Repeated positive fighting experience in male inbred mice

Repeated aggression is a frequent symptom of many psychiatric and neurological disorders, including obsessive-compulsive and attention deficit hyperactivity disorders, bipolar and post-traumatic stress disorders, epilepsy, autism, schizophrenia and drug abuse. However, repeated aggression is insufficiently studied because there is a lack of adequate models in animals. The sensory contact model (SCM), widely used to study the effects of chronic social defeat stress, can also be used to investigate the effects of repeated aggression. Mice with repeated positive fighting experience in daily agonistic interactions in this model develop pronounced aggressiveness, anxiety and impulsivity, disturbances in motivated and cognitive behaviors, and impairments of sociability; they also demonstrate hyperactivity, attention-deficit behavior, motor dysfunctions and repetitive stereotyped behaviors, such as jerks, rotations and head twitches. In this protocol, we describe how to apply the SCM to study repeated aggression in mice. Severe neuropathology develops in male mice after 20–21 d of agonistic interactions.

[1]  P. Brain,et al.  Effects of residence, aggressive experience and intruder familiarity on attack shown by male mice , 1983, Behavioural Processes.

[2]  Danielle L. Graham,et al.  Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress , 2006, Science.

[3]  N. Kudryavtseva.  Straub tail, the deprivation effect and addiction to aggression , 2006, q-bio/0602017.

[4]  P. Brain,et al.  Some studies on the use of "standard opponents" in intermale aggression testing in TT albino mice. , 1974, Behaviour.

[5]  N. E. Van de Poll,et al.  Aggressive behaviour in rats: Effects of winning or losing on subsequent aggressive interactions , 1982, Behavioural Processes.

[6]  Vitali Proutski,et al.  The effect of chronic exposure to highly aggressive mice on hippocampal gene expression of non-aggressive subordinates , 2006, Brain Research.

[7]  N. K. Popova,et al.  Correlation between tryptophan hydroxylase activity in the brain and predisposition to pinch-induced catalepsy in mice , 1995, Pharmacology Biochemistry and Behavior.

[8]  S. Russo,et al.  A standardized protocol for repeated social defeat stress in mice , 2011, Nature Protocols.

[9]  A. Lopez-Lujan,et al.  Social structure features in three inbred strains of mice, C57Bl/6J, Balb/cj, and NIH: a comparative study. , 1987, Behavioral and neural biology.

[10]  T. Amstislavskaya,et al.  Effects of repeated aggressive encounters on approach to a female and plasma testosterone in male mice , 2004, Hormones and Behavior.

[11]  J. Koolhaas,et al.  The stress response to sensory contact in mice: genotype effect of the stimulus animal , 2005, Psychoneuroendocrinology.

[12]  N. Kudryavtseva.  An experimental approach to the study of learned aggression , 2000 .

[13]  O. Alekseyenko,et al.  Behavioral correlates of learned aggression in male mice , 2000 .

[14]  N. Kudryavtseva,et al.  A sensory contact model for the study of aggressive and submissive behavior in male mice , 1991 .

[15]  R. Porsolt,et al.  Behavioral despair in mice: a primary screening test for antidepressants. , 1977, Archives internationales de pharmacodynamie et de therapie.

[16]  Maxim L. Filipenko,et al.  Molecular Implications of Repeated Aggression: Th, Dat1, Snca and Bdnf Gene Expression in the VTA of Victorious Male Mice , 2009, PloS one.

[17]  P. Ropartz.  The relation between olfactory stimulation and aggressive behaviour in mice. , 1968, Animal behaviour.

[18]  N. van de Poll,et al.  Aggressive behaviour in rats: Effects of winning or losing on subsequent aggressive interactions. , 1982, Behavioural processes.

[19]  J. P. Scott.  Agonistic behavior of mice and rats: a review. , 1966, American zoologist.

[20]  Natalia N. Kudryavtseva,et al.  Association between experience of aggression and anxiety in male mice , 2002, Behavioural Brain Research.

[21]  D. Smagin,et al.  Modeling fighting deprivation effect in mouse repeated aggression paradigm , 2011, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[22]  S. Hogg,et al.  Behavioural consequences of repeated social defeat in the mouse: preliminary evaluation of a potential animal model of depression. , 1999, Behavioural pharmacology.

[23]  D. Avgustinovich,et al.  [The effect of the repeated experience of aggression in daily confrontations on the individual and social behavior of male mice]. , 1997, Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova.

[24]  Kudriavtseva Nn,et al.  [The development of catatonic reactions in male mice of CBA/Lac strain: the effect of repeated experience of aggression and submission]. , 2003, Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova.

[25]  E. Nestler,et al.  Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action , 2006, Nature Neuroscience.

[26]  J. Koolhaas,et al.  Acute and Chronic Social Defeat: Stress Protocols and Behavioral Testing , 2009 .

[27]  R. Lister.  The use of a plus-maze to measure anxiety in the mouse , 2004, Psychopharmacology.

[28]  N. Kudryavtseva.  Use of the “Partition” Test in Behavioral and Pharmacological Experiments , 2003, Neuroscience and Behavioral Physiology.

[29]  N. Kudryavtseva,et al.  Comparative analysis of anxiety-like behavior in partition and plus-maze tests after agonistic interactions in mice , 1997, Physiology & Behavior.

[30]  N. Kudryavtseva.  Partition test and sexual motivation in male mice , 2007, 0708.0297.

[31]  N. Kudryavtseva,et al.  Agonistic behavior: A model, experimental studies, and perspectives , 2000, Neuroscience and Behavioral Physiology.

[32]  J. Koolhaas,et al.  Development of violence in mice through repeated victory along with changes in prefrontal cortex neurochemistry , 2008, Behavioural Brain Research.

[33]  K. Miczek,et al.  Aggressive behavior as a reinforcer in mice: activation by allopregnanolone , 2002, Psychopharmacology.

[34]  R. Rodgers,et al.  Anxiety enhancement in the murine elevated plus maze by immediate prior exposure to social stressors , 1993, Physiology & Behavior.

[35]  N. Kudryavtseva.  Experience of defeat decreases the behavioural reactivity to conspecifics in the partition test , 1994, Behavioural Processes.

[36]  Natalia N. Kudryavtseva,et al.  Behavioral and Physiological Markers of Experimental Depression Induced by Social Conflicts (DISC) , 1998 .

[37]  Scott J. Russo,et al.  Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions , 2007, Cell.

[38]  N. Kudryavtseva.  Sensory Contact Model: Protocol, Control, Applications , 2009 .

[39]  I. Kovalenko,et al.  An experimental approach for the study of psychotropic drug effects under simulated clinical conditions. , 2008, Current drug metabolism.

[40]  G. Flügge,et al.  CRE/CREB-Driven Up-Regulation of Gene Expression by Chronic Social Stress in CRE-Luciferase Transgenic Mice: Reversal by Antidepressant Treatment , 2007, PloS one.

[41]  D. Segal.  Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) , 2010 .

[42]  H. Sershen,et al.  Differential regulation of catechol-O-methyltransferase expression in a mouse model of aggression , 2011, Brain Structure and Function.

[43]  N. Bondar,et al.  [Impaired social recognition in male mice with repeated experience of aggression]. , 2005, Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova.

[44]  W. Bunney,et al.  Animal model of depression. I. Review of evidence: implications for research. , 1969, Archives of general psychiatry.

[45]  N. Kudryavtseva,et al.  Experience of defeat increases the susceptibility to catatonic - like state in mice , 1989, Behavioural Processes.

[46]  N. Kudryavtseva,et al.  Social model of depression in mice of C57BL/6J strain , 1991, Pharmacology Biochemistry and Behavior.

[47]  C. Hall.  Genetic differences in fatal audiogenic seizures between two inbred strains of house mice. , 1947, The Journal of heredity.

[48]  Porsolt Rd.  Animal model of depression. , 1979 .

[49]  J. P. Scott.  Theoretical Issues Concerning the Origin and Causes of Fighting , 1971 .