Perspective on opportunities in industrial biotechnology in renewable chemicals

From biomass to renewable chemicals: while industrial biotechnology offers a clear value proposition, a number of hurdles need to be addressed to fully realize the commercial potential of bio-based products and chemicals over the coming decade. A review of an early roadmap for biological production of chemicals from renewable sugars reveals a focus on those that would provide co-products for integrated biorefineries producing biofuels and bioenergy. A growing number of companies are now focusing on specialty chemicals as an entry point to build the bio-based economy.

[1]  A. Contin,et al.  Complementare/Lezione 2/Top Value-Added Chemicals from Biomass, Volume II: Results of Screening for Potential, Candidates from Biorefinery Lignin, PNNL-16983 (2007) , 2012 .

[2]  A. Burgard,et al.  Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol. , 2011, Nature chemical biology.

[3]  R. Singh.  Facts, Growth, and Opportunities in Industrial Biotechnology , 2011 .

[4]  Marguerite A. Cervin,et al.  TECHNOLOGY UPDATE: Development of a gas-phase bioprocess for isoprene-monomer production using metabolic pathway engineering , 2010 .

[5]  James C. Liao,et al.  Engineering the isobutanol biosynthetic pathway in Escherichia coli by comparison of three aldehyde reductase/alcohol dehydrogenase genes , 2009, Applied Microbiology and Biotechnology.

[6]  J. Bang,et al.  Industrial biotechnology: more than green fuel in a dirty economy? Exploring the transformational potential of industrial biotechnology on the way to a green economy. , 2009 .

[7]  J. Dorgan,et al.  Bioengineering for pollution prevention through development of biobased energy and materials state of the science report , 2007 .

[8]  David K. Johnson,et al.  Top Value-Added Chemicals from Biomass - Volume II—Results of Screening for Potential Candidates from Biorefinery Lignin , 2007 .

[9]  S. Lee,et al.  Metabolic Engineering of Escherichia coli for Enhanced Production of Succinic Acid, Based on Genome Comparison and In Silico Gene Knockout Simulation , 2005, Applied and Environmental Microbiology.

[10]  Johnathan E. Holladay,et al.  Top Value Added Chemicals From Biomass. Volume 1 - Results of Screening for Potential Candidates From Sugars and Synthesis Gas , 2004 .