Emergence of exosomal miRNAs as a diagnostic biomarker for Alzheimer's disease

[1]  Y. Tong,et al.  Dysregulation and diagnostic potential of microRNA in Alzheimer's disease. , 2015, Journal of Alzheimer's disease : JAD.

[2]  S. An,et al.  Role of apolipoprotein E in neurodegenerative diseases , 2015, Neuropsychiatric disease and treatment.

[3]  W. Lukiw,et al.  microRNA-Based Biomarkers and the Diagnosis of Alzheimer’s Disease , 2015, Front. Neurol..

[4]  S. An,et al.  Gene panels and primers for next generation sequencing studies on neurodegenerative disorders , 2015, Molecular & Cellular Toxicology.

[5]  R. Petersen,et al.  Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study , 2015, Alzheimer's & Dementia.

[6]  Jeong Ah Kim,et al.  In situ single step detection of exosome microRNA using molecular beacon. , 2015, Biomaterials.

[7]  Xi Chen,et al.  Serum MicroRNA Profiles Serve as Novel Biomarkers for the Diagnosis of Alzheimer's Disease , 2015, Disease markers.

[8]  Christine S. Siegismund,et al.  MicroRNA Profiling of CSF Reveals Potential Biomarkers to Detect Alzheimer`s Disease , 2015, PloS one.

[9]  R. Petersen,et al.  Low neural exosomal levels of cellular survival factors in Alzheimer’s disease , 2015, Annals of clinical and translational neurology.

[10]  Ilona B. Bruinsma,et al.  MicroRNA-29a Is a Candidate Biomarker for Alzheimer’s Disease in Cell-Free Cerebrospinal Fluid , 2015, Molecular Neurobiology.

[11]  Christina Backes,et al.  MicroRNA in vitro diagnostics using immunoassay analyzers. , 2015, Clinical chemistry.

[12]  A. Zepeda,et al.  Identification of age- and disease-related alterations in circulating miRNAs in a mouse model of Alzheimer's disease , 2015, Front. Cell. Neurosci..

[13]  M. Turner,et al.  Identification of distinct circulating exosomes in Parkinson's disease , 2015, Annals of clinical and translational neurology.

[14]  Rajan P Kulkarni,et al.  Rapid inertial solution exchange for enrichment and flow cytometric detection of microvesicles. , 2015, Biomicrofluidics.

[15]  T. Tuschl,et al.  Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau. , 2015, The Journal of clinical investigation.

[16]  D. Wong,et al.  Detection of exosomal biomarker by electric field-induced release and measurement (EFIRM). , 2015, Journal of visualized experiments : JoVE.

[17]  Artur Lichtenberg,et al.  An Innovative Method for Exosome Quantification and Size Measurement , 2015, Journal of visualized experiments : JoVE.

[18]  Shumpei Niida,et al.  MicroRNA-Seq Data Analysis Pipeline to Identify Blood Biomarkers for Alzheimer’s Disease from Public Data , 2015, Biomarker insights.

[19]  A. Hill,et al.  The Neutral Sphingomyelinase Pathway Regulates Packaging of the Prion Protein into Exosomes* , 2014, The Journal of Biological Chemistry.

[20]  Rochelle Buffenstein,et al.  Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice , 2014, Front. Mol. Neurosci..

[21]  B. Strooper,et al.  Variance in the identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: The need of larger datasets , 2014, Ageing Research Reviews.

[22]  Wei Zhang,et al.  Genome-Wide Analysis of miRNA Signature in the APPswe/PS1ΔE9 Mouse Model of Alzheimer's Disease , 2014, PloS one.

[23]  Clotilde Théry,et al.  Biogenesis and secretion of exosomes. , 2014, Current opinion in cell biology.

[24]  Gunhild Waldemar,et al.  The potential of microRNAs as biofluid markers of neurodegenerative diseases – a systematic review , 2014, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

[25]  H. Shill,et al.  Profiles of Extracellular miRNA in Cerebrospinal Fluid and Serum from Patients with Alzheimer's and Parkinson's Diseases Correlate with Disease Status and Features of Pathology , 2014, PloS one.

[26]  Hakho Lee,et al.  Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor , 2014, Nature Biotechnology.

[27]  M. Wildung,et al.  Extracellular Vesicles in Luminal Fluid of the Ovine Uterus , 2014, PloS one.

[28]  E. Wang,et al.  Increased microRNA-34c abundance in Alzheimer's disease circulating blood plasma , 2014, Front. Mol. Neurosci..

[29]  Nan Hu,et al.  Circulating miR-125b as a biomarker of Alzheimer's disease , 2014, Journal of the Neurological Sciences.

[30]  Lesley Cheng,et al.  Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood , 2014, Journal of extracellular vesicles.

[31]  K. Blennow,et al.  Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease , 2013, Neurology.

[32]  Lesley Cheng,et al.  The detection of microRNA associated with Alzheimer's disease in biological fluids using next-generation sequencing technologies , 2013, Front. Genet..

[33]  D. Walsh,et al.  De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease. , 2013, Human molecular genetics.

[34]  Sabine C. Mueller,et al.  A blood based 12-miRNA signature of Alzheimer disease patients , 2013, Genome Biology.

[35]  Oana A. Tomescu,et al.  More than cell dust: microparticles isolated from cerebrospinal fluid of brain injured patients are messengers carrying mRNAs, miRNAs, and proteins. , 2013, Journal of neurotrauma.

[36]  Zoltan Dezso,et al.  Circulating miRNA Biomarkers for Alzheimer's Disease , 2013, Alzheimer's & Dementia.

[37]  F. Peruzzi,et al.  Cerebrospinal fluid miRNA profile in HIV‐encephalitis , 2013, Journal of cellular physiology.

[38]  C. Rowe,et al.  Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study , 2013, The Lancet Neurology.

[39]  A. Saykin,et al.  Neuroimaging and other biomarkers for Alzheimer's disease: the changing landscape of early detection. , 2013, Annual review of clinical psychology.

[40]  Patrick C. N. Rensen,et al.  Cryo-electron microscopy of extracellular vesicles in fresh plasma , 2013, Journal of extracellular vesicles.

[41]  W. Lukiw,et al.  microRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF). , 2012, International journal of biochemistry and molecular biology.

[42]  Mahdieh Khosroheidari,et al.  Comparison of protein, microRNA, and mRNA yields using different methods of urinary exosome isolation for the discovery of kidney disease biomarkers. , 2012, Kidney international.

[43]  M. Mullan,et al.  Plasma microRNA biomarkers for detection of mild cognitive impairment , 2012, Aging.

[44]  M. Kurosaka,et al.  Stem Cell Transplantation in Amyotrophic Lateral Sclerosis Patients: Methodological Approach, Safety, and Feasibility , 2012, Cell transplantation.

[45]  J. Trojanowski,et al.  TMEM106B, the Risk Gene for Frontotemporal Dementia, Is Regulated by the microRNA-132/212 Cluster and Affects Progranulin Pathways , 2012, The Journal of Neuroscience.

[46]  S. Lim,et al.  Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome , 2012, International journal of proteomics.

[47]  W. Lukiw,et al.  Spreading of Alzheimer's disease inflammatory signaling through soluble micro‐RNA , 2012, Neuroreport.

[48]  Paul Harrison,et al.  Classification, Functions, and Clinical Relevance of Extracellular Vesicles , 2012, Pharmacological Reviews.

[49]  G. Jicha,et al.  Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease , 2012, Experimental Neurology.

[50]  N. Schonrock,et al.  MicroRNA networks surrounding APP and amyloid-β metabolism — Implications for Alzheimer's disease , 2012, Experimental Neurology.

[51]  J. Satoh Molecular network of microRNA targets in Alzheimer's disease brains , 2012, Experimental Neurology.

[52]  P. Kenny,et al.  MicroRNAs in neuronal function and dysfunction , 2012, Trends in Neurosciences.

[53]  Winston Patrick Kuo,et al.  Impact of Biofluid Viscosity on Size and Sedimentation Efficiency of the Isolated Microvesicles , 2012, Front. Physio..

[54]  A. Hill,et al.  Exosomes: Vehicles for the Transfer of Toxic Proteins Associated with Neurodegenerative Diseases? , 2012, Front. Physio..

[55]  Richard J Simpson,et al.  Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes. , 2012, Methods.

[56]  F. Hamdy,et al.  Changes in circulating microRNA levels associated with prostate cancer , 2012, British Journal of Cancer.

[57]  Richard J. Simpson,et al.  ExoCarta as a resource for exosomal research , 2012, Journal of extracellular vesicles.

[58]  Paul J. Harrison,et al.  Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis , 2011, Nanomedicine : nanotechnology, biology, and medicine.

[59]  H. Rosenmann CSF Biomarkers for Amyloid and Tau Pathology in Alzheimer's Disease , 2011, Journal of Molecular Neuroscience.

[60]  Ger J.A. Arkesteijn,et al.  Quantitative and qualitative flow cytometric analysis of nanosized cell-derived membrane vesicles , 2011, Nanomedicine: Nanotechnology, Biology and Medicine.

[61]  Suresh Mathivanan,et al.  ExoCarta 2012: database of exosomal proteins, RNA and lipids , 2011, Nucleic Acids Res..

[62]  Chris Gardiner,et al.  Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission , 2011, Neurobiology of Disease.

[63]  H. Kettenmann,et al.  Physiology of microglia. , 2011, Physiological reviews.

[64]  G. Lachenal,et al.  Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity , 2011, Molecular and Cellular Neuroscience.

[65]  Peter T. Nelson,et al.  Patterns of microRNA expression in normal and early Alzheimer’s disease human temporal cortex: white matter versus gray matter , 2011, Acta Neuropathologica.

[66]  Vladimir I. Vladimirov,et al.  MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders , 2010, Schizophrenia Research.

[67]  Jessica A. Weber,et al.  The microRNA spectrum in 12 body fluids. , 2010, Clinical chemistry.

[68]  Markus Tolnay,et al.  The propagation of prion-like protein inclusions in neurodegenerative diseases , 2010, Trends in Neurosciences.

[69]  T. Preiss,et al.  Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-β , 2010, PloS one.

[70]  Menggui Huang,et al.  Wnt1-cre-mediated conditional loss of Dicer results in malformation of the midbrain and cerebellum and failure of neural crest and dopaminergic differentiation in mice. , 2010, Journal of molecular cell biology.

[71]  J. Satoh,et al.  Aberrant microRNA expression in the brains of neurodegenerative diseases: miR‐29a decreased in Alzheimer disease brains targets neurone navigator 3 , 2010, Neuropathology and applied neurobiology.

[72]  M. Ntzouni,et al.  Cell-Produced α-Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival , 2010, The Journal of Neuroscience.

[73]  Deming Zhao,et al.  Cellular prion protein released on exosomes from macrophages binds to Hsp70. , 2010, Acta biochimica et biophysica Sinica.

[74]  Xi-sha Chen,et al.  MicroRNA‐146a and Human Disease , 2010, Scandinavian journal of immunology.

[75]  N. Aronin,et al.  Aberrant Rab11-Dependent Trafficking of the Neuronal Glutamate Transporter EAAC1 Causes Oxidative Stress and Cell Death in Huntington's Disease , 2010, The Journal of Neuroscience.

[76]  T. D. de Gruijl,et al.  Functional delivery of viral miRNAs via exosomes , 2010, Proceedings of the National Academy of Sciences.

[77]  Michael Schmidt,et al.  Structural-mechanical characterization of nanoparticle exosomes in human saliva, using correlative AFM, FESEM, and force spectroscopy. , 2010, ACS nano.

[78]  T. Wurdinger,et al.  Microfluidic isolation and transcriptome analysis of serum microvesicles. , 2010, Lab on a chip.

[79]  Juan Nunez-Iglesias,et al.  Joint Genome-Wide Profiling of miRNA and mRNA Expression in Alzheimer's Disease Cortex Reveals Altered miRNA Regulation , 2010, PloS one.

[80]  J. Klein,et al.  Microfiltration isolation of human urinary exosomes for characterization by MS , 2010, Proteomics. Clinical applications.

[81]  K. Kosik,et al.  MicroRNAs Potentiate Neural Development , 2009, Neuron.

[82]  T. Sun,et al.  Different timings of dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system , 2009, Developmental dynamics : an official publication of the American Association of Anatomists.

[83]  Richard Wade-Martins,et al.  LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. , 2009, Human molecular genetics.

[84]  Peng Liu,et al.  miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation , 2009, Brain Research Bulletin.

[85]  J. Im,et al.  Repression of α-synuclein expression and toxicity by microRNA-7 , 2009, Proceedings of the National Academy of Sciences.

[86]  C. Théry,et al.  Membrane vesicles as conveyors of immune responses , 2009, Nature Reviews Immunology.

[87]  Trairak Pisitkun,et al.  Large-scale proteomics and phosphoproteomics of urinary exosomes. , 2009, Journal of the American Society of Nephrology : JASN.

[88]  Jacopo Meldolesi,et al.  Shedding microvesicles: artefacts no more. , 2009, Trends in cell biology.

[89]  Yi Xing,et al.  The Bifunctional microRNA miR-9/miR-9* Regulates REST and CoREST and Is Downregulated in Huntington's Disease , 2008, The Journal of Neuroscience.

[90]  Lianbo Yu,et al.  Detection of microRNA Expression in Human Peripheral Blood Microvesicles , 2008, PloS one.

[91]  J. Schorey,et al.  The mycobacterial glycopeptidolipids: structure, function, and their role in pathogenesis. , 2008, Glycobiology.

[92]  R. Vassar,et al.  The Role of Amyloid Precursor Protein Processing by BACE1, the β-Secretase, in Alzheimer Disease Pathophysiology* , 2008, Journal of Biological Chemistry.

[93]  G. Raposo,et al.  Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles , 2008, Biology of the cell.

[94]  Johan Skog,et al.  Glioblastoma microvesicles transport RNA and protein that promote tumor growth and provide diagnostic biomarkers , 2008, Nature Cell Biology.

[95]  V. Scheinker,et al.  Transrenal Nucleic Acids: From Proof of Principle to Clinical Tests , 2008, Annals of the New York Academy of Sciences.

[96]  Daniel B. Martin,et al.  Circulating microRNAs as stable blood-based markers for cancer detection , 2008, Proceedings of the National Academy of Sciences.

[97]  A. Delacourte,et al.  Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression , 2008, Proceedings of the National Academy of Sciences.

[98]  Elena Cattaneo,et al.  A microRNA-based gene dysregulation pathway in Huntington's disease , 2008, Neurobiology of Disease.

[99]  Guiliang Tang,et al.  The Expression of MicroRNA miR-107 Decreases Early in Alzheimer's Disease and May Accelerate Disease Progression through Regulation of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 , 2008, The Journal of Neuroscience.

[100]  P. Altevogt,et al.  Evidence for secretion of Cu,Zn superoxide dismutase via exosomes from a cell model of amyotrophic lateral sclerosis , 2007, Neuroscience Letters.

[101]  P. Altevogt,et al.  CD24 is a marker of exosomes secreted into urine and amniotic fluid. , 2007, Kidney international.

[102]  G. Hannon,et al.  A MicroRNA Feedback Circuit in Midbrain Dopamine Neurons , 2007, Science.

[103]  Riitta Lahesmaa,et al.  Exosomes with Immune Modulatory Features Are Present in Human Breast Milk1 , 2007, The Journal of Immunology.

[104]  J. Lötvall,et al.  Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells , 2007, Nature Cell Biology.

[105]  Trairak Pisitkun,et al.  Rapid isolation of urinary exosomal biomarkers using a nanomembrane ultrafiltration concentrator. , 2007, American journal of physiology. Renal physiology.

[106]  R. Cappai,et al.  Packaging of prions into exosomes is associated with a novel pathway of PrP processing , 2007, The Journal of pathology.

[107]  Joel S Parker,et al.  microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder , 2007, Genome Biology.

[108]  R. J. Kelleher,et al.  The presenilin hypothesis of Alzheimer's disease: Evidence for a loss-of-function pathogenic mechanism , 2007, Proceedings of the National Academy of Sciences.

[109]  P. Verkade,et al.  Alzheimer's disease beta-amyloid peptides are released in association with exosomes. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[110]  G. Raposo,et al.  Exosomes: a common pathway for a specialized function. , 2006, Journal of biochemistry.

[111]  J. Dear,et al.  Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery. , 2006, Kidney international.

[112]  H. Schluesener,et al.  Role of exosomes in immune regulation , 2006, Journal of cellular and molecular medicine.

[113]  G. Lachenal,et al.  Exosomes are released by cultured cortical neurones , 2006, Molecular and Cellular Neuroscience.

[114]  A. Booth,et al.  Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane , 2006, The Journal of cell biology.

[115]  Aled Clayton,et al.  Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids , 2006, Current protocols in cell biology.

[116]  K. Blennow,et al.  Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study , 2006, The Lancet Neurology.

[117]  Sibel Akyol,et al.  Pregnancy-Associated Exosomes and Their Modulation of T Cell Signaling1 , 2006, The Journal of Immunology.

[118]  M. Record,et al.  Characterization of exosome subpopulations from RBL-2H3 cells using fluorescent lipids. , 2005, Blood cells, molecules & diseases.

[119]  Graça Raposo,et al.  Exosomal-like vesicles are present in human blood plasma. , 2005, International immunology.

[120]  Dominic M. Walsh,et al.  Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease , 2004, Neuron.

[121]  Rong-Fong Shen,et al.  Identification and proteomic profiling of exosomes in human urine. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[122]  W. Faigle,et al.  Cells release prions in association with exosomes. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[123]  Sébastien Roy,et al.  Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization. , 2004, The Biochemical journal.

[124]  V. Ambros,et al.  Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation , 2004, Genome Biology.

[125]  Konstantin Khrapko,et al.  A microRNA array reveals extensive regulation of microRNAs during brain development. , 2003, RNA.

[126]  J. Thyberg,et al.  Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid , 2003, European Respiratory Journal.

[127]  J. Slot,et al.  Proteomic and Biochemical Analyses of Human B Cell-derived Exosomes , 2003, The Journal of Biological Chemistry.

[128]  J. Le Pecq,et al.  Production and characterization of clinical grade exosomes derived from dendritic cells. , 2002, Journal of immunological methods.

[129]  A. Levey,et al.  Huntingtin-associated Protein 1 Interacts with Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate and Functions in Endosomal Trafficking* , 2002, The Journal of Biological Chemistry.

[130]  Laurence Zitvogel,et al.  Exosomes: composition, biogenesis and function , 2002, Nature Reviews Immunology.

[131]  A. Régnault,et al.  TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/ζ Complex1 , 2002, The Journal of Immunology.

[132]  G. Raposo,et al.  Intestinal epithelial cells secrete exosome-like vesicles. , 2001, Gastroenterology.

[133]  S. Prusiner,et al.  Shattuck lecture--neurodegenerative diseases and prions. , 2001, The New England journal of medicine.

[134]  M. DiFiglia,et al.  Huntingtin Expression Stimulates Endosomal–Lysosomal Activity, Endosome Tubulation, and Autophagy , 2000, The Journal of Neuroscience.

[135]  Laurence Zitvogel,et al.  Molecular Characterization of Dendritic Cell-Derived Exosomes , 1999, The Journal of cell biology.

[136]  Manho Kim,et al.  Are there multiple pathways in the pathogenesis of Huntington's disease? , 1999, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[137]  H. Geuze,et al.  Selective Enrichment of Tetraspan Proteins on the Internal Vesicles of Multivesicular Endosomes and on Exosomes Secreted by Human B-lymphocytes* , 1998, The Journal of Biological Chemistry.

[138]  Laurence Zitvogel,et al.  Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes , 1998, Nature Medicine.

[139]  G. Raposo,et al.  Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation. , 1997, Molecular biology of the cell.

[140]  C. Melief,et al.  B lymphocytes secrete antigen-presenting vesicles , 1996, The Journal of experimental medicine.

[141]  R. Johnstone,et al.  Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). , 1987, The Journal of biological chemistry.

[142]  M. Adam,et al.  Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes , 1985, The Journal of cell biology.

[143]  P. Stahl,et al.  Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes , 1983, The Journal of cell biology.

[144]  C. Reyero,et al.  Isolation of porcine colostral immunoglobulins and preparation of monospecific anti-γ, anti-α, and anti-μ chain antibodies using agarose-linked immunosorbents , 1977 .

[145]  Maire Peters,et al.  Comparison of serum exosome isolation methods for microRNA profiling. , 2014, Clinical biochemistry.

[146]  Peter T Nelson,et al.  A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls. , 2013, Journal of Alzheimer's disease : JAD.

[147]  C. Rowe,et al.  Increasing the predictive accuracy of amyloid-β blood-borne biomarkers in Alzheimer's disease. , 2011, Journal of Alzheimer's disease : JAD.

[148]  P. Nelson,et al.  MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study. , 2010, Journal of Alzheimer's disease : JAD.

[149]  Miguel C. Seabra,et al.  Rab27a and Rab27b control different steps of the exosome secretion pathway , 2010, Nature Cell Biology.

[150]  N. Wang,et al.  Isolation and purification of exosomes in urine. , 2010, Methods in molecular biology.

[151]  A. Roses,et al.  Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways , 2008 .

[152]  A. Minagar,et al.  Cell-derived microparticles and exosomes in neuroinflammatory disorders. , 2007, International review of neurobiology.

[153]  M. Mason,et al.  Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry. , 2001, Journal of immunological methods.

[154]  J. Hardy,et al.  Amyloid deposition as the central event in the aetiology of Alzheimer's disease. , 1991, Trends in pharmacological sciences.