Apparent diffusion coefficient values during magnetic resonance-guided biopsy of the prostate : correlation with histological results

Introduction: Recently, diffusion-weighted imaging (DWI) and dynamic contrast-enhanced MR imaging (DCE-MRI) are introduced as additional imaging methods to improve the specificity. Langer et al. found significant differences in ADC values between normal peripheral zone tissue and cancerous tissue. In this study whole mount section histopathology was used as standard of reference. However, the correlation between imaging and histopathology is influenced by shrinkage and deformation of the resected prostate. Furthermore, there was a time lap between imaging and radical prostatectomy in which the histopathology may have changed. To overcome these problems we investigated the correlation between DWI and histopathology obtained during the same MRI guided biopsy session.