dependent degradation of the Notch1 intracellular domain , 2016, Oncotarget.

[194]  S. Larson,et al.  The epichaperome is an integrated chaperome network that facilitates tumour survival , 2016, Nature.

[195]  D. Prockop,et al.  Cancer cells enter dormancy after cannibalizing mesenchymal stem/stromal cells (MSCs) , 2016, Proceedings of the National Academy of Sciences.

[196]  F. Esposito,et al.  TRAP1 regulates stemness through Wnt/β-catenin pathway in human colorectal carcinoma , 2016, Cell Death and Differentiation.

[197]  Chang S. Chan,et al.  Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells , 2016, Genes & development.

[198]  David Balchin,et al.  In vivo aspects of protein folding and quality control , 2016, Science.

[199]  A. Vaseghi,et al.  Overexpression of molecular chaperons GRP78 and GRP94 in CD44hi/CD24lo breast cancer stem cells , 2016, BioImpacts : BI.

[200]  H. Zhang,et al.  Aurora kinase A revives dormant laryngeal squamous cell carcinoma cells via FAK/PI3K/Akt pathway activation , 2016, Oncotarget.

[201]  Wen-Chao Liu,et al.  BKCa promotes growth and metastasis of prostate cancer through facilitating the coupling between αvβ3 integrin and FAK , 2016, Oncotarget.

[202]  U. Manne,et al.  Targeting Hsp70: A possible therapy for cancer. , 2016, Cancer letters.

[203]  D. Tuveson,et al.  Title : Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis , 2016 .

[204]  S. Calderwood,et al.  Heat Shock Proteins Promote Cancer: It's a Protection Racket. , 2016, Trends in biochemical sciences.

[205]  Laura D. Healy,et al.  Heat shock protein 70 regulates platelet integrin activation, granule secretion and aggregation. , 2016, American journal of physiology. Cell physiology.

[206]  Bruce A. Posner,et al.  Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells , 2016, Nature Communications.

[207]  F. DeMayo,et al.  Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development , 2016, Oncotarget.

[208]  W. Huber,et al.  Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause , 2016, Cell.

[209]  Jun Luo,et al.  High level of αB-crystallin contributes to the progression of osteosarcoma , 2016, Oncotarget.

[210]  G. Nagaraju,et al.  Targeting the Janus-activated kinase-2-STAT3 signalling pathway in pancreatic cancer using the HSP90 inhibitor ganetespib. , 2016, European journal of cancer.

[211]  Li Zhou,et al.  Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer , 2015, Scientific Reports.

[212]  B. Tian,et al.  A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1/XBP1 , 2015, Oncotarget.

[213]  E. Guney,et al.  FN14 and GRP94 expression are prognostic/predictive biomarkers of brain metastasis outcome that open up new therapeutic strategies , 2015, Oncotarget.

[214]  Chih-Yang Wang,et al.  Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells , 2015, Nature.

[215]  M. Frame,et al.  p70S6K is regulated by focal adhesion kinase and is required for Src-selective autophagy , 2015, Cellular signalling.

[216]  Yibin Kang,et al.  Bone metastasis and the metastatic niche , 2015, Journal of Molecular Medicine.

[217]  Junwei Hou,et al.  Plasma membrane gp96 enhances invasion and metastatic potential of liver cancer via regulation of uPAR , 2015, Molecular oncology.

[218]  Yaoping Li,et al.  Overexpressed GRP78 affects EMT and cell-matrix adhesion via autocrine TGF-β/Smad2/3 signaling. , 2015, The international journal of biochemistry & cell biology.

[219]  Jiasheng Wang,et al.  Glucose-regulated protein 94 is a novel glioma biomarker and promotes the aggressiveness of glioma via Wnt/β-catenin signaling pathway , 2015, Tumor Biology.

[220]  P. Nelson,et al.  Cellular Adhesion Promotes Prostate Cancer Cells Escape from Dormancy , 2015, PloS one.

[221]  J. McGee,et al.  Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids , 2015, Oncotarget.

[222]  F. Ciccosanti,et al.  Oncogenic BRAF induces chronic ER stress condition resulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma , 2014, Cell Death and Differentiation.

[223]  Liang Zhao,et al.  The role of c-Src in the invasion and metastasis of hepatocellular carcinoma cells induced by association of cell surface GRP78 with activated α2M , 2015, BMC Cancer.

[224]  B. Pasquier.  SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells , 2015, Autophagy.

[225]  M. Todaro,et al.  Dynamic regulation of the cancer stem cell compartment by Cripto-1 in colorectal cancer , 2015, Cell Death and Differentiation.

[226]  K. Lauber,et al.  Tumor Biology: With a Little Help from My Dying Friends , 2015, Current Biology.

[227]  P. Panda,et al.  Mechanism of autophagic regulation in carcinogenesis and cancer therapeutics. , 2015, Seminars in cell & developmental biology.

[228]  F. DeMayo,et al.  Targeting the Glucose Regulated Protein-78 (GRP78) abrogates Pten-null driven AKT-activation and endometrioid tumorigenesis , 2015, Oncogene.

[229]  E. Bernstein,et al.  NR2F1 controls tumor cell dormancy via SOX9 and RARβ driven quiescence programs , 2014, Nature Communications.

[230]  Bo Yang,et al.  Stem cell characteristics of dormant cells and cisplatin‑induced effects on the stemness of epithelial ovarian cancer cells. , 2014, Molecular medicine reports.

[231]  John M. Asara,et al.  Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function , 2014, Nature.

[232]  W. Baumann,et al.  Knockdown of estrogen receptor‐α induces autophagy and inhibits antiestrogen‐mediated unfolded protein response activation, promoting ROS‐induced breast cancer cell death , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[233]  J. McGee,et al.  Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability. , 2014, Carcinogenesis.

[234]  P. Bragado,et al.  Mechanisms of disseminated cancer cell dormancy: an awakening field , 2014, Nature Reviews Cancer.

[235]  Marc L. Mendillo,et al.  The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy , 2014, Cell.

[236]  R. Bast,et al.  ARHI (DIRAS3) induces autophagy in ovarian cancer cells by downregulating the epidermal growth factor receptor, inhibiting PI3K and Ras/MAP signaling and activating the FOXo3a-mediated induction of Rab7 , 2014, Cell Death and Differentiation.

[237]  D. Levine,et al.  DIRAS3 regulates the autophagosome initiation complex in dormant ovarian cancer cells , 2014, Autophagy.

[238]  M. Ferrari,et al.  XBP1 Promotes Triple Negative Breast Cancer By Controlling the HIF1 α Pathway , 2014, Nature.

[239]  Baocun Sun,et al.  Generation of cancer stem-like cells through the formation of polyploid giant cancer cells , 2014, Oncogene.

[240]  M. Dong,et al.  GRP78 promotes the invasion of pancreatic cancer cells by FAK and JNK , 2014, Molecular and Cellular Biochemistry.

[241]  Jieqing Zhu,et al.  Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition , 2014, BMC Cancer.

[242]  Zongwei Li,et al.  GRP78 secreted by tumor cells stimulates differentiation of bone marrow mesenchymal stem cells to cancer-associated fibroblasts. , 2013, Biochemical and biophysical research communications.

[243]  Zai-quan Li,et al.  GRP78 mediates radiation resistance of a stem cell-like subpopulation within the MCF-7 breast cancer cell line. , 2013, Oncology reports.

[244]  J. T. Chang,et al.  Grp78 as a therapeutic target for refractory head–neck cancer with CD24−CD44+ stemness phenotype , 2013, Cancer Gene Therapy.

[245]  P. Bragado,et al.  TGFβ2 dictates disseminated tumour cell fate in target organs through TGFβ-RIII and p38α/β signalling , 2013, Nature Cell Biology.

[246]  J. Debnath,et al.  Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK , 2013, Oncogene.

[247]  S. Qiu,et al.  Autophagy inhibition suppresses pulmonary metastasis of HCC in mice via impairing anoikis resistance and colonization of HCC cells , 2013, Autophagy.

[248]  K. Pienta,et al.  TBK1 regulates prostate cancer dormancy through mTOR inhibition. , 2013, Neoplasia.

[249]  V. Carraro,et al.  The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression , 2013, Nucleic acids research.

[250]  Alfons Meindl,et al.  High expression of crystallin αB represents an independent molecular marker for unfavourable ovarian cancer patient outcome and impairs TRAIL‐ and cisplatin‐induced apoptosis in human ovarian cancer cells , 2013, International journal of cancer.

[251]  Mina J. Bissell,et al.  The perivascular niche regulates breast tumor dormancy , 2013, Nature Cell Biology.

[252]  Zi-fang Song,et al.  Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial-mesenchymal transition. , 2013, Carcinogenesis.

[253]  S. Pizzo,et al.  The monomeric receptor binding domain of tetrameric α2-macroglobulin binds to cell surface GRP78 triggering equivalent activation of signaling cascades. , 2013, Biochemistry.

[254]  A. Rosenwald,et al.  The Natural Human IgM Antibody PAT-SM6 Induces Apoptosis in Primary Human Multiple Myeloma Cells by Targeting Heat Shock Protein GRP78 , 2013, PloS one.

[255]  Zongwei Li,et al.  Cell-surface GRP78 facilitates colorectal cancer cell migration and invasion. , 2013, The international journal of biochemistry & cell biology.

[256]  Dianqing Wu,et al.  Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway , 2013, Proceedings of the National Academy of Sciences.

[257]  J. Frydman,et al.  The Cotranslational Function of Ribosome-Associated Hsp70 in Eukaryotic Protein Homeostasis , 2013, Cell.

[258]  C. Paraskeva,et al.  Autolysosomal β‐catenin degradation regulates Wnt‐autophagy‐p62 crosstalk , 2012, The EMBO journal.

[259]  B. Zhai,et al.  Blocking autophagy enhances the apoptosis effect of bufalin on human hepatocellular carcinoma cells through endoplasmic reticulum stress and JNK activation , 2013, Apoptosis.

[260]  Yaoh-Shiang Lin,et al.  Quercetin Suppresses Drug-Resistant Spheres via the p38 MAPK–Hsp27 Apoptotic Pathway in Oral Cancer Cells , 2012, PloS one.

[261]  A. Brivanlou,et al.  The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites , 2012, Cell.

[262]  L. Shewchuk,et al.  Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). , 2012, Journal of medicinal chemistry.

[263]  Marc L. Mendillo,et al.  HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers , 2012, Cell.

[264]  A. Causse,et al.  MAPK14/p38α confers irinotecan resistance to TP53-defective cells by inducing survival autophagy , 2012, Autophagy.

[265]  A. Sepulveda,et al.  Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency , 2012, Proceedings of the National Academy of Sciences.

[266]  T. Santhoshkumar,et al.  Identification of heat shock protein 90 inhibitors to sensitize drug resistant side population tumor cells using a cell based assay platform. , 2012, Cancer letters.

[267]  F. Hoogstra-Berends,et al.  Heat shock protein-inducing compounds as therapeutics to restore proteostasis in atrial fibrillation. , 2012, Trends in cardiovascular medicine.

[268]  D. Harrison,et al.  The Jak/STAT pathway. , 2012, Cold Spring Harbor perspectives in biology.

[269]  Owen J. Sansom,et al.  Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling , 2011, Nature Cell Biology.

[270]  G. Dimattia,et al.  Modulation of AKT activity is associated with reversible dormancy in ascites-derived epithelial ovarian cancer spheroids. , 2012, Carcinogenesis.

[271]  J. Massagué,et al.  VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors. , 2011, Cancer cell.

[272]  M. Watabe,et al.  Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone , 2011, The Journal of experimental medicine.

[273]  M. J. van de Vijver,et al.  Expression of endoplasmic reticulum stress proteins is a candidate marker of brain metastasis in both ErbB-2+ and ErbB-2- primary breast tumors. , 2011, The American journal of pathology.

[274]  J. Guan,et al.  Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. , 2011, Genes & development.

[275]  Zhigang Zhang,et al.  Cell surface heat shock protein 90 modulates prostate cancer cell adhesion and invasion through the integrin-β1/focal adhesion kinase/c-Src signaling pathway. , 2011, Oncology reports.

[276]  Y. Eishi,et al.  Autophagy-deficient mice develop multiple liver tumors. , 2011, Genes & development.

[277]  A. Koong,et al.  Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. , 2011, Blood.

[278]  J. Buchner,et al.  The heat shock response: life on the verge of death. , 2010, Molecular cell.

[279]  Giuseppe Floris,et al.  Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST) , 2010, Proceedings of the National Academy of Sciences.

[280]  K. Pantel,et al.  Discovery of a novel unfolded protein response phenotype of cancer stem/progenitor cells from the bone marrow of breast cancer patients. , 2010, Journal of proteome research.

[281]  Young-Soo Hong,et al.  Geldanamycin inhibits TGF-beta signaling through induction of Hsp70. , 2010, Archives of biochemistry and biophysics.

[282]  D. Ma,et al.  Wnt/beta-catenin signaling regulates cancer stem cells in lung cancer A549 cells. , 2010, Biochemical and biophysical research communications.

[283]  M. Backer,et al.  Chaperone-targeting cytotoxin and endoplasmic reticulum stress-inducing drug synergize to kill cancer cells. , 2009, Neoplasia.

[284]  R. Weinberg,et al.  Integrin β1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs , 2009, Proceedings of the National Academy of Sciences.

[285]  J. C. Belmonte,et al.  Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways , 2009, Oncogene.

[286]  Lichuan Zhang,et al.  Upregulation of GRP78 and GRP94 and Its Function in Chemotherapy Resistance to VP-16 in Human Lung Cancer Cell Line SK-MES-1 , 2009, Cancer investigation.

[287]  W. Dalton,et al.  HSP70 inhibition reverses cell adhesion mediated and acquired drug resistance in multiple myeloma , 2008, British journal of haematology.

[288]  J. Aguirre-Ghiso,et al.  ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo , 2008, Proceedings of the National Academy of Sciences.

[289]  Bin Chen,et al.  Guidelines for the nomenclature of the human heat shock proteins , 2008, Cell Stress and Chaperones.

[290]  D. Roberts,et al.  Thrombospondins: from structure to therapeutics , 2008, Cellular and Molecular Life Sciences.

[291]  S. Fuqua,et al.  The c-Yes 3′-UTR contains adenine/uridine-rich elements that bind AUF1 and HuR involved in mRNA decay in breast cancer cells , 2005, The Journal of Steroid Biochemistry and Molecular Biology.

[292]  M. Hussein.  Transforming growth factor‐β and malignant melanoma: molecular mechanisms , 2005 .

[293]  L. Neckers.  Development of small molecule Hsp90 inhibitors: utilizing both forward and reverse chemical genomics for drug identification. , 2003, Current medicinal chemistry.

[294]  Hiroki Ueda,et al.  Regulation of focal adhesion kinase by a novel protein inhibitor FIP200. , 2002, Molecular biology of the cell.

[295]  J. Aguirre-Ghiso,et al.  Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo. , 2001, Molecular biology of the cell.

[296]  T. Mcclanahan,et al.  Involvement of chemokine receptors in breast cancer metastasis , 2001, Nature.

[297]  J. W. Brewer,et al.  PERK mediates cell-cycle exit during the mammalian unfolded protein response. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[298]  R. Scheuermann,et al.  Tumor dormancy and cell signaling. II. Antibody as an agonist in inducing dormancy of a B cell lymphoma in SCID mice , 1995, The Journal of experimental medicine.

[299]  Lars Holmgren,et al.  Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression , 1995, Nature Medicine.