Long non-coding RNAs as the critical regulators of PI3K/AKT, TGF-β, and MAPK signaling pathways during breast tumor progression

[1]  Rui Yang,et al.  LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway , 2022, Cancer biology & therapy.

[2]  Mahmoud A. Bassal,et al.  Long noncoding RNA–mediated activation of PROTOR1/PRR5-AKT signaling shunt downstream of PI3K in triple-negative breast cancer , 2022, Proceedings of the National Academy of Sciences of the United States of America.

[3]  Ming Xu,et al.  Cancer-associated fibroblasts facilitate premetastatic niche formation through lncRNA SNHG5-mediated angiogenesis and vascular permeability in breast cancer , 2022, Theranostics.

[4]  G. Hu,et al.  TGFB2-AS1 inhibits triple-negative breast cancer progression via interaction with SMARCA4 and regulating its targets TGFB2 and SOX2 , 2022, Proceedings of the National Academy of Sciences of the United States of America.

[5]  M. Abbaszadegan,et al.  PI3K/AKT signaling pathway as a critical regulator of Cisplatin response in tumor cells , 2022, Oncology research.

[6]  Ji-fan Hu,et al.  HULC targets the IGF1R-PI3K-AKT axis in trans to promote breast cancer metastasis and cisplatin resistance. , 2022, Cancer letters.

[7]  Mona Sadeghalvad,et al.  Long non-coding RNA HOTAIR induces the PI3K/AKT/mTOR signaling pathway in breast cancer cells. , 2022, Revista da Associacao Medica Brasileira.

[8]  Li Liu,et al.  Long noncoding RNA KB-1980E6.3 promotes breast cancer progression through the PI3K/AKT signalling pathway. , 2022, Pathology, research and practice.

[9]  Hong Zhao,et al.  Up-regulation of LncRNA UCA1 by TGF-β promotes doxorubicin resistance in breast cancer cells , 2022, Immunopharmacology and immunotoxicology.

[10]  M. Moghbeli,et al.  Long non-coding RNAs as the critical regulators of epithelial mesenchymal transition in colorectal tumor cells: an overview , 2022, Cancer Cell International.

[11]  Guoqiang Chen,et al.  Epithelial cells-enriched lncRNA SNHG8 regulates chromatin condensation by binding to Histone H1s , 2022, Cell Death & Differentiation.

[12]  Q. Ni,et al.  Up-regulation of long noncoding RNA MBNL1-AS1 suppresses breast cancer progression by modulating miR-423-5p/CREBZF axis , 2022, Bioengineered.

[13]  Hui Hu,et al.  Knockdown of lncRNA FOXD2-AS1 Inhibits Proliferation, Migration, and Drug Resistance of Breast Cancer Cells , 2021, Computational and mathematical methods in medicine.

[14]  Lang He,et al.  Overexpression of the lncRNA AC012213.3 Promotes Proliferation, Migration and Invasion of Breast Cancer via RAD54B/PI3K/AKT Axis and is Associated with Worse Patient Prognosis , 2021, Cancer management and research.

[15]  X. Cui,et al.  Hypoxia‐stimulated ATM activation regulates autophagy‐associated exosome release from cancer‐associated fibroblasts to promote cancer cell invasion , 2021, Journal of extracellular vesicles.

[16]  M. Moghbeli,et al.  Long non-coding RNAs as the critical regulators of doxorubicin resistance in tumor cells , 2021, Cellular & Molecular Biology Letters.

[17]  M. Moghbeli,et al.  Molecular mechanisms of the microRNA-132 during tumor progressions , 2021, Cancer Cell International.

[18]  M. He,et al.  Long non-coding RNA ARHGAP5-AS1 inhibits migration of breast cancer cell via stabilizing SMAD7 protein , 2021, Breast Cancer Research and Treatment.

[19]  Qinglin Li,et al.  Study of lncRNA TPA in Promoting Invasion and Metastasis of Breast Cancer Mediated by TGF-β Signaling Pathway , 2021, Frontiers in Cell and Developmental Biology.

[20]  Yichun Zhu,et al.  The lncRNA ADAMTS9-AS2 Regulates RPL22 to Modulate TNBC Progression via Controlling the TGF-β Signaling Pathway , 2021, Frontiers in Oncology.

[21]  Xia Zhao,et al.  Long non-coding RNA FOXD2-AS1 promotes proliferation, migration and invasion of ovarian cancer cells via regulating the expression of miR-4492. , 2021, Experimental and therapeutic medicine.

[22]  Juan Chen,et al.  LncRNA SNHG6 promotes breast cancer progression and epithelial-mesenchymal transition via miR-543/LAMC1 axis , 2021, Breast Cancer Research and Treatment.

[23]  Han-ning Li,et al.  LINC00052 promotes breast cancer cell progression and metastasis by sponging miR-145-5p to modulate TGFBR2 expression , 2021, Oncology letters.

[24]  Longyang Jiang,et al.  LncRNA CBR3-AS1 regulates of breast cancer drug sensitivity as a competing endogenous RNA through the JNK1/MEK4-mediated MAPK signal pathway , 2021, Journal of Experimental & Clinical Cancer Research.

[25]  Linlin Zhang,et al.  Silencing long non-coding RNA HNF1A-AS1 inhibits growth and resistance to TAM of breast cancer cells via the microRNA-363/SERTAD3 axis , 2021, Journal of drug targeting.

[26]  A. Jemal,et al.  Cancer Statistics, 2021 , 2021, CA: a cancer journal for clinicians.

[27]  Fei Li,et al.  Long non-coding RNA IGF2-AS represses breast cancer tumorigenesis by epigenetically regulating IGF2 , 2020, Experimental biology and medicine.

[28]  Hong Xu,et al.  Long-Chain Non-Coding SOX21-AS1 Promotes Proliferation and Migration of Breast Cancer Cells Through the PI3K/AKT Signaling Pathway , 2020, Cancer management and research.

[29]  Zhiyang Zhou,et al.  Long non-coding RNA MIR100HG promotes the migration, invasion and proliferation of triple-negative breast cancer cells by targeting the miR-5590-3p/OTX1 axis , 2020, Cancer cell international.

[30]  M. Zhang,et al.  LncRNA CBR3-AS1 regulates of breast cancer drug sensitivity as a competing endogenous RNA through the JNK1/MEK4-mediated MAPK signal pathway , 2020, Journal of experimental & clinical cancer research : CR.

[31]  R. Ahmad,et al.  A novel coordination complex of platinum (PT) induces cell death in colorectal cancer by altering redox balance and modulating MAPK pathway , 2020, BMC Cancer.

[32]  M. Velarde,et al.  Cellular Senescence Promotes Skin Carcinogenesis through p38MAPK and p44/42MAPK Signaling , 2020, Cancer Research.

[33]  Joe T. Sharick,et al.  MEK activation modulates glycolysis and supports suppressive myeloid cells in TNBC , 2020, JCI insight.

[34]  Hui Chen,et al.  A nuclear lncRNA Linc00839 as a Myc target to promote breast cancer chemoresistance via PI3K/AKT signaling pathway , 2020, Cancer science.

[35]  O. Abdel-Wahab,et al.  MAP-Kinase-Driven Hematopoietic Neoplasms: A Decade of Progress in the Molecular Age. , 2020, Cold Spring Harbor perspectives in medicine.

[36]  Song-Lin Shi,et al.  The roles of hnRNP A2/B1 in RNA biology and disease , 2020, Wiley interdisciplinary reviews. RNA.

[37]  H. Yao,et al.  Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade. , 2020, Cell reports.

[38]  Jian Zheng,et al.  Silencing SCAMP1-TV2 Inhibited the Malignant Biological Behaviors of Breast Cancer Cells by Interaction With PUM2 to Facilitate INSM1 mRNA Degradation , 2020, Frontiers in Oncology.

[39]  Junn-Liang Chang,et al.  Critical role of SOX2–IGF2 signaling in aggressiveness of bladder cancer , 2020, Scientific Reports.

[40]  Yong-peng Wang,et al.  LncRNA PRNCR1 Promotes Breast Cancer Proliferation and Inhibits Apoptosis by Modulating microRNA-377/CCND2/MEK/MAPK Axis. , 2020, Archives of medical research.

[41]  M. Tao,et al.  LncRNA ZFAS1/miR-589 regulates the PTEN/PI3K/AKT signal pathway in the proliferation, invasion and migration of breast cancer cells , 2020, Cytotechnology.

[42]  L. Tang,et al.  DCST1-AS1 Promotes TGF-β-Induced Epithelial–Mesenchymal Transition and Enhances Chemoresistance in Triple-Negative Breast Cancer Cells via ANXA1 , 2020, Frontiers in Oncology.

[43]  A. Moustakas,et al.  TGF-β Signaling , 2020, Biomolecules.

[44]  R. Jain,et al.  A framework for advancing our understanding of cancer-associated fibroblasts , 2020, Nature Reviews Cancer.

[45]  Jian Sun,et al.  Musashi2 promotes EGF-induced EMT in pancreatic cancer via ZEB1-ERK/MAPK signaling , 2020, Journal of Experimental & Clinical Cancer Research.

[46]  Ying Xu,et al.  ERK/MAPK signalling pathway and tumorigenesis , 2020, Experimental and therapeutic medicine.

[47]  M. Mojarrad,et al.  Long non-coding RNAs as the critical factors during tumor progressions among Iranian population: an overview , 2020, Cell & Bioscience.

[48]  Zeming Liu,et al.  Down-regulation of long non-coding RNA HOTAIR sensitizes breast cancer to trastuzumab , 2019, Scientific Reports.

[49]  Yifeng Zhou,et al.  Micropeptide CIP2A‐BP encoded by LINC00665 inhibits triple‐negative breast cancer progression , 2019, The EMBO journal.

[50]  R. Eferl,et al.  Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer , 2019, Angiogenesis.

[51]  X. Tan,et al.  Dysregulated Tgfbr2/ERK-Smad4/SOX2 signaling promotes lung squamous cell carcinoma formation. , 2019, Cancer research.

[52]  Yongjie Sun,et al.  Long noncoding RNA MIR31HG abrogates the availability of tumor suppressor microRNA-361 for the growth of osteosarcoma , 2019, Cancer management and research.

[53]  M. Moghbeli.  Genetic and molecular biology of breast cancer among Iranian patients , 2019, Journal of translational medicine.

[54]  Lianhong Li,et al.  PTENP1/miR-20a/PTEN axis contributes to breast cancer progression by regulating PTEN via PI3K/AKT pathway , 2019, Journal of Experimental & Clinical Cancer Research.

[55]  D. Granger,et al.  Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation , 2019, Circulation.

[56]  J. Qian,et al.  Knockdown of lncRNA-HOTAIR downregulates the drug-resistance of breast cancer cells to doxorubicin via the PI3K/AKT/mTOR signaling pathway , 2019, Experimental and therapeutic medicine.

[57]  P. ten Dijke,et al.  Epigenetic Reprogramming of TGF-β Signaling in Breast Cancer , 2019, Cancers.

[58]  Ling-Ling Chen,et al.  Cellular functions of long noncoding RNAs , 2019, Nature Cell Biology.

[59]  Wenfang Li,et al.  High long non-coding RNA NORAD expression predicts poor prognosis and promotes breast cancer progression by regulating TGF-β pathway , 2019, Cancer Cell International.

[60]  Hai-Jun Li,et al.  [Corrigendum] Long non-coding RNA UCA1 confers tamoxifen resistance in breast cancer endocrinotherapy through regulation of the EZH2/p21 axis and the PI3K/AKT signaling pathway , 2019, International journal of oncology.

[61]  Guoxin Zhang,et al.  Long non‐coding RNA ZEB2‐AS1 promotes the proliferation, metastasis and epithelial mesenchymal transition in triple‐negative breast cancer by epigenetically activating ZEB2 , 2019, Journal of cellular and molecular medicine.

[62]  X. Cui,et al.  Oxidized ATM-mediated glycolysis enhancement in breast cancer-associated fibroblasts contributes to tumor invasion through lactate as metabolic coupling , 2019, EBioMedicine.

[63]  Weiguang Yu,et al.  Upregulation of lncRNA CASC2 Suppresses Cell Proliferation and Metastasis of Breast Cancer via Inactivation of the TGF-β Signaling Pathway. , 2019, Oncology research.

[64]  Jun Wang,et al.  Lamc1 promotes the Warburg effect in hepatocellular carcinoma cells by regulating PKM2 expression through AKT pathway , 2019, Cancer biology & therapy.

[65]  Dan Yang,et al.  Cancer-associated fibroblast (CAF)-derived IL32 promotes breast cancer cell invasion and metastasis via integrin β3-p38 MAPK signalling. , 2019, Cancer letters.

[66]  Yuanting Gu,et al.  lncRNA GHET1 knockdown suppresses breast cancer activity in vitro and in vivo. , 2019, American journal of translational research.

[67]  M. Abbaszadegan,et al.  ErbB1 and ErbB3 co-over expression as a prognostic factor in gastric cancer , 2019, Biological Research.

[68]  Jeannie T. Lee,et al.  Xist RNA antagonizes the SWI/SNF chromatin remodeler BRG1 on the inactive X chromosome , 2018, Nature Structural & Molecular Biology.

[69]  E. Song,et al.  Turning foes to friends: targeting cancer-associated fibroblasts , 2018, Nature Reviews Drug Discovery.

[70]  Chun-Ming Huang,et al.  Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1/JAK2/STAT3 signaling pathway , 2018, Journal of experimental & clinical cancer research : CR.

[71]  J. Tu,et al.  Long noncoding RNA ROR promotes breast cancer by regulating the TGF-β pathway , 2018, Cancer Cell International.

[72]  Jun Zhou,et al.  Long noncoding RNA GAS5 suppresses triple negative breast cancer progression through inhibition of proliferation and invasion by competitively binding miR-196a-5p. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[73]  Xian-biao Shi,et al.  Overexpression of Long Noncoding RNA PTENP1 Inhibits Cell Proliferation and Migration via Suppression of miR-19b in Breast Cancer Cells , 2018, Oncology research.

[74]  F. Hakuno,et al.  IGF1 receptor signaling pathways. , 2018, Journal of molecular endocrinology.

[75]  Y-K Hong,et al.  Mechanism of lncRNA DUXAP8 in promoting proliferation of bladder cancer cells by regulating PTEN. , 2018, European review for medical and pharmacological sciences.

[76]  C. Brezden-Masley,et al.  Overcoming endocrine resistance in hormone receptor-positive breast cancer. , 2018, Current oncology.

[77]  E. Zhang,et al.  Upregulation of the long noncoding RNA FOXD2-AS1 promotes carcinogenesis by epigenetically silencing EphB3 through EZH2 and LSD1, and predicts poor prognosis in gastric cancer , 2018, Oncogene.

[78]  Hua Han,et al.  Long non-coding RNAs AC026904.1 and UCA1: a “one-two punch” for TGF-β-induced SNAI2 activation and epithelial-mesenchymal transition in breast cancer , 2018, Theranostics.

[79]  E. Solito,et al.  Annexin A1: Uncovering the Many Talents of an Old Protein , 2018, International journal of molecular sciences.

[80]  M. Odenthal,et al.  LIN28B enhanced tumorigenesis in an autochthonous KRASG12V-driven lung carcinoma mouse model , 2018, Oncogene.

[81]  S. Savas,et al.  The SWI/SNF complex subunit genes: Their functions, variations, and links to risk and survival outcomes in human cancers. , 2018, Critical reviews in oncology/hematology.

[82]  Dhiraj Kumar,et al.  Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challenges , 2018, Molecular Cancer.

[83]  Tianxin Lin,et al.  The long non-coding RNA FOXD2-AS1 promotes bladder cancer progression and recurrence through a positive feedback loop with Akt and E2F1 , 2018, Cell Death & Disease.

[84]  P. Romero,et al.  Rationale for immunological approaches to breast cancer therapy. , 2018, Breast.

[85]  Xiulan Zhao,et al.  Paracrine and epigenetic control of CAF-induced metastasis: the role of HOTAIR stimulated by TGF-ß1 secretion , 2018, Molecular Cancer.

[86]  J. Hsu,et al.  IGF-1R Promotes Symmetric Self-Renewal and Migration of Alkaline Phosphatase+ Germ Stem Cells through HIF-2α-OCT4/CXCR4 Loop under Hypoxia , 2018, Stem cell reports.

[87]  Liuqing Yang,et al.  Long Noncoding RNA in Cancer: Wiring Signaling Circuitry. , 2017, Trends in cell biology.

[88]  Y. Mo,et al.  Linc-RoR promotes MAPK/ERK signaling and confers estrogen-independent growth of breast cancer , 2017, Molecular Cancer.

[89]  J. Lawrence,et al.  XIST RNA: a window into the broader role of RNA in nuclear chromosome architecture , 2017, Philosophical Transactions of the Royal Society B: Biological Sciences.

[90]  Deepak K. Singh,et al.  Long Noncoding RNA PURPL Suppresses Basal p53 Levels and Promotes Tumorigenicity in Colorectal Cancer. , 2017, Cell reports.

[91]  Qiang Sun,et al.  Long non-coding RNA PTENP1 inhibits proliferation and migration of breast cancer cells via AKT and MAPK signaling pathways , 2017, Oncology letters.

[92]  K. McManus,et al.  The enigmatic oncogene and tumor suppressor‐like properties of RAD54B: Insights into genome instability and cancer , 2017, Genes, chromosomes & cancer.

[93]  Jun Lu,et al.  LncRNA ANCR down-regulation promotes TGF-β-induced EMT and metastasis in breast cancer , 2017, Oncotarget.

[94]  I. Dusanter-Fourt,et al.  PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells. , 2017, Blood.

[95]  Qingyuan Zhang,et al.  Long non-coding RNA HOXA-AS2 promotes proliferation and invasion of breast cancer by acting as a miR-520c-3p sponge , 2017, Oncotarget.

[96]  A. Toker,et al.  PI3K signaling in cancer: beyond AKT. , 2017, Current opinion in cell biology.

[97]  Jiajie Zhang,et al.  Gaining insight into crizotinib resistance mechanisms caused by L2026M and G2032R mutations in ROS1 via molecular dynamics simulations and free-energy calculations , 2017, Journal of Molecular Modeling.

[98]  Ming Sun,et al.  The Pseudogene DUXAP8 Promotes Non-small-cell Lung Cancer Cell Proliferation and Invasion by Epigenetically Silencing EGR1 and RHOB. , 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

[99]  Y. Li,et al.  Long non-coding RNA CCAT2 promotes the breast cancer growth and metastasis by regulating TGF-β signaling pathway. , 2017, European review for medical and pharmacological sciences.

[100]  S. Fuqua,et al.  Targeted therapy for breast cancer and molecular mechanisms of resistance to treatment. , 2016, Current opinion in pharmacology.

[101]  M. Blasco,et al.  Tissue damage and senescence provide critical signals for cellular reprogramming in vivo , 2016, Science.

[102]  K. Gelmon,et al.  Palbociclib and Letrozole in Advanced Breast Cancer. , 2016, The New England journal of medicine.

[103]  Xuetao Cao,et al.  Characteristics and Significance of the Pre-metastatic Niche. , 2016, Cancer cell.

[104]  G. Stein,et al.  A microRNA/Runx1/Runx2 network regulates prostate tumor progression from onset to adenocarcinoma in TRAMP mice , 2016, Oncotarget.

[105]  D. Saur,et al.  RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis. , 2016, The Journal of clinical investigation.

[106]  B. Ejlertsen,et al.  Review of hormone-based treatments in postmenopausal patients with advanced breast cancer focusing on aromatase inhibitors and fulvestrant , 2016, ESMO Open.

[107]  D. Sarkar,et al.  Emerging role of lncRNA in cancer: a potential avenue in molecular medicine. , 2016, Annals of translational medicine.

[108]  J. Dou,et al.  Next-generation proteasome inhibitor MLN9708 sensitizes breast cancer cells to doxorubicin-induced apoptosis , 2016, Scientific Reports.

[109]  P. Gascard,et al.  Carcinoma-associated fibroblasts: orchestrating the composition of malignancy , 2016, Genes & development.

[110]  D. Foran,et al.  The transcription factor RUNX2 regulates receptor tyrosine kinase expression in melanoma , 2016, Oncotarget.

[111]  Jing Wang,et al.  SUMOylation of HP1α supports association with ncRNA to define responsiveness of breast cancer cells to chemotherapy , 2016, Oncotarget.

[112]  Peng Zhang,et al.  Transcription factor RUNX2 up-regulates chemokine receptor CXCR4 to promote invasive and metastatic potentials of human gastric cancer , 2016, Oncotarget.

[113]  G. Hortobagyi,et al.  Mechanisms of resistance and sensitivity to anti-HER2 therapies in HER2+ breast cancer , 2016, Oncotarget.

[114]  H. Xiong,et al.  Screening of potential diagnostic markers and therapeutic targets against colorectal cancer , 2015, OncoTargets and therapy.

[115]  Shukun Tang,et al.  Stromal miR-200s contribute to breast cancer cell invasion through CAF activation and ECM remodeling , 2015, Cell Death and Differentiation.

[116]  Adrian V. Lee,et al.  Role of IGF1R in Breast Cancer Subtypes, Stemness, and Lineage Differentiation , 2015, Front. Endocrinol..

[117]  C. Croce,et al.  Role of MYC-regulated long noncoding RNAs in cell cycle regulation and tumorigenesis. , 2015, Journal of the National Cancer Institute.

[118]  L. Havel,et al.  FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells , 2015, Oncotarget.

[119]  Guodong Yang,et al.  LncRNA: a link between RNA and cancer. , 2014, Biochimica et biophysica acta.

[120]  Qun Zhou,et al.  Long non-coding RNAs in stem cells and cancer. , 2014, World journal of clinical oncology.

[121]  R. O'Regan,et al.  The PI3K/AKT/mTOR pathway in breast cancer: targets, trials and biomarkers , 2014, Therapeutic advances in medical oncology.

[122]  P. Pandolfi,et al.  The multilayered complexity of ceRNA crosstalk and competition , 2014, Nature.

[123]  F. Pallone,et al.  The Dual Role of Smad7 in the Control of Cancer Growth and Metastasis , 2013, International journal of molecular sciences.

[124]  Jun Lu,et al.  CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression , 2013, Scientific Reports.

[125]  Rong Yin,et al.  Long noncoding RNA: an emerging paradigm of cancer research , 2013, Tumor Biology.

[126]  G. Berx,et al.  Regulatory networks defining EMT during cancer initiation and progression , 2013, Nature Reviews Cancer.

[127]  N. Erez,et al.  From sentinel cells to inflammatory culprits: cancer‐associated fibroblasts in tumour‐related inflammation , 2013, The Journal of pathology.

[128]  M. Aumailley,et al.  The laminin family , 2013, Cell adhesion & migration.

[129]  S. Llanos,et al.  The transcription factor CREBZF is a novel positive regulator of p53 , 2012, Cell cycle.

[130]  Piero Carninci,et al.  Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat , 2012, Nature.

[131]  Xiaochu Yan,et al.  Nanog regulates self‐renewal of cancer stem cells through the insulin‐like growth factor pathway in human hepatocellular carcinoma , 2012, Hepatology.

[132]  Kotb Abdelmohsen,et al.  LincRNA-p21 suppresses target mRNA translation. , 2012, Molecular cell.

[133]  Steven J. M. Jones,et al.  Comprehensive molecular portraits of human breast tumors , 2012, Nature.

[134]  T. Nakazawa,et al.  Transcription factor Runx2 is a regulator of epithelial–mesenchymal transition and invasion in thyroid carcinomas , 2012, Laboratory Investigation.

[135]  Y. Inoue,et al.  The roles of TGF-β signaling in carcinogenesis and breast cancer metastasis , 2012, Breast Cancer.

[136]  David S. Lapointe,et al.  Genomic Promoter Occupancy of Runt-related Transcription Factor RUNX2 in Osteosarcoma Cells Identifies Genes Involved in Cell Adhesion and Motility* , 2011, The Journal of Biological Chemistry.

[137]  Gillian H. Little,et al.  Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2 , 2011, Breast Cancer Research.

[138]  D. Cacchiarelli,et al.  A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA , 2011, Cell.

[139]  A. Siitonen,et al.  Ribosomal Mutations as the Main Cause of Macrolide Resistance in Campylobacter jejuni and Campylobacter coli , 2011, Antimicrobial Agents and Chemotherapy.

[140]  X. Chen,et al.  Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. , 2011, The Journal of clinical investigation.

[141]  Koji Sugioka,et al.  TGF-β induces sustained upregulation of SNAI1 and SNAI2 through Smad and non-Smad pathways in a human corneal epithelial cell line. , 2011, Investigative ophthalmology & visual science.

[142]  Hiroyuki Tomita,et al.  Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. , 2011, Cancer cell.

[143]  D. Miles,et al.  Rechallenging with anthracyclines and taxanes in metastatic breast cancer , 2010, Nature Reviews Clinical Oncology.

[144]  O. Kallioniemi,et al.  FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells. , 2010, Cancer research.

[145]  K. Møllgård,et al.  Expression of the Homeobox Genes OTX2 and OTX1 in the Early Developing Human Brain , 2010, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[146]  Howard Y. Chang,et al.  Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis , 2010, Nature.

[147]  Peter Olson,et al.  Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner. , 2010, Cancer cell.

[148]  Shuang Huang,et al.  Extracellular signal-regulated kinase signaling pathway regulates breast cancer cell migration by maintaining slug expression. , 2009, Cancer research.

[149]  J. Russo,et al.  ERalpha-negative and triple negative breast cancer: molecular features and potential therapeutic approaches. , 2009, Biochimica et biophysica acta.

[150]  R. Huang,et al.  Epithelial-Mesenchymal Transitions in Development and Disease , 2009, Cell.

[151]  Pixu Liu,et al.  Targeting the phosphoinositide 3-kinase pathway in cancer , 2009, Nature Reviews Drug Discovery.

[152]  E. Neilson,et al.  Biomarkers for epithelial-mesenchymal transitions. , 2009, The Journal of clinical investigation.

[153]  K. B. McIntosh,et al.  How common are extraribosomal functions of ribosomal proteins? , 2009, Molecular cell.

[154]  Samy Lamouille,et al.  TGF-β-induced epithelial to mesenchymal transition , 2009, Cell Research.

[155]  I. Kasman,et al.  PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. , 2009, Cancer cell.

[156]  M. Pollak,et al.  Insulin and insulin-like growth factor signalling in neoplasia , 2008, Nature Reviews Cancer.

[157]  J. Massagué,et al.  TGFβ in Cancer , 2008, Cell.

[158]  T. Çolakoğlu,et al.  Clinicopathological significance of PTEN loss and the phosphoinositide 3-kinase/Akt pathway in sporadic colorectal neoplasms: is PTEN loss predictor of local recurrence? , 2008, American journal of surgery.

[159]  Robert T Abraham,et al.  Targeting the mTOR signaling network in cancer. , 2007, Trends in molecular medicine.

[160]  Adrian V. Lee,et al.  Constitutively Active Type I Insulin-Like Growth Factor Receptor Causes Transformation and Xenograft Growth of Immortalized Mammary Epithelial Cells and Is Accompanied by an Epithelial-to-Mesenchymal Transition Mediated by NF-κB and Snail , 2007, Molecular and Cellular Biology.

[161]  G. Stein,et al.  Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone , 2006, Cancer and Metastasis Reviews.

[162]  J. Massagué,et al.  Smad transcription factors. , 2005, Genes & development.

[163]  H. Yokoo,et al.  New twist on neuronal insulin receptor signaling in health, disease, and therapeutics. , 2005, Journal of pharmacological sciences.

[164]  C. Savage-Dunn,et al.  TGF-beta signaling. , 2005, WormBook : the online review of C. elegans biology.

[165]  Jiri Zavadil,et al.  TGF-β and epithelial-to-mesenchymal transitions , 2005, Oncogene.

[166]  Dennis C. Sgroi,et al.  Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion , 2005, Cell.

[167]  C. Heldin,et al.  TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. , 2005, Molecular biology of the cell.

[168]  N. Fusenig,et al.  Friends or foes — bipolar effects of the tumour stroma in cancer , 2004, Nature Reviews Cancer.

[169]  Celso A. Espinoza,et al.  B2 RNA binds directly to RNA polymerase II to repress transcript synthesis , 2004, Nature Structural &Molecular Biology.

[170]  M. Bogoyevitch,et al.  Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential. , 2004, Biochimica et biophysica acta.

[171]  Ying E. Zhang,et al.  Smad-dependent and Smad-independent pathways in TGF-β family signalling , 2003, Nature.

[172]  Lei Xu,et al.  Tumour biology: Herceptin acts as an anti-angiogenic cocktail , 2002, Nature.

[173]  R. McPherson,et al.  The role of mitogen-activated protein (MAP) kinase in breast cancer , 2002, The Journal of Steroid Biochemistry and Molecular Biology.

[174]  M. Bogoyevitch,et al.  The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs). , 2001, The international journal of biochemistry & cell biology.

[175]  D. Leroith,et al.  Insulin-like Growth Factor 1 (IGF-1)-induced Twist Expression Is Involved in the Anti-apoptotic Effects of the IGF-1 Receptor* , 2001, The Journal of Biological Chemistry.

[176]  Tomoki Chiba,et al.  Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation* , 2001, The Journal of Biological Chemistry.

[177]  C. Heldin,et al.  TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. , 1999, Journal of cell science.

[178]  C. Heldin,et al.  Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling , 1997, Nature.

[179]  L. Mahadevan,et al.  Parallel signal processing among mammalian MAPKs. , 1995, Trends in biochemical sciences.

[180]  C. Fisher.  Metastasis , 1989, Ciba Foundation symposium.

[181]  Q. Ni,et al.  LncRNA TTN-AS1 confers tamoxifen resistance in breast cancer via sponging miR-107 to modulate PI3K/AKT signaling pathway. , 2022, American journal of translational research.

[182]  F. Wang,et al.  Long Noncoding RNA CAMTA1 Promotes Proliferation and Mobility of the Human Breast Cancer Cell Line MDA-MB-231 via Targeting miR-20b. , 2018, Oncology research.

[183]  A. Jemal,et al.  Cancer statistics, 2018 , 2018, CA: a cancer journal for clinicians.

[184]  L-Q Wang,et al.  Exosomes mediated transfer of lncRNA UCA1 results in increased tamoxifen resistance in breast cancer cells. , 2016, European review for medical and pharmacological sciences.

[185]  M. Paknahad,et al.  Breast cancer and associated factors: a review , 2015, Journal of medicine and life.

[186]  Steven J. M. Jones,et al.  Comprehensive molecular portraits of human breast tumours , 2013 .

[187]  J. Zavadil,et al.  TGF-beta and epithelial-to-mesenchymal transitions. , 2005, Oncogene.

[188]  R. Derynck,et al.  Smad-dependent and Smad-independent pathways in TGF-beta family signalling. , 2003, Nature.

[189]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..

[190]  C. Heldin,et al.  TGF-β type I receptor / ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells , 1999 .

[191]  C. Heldin,et al.  Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. , 1997, Nature.

[192]  J. Obrecht.  [Cancer therapy]. , 1977, Deutsche medizinische Wochenschrift.