Role of the Fastigial Nucleus in Controlling Horizontal Saccades during Adaptation

Abstract: Saccade size was adapted in rhesus monkeys using surgical weakening of the muscles of one eye combined with monocular viewing. Neurons in the caudal fastigial nucleus were recorded during the adaptation. Neuronal discharges changed in a way that could be interpreted as causing the changes in saccade size given our current knowledge of the projections of these neurons to the saccadic burst generator in the brain stem.

[1]  A. Fuchs.  Saccadic and smooth pursuit eye movements in the monkey , 1967, The Journal of physiology.

[2]  D. Robinson.  Oculomotor unit behavior in the monkey. , 1970, Journal of neurophysiology.

[3]  A. Fuchs,et al.  Activity of brain stem neurons during eye movements of alert monkeys. , 1972, Journal of neurophysiology.

[4]  G. Kommerell,et al.  Adaptive programming of phasic and tonic components in saccadic eye movements. Investigations of patients with abducens palsy. , 1976, Investigative ophthalmology.

[5]  L. Dell’Osso,et al.  Saccadic system plasticity in humans , 1978, Annals of neurology.

[6]  L. Optican,et al.  Cerebellar-dependent adaptive control of primate saccadic system. , 1980, Journal of neurophysiology.

[7]  W. B. Templeton,et al.  Saccadic plasticity: parametric adaptive control by retinal feedback. , 1981, Journal of experimental psychology. Human perception and performance.

[8]  E. L. Keller,et al.  Microstimulation of the primate cerebellar vermis during saccadic eye movements , 1983, Brain Research.

[9]  Edward L. Keller,et al.  Cerebellar vermis involvement in monkey saccadic eye movements: Microstimulation , 1984, Experimental Neurology.

[10]  A. Fuchs,et al.  Brainstem control of saccadic eye movements. , 1985, Annual review of neuroscience.

[11]  H Deubel,et al.  Adaptive gain control of saccadic eye movements. , 1986, Human neurobiology.

[12]  H. Deubel.  ADAPTIVITY OF GAIN AND DIRECTION IN OBLIQUE SACCADES1 , 1987 .

[13]  T Fujikado,et al.  Topography of the oculomotor area of the cerebellar vermis in macaques as determined by microstimulation. , 1987, Journal of neurophysiology.

[14]  H. Noda,et al.  Afferent and efferent connections of the oculomotor region of the fastigial nucleus in the macaque monkey , 1990, The Journal of comparative neurology.

[15]  K. Ohtsuka,et al.  Saccadic burst neurons in the oculomotor region of the fastigial nucleus of macaque monkeys. , 1991, Journal of neurophysiology.

[16]  K. Ohtsuka,et al.  The effect of microstimulation of the oculomotor vermis on discharges of fastigial neurons and visually-directed saccades in macaques , 1991, Neuroscience Research.

[17]  J. Hore,et al.  Cerebellar dysmetria at the elbow, wrist, and fingers. , 1991, Journal of neurophysiology.

[18]  P. Thier,et al.  Patterns of projections from the pontine nuclei and the nucleus reticularis tegmenti pontis to the posterior vermis in the rhesus monkey: A study using retrograde tracers , 1993, The Journal of comparative neurology.

[19]  S. Mori,et al.  Fastigiofugal projection to the brainstem nuclei in the cat: an anterograde PHA-L tracing study , 1995, Neuroscience Research.

[20]  A. Opstal,et al.  Monkey Superior Colliculus Activity During Short-Term Saccadic Adaptation , 1997, Brain Research Bulletin.

[21]  A. Fuchs,et al.  Characteristics of saccadic gain adaptation in rhesus macaques. , 1997, Journal of neurophysiology.

[22]  D. Linden,et al.  Polarity of Long-Term Synaptic Gain Change Is Related to Postsynaptic Spike Firing at a Cerebellar Inhibitory Synapse , 1998, Neuron.

[23]  W. T. Thach.  A Role for the Cerebellum in Learning Movement Coordination , 1998, Neurobiology of Learning and Memory.

[24]  C. Scudder,et al.  Comparison of two methods of producing adaptation of saccade size and implications for the site of plasticity. , 1998, Journal of neurophysiology.

[25]  D. Zee,et al.  Effects of lesions of the oculomotor vermis on eye movements in primate: saccades. , 1998, Journal of neurophysiology.

[26]  P. Buisseret,et al.  Brainstem efferents from the interface between the nucleus medialis and the nucleus interpositus in the rat , 1998, The Journal of comparative neurology.

[27]  P. Thier,et al.  Saccadic Dysmetria and Adaptation after Lesions of the Cerebellar Cortex , 1999, The Journal of Neuroscience.

[28]  E. D'Angelo,et al.  Long-Term Potentiation of Intrinsic Excitability at the Mossy Fiber–Granule Cell Synapse of Rat Cerebellum , 2000, The Journal of Neuroscience.

[29]  Masao Ito.  Mechanisms of motor learning in the cerebellum 1 1 Published on the World Wide Web on 24 November 2000. , 2000, Brain Research.

[30]  E. D’Angelo,et al.  Beyond parallel fiber LTD: the diversity of synaptic and non-synaptic plasticity in the cerebellum , 2001, Nature Neuroscience.

[31]  A. Fuchs,et al.  The brainstem burst generator for saccadic eye movements , 2002, Experimental Brain Research.

[32]  C. Scudder,et al.  Adaptive modification of saccade size produces correlated changes in the discharges of fastigial nucleus neurons. , 2003, Journal of neurophysiology.