Mycoplasma Pneumoniae Associated with Stevens Johnson Syndrome

We describe a case of Mycoplasma pneumoniae chest infection associated with Stevens Johnson syndrome. The patient had extensive epidermal bullous vesicles, oropharyngeal and genital ulceration and required prolonged ventilation due to respiratory failure. Mycoplasma pneumoniae infections are often asymptomatic but can involve multiple organ systems. Respiratory tract involvement is generally benign though 3 to 10% of patients develop clinical pneumonia. Secondary skin reactions are common (20 to 25%), although few patients infected develop Stevens Johnson syndrome. It has been suggested that Mycoplasma pneumoniae may be the most common infectious cause of Stevens Johnson syndrome.

[1]  M. Meseguer,et al.  Stevens-Johnson syndrome with isolation ofMycoplasma pneumoniae from skin lesions , 1986, European Journal of Clinical Microbiology.

[2]  Yao-Hsu Yang,et al.  Clinical characteristics of childhood erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis in Taiwanese children. , 2004, Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.

[3]  A. Evangelista,et al.  In vitro activity of levofloxacin against contemporary clinical isolates of Legionella pneumophila, Mycoplasma pneumoniae and Chlamydia pneumoniae from North America and Europe. , 2002, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[4]  A. Taïeb,et al.  Diagnosis, classification, and management of erythema multiforme and Stevens–Johnson syndrome , 2000, Archives of disease in childhood.

[5]  R. Patterson,et al.  Corticosteroid therapy in an additional 13 cases of Stevens-Johnson syndrome: a total series of 67 cases. , 2000, Allergy and asthma proceedings.

[6]  J. Huff,et al.  Mycoplasma pneumoniae infection is associated with Stevens-Johnson syndrome, not erythema multiforme (von Hebra). , 1996, Journal of the American Academy of Dermatology.

[7]  R. Stern,et al.  Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. , 1996, The New England journal of medicine.

[8]  M. Mockenhaupt,et al.  Low N‐acetylating capacity in patients with Stevens‐Johnson syndrome and toxic epidermal necrolysis * , 1995, Experimental dermatology.

[9]  B. Cunha.  The antibiotic treatment of community-acquired, atypical, and nosocomial pneumonias. , 1995, The Medical clinics of North America.

[10]  E. Jacobs.  Serological diagnosis of Mycoplasma pneumoniae infections: a critical review of current procedures. , 1993, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[11]  Hu Ry,et al.  [Stevens-Johnson syndrome: a review of 42 cases]. , 1993 .

[12]  B. Strom,et al.  A population-based study of Stevens-Johnson syndrome. Incidence and antecedent drug exposures. , 1991, Archives of dermatology.

[13]  N. Shear,et al.  Mycoplasma Pneumoniae Infections and Stevens-Johnson Syndrome , 1991, Clinical pediatrics.

[14]  O. I. Troshina,et al.  [Mycoplasma and Ureaplasma infections in chronic genital inflammatory processes, abortion and infertility]. , 1991, Vestnik Akademii meditsinskikh nauk SSSR.

[15]  H. Stutman.  Stevens-Johnson syndrome and Mycoplasma pneumoniae: evidence for cutaneous infection. , 1987, The Journal of pediatrics.

[16]  G. Shires,et al.  Improved Burn Center Survival of Patients with Toxic Epidermal Necrolysis Managed without Corticosteroids , 1986, Annals of surgery.

[17]  K. Lind.  MUCOCUTANEOUS REACTIONS DURING MYCOPLASMA PNEUMONIÆ INFECTION , 1978, The Lancet.

[18]  V. Kolze,et al.  Stevens-Johnson Syndrome associated with mycoplasma pneumoniae infection , 1973, The Journal of Laryngology & Otology.

[19]  Adelstein Am,et al.  Revision of the international classification of diseases. , 1971, Lancet.

[20]  H. Cannell,et al.  STEVSENS‐JOHNSON SYNDROME ASSOCIATED WITH MYCOPLASMA PNEUMONILAE INFECTION , 1969 .

[21]  H. Katz,et al.  Stevens-Johnson syndrome. Report of a case associated with culturally proven Mycoplasma pneumoniae infection. , 1967, JAMA.

[22]  J. B. Bridges,et al.  ASSOCIATION OF STEVENS-JOHNSON SYNDROME WITH ANTIBODY FOR MYCOPLASMA PNEUMONIAE. , 1964, Lancet.