Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
暂无分享,去创建一个
T. Mizushima | Keiji Tanaka | S. Kageyama | M. Komatsu | A. Hirao | Masayuki Yamamoto | K. Takagi | S. Waguri | Tetsuya Saito | Ryosuke Ishimura | T. Kouno | Myung-Shik Lee | T. Yoshimori | J. Hasegawa | H. Motohashi | Yoshinobu Ichimura | T. Fukutomi | Takayuki Hoshii | Yinjie Yang | Yu-Shin Sou
[1] Hye Eun Lee,et al. Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. , 2013, Cell metabolism.
[2] S. Tooze,et al. Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2 , 2013, Autophagy.
[3] Steven B. Bradfute,et al. TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation. , 2012, Immunity.
[4] Masaaki Komatsu,et al. Keap1 degradation by autophagy for the maintenance of redox homeostasis , 2012, Proceedings of the National Academy of Sciences.
[5] M. Sporn,et al. NRF2 and cancer: the good, the bad and the importance of context , 2012, Nature Reviews Cancer.
[6] H. Aburatani,et al. Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. , 2012, Cancer cell.
[7] E. White. Deconvoluting the context-dependent role for autophagy in cancer , 2012, Nature Reviews Cancer.
[8] T. Soga,et al. mTORC1 is essential for leukemia propagation but not stem cell self-renewal. , 2012, The Journal of clinical investigation.
[9] Ruiying Zhao,et al. KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. , 2012, Cancer cell.
[10] N. Nukina,et al. Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins. , 2011, Molecular cell.
[11] Ximing J. Yang,et al. An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma. , 2011, Cancer cell.
[12] Aleksey A. Porollo,et al. p62 is a key regulator of nutrient sensing in the mTORC1 pathway. , 2011, Molecular cell.
[13] D. Rubinsztein,et al. Autophagy and Aging , 2011, Cell.
[14] Scott E. Kern,et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis , 2011, Nature.
[15] Z. Elazar,et al. Biogenesis and cargo selectivity of autophagosomes. , 2011, Annual review of biochemistry.
[16] Keiji Tanaka,et al. Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells , 2011, The Journal of cell biology.
[17] Y. Eishi,et al. Autophagy-deficient mice develop multiple liver tumors. , 2011, Genes & development.
[18] T. Lamark,et al. Selective autophagy mediated by autophagic adapter proteins , 2011, Autophagy.
[19] Keiji Tanaka,et al. The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice , 2011, Nature communications.
[20] Masayuki Yamamoto,et al. Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution , 2011, Genes to cells : devoted to molecular & cellular mechanisms.
[21] N. Mizushima,et al. p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding , 2011, The Journal of cell biology.
[22] Donna D. Zhang,et al. Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases. , 2010, Antioxidants & redox signaling.
[23] R. Youle,et al. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both , 2010, Autophagy.
[24] Guido Kroemer,et al. Autophagy and the integrated stress response. , 2010, Molecular cell.
[25] M. McMahon,et al. p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription* , 2010, The Journal of Biological Chemistry.
[26] E. White,et al. A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62 , 2010, Molecular and Cellular Biology.
[27] Mihee M. Kim,et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 , 2010, Nature Cell Biology.
[28] Fabienne C. Fiesel,et al. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1 , 2010, Nature Cell Biology.
[29] Y. Hiraoka,et al. Artificial induction of autophagy around polystyrene beads in nonphagocytic cells , 2010, Autophagy.
[30] R. Youle,et al. Mechanisms of mitophagy , 2010, Nature Reviews Molecular Cell Biology.
[31] Alexei Vagin,et al. Molecular replacement with MOLREP. , 2010, Acta crystallographica. Section D, Biological crystallography.
[32] T. Lamark,et al. The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway1 , 2009, The Journal of Immunology.
[33] P. Sansonetti,et al. Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy. , 2009, Cell host & microbe.
[34] V. Deretic,et al. Autophagy, immunity, and microbial adaptations. , 2009, Cell host & microbe.
[35] Ivan Dikic,et al. A role for ubiquitin in selective autophagy. , 2009, Molecular cell.
[36] J. Guan,et al. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. , 2009, Molecular biology of the cell.
[37] M. McMahon,et al. NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. , 2009, Trends in biochemical sciences.
[38] Tsutomu Ohta,et al. Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy , 2008, Proceedings of the National Academy of Sciences.
[39] James Lowe,et al. Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies , 2008, The Journal of Neuroscience.
[40] J. Flores,et al. The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis. , 2008, Cancer cell.
[41] Daniel J. Klionsky,et al. Autophagy fights disease through cellular self-digestion , 2008, Nature.
[42] Masaaki Komatsu,et al. Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice , 2007, Cell.
[43] Shyam Biswal,et al. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. , 2007, Annual review of pharmacology and toxicology.
[44] Tsutomu Ohta,et al. Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. , 2006, Molecular cell.
[45] Terje Johansen,et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death , 2005, The Journal of cell biology.
[46] Kevin Cowtan,et al. research papers Acta Crystallographica Section D Biological , 2005 .
[47] Kurt Zatloukal,et al. p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases. , 2002, The American journal of pathology.
[48] G. Murshudov,et al. Refinement of macromolecular structures by the maximum-likelihood method. , 1997, Acta crystallographica. Section D, Biological crystallography.
[49] Z. Otwinowski,et al. Processing of X-ray diffraction data collected in oscillation mode. , 1997, Methods in enzymology.
[50] S. Colowick,et al. Methods in Enzymology , Vol , 1966 .