Imaging in Neurocritical Care Practice

Abstract The use of neuroimaging in conjunction with serial neurological examinations is a core component of modern neurocritical care practice. Although there is a growing role for other neuromonitoring techniques, the ability to quickly and accurately interpret images in the context of a patient's clinical status arguably remains the indispensable skill for neurocritical care practitioners. Due to its rapid acquisition time and excellent ability to detect intracerebral hemorrhage (ICH), cerebral edema, and signs of elevated intracranial pressure, computed tomography (CT) remains the most useful neuroimaging technique for intensive care unit (ICU) patients. An emergent head CT is obtained to inform most time‐sensitive decisions that arise in the neurological ICU (NICU). CT features also figure prominently in prognostic scores for common NICU conditions such as traumatic brain injury (TBI), ICH, and subarachnoid hemorrhage (SAH). Among patients who are sufficiently stable to leave the ICU and lie flat for an extended period, magnetic resonance imaging provides much more detailed, high‐contrast images which can aid in the detection of ischemia, diffuse axonal injury, and neuroprognostication. Though primarily used in neurocritical care research, nuclear medicine imaging techniques have some clinical applications, particularly in ancillary testing for brain death. Finally, as in the field of critical care as a whole, formal and point‐of‐care ultrasound studies are increasingly utilized in the NICU, and are an important tool in the neurointensivist's armamentarium. We review here the common applications of imaging in the neurocritical care setting. As ICU patients are frequently unstable and their risk of clinical decompensation increases substantially during transport away from the ICU, guidelines and recommendations for maximizing patient safety during transport to radiology studies are also explored.

[1]  T. Glenn,et al.  Vasospasm probability index: a combination of transcranial doppler velocities, cerebral blood flow, and clinical risk factors to predict cerebral vasospasm after aneurysmal subarachnoid hemorrhage. , 2007, Journal of neurosurgery.

[2]  A. Lerman,et al.  Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction. , 2008, American heart journal.

[3]  M. Matsumae,et al.  Problems with diagnosis by fluid-attenuated inversion recovery magnetic resonance imaging in patients with acute aneurysmal subarachnoid hemorrhage. , 2010, Neurologia medico-chirurgica.

[4]  Neeraj,et al.  Digital Commons@Becker Digital Commons@Becker Classification of traumatic brain injury for targeted therapies Classification of traumatic brain injury for targeted therapies Classification of Traumatic Brain Injury for Targeted Therapies , 2008 .

[5]  S. Greenberg,et al.  Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston Criteria , 2003, Current atherosclerosis reports.

[6]  G. Manley,et al.  Classification of traumatic brain injury for targeted therapies. , 2008, Journal of neurotrauma.

[7]  Carl E. Johnson,et al.  Using Quantitative CT Perfusion for Evaluation of Delayed Cerebral Ischemia Following Aneurysmal Subarachnoid Hemorrhage , 2011, American Journal of Neuroradiology.

[8]  S. Manaka,et al.  Estimation of intracranial pressure using computed tomography scan findings in patients with severe head injury. , 1990, Surgical neurology.

[9]  D. Gladstone,et al.  CT Angiography “Spot Sign” Predicts Hematoma Expansion in Acute Intracerebral Hemorrhage , 2007, Stroke.

[10]  Fang Sun,et al.  Willful modulation of brain activity in disorders of consciousness. , 2010, The New England journal of medicine.

[11]  B. Souweine,et al.  Safety of Intrahospital Transport in Ventilated Critically Ill Patients: A Multicenter Cohort Study* , 2013, Critical care medicine.

[12]  Carl E. Johnson,et al.  Diagnostic Accuracy of CT Angiography and CT Perfusion for Cerebral Vasospasm: A Meta-Analysis , 2010, American Journal of Neuroradiology.

[13]  J. Ghajar,et al.  In Reply: Guidelines for the Management of Severe Traumatic Brain Injury: 2020 Update of the Decompressive Craniectomy Recommendations. , 2020, Neurosurgery.

[14]  Rose Du,et al.  Sensitivity of CT angiography, T2-weighted MRI, and magnetic resonance angiography in detecting cerebral arteriovenous malformations and associated aneurysms , 2012, Journal of Clinical Neuroscience.

[15]  L. Caplan,et al.  Avoiding pitfalls in the diagnosis of subarachnoid hemorrhage. , 2000, The New England journal of medicine.

[16]  Jan Claassen,et al.  Defining Vasospasm After Subarachnoid Hemorrhage: What Is the Most Clinically Relevant Definition? , 2009, Stroke.

[17]  P. L. Le Roux,et al.  Portable head CT scan and its effect on intracranial pressure, cerebral perfusion pressure, and brain oxygen. , 2011, Journal of neurosurgery.

[18]  Eric E. Smith,et al.  Defining hematoma expansion in intracerebral hemorrhage , 2011, Neurology.

[19]  M. Knauth,et al.  Transcranial color-coded duplex sonography in suspected acute basilar artery occlusion. , 2006, Ultrasound in medicine & biology.

[20]  Robert E. Fromm,et al.  Guidelines for the inter- and intrahospital transport of critically ill patients* , 2004, Critical care medicine.

[21]  Odette A. Harris,et al.  Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition , 2016, Neurosurgery.

[22]  W. Ziai,et al.  The role of transcranial Doppler ultrasonography in the diagnosis and management of vasospasm after aneurysmal subarachnoid hemorrhage. , 2010, Neurosurgery clinics of North America.

[23]  J. Detre,et al.  Inter-Subject Variability of Axonal Injury in Diffuse Traumatic Brain Injury. , 2017, Journal of neurotrauma.

[24]  J. Shimony,et al.  Resting-State fMRI: A Review of Methods and Clinical Applications , 2013, American Journal of Neuroradiology.

[25]  Paul Vespa,et al.  Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association , 2012, Stroke.

[26]  D. Lichtenstein,et al.  The comet-tail artifact. An ultrasound sign of alveolar-interstitial syndrome. , 1997, American journal of respiratory and critical care medicine.

[27]  H. Eisenberg,et al.  Initial CT findings in 753 patients with severe head injury. A report from the NIH Traumatic Coma Data Bank. , 1990, Journal of neurosurgery.

[28]  J. Little,et al.  Brain Hemorrhage from Intracranial Tumor , 1979, Stroke.

[29]  L. Puybasset,et al.  [Management of severe traumatic brain injury]. , 2007, Presse medicale.

[30]  H. Diener,et al.  Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. , 2015, The New England journal of medicine.

[31]  M. Pasquale,et al.  Initial head computed tomographic scan characteristics have a linear relationship with initial intracranial pressure after trauma. , 2004, The Journal of trauma.

[32]  H. Adams,et al.  CT and clinical correlations in recent aneurysmal subarachnoid hemorrhage , 1983, Neurology.

[33]  N. Carney,et al.  A trial of intracranial-pressure monitoring in traumatic brain injury. , 2012, The New England journal of medicine.

[34]  A Gregory Sorensen,et al.  Diffusion-Weighted Imaging for the Evaluation of Diffuse Axonal Injury in Closed Head Injury , 2003, Journal of computer assisted tomography.

[35]  M. Cusimano,et al.  The natural history of brain contusion: an analysis of radiological and clinical progression. , 2010, Journal of neurosurgery.

[36]  L. Gentry,et al.  Imaging of closed head injury. , 1994, Radiology.

[37]  M. Harrigan,et al.  CT perfusion cerebral blood flow imaging in neurological critical care , 2005, Neurocritical care.

[38]  T. Marwick,et al.  Comparison of transcranial Doppler ultrasound and transesophageal contrast echocardiography in the detection of interatrial right-to-left shunts. , 1991, The American journal of cardiology.

[39]  A. Aralaşmak,et al.  CT angiography and perfusion imaging in patients with subarachnoid hemorrhage: correlation of vasospasm to perfusion abnormality , 2009, Neuroradiology.

[40]  T. McAllister,et al.  Imaging of Traumatic Brain Injury , 2011 .

[41]  R. Macdonald,et al.  Can angiographic vasospasm be used as a surrogate marker in evaluating therapeutic interventions for cerebral vasospasm? , 2006, Neurosurgical focus.

[42]  E. Wijdicks,et al.  Prediction of Angiographic Vasospasm After Aneurysmal Subarachnoid Hemorrhage: Value of the Hijdra Sum Scoring System , 2009, Neurocritical care.

[43]  Bizhan Aarabi,et al.  Hemorrhagic progression of a contusion after traumatic brain injury: a review. , 2012, Journal of neurotrauma.

[44]  J. Broderick,et al.  Early hemorrhage growth in patients with intracerebral hemorrhage. , 1997, Stroke.

[45]  A I Mushlin,et al.  Cost-Effectiveness of CT Angiography and Perfusion Imaging for Delayed Cerebral Ischemia and Vasospasm in Aneurysmal Subarachnoid Hemorrhage , 2014, American Journal of Neuroradiology.

[46]  A. Cruickshank,et al.  Subarachnoid haemorrhage , 2007, The Lancet.

[47]  P. Ferdinande,et al.  Recommendations for intra-hospital transport of the severely head injured patient , 1999, Intensive Care Medicine.

[48]  J. van Gijn,et al.  Grading the amount of blood on computed tomograms after subarachnoid hemorrhage. , 1990, Stroke.

[49]  Ewout W Steyerberg,et al.  Prediction of Outcome in Traumatic Brain Injury with Computed Tomographic Characteristics: A Comparison between the Computed Tomographic Classification and Combinations of Computed Tomographic Predictors , 2005, Neurosurgery.

[50]  A. Sorensen,et al.  Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury. , 2004, AJNR. American journal of neuroradiology.

[51]  C. Anderson,et al.  Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association , 2015, Stroke.

[52]  B. Thompson,et al.  Spontaneous intracerebral hemorrhage: a review. , 2003, Neurosurgical focus.

[53]  AIUM Practice Guideline for the Performance of a Transcranial Doppler Ultrasound Examination for Adults and Children , 2012, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[54]  E. de Jonge,et al.  A comprehensive method to develop a checklist to increase safety of intra-hospital transport of critically ill patients , 2015, Critical Care.

[55]  E. Ringelstein,et al.  Contrast transcranial Doppler ultrasound in the detection of right-to-left shunts. Reproducibility, comparison of 2 agents, and distribution of microemboli. , 1999, Stroke.

[56]  Fisher Cm,et al.  Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning. , 1980, Neurosurgery.

[57]  W. Hacke,et al.  CT angiography and Doppler sonography for emergency assessment in acute basilar artery ischemia. , 1999, Stroke.

[58]  P. Podolec,et al.  Transcranial doppler ultrasonography should it be the first choice for persistent foramen ovale screening? , 2014, Cardiovascular Ultrasound.

[59]  I. C. van der Schaaf,et al.  Diagnosing Delayed Cerebral Ischemia With Different CT Modalities in Patients With Subarachnoid Hemorrhage With Clinical Deterioration , 2009, Stroke.

[60]  N. Sakai,et al.  Brain tumors manifesting as intracranial hemorrhage. , 1992, Neurologia medico-chirurgica.

[61]  W. Hacke,et al.  MRI in acute subarachnoid haemorrhage; findings with a standardised stroke protocol , 2003, Neuroradiology.

[62]  Sameer H. Halani,et al.  Comparison Between CTA and Digital Subtraction Angiography in the Diagnosis of Ruptured Aneurysms , 2017, Neurosurgery.

[63]  Kayvan Najarian,et al.  Predictability of intracranial pressure level in traumatic brain injury: features extraction, statistical analysis and machine learning-based evaluation , 2013, Int. J. Data Min. Bioinform..

[64]  R. Chesnut,et al.  Talk and die revisited: bifrontal contusions and late deterioration. , 2011, The Journal of trauma.

[65]  Nicole M. Dubosh,et al.  Sensitivity of Early Brain Computed Tomography to Exclude Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis , 2016, Stroke.

[66]  S. Cortnum,et al.  Determining the Sensitivity of Computed Tomography Scanning in Early Detection of Subarachnoid Hemorrhage , 2010, Neurosurgery.

[67]  J. Noth,et al.  Occurrence of transcranial Doppler high-intensity transient signals in patients with potential cardiac sources of embolism. A prospective study. , 1995, Stroke.

[68]  D. Kondziolka,et al.  Significance of hemorrhage into brain tumors: clinicopathological study. , 1987, Journal of neurosurgery.

[69]  P. Sinha,et al.  Scintigraphy as a confirmatory test of brain death. , 2003, Seminars in nuclear medicine.

[70]  D. Gandhi,et al.  Intracranial Dural Arteriovenous Fistulas: Classification, Imaging Findings, and Treatment , 2012, American Journal of Neuroradiology.

[71]  J Persliden,et al.  Mobile computerized tomography scanning in the neurosurgery intensive care unit: increase in patient safety and reduction of staff workload. , 2000, Journal of neurosurgery.

[72]  M. Krause,et al.  Endovascular therapy for ischemic stroke with perfusion-imaging selection. , 2015, The New England journal of medicine.

[73]  Didier Frappaz,et al.  [Intracranial tumor]. , 2008, La Revue du praticien.

[74]  J. B. C. de Andrade,et al.  Hemorrhagic Stroke , 2021, Neurocritical Care for Neurosurgeons.

[75]  J. Dion,et al.  Risk of cerebral angiography in patients with subarachnoid hemorrhage, cerebral aneurysm, and arteriovenous malformation: a meta-analysis. , 1999, Stroke.

[76]  M. Oudkerk,et al.  Intracranial aneurysms in patients with subarachnoid hemorrhage: CT angiography as a primary examination tool for diagnosis--systematic review and meta-analysis. , 2011, Radiology.

[77]  C. Shih,et al.  Neurogenic pulmonary edema. , 1987, American family physician.

[78]  M Wintermark,et al.  Vasospasm after subarachnoid hemorrhage: utility of perfusion CT and CT angiography on diagnosis and management. , 2006, AJNR. American journal of neuroradiology.

[79]  P. Parizel,et al.  Imaging findings in diffuse axonal injury after closed head trauma , 1998, European Radiology.

[80]  B. Thompson,et al.  MR imaging of head trauma: review of the distribution and radiopathologic features of traumatic lesions. , 1988, AJR. American journal of roentgenology.

[81]  Lori Shutter,et al.  A trial of intracranial pressure monitoring in traumatic brain injury , 2014, Critical Care.

[82]  Matus Straka,et al.  Computed tomographic perfusion to Predict Response to Recanalization in ischemic stroke , 2017, Annals of neurology.

[83]  Kayvan Najarian,et al.  Automated midline shift and intracranial pressure estimation based on brain CT images. , 2013, Journal of visualized experiments : JoVE.

[84]  C. Williamson,et al.  Accuracy of Daily Lung Ultrasound for the Detection of Pulmonary Edema Following Subarachnoid Hemorrhage , 2016, Neurocritical Care.

[85]  Anthony Marmarou,et al.  A new classification of head injury based on computerized tomography , 1991 .

[86]  R. Showkathali,et al.  TakoTsubo Cardiomyopathy A Short Review , 2013, Current cardiology reviews.

[87]  R. T. Bocchieri,et al.  Biophysical Mechanisms of Traumatic Brain Injuries , 2015, Seminars in Neurology.

[88]  William J Powers,et al.  Extracranial-intracranial bypass surgery for stroke prevention in hemodynamic cerebral ischemia: the Carotid Occlusion Surgery Study randomized trial. , 2011, JAMA.

[89]  Hervé Abdi,et al.  Diffusion tensor tractography of traumatic diffuse axonal injury. , 2008, Archives of neurology.

[90]  Yunling E. Du,et al.  Effect of Cisternal and Ventricular Blood on Risk of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage:: The Fisher Scale Revisited , 2001, Stroke.