Lymphocyte‐activation gene‐3, an important immune checkpoint in cancer
暂无分享,去创建一个
F. Hirsch | C. Rivard | Hui Yu | Caicun Zhou | Yayi He | Ashley A. Kowalewski | K. Ellison | L. Rozeboom | F. Hirsch
[1] Y. Shentu,et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial , 2016, The Lancet.
[2] Yehong Liu,et al. Lymphocyte activation gene 3 negatively regulates the function of intrahepatic hepatitis C virus‐specific CD8+ T cells , 2015, Journal of gastroenterology and hepatology.
[3] L. Diaz,et al. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. , 2015, The New England journal of medicine.
[4] C. Rudin,et al. Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer. , 2015, The New England journal of medicine.
[5] L. Crinò,et al. Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer. , 2015, The New England journal of medicine.
[6] Bert Vogelstein,et al. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. , 2015, The New England journal of medicine.
[7] B. Vogelstein,et al. PD-1 blockade in tumors with mismatch repair deficiency. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[8] J. Lunceford,et al. Pembrolizumab for the treatment of non-small-cell lung cancer. , 2015, The New England journal of medicine.
[9] C. Qiu,et al. The Upregulation of LAG-3 on T Cells Defines a Subpopulation with Functional Exhaustion and Correlates with Disease Progression in HIV-Infected Subjects , 2015, The Journal of Immunology.
[10] H. Saito,et al. Upregulation of Immune Checkpoint Molecules, PD-1 and LAG-3, on CD4+ and CD8+ T Cells after Gastric Cancer Surgery , 2015, Yonago acta medica.
[11] M. Kimani,et al. Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment , 2015, Retrovirology.
[12] H. Kohrt,et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients , 2014, Nature.
[13] P. Hegde,et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer , 2014, Nature.
[14] R. Emerson,et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance , 2014, Nature.
[15] B. Vergani,et al. Alternative activation of human plasmacytoid DCs in vitro and in melanoma lesions: involvement of LAG-3. , 2014, The Journal of investigative dermatology.
[16] N. Jones,et al. Lymphocyte activation gene-3 expression defines a discrete subset of HIV-specific CD8+ T cells that is associated with lower viral load. , 2014, AIDS research and human retroviruses.
[17] R. Luong,et al. Role of Lymphocyte Activation Gene-3 (Lag-3) in Conventional and Regulatory T Cell Function in Allogeneic Transplantation , 2014, PloS one.
[18] Jennifer Couzin-Frankel,et al. Breakthrough of the year 2013. Cancer immunotherapy. , 2013, Science.
[19] Antoni Ribas,et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. , 2013, The New England journal of medicine.
[20] L. Yao,et al. Expression of LAG-3 is coincident with the impaired effector function of HBV-specific CD8(+) T cell in HCC patients. , 2013, Immunology letters.
[21] Kumar Kuna,et al. Research Highlights and Editors’ Picks , 2013 .
[22] Yong-hoon Chung,et al. Construction, and in vitro and in vivo analyses of tetravalent immunoadhesins. , 2012, Journal of microbiology and biotechnology.
[23] C. Drake,et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. , 2012, The New England journal of medicine.
[24] David C. Smith,et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. , 2012, The New England journal of medicine.
[25] P. Klenerman. Faculty Opinions recommendation of Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection. , 2012 .
[26] C. Drake,et al. Cutting Edge: Accelerated Autoimmune Diabetes in the Absence of LAG-3 , 2011, The Journal of Immunology.
[27] S. Beyaz,et al. LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L. , 2011, Blood.
[28] F. Aoudjit,et al. MHC Class II Engagement by Its Ligand LAG-3 (CD223) Contributes to Melanoma Resistance to Apoptosis , 2011, The Journal of Immunology.
[29] T. Okazaki,et al. PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice , 2011, The Journal of experimental medicine.
[30] N. Rothman,et al. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut , 2010, American journal of hematology.
[31] J. Taube,et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[32] G. Parmiani,et al. LAG-3 Expression Defines a Subset of CD4+CD25highFoxp3+ Regulatory T Cells That Are Expanded at Tumor Sites , 2010, The Journal of Immunology.
[33] Š. Pospíšilová,et al. High expression of lymphocyte-activation gene 3 (LAG3) in chronic lymphocytic leukemia cells is associated with unmutated immunoglobulin variable heavy chain region (IGHV) gene and reduced treatment-free survival. , 2010, The Journal of molecular diagnostics : JMD.
[34] Lloyd J. Old,et al. Tumor-infiltrating NY-ESO-1–specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer , 2010, Proceedings of the National Academy of Sciences.
[35] Sang Yeol Lee,et al. Molecular cloning and expression analysis of pig lymphocyte activation gene-3 (LAG-3; CD223). , 2010, Veterinary immunology and immunopathology.
[36] D. Getnet,et al. Functionally Distinct LAG-3 and PD-1 Subsets on Activated and Chronically Stimulated CD8 T Cells1 , 2009, The Journal of Immunology.
[37] C. Drake,et al. LAG-3 Regulates Plasmacytoid Dendritic Cell Homeostasis1 , 2009, The Journal of Immunology.
[38] S. Chanock,et al. Abstract A78: Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut , 2008 .
[39] D. Getnet,et al. LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems. , 2007, The Journal of clinical investigation.
[40] Bing Li,et al. CD4+CD25+Tregs express an increased LAG-3 and CTLA-4 in anterior chamber-associated immune deviation , 2007, Graefe's Archive for Clinical and Experimental Ophthalmology.
[41] G. Freeman,et al. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection , 2007, Nature Immunology.
[42] R. Khanna,et al. Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients. , 2006, Blood.
[43] F. Triebel,et al. A soluble LAG-3 protein as an immunopotentiator for therapeutic vaccines: Preclinical evaluation of IMP321. , 2006, Vaccine.
[44] G. Parmiani,et al. Soluble human LAG-3 molecule amplifies the in vitro generation of type 1 tumor-specific immunity. , 2006, Cancer research.
[45] Malgorzata Kisielow,et al. Expression of lymphocyte activation gene 3 (LAG‐3) on B cells is induced by T cells , 2005, European journal of immunology.
[46] P. Musiani,et al. Immunological mechanisms elicited at the tumour site by lymphocyte activation gene‐3 (LAG‐3) versus IL‐12: sharing a common Th1 anti‐tumour immune pathway , 2005, The Journal of pathology.
[47] In-Jeong Kim,et al. Lymphocyte Activation Gene-3 (CD223) Regulates the Size of the Expanding T Cell Population Following Antigen Activation In Vivo1 , 2004, The Journal of Immunology.
[48] F. Triebel. LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination. , 2003, Trends in immunology.
[49] S. Buisson,et al. MHC class II signal transduction in human dendritic cells induced by a natural ligand, the LAG-3 protein (CD223). , 2003, Blood.
[50] P. Musiani,et al. LAG-3 enables DNA vaccination to persistently prevent mammary carcinogenesis in HER-2/neu transgenic BALB/c mice. , 2003, Cancer research.
[51] D. Vignali,et al. The CD4‐related molecule, LAG‐3 (CD223), regulates the expansion of activated T cells , 2003, European journal of immunology.
[52] S. Buisson,et al. MHC class II engagement by its ligand LAG-3 (CD223) leads to a distinct pattern of chemokine and chemokine receptor expression by human dendritic cells. , 2003, Vaccine.
[53] Haidong Dong,et al. Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion , 2002, Nature Medicine.
[54] M. D’Elios,et al. Active tuberculosis in Africa is associated with reduced Th1 and increased Th2 activity in vivo , 2002, European journal of immunology.
[55] N. Burdin,et al. Maturation and Activation of Dendritic Cells Induced by Lymphocyte Activation Gene-3 (CD223)1 , 2002, The Journal of Immunology.
[56] P. Gaulard,et al. T Lymphocytes infiltrating various tumour types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of LAG-3/MHC class II interactions in cell-cell contacts. , 2001, European journal of cancer.
[57] S. Dzik. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin 10 secretion , 2000 .
[58] F. Triebel,et al. A Soluble Lymphocyte Activation Gene-3 Molecule Used as a Vaccine Adjuvant Elicits Greater Humoral and Cellular Immune Responses to Both Particulate and Soluble Antigens1 , 2000, The Journal of Immunology.
[59] M. Dréano,et al. Lymphocyte activation gene‐3 induces tumor regression and antitumor immune responses , 1999, European journal of immunology.
[60] G. Zhu,et al. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion , 1999, Nature Medicine.
[61] S. Hannier,et al. The MHC class II ligand lymphocyte activation gene-3 is co-distributed with CD8 and CD3-TCR molecules after their engagement by mAb or peptide-MHC class I complexes. , 1999, International immunology.
[62] M. Avice,et al. Lymphocyte activation gene-3, a MHC class II ligand expressed on activated T cells, stimulates TNF-alpha and IL-12 production by monocytes and dendritic cells. , 1999, Journal of immunology.
[63] G. Bismuth,et al. CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling. , 1998, Journal of immunology.
[64] T. Satoh,et al. CD4 dimerization and oligomerization: implications for T-cell function and structure-based drug design. , 1998, Immunology today.
[65] F. Annunziato,et al. Expression and release of LAG‐3‐encoded protein by human CD4+ T cells are associated with IFN‐γ production , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[66] F. Pagès,et al. T cell major histocompatibility complex class II molecules down‐regulate CD4+ T cell clone responses following LAG‐3 binding , 1996, European journal of immunology.
[67] D. Bruniquel,et al. CD4/major histocompatibility complex class II interaction analyzed with CD4‐ and lymphocyte activation gene‐3 (LAG‐3)‐Ig fusion proteins , 1995, European journal of immunology.
[68] A. Smolyar,et al. Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[69] C. Auffray,et al. Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens , 1992, The Journal of experimental medicine.
[70] S. Roman-Roman,et al. LAG-3, a novel lymphocyte activation gene closely related to CD4 , 1990, The Journal of experimental medicine.
[71] C. Liu,et al. Microenvironment and Immunology Immune InhibitoryMolecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape , 2012 .
[72] A. Oxenius,et al. On the role of the inhibitory receptor LAG-3 in acute and chronic LCMV infection. , 2010, International immunology.
[73] Antonio Polley,et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection , 2009, Nature Immunology.
[74] G. Zhu,et al. Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion , 2002, Nature Medicine.
[75] D. Bruniquel,et al. Genomic organization of the human LAG-3/CD4 locus , 1997, Immunogenetics.
[76] T. Iijima,et al. Expression of MHC class II antigens in human lung cancer cells , 1991, Virchows Archiv. B, Cell pathology including molecular pathology.
[77] Peter Vogel,et al. Microenvironment and Immunology Immune Inhibitory Molecules Lag-3 and Pd-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape , 2022 .
[78] M. Selman,et al. IMMUNOPATHOLOGY AND INFECTIOUS DISEASES LAG 3 Expression in Active Mycobacterium tuberculosis Infections , 2022 .
[79] A. Smolyar. Oligomerization of CD 4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gpl 20 , 2022 .