A Convenient Synthesis of Diribonucleoside Monophosphates by the Use of Unblocked Nucleosides

A convenient modified method for the preparation of ribonucleotidyl-(2'-5') and (3'-5')-ribonucleoside by employing unblocked ribonucleoside was developed. Particularly, this method is useful for the synthesis of diribonucleoside monophosphates (XpA or XpG) involving adenosine or guanosine in 2'or 3' OH end.