Alternative mechanisms for tiotropium.

[1]  P. Barnes,et al.  Autonomic Factors in Hyperreactivity of Airway Smooth Muscle , 2011 .

[2]  M. Decramer,et al.  Effectiveness of Tiotropium as First Maintenance Drug in Patients with COPD. Secondary Analysis of the UPLIFT Trial. , 2009, ATS 2009.

[3]  A. Negassa,et al.  Effect of Tiotropium on Cough Reflex Sensitivity in Acute Viral Cough , 2008, Lung.

[4]  K. Racké,et al.  Muscarinic receptors mediate stimulation of collagen synthesis in human lung fibroblasts , 2008, European Respiratory Journal.

[5]  Liam Ck A 4-year trial of tiotropium in chronic obstructive pulmonary disease. , 2008 .

[6]  K. Racké,et al.  Pulmonary fibroblasts, an emerging target for anti-obstructive drugs , 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

[7]  T. Welte,et al.  Tiotropium suppresses acetylcholine-induced release of chemotactic mediators in vitro. , 2007, Respiratory medicine.

[8]  A. Halayko,et al.  Cooperative regulation of GSK-3 by muscarinic and PDGF receptors is associated with airway myocyte proliferation. , 2007, American journal of physiology. Lung cellular and molecular physiology.

[9]  A. Halayko,et al.  Inhibition of allergen-induced airway remodelling by tiotropium and budesonide: a comparison , 2007, European Respiratory Journal.

[10]  G. Donaldson,et al.  Effect of tiotropium on sputum and serum inflammatory markers and exacerbations in COPD , 2007, European Respiratory Journal.

[11]  L. Kunz,et al.  Ovarian acetylcholine and ovarian KCNQ channels: insights into cellular regulatory systems of steroidogenic granulosa cells. , 2007, Life sciences.

[12]  C. Kirkpatrick,et al.  Recent progress in understanding the non-neuronal cholinergic system in humans. , 2007, Life sciences.

[13]  O. Holz,et al.  MAPK pathway mediates muscarinic receptor-induced human lung fibroblast proliferation. , 2007, Life sciences.

[14]  J. Park,et al.  Acetylcholine-induced proliferation of fibroblasts and myofibroblasts in vitro is inhibited by tiotropium bromide. , 2007, Life sciences.

[15]  P. Paré,et al.  Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. , 2007, The European respiratory journal.

[16]  J. Nadel Innate immune mucin production via epithelial cell surface signaling: relationship to allergic disease , 2007, Current opinion in allergy and clinical immunology.

[17]  M. Pittelkow,et al.  Adrenergic and cholinergic control in the biology of epidermis: physiological and clinical significance. , 2006, The Journal of investigative dermatology.

[18]  K. Racké,et al.  Muscarinic receptors mediate stimulation of human lung fibroblast proliferation. , 2006, American journal of respiratory cell and molecular biology.

[19]  D. Bolser Current and future centrally acting antitussives , 2006, Respiratory Physiology & Neurobiology.

[20]  J. Wess,et al.  Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse , 2006, Respiratory research.

[21]  M. Lenburg,et al.  Cholinergic receptor and cyclic stretch-mediated inflammatory gene expression in intact ASM. , 2006, American journal of respiratory cell and molecular biology.

[22]  Jeffrey M Drazen,et al.  Chronic effects of mechanical force on airways. , 2006, Annual review of physiology.

[23]  V. Brusasco,et al.  Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD. , 2003, Thorax.

[24]  L. Boulet,et al.  Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines. , 2006, Chest.

[25]  C. Billington,et al.  Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth. , 2005, Biochemistry.

[26]  R. Gosens,et al.  Protective effects of tiotropium bromide in the progression of airway smooth muscle remodeling. , 2005, American journal of respiratory and critical care medicine.

[27]  H. Koepsell,et al.  Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. , 2005, American journal of respiratory cell and molecular biology.

[28]  A. Anzueto,et al.  One-year analysis of longitudinal changes in spirometry in patients with COPD receiving tiotropium. , 2005, Pulmonary pharmacology & therapeutics.

[29]  J. Nadel,et al.  Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[30]  K. Belmonte Cholinergic pathways in the lungs and anticholinergic therapy for chronic obstructive pulmonary disease. , 2005, Proceedings of the American Thoracic Society.

[31]  A. Fryer,et al.  Beta2-agonist and anticholinergic drugs in the treatment of lung disease. , 2005, Proceedings of the American Thoracic Society.

[32]  K. Chung The role of airway smooth muscle in the pathogenesis of airway wall remodeling in chronic obstructive pulmonary disease. , 2005, Proceedings of the American Thoracic Society.

[33]  J. Luketich,et al.  Nicotine signals through muscle-type and neuronal nicotinic acetylcholine receptors in both human bronchial epithelial cells and airway fibroblasts , 2004, Respiratory research.

[34]  R. Gosens,et al.  Acetylcholine: a novel regulator of airway smooth muscle remodelling? , 2004, European journal of pharmacology.

[35]  K. Kawashima,et al.  Expression of non-neuronal acetylcholine in lymphocytes and its contribution to the regulation of immune function. , 2004, Frontiers in bioscience : a journal and virtual library.

[36]  J. Hogg,et al.  Pathophysiology of airflow limitation in chronic obstructive pulmonary disease , 2004, The Lancet.

[37]  K. Racké,et al.  The airway cholinergic system: physiology and pharmacology. , 2004, Pulmonary pharmacology & therapeutics.

[38]  P. Paré,et al.  The nature of small-airway obstruction in chronic obstructive pulmonary disease. , 2004, The New England journal of medicine.

[39]  B. Make,et al.  Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD , 2004, European Respiratory Journal.

[40]  M. Pfeifer,et al.  Activation of bronchial epithelial cells in smokers without airway obstruction and patients with COPD. , 2004, Chest.

[41]  J. Agnew,et al.  The effect of inhaled tiotropium bromide on lung mucociliary clearance in patients with COPD. , 2004, Chest.

[42]  M. Decramer,et al.  Clinical Trial Design Considerations in Assessing Long‐Term Functional Impacts of Tiotropium in COPD: The Uplift Trial , 2004, COPD.

[43]  M. Acevedo Effect of acetyl choline on ion transport in sheep tracheal epithelium , 1994, Pflügers Archiv.

[44]  Nicholas J Gross,et al.  Tiotropium Bromide , 2012 .

[45]  S. Sinha,et al.  Effect of single inhalation of a salbutamol, ipratropium bromide and beclomethasone on mucociliary clearance in patients with chronic obstructive airway disease. , 2003, The Indian journal of chest diseases & allied sciences.

[46]  R. Pauwels,et al.  Chronic obstructive pulmonary disease: molecular and cellularmechanisms , 2003, European Respiratory Journal.

[47]  J. McConville,et al.  The RhoA/Rho kinase pathway regulates nuclear localization of serum response factor. , 2003, American journal of respiratory cell and molecular biology.

[48]  D. Zoukhri,et al.  Cholinergic agonists transactivate EGFR and stimulate MAPK to induce goblet cell secretion. , 2003, American journal of physiology. Cell physiology.

[49]  H. Kilbinger,et al.  Increased acetylcholine levels in skin biopsies of patients with atopic dermatitis. , 2003, Life sciences.

[50]  K. Kawashima,et al.  Evolutional study on acetylcholine expression. , 2003, Life sciences.

[51]  R. Gosens,et al.  Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle. , 2003, American journal of respiratory cell and molecular biology.

[52]  V. Brusasco,et al.  Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD. , 2003, Thorax.

[53]  P. Barnes,et al.  Tiotropium bromide: a novel once-daily anticholinergic bronchodilator for the treatment of COPD. , 2002, Drugs of today.

[54]  R. Zuwallack,et al.  A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease , 2002, European Respiratory Journal.

[55]  J. V. van Noord,et al.  Improved health outcomes in patients with COPD during 1 yr's treatment with tiotropium , 2002, European Respiratory Journal.

[56]  J. Vestbo Epidemiological studies in mucus hypersecretion. , 2002, Novartis Foundation symposium.

[57]  J. Wess,et al.  Heterogeneity of release-inhibiting muscarinic autoreceptors in heart atria and urinary bladder: a study with M2- and M4-receptor-deficient mice , 2002, Naunyn-Schmiedeberg's Archives of Pharmacology.

[58]  C. Kirkpatrick,et al.  The Non-neuronal cholinergic system: an emerging drug target in the airways. , 2001, Pulmonary pharmacology & therapeutics.

[59]  H. Kilbinger,et al.  Release of non‐neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters , 2001, British journal of pharmacology.

[60]  B. Rubin,et al.  Regulation of secretion from mucous and serous cells in the excised ferret trachea. , 2001, Respiration physiology.

[61]  M. Triggiani,et al.  Histamine Induces Exocytosis and IL-6 Production from Human Lung Macrophages Through Interaction with H1 Receptors1 , 2001, The Journal of Immunology.

[62]  H. Kilbinger,et al.  The biological role of non-neuronal acetylcholine in plants and humans. , 2001, Japanese journal of pharmacology.

[63]  I. Wessler,et al.  Muscarinic control of histamine release from airways. Inhibitory M1-receptors in human bronchi but absence in rat trachea. , 2000, American journal of respiratory and critical care medicine.

[64]  P. Jeffery,et al.  Comparison of the structural and inflammatory features of COPD and asthma. Giles F. Filley Lecture. , 2000, Chest.

[65]  A. O. Opazo Saez,et al.  Peripheral airway smooth muscle mechanics in obstructive airways disease. , 2000, American journal of respiratory and critical care medicine.

[66]  J. Benovic,et al.  Mechanisms of proliferation synergy by receptor tyrosine kinase and G protein-coupled receptor activation in human airway smooth muscle. , 2000, American journal of respiratory cell and molecular biology.

[67]  Rutgers,et al.  Protective effect of oral terfenadine and not inhaled ipratropium on adenosine 5′‐monophosphate‐induced bronchoconstriction in patients with COPD , 1999, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[68]  D. Lauffenburger,et al.  Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[69]  C. Kirkpatrick,et al.  THE CHOLINERGIC ‘PITFALL’: ACETYLCHOLINE, A UNIVERSAL CELL MOLECULE IN BIOLOGICAL SYSTEMS, INCLUDING HUMANS , 1999, Clinical and experimental pharmacology & physiology.

[70]  C. Kirkpatrick,et al.  Airway epithelium: more than just a barrier! , 1999, Trends in pharmacological sciences.

[71]  T. Witek,et al.  Tiotropium (Spiriva): mechanistical considerations and clinical profile in obstructive lung disease. , 1999, Life sciences.

[72]  K. Kubo,et al.  Acetylcholine and substance P stimulate bronchial epithelial cells to release eosinophil chemotactic activity. , 1998, Journal of applied physiology.

[73]  A. Ullrich,et al.  Signal characteristics of G protein‐transactivated EGF receptor , 1997, The EMBO journal.

[74]  C. Kirkpatrick,et al.  Non-neuronal acetylcholine, a signalling molecule synthezised by surface cells of rat and man , 1997, Naunyn-Schmiedeberg's Archives of Pharmacology.

[75]  J. Vestbo,et al.  Chronic mucus hypersecretion in COPD and death from pulmonary infection. , 1995, The European respiratory journal.

[76]  J. Widdicombe,et al.  Neurophysiology of the cough reflex. , 1995, The European respiratory journal.

[77]  S. Rennard,et al.  Bradykinin stimulates bronchial epithelial cells to release neutrophil and monocyte chemotactic activity. , 1992, The American journal of physiology.

[78]  W. Bailey,et al.  Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study. , 1995, JAMA.

[79]  E. Tagaya,et al.  Effect of long term treatment with oxitropium bromide on airway secretion in chronic bronchitis and diffuse panbronchiolitis. , 1994, Thorax.

[80]  R. Lowry,et al.  The effect of anticholinergic bronchodilator therapy on cough during upper respiratory tract infections. , 1994, British journal of clinical pharmacology.

[81]  W. Bennett,et al.  The acute effect of ipratropium bromide bronchodilator therapy on cough clearance in COPD. , 1993, Chest.

[82]  R. Pierce,et al.  Chronic persistent cough: use of ipratropium bromide in undiagnosed cases following upper respiratory tract infection. , 1992, Respiratory medicine.

[83]  M. Fujimura,et al.  Effects of methacholine induced bronchoconstriction and procaterol induced bronchodilation on cough receptor sensitivity to inhaled capsaicin and tartaric acid. , 1992, Thorax.

[84]  S. Rennard,et al.  Acetylcholine stimulates bronchial epithelial cells to release neutrophil and monocyte chemotactic activity. , 1992, The American journal of physiology.

[85]  W. Foster,et al.  Influence of inhaled atropine on lung mucociliary function in humans. , 1991, The American review of respiratory disease.

[86]  N. Choudry,et al.  The effect of altering airway tone on the sensitivity of the cough reflex in normal volunteers. , 1991, The European respiratory journal.

[87]  K. Chung,et al.  Prostaglandin F2 alpha enhancement of capsaicin induced cough in man: modulation by beta 2 adrenergic and anticholinergic drugs. , 1990, Thorax.

[88]  N. Gross,et al.  Cholinergic bronchomotor tone in COPD. Estimates of its amount in comparison with that in normal subjects. , 1989, Chest.

[89]  P. Barnes,et al.  Muscarinic receptor subtypes in human and guinea pig lung. , 1989, European journal of pharmacology.

[90]  L. Schwartz,et al.  Elevated histamine and tryptase levels in smokers' bronchoalveolar lavage fluid. Do lung mast cells contribute to smokers' emphysema? , 1988, Chest.

[91]  R. Lowry,et al.  Antitussive properties of inhaled bronchodilators on induced cough. , 1988, Chest.

[92]  D. Pavia,et al.  Effect of four weeks' high dose ipratropium bromide treatment on lung mucociliary clearance. , 1986, Thorax.

[93]  J. Pounsford,et al.  Effect of bronchodilators on the cough response to inhaled citric acid in normal and asthmatic subjects. , 1985, Thorax.

[94]  H. Matthys,et al.  Influence of 0.2 mg ipratropium bromide on mucociliary clearance in patients with chronic bronchitis. , 1985, Respiration; international review of thoracic diseases.

[95]  N. Sheahan,et al.  Effect of ipratropium bromide on mucociliary clearance and pulmonary function in reversible airways obstruction. , 1979, Thorax.

[96]  M. Newhouse,et al.  Aerosol therapy with Sch 1000. Short-term mucociliary clearance in normal and bronchitic subjects and toxicology in normal subjects. , 1978, Chest.

[97]  D. Pavia,et al.  Ipratropium bromide: mucociliary clearance rate and airway resistance in normal subjects. , 1977, British journal of diseases of the chest.

[98]  P. Annis,et al.  Effects of atropine on velocity of tracheal mucus in anesthetized patients. , 1976, Anesthesiology.