Do polyomavirus hominis strains BK and JC play a role in oral squamous cell carcinoma?

INTRODUCTION Head and neck cancers are the most common cancers worldwide. It is estimated that approximately 90% of all head and neck cancers are represented by squamous cell carcinoma (SCC). There are many risk factors causing this type of cancer, including environmental factors and lifestyle choices, such as tobacco smoking or abusing alcohol. Other important risk factor include infectious factors. OBJECTIVE The aim of this study was to analyze the prevalence of BK and JC virus infections among patients with oral squamous cell carcinoma (OSCC). MATERIALS AND METHOD The correlation between BKV infection and OSCC, and correlation between BKV, OSCC, alcohol abuse, tobacco smoking, demographic data, pre-treatment staging, metastases of lymph node evidence, and grading, was analyzed. The study group consisted of 92 patients with squamous cell carcinoma (OSCC), 75 males, and 17 females, aged between 40 - 87 (average 56.8). All the patients underwent surgery and were not subjected to chemotherapy or radiotherapy prior to treatment. The analyzed samples were collected from paraffin sections. RESULTS BKV DNA was detected in 18.5% of patients with OSCC. In the control group, BKV DNA was detected in 3.3%. BKV DNA was statistically more frequently detected among patients with squamous carcinoma, compared to the control group (p<0.05). CONCLUSIONS The obtained results suggest that the BKV virus may play an important role in the development of oral squamous cell carcinoma.

[1]  M. Imperiale,et al.  BK polyomavirus: emerging pathogen. , 2012, Microbes and infection.

[2]  W. Reinhold,et al.  Entry Tropism of BK and Merkel Cell Polyomaviruses in Cell Culture , 2012, PloS one.

[3]  E. Lerut,et al.  Renal Cell Carcinoma in the Allograft: What Is the Role of Polyomavirus? , 2012, Case Reports in Nephrology and Dialysis.

[4]  B. Kessler,et al.  Detection of BK virus in urine from renal transplant subjects by mass spectrometry , 2012, Clinical Proteomics.

[5]  A. Lennon,et al.  BK virus as a potential co-factor for HPV in the development of cervical neoplasia. , 2012, Annals of clinical and laboratory science.

[6]  S. Moghim,et al.  Urinary BK Virus Excretion in Children Newly Diagnosed with Acute Lymphoblastic Leukemia , 2012, International journal of preventive medicine.

[7]  R. Grenman,et al.  HPV genotypes and their prognostic significance in head and neck squamous cell carcinomas. , 2012, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[8]  J. Szumiło,et al.  [Epidemiology and risk factors of the oral carcinoma]. , 2012, Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.

[9]  K. Amara,et al.  Investigation of human JC and BK polyomaviruses in breast carcinomas , 2012, Breast Cancer Research and Treatment.

[10]  P. Boffetta,et al.  Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer. , 2011, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[11]  L. Torelli,et al.  High prevalence of BK Polyomavirus Sequences in Human Papillomavirus‐16‐Positive Precancerous Cervical Lesions , 2011, Journal of medical virology.

[12]  J. Kowalewska,et al.  The status of BK polyomavirus replication in adult renal transplant recipients in northeastern Poland. , 2011, Transplantation proceedings.

[13]  A. Nadal,et al.  Carcinoma of the head and neck in the HPV era. , 2011, Acta dermatovenerologica Alpina, Pannonica, et Adriatica.

[14]  R. Lambert,et al.  Epidemiology of cancer from the oral cavity and oropharynx , 2011, European journal of gastroenterology & hepatology.

[15]  A. Palmieri,et al.  Absence of Simian virus 40, BK, and JC polyomavirus DNA in squamous cell carcinoma limited to the oral cavity , 2009, Head & neck.

[16]  V. Madden,et al.  BK virus has tropism for human salivary gland cells in vitro: implications for transmission. , 2009, Virology.

[17]  Stina Syrj.  Human papillomavirus (HPV) in head and neck cancer , 2005 .

[18]  M. Negrini,et al.  Oncogenic transformation by BK virus and association with human tumors , 2003, Oncogene.

[19]  W. Golusiński,et al.  [Patients under 45 years of age "young adults" with head and neck squamous cell carcinoma. Retrospective, multivariable analysis--preliminary report ]. , 2003, Otolaryngologia polska = The Polish otolaryngology.

[20]  K. Shah,et al.  Detection of BK virus and JC virus in urine and brain tissue by the polymerase chain reaction , 1989, Journal of clinical microbiology.

[21]  S. Syrjänen,et al.  Morphological and immunohistochemical evidence suggesting human papillomavirus (HPV) involvement in oral squamous cell carcinogenesis. , 1983, International journal of oral surgery.