Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3–like protein 1

[1]  J. Elias,et al.  Role of Chitinase 3-Like-1 in Interleukin-18-Induced Pulmonary Type 1, Type 2, and Type 17 Inflammation; Alveolar Destruction; and Airway Fibrosis in the Murine Lung. , 2015, American journal of respiratory cell and molecular biology.

[2]  M. Weatherall,et al.  Treatment responsiveness of phenotypes of symptomatic airways obstruction in adults. , 2015, The Journal of allergy and clinical immunology.

[3]  Borislav D. Dimitrov,et al.  Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms , 2015, The Journal of allergy and clinical immunology.

[4]  E. Bleecker,et al.  Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40. , 2015, The Journal of allergy and clinical immunology.

[5]  Gary S Collins,et al.  Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD): Explanation and Elaboration , 2015, Annals of Internal Medicine.

[6]  J. Elias,et al.  Role of Chitinase 3-like-1 in IL-18-induced pulmonary Type- 1, -2 and -17 inflammation, alveolar destruction and airway fibrosis in the murine lung , 2015 .

[7]  P. Burton,et al.  Statistical Cluster Analysis of the British Thoracic Society Severe Refractory Asthma Registry: Clinical Outcomes and Phenotype Stability , 2014, PloS one.

[8]  D. Curran‐Everett,et al.  Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data. , 2014, The Journal of allergy and clinical immunology.

[9]  Hana Hazgui,et al.  Ten-year follow-up of cluster-based asthma phenotypes in adults. A pooled analysis of three cohorts. , 2013, American journal of respiratory and critical care medicine.

[10]  P. Y. Lum,et al.  Extracting insights from the shape of complex data using topology , 2013, Scientific Reports.

[11]  Hao Tang,et al.  YKL-40 Induces IL-8 Expression from Bronchial Epithelium via MAPK (JNK and ERK) and NF-κB Pathways, Causing Bronchial Smooth Muscle Proliferation and Migration , 2012, The Journal of Immunology.

[12]  N. Thomson,et al.  Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: relationship to disease severity. , 2012, The Journal of allergy and clinical immunology.

[13]  S. Muro,et al.  Sputum YKL-40 Levels and Pathophysiology of Asthma and Chronic Obstructive Pulmonary Disease , 2011, Respiration.

[14]  B. Hargadon,et al.  Profiling of Sputum Inflammatory Mediators in Asthma and Chronic Obstructive Pulmonary Disease , 2011, Respiration.

[15]  Adnan Custovic,et al.  Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. , 2011, The Journal of allergy and clinical immunology.

[16]  C. Palmer,et al.  Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults. , 2010, The Journal of allergy and clinical immunology.

[17]  G. Cooke,et al.  MMP12, lung function, and COPD in high-risk populations. , 2010, The New England journal of medicine.

[18]  D. Curran‐Everett,et al.  Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. , 2010, American journal of respiratory and critical care medicine.

[19]  Gunnar E. Carlsson,et al.  Topology and data , 2009 .

[20]  G. Anderson,et al.  Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease , 2008, The Lancet.

[21]  M. Wills-Karp,et al.  Matrix metalloproteinase 8 contributes to solubilization of IL-13 receptor alpha2 in vivo. , 2008, The Journal of allergy and clinical immunology.

[22]  Mike Thomas,et al.  Cluster analysis and clinical asthma phenotypes. , 2008, American journal of respiratory and critical care medicine.

[23]  Ying Sun,et al.  Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. , 2008, The New England journal of medicine.

[24]  J. Dziura,et al.  A chitinase-like protein in the lung and circulation of patients with severe asthma. , 2007, The New England journal of medicine.

[25]  R. El Bekay,et al.  Neutrophils as a Novel Source of Eosinophil Cationic Protein in IgE-Mediated Processes1 , 2007, The Journal of Immunology.

[26]  D. Curran‐Everett,et al.  Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. , 2007, The Journal of allergy and clinical immunology.

[27]  R. Scott,et al.  Inflammatory subtypes in asthma: Assessment and identification using induced sputum , 2006, Respirology.

[28]  J. Piccirillo,et al.  Psychometric and Clinimetric Validity of the 20-Item Sino-Nasal Outcome Test (Snot-20) , 2002, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[29]  E. Juniper,et al.  Measuring asthma control. Clinic questionnaire or daily diary? , 2000, American journal of respiratory and critical care medicine.

[30]  S. Shapiro,et al.  Animal models for chronic obstructive pulmonary disease: age of klotho and marlboro mice. , 2000, American journal of respiratory cell and molecular biology.

[31]  D. Hartmann,et al.  Contribution of 92 kDa gelatinase/type IV collagenase in bronchial inflammation during status asthmaticus. , 1999, American journal of respiratory and critical care medicine.

[32]  S. Shapiro,et al.  Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. , 1997, Science.

[33]  H. Kita,et al.  Eosinophil major basic protein induces degranulation and IL-8 production by human eosinophils. , 1995, Journal of immunology.

[34]  Y. Okada,et al.  Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema , 1992, Cell.

[35]  C. Sherbourne,et al.  The MOS 36-Item Short-Form Health Survey (SF-36) , 1992 .

[36]  G. Guyatt,et al.  Evaluation of impairment of health related quality of life in asthma: development of a questionnaire for use in clinical trials. , 1992, Thorax.

[37]  Ware J.E.Jr.,et al.  THE MOS 36- ITEM SHORT FORM HEALTH SURVEY (SF- 36) CONCEPTUAL FRAMEWORK AND ITEM SELECTION , 1992 .

[38]  G. Huston.  The Hospital Anxiety and Depression Scale. , 1987, The Journal of rheumatology.

[39]  Paul Shaman,et al.  University of pennsylvania smell identification test: A rapid quantitative olfactory function test for the clinic , 1984, The Laryngoscope.