Evaluation of diacetyl mediated pulmonary effects in physiologically relevant air-liquid interface models of human primary bronchial epithelial cells.

[1]  A. Nixon,et al.  EGFR-Dependent IL8 Production by Airway Epithelial Cells After Exposure to the Food Flavoring Chemical 2,3-Butanedione. , 2019, Toxicological sciences : an official journal of the Society of Toxicology.

[2]  L. Palmberg,et al.  Air-Liquid Interface: Relevant In Vitro Models for Investigating Air Pollutant-Induced Pulmonary Toxicity. , 2018, Toxicological sciences : an official journal of the Society of Toxicology.

[3]  T. Sandström,et al.  Multi-cellular human bronchial models exposed to diesel exhaust particles: assessment of inflammation, oxidative stress and macrophage polarization , 2018, Particle and Fibre Toxicology.

[4]  C. Pilette,et al.  Aberrant epithelial differentiation by cigarette smoke dysregulates respiratory host defence , 2018, European Respiratory Journal.

[5]  M. Wilson,et al.  Reactive Oxygen Species in Chronic Obstructive Pulmonary Disease , 2018, Oxidative medicine and cellular longevity.

[6]  L. Palmberg,et al.  Inflammatory effects of acrolein, crotonaldehyde and hexanal vapors on human primary bronchial epithelial cells cultured at air-liquid interface. , 2018, Toxicology in vitro : an international journal published in association with BIBRA.

[7]  I. Rahman,et al.  Inflammatory and Oxidative Responses Induced by Exposure to Commonly Used e-Cigarette Flavoring Chemicals and Flavored e-Liquids without Nicotine , 2018, Front. Physiol..

[8]  D. Christiani,et al.  Flavoring Chemicals and Aldehydes in E-Cigarette Emissions. , 2017, Environmental science & technology.

[9]  C. Rose.  Early detection, clinical diagnosis, and management of lung disease from exposure to diacetyl. , 2017, Toxicology.

[10]  D. Morgan,et al.  Pathology of diacetyl and 2,3-pentanedione airway lesions in a rat model of obliterative bronchiolitis. , 2017, Toxicology.

[11]  D. Morgan,et al.  Airway injury in an in vitro human epithelium-fibroblast model of diacetyl vapor exposure: diacetyl-induced basal/suprabasal spongiosis , 2017, Inhalation toxicology.

[12]  D. Morgan,et al.  The Diacetyl‐Exposed Human Airway Epithelial Secretome: New Insights into Flavoring‐Induced Airways Disease , 2017, American journal of respiratory cell and molecular biology.

[13]  J. Tran van Nhieu,et al.  Interleukin-6 displays lung anti-inflammatory properties and exerts protective hemodynamic effects in a double-hit murine acute lung injury , 2017, Respiratory Research.

[14]  I. Rahman,et al.  Inflammatory Response and Barrier Dysfunction by Different e-Cigarette Flavoring Chemicals Identified by Gas Chromatography–Mass Spectrometry in e-Liquids and e-Vapors on Human Lung Epithelial Cells and Fibroblasts , 2017, Applied in vitro toxicology.

[15]  P. Bakke,et al.  Antimicrobial peptide levels are linked to airway inflammation, bacterial colonisation and exacerbations in chronic obstructive pulmonary disease , 2017, European Respiratory Journal.

[16]  Maria Malmlöf,et al.  Development of Combining of Human Bronchial Mucosa Models with XposeALI® for Exposure of Air Pollution Nanoparticles , 2017, PloS one.

[17]  D. Morgan,et al.  Proteomic Analysis of Primary Human Airway Epithelial Cells Exposed to the Respiratory Toxicant Diacetyl. , 2017, Journal of proteome research.

[18]  W. Goldsmith,et al.  Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity. , 2016, The American journal of pathology.

[19]  C. Irvin,et al.  Interleukin-6 as a biomarker for asthma: hype or is there something else? , 2016, European Respiratory Journal.

[20]  M. Mann,et al.  Glutathione peroxidase 3 localizes to the epithelial lining fluid and the extracellular matrix in interstitial lung disease , 2016, Scientific Reports.

[21]  K. Murzyn,et al.  Secretory leukocyte protease inhibitor (SLPI), a multifunctional protein in the host defense response. , 2016, Cytokine & growth factor reviews.

[22]  D. Morgan,et al.  Chemical Reactivity and Respiratory Toxicity of the α-Diketone Flavoring Agents , 2016, Toxicologic pathology.

[23]  Joseph G. Allen,et al.  Flavoring Chemicals in E-Cigarettes: Diacetyl, 2,3-Pentanedione, and Acetoin in a Sample of 51 Products, Including Fruit-, Candy-, and Cocktail-Flavored E-Cigarettes , 2015, Environmental health perspectives.

[24]  B. Kerger,et al.  Pathology, toxicology, and latency of irritant gases known to cause bronchiolitis obliterans disease: Does diacetyl fit the pattern? , 2015, Toxicology reports.

[25]  Jia-ming Wei,et al.  Association between serum interleukin-6 concentrations and chronic obstructive pulmonary disease: a systematic review and meta-analysis , 2015, PeerJ.

[26]  M. Hatano,et al.  Bidirectional role of IL-6 signal in pathogenesis of lung fibrosis , 2015, Respiratory Research.

[27]  M. Lindsey,et al.  Tissue Inhibitor of Metalloproteinase-1: Actions beyond Matrix Metalloproteinase Inhibition , 2015, Cardiology.

[28]  J. Deddens,et al.  Flavoring exposure in food manufacturing , 2014, Journal of Exposure Science and Environmental Epidemiology.

[29]  D. Morgan,et al.  Diacetyl induces amphiregulin shedding in pulmonary epithelial cells and in experimental bronchiolitis obliterans. , 2014, American journal of respiratory cell and molecular biology.

[30]  P. Kirkham,et al.  Oxidative stress in COPD. , 2013, Chest.

[31]  J. Jung,et al.  Expression pattern of GSTP1 and GSTA1 in the pathogenesis of asthma , 2013, Experimental lung research.

[32]  V. Kennedy,et al.  Bronchoalveolar Lavage as a Tool to Predict, Diagnose and Understand Bronchiolitis Obliterans Syndrome , 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[33]  Errol M. Thomson,et al.  Overexpression of tumor necrosis factor-α in the lungs alters immune response, matrix remodeling, and repair and maintenance pathways. , 2012, The American journal of pathology.

[34]  L. Palmberg,et al.  Toll-like receptor expression in smokers with and without COPD. , 2011, Respiratory medicine.

[35]  D. Hayes.  A review of bronchiolitis obliterans syndrome and therapeutic strategies , 2011, Journal of cardiothoracic surgery.

[36]  J. Scheller,et al.  The pro- and anti-inflammatory properties of the cytokine interleukin-6. , 2011, Biochimica et biophysica acta.

[37]  T. Betsuyaku,et al.  The role of matrix metalloproteinase-9 in cigarette smoke-induced emphysema. , 2011, American journal of respiratory and critical care medicine.

[38]  D. Morgan,et al.  Severe Airway Epithelial Injury, Aberrant Repair and Bronchiolitis Obliterans Develops after Diacetyl Instillation in Rats , 2011, PloS one.

[39]  I. Čepelak,et al.  Glutathione cycle in stable chronic obstructive pulmonary disease , 2010, Cell biochemistry and function.

[40]  T. Lawrence.  The nuclear factor NF-kappaB pathway in inflammation. , 2009, Cold Spring Harbor perspectives in biology.

[41]  A. Marchevsky,et al.  Presence of c-KIT-positive mast cells in obliterative bronchiolitis from diverse causes. , 2009, Archives of pathology & laboratory medicine.

[42]  Manfred Keller,et al.  Lung deposition of a liposomal cyclosporine A inhalation solution in patients after lung transplantation. , 2009, Journal of aerosol medicine and pulmonary drug delivery.

[43]  J. Allard,et al.  Lung transplantation: does oxidative stress contribute to the development of bronchiolitis obliterans syndrome? , 2009, Transplantation reviews.

[44]  A. Hubbs,et al.  Inhalation dosimetry of diacetyl and butyric acid, two components of butter flavoring vapors. , 2009, Toxicological sciences : an official journal of the Society of Toxicology.

[45]  W. Mazur,et al.  Glutathione-S-transferases in lung and sputum specimens, effects of smoking and COPD severity , 2008, Respiratory research.

[46]  D. Heederik,et al.  A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings , 2008, Occupational and Environmental Medicine.

[47]  H. Takano,et al.  Role of interleukin-6 in bleomycin-induced lung inflammatory changes in mice. , 2008, American journal of respiratory cell and molecular biology.

[48]  D. Morgan,et al.  Respiratory toxicity of diacetyl in C57BL/6 mice. , 2008, Toxicological sciences : an official journal of the Society of Toxicology.

[49]  W. Goldsmith,et al.  Respiratory Toxicologic Pathology of Inhaled Diacetyl in Sprague-Dawley Rats , 2008, Toxicologic pathology.

[50]  M. Prokop,et al.  Bronchiolitis obliterans syndrome in chemical workers producing diacetyl for food flavorings. , 2007, American journal of respiratory and critical care medicine.

[51]  R. Bals,et al.  Interactions between epithelial cells and leukocytes in immunity and tissue homeostasis , 2007, Journal of leukocyte biology.

[52]  L. Palmberg,et al.  Effect of formoterol and salmeterol on IL-6 and IL-8 release in airway epithelial cells. , 2007, Respiratory medicine.

[53]  K. Kreiss,et al.  Evaluation of Flavorings-Related Lung Disease Risk at Six Microwave Popcorn Plants , 2006, Journal of occupational and environmental medicine.

[54]  N. McElvaney,et al.  Secretory leucoprotease inhibitor binds to NF-κB binding sites in monocytes and inhibits p65 binding , 2005, The Journal of experimental medicine.

[55]  D. Madtes,et al.  Tissue inhibitor of metalloproteinase-1 deficiency amplifies acute lung injury in bleomycin-exposed mice. , 2005, American journal of respiratory cell and molecular biology.

[56]  T. Pufe,et al.  Matrix metalloproteinase-9 in bronchiolitis obliterans syndrome after lung transplantation , 2005, European Respiratory Journal.

[57]  N. Krug,et al.  The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo. , 2005, The Journal of clinical investigation.

[58]  W. Travis,et al.  Bronchiolitis obliterans syndrome in popcorn production plant workers , 2004, European Respiratory Journal.

[59]  J. S. Parrish,et al.  Toxic inhalational injury: gas, vapor and vesicant exposure. , 2004, Respiratory care clinics of North America.

[60]  H. Erdjument-Bromage,et al.  Conversion of Proepithelin to Epithelins Roles of SLPI and Elastase in Host Defense and Wound Repair , 2002, Cell.

[61]  J. Reynolds,et al.  Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring. , 2002, Toxicology and applied pharmacology.

[62]  P. Enright,et al.  Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. , 2002, The New England journal of medicine.

[63]  T. Betsuyaku,et al.  Role of secretory leukocyte protease inhibitor in the development of subclinical emphysema , 2002, European Respiratory Journal.

[64]  T. van der Poll,et al.  Differential role of interleukin-6 in lung inflammation induced by lipoteichoic acid and peptidoglycan from Staphylococcus aureus. , 2002, American journal of respiratory and critical care medicine.

[65]  Y. Nishimura,et al.  Induction of MMP-9 in normal human bronchial epithelial cells by TNF-α via NF-κB-mediated pathway , 2001 .

[66]  J. Sallenave.  The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease , 2000, Respiratory research.

[67]  R. Homer,et al.  Interleukin-6-induced protection in hyperoxic acute lung injury. , 2000, American journal of respiratory cell and molecular biology.

[68]  M. Jordana,et al.  IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. , 1998, The Journal of clinical investigation.

[69]  N. Kohno,et al.  Circulating interleukin-6 levels in patients with bronchial asthma. , 1995, American journal of respiratory and critical care medicine.

[70]  S. Lakshminarayan,et al.  Acute inhalation injury. , 1994, Clinics in chest medicine.

[71]  P. Kovacic,et al.  Electron transfer as a potential cause of diacetyl toxicity in popcorn lung disease. , 2010, Reviews of environmental contamination and toxicology.

[72]  N. McElvaney,et al.  THEMED SECTION: MEDIATORS AND RECEPTORS IN THE RESOLUTION OF INFLAMMATION REVIEW Proteases and antiproteases in chronic neutrophilic lung disease - relevance to drug discovery , 2009 .

[73]  E. Schachter,et al.  Occupational Airway Diseases , 2001, Reviews on environmental health.

[74]  K. Shirato,et al.  Secretion and gene expression of secretory leukocyte protease inhibitor by human airway submucosal glands. , 2001, American journal of physiology. Lung cellular and molecular physiology.

[75]  J. Schalkwijk,et al.  Regulation of SLPI and elafin release from bronchial epithelial cells by neutrophil defensins. , 2000, American journal of physiology. Lung cellular and molecular physiology.

[76]  A. Lentsch,et al.  Essential Role of Alveolar Macrophages in Intrapulmonary Activation of NF- κ B , 1999 .

[77]  S. Akira,et al.  Interleukin-6 in biology and medicine. , 1993, Advances in immunology.

[78]  E. Schachter.  Occupational airway diseases. , 1991, The Mount Sinai journal of medicine, New York.