Metabolomics Reveals that Cysteine Metabolism Plays a Role in Celastrol-Induced Mitochondrial Apoptosis in HL-60 and NB-4 Cells

[1]  M. Voso,et al.  Early and sensitive detection of PML-A216V mutation by droplet digital PCR in ATO-resistant acute promyelocytic leukemia , 2019, Leukemia.

[2]  Lu Liu,et al.  ACTL6A interacts with p53 in acute promyelocytic leukemia cell lines to affect differentiation via the Sox2/Notch1 signaling pathway. , 2019, Cellular signalling.

[3]  Yankai Xia,et al.  Metabolomics Reveals Metabolic Changes Caused by Low-Dose 4-Tert-Octylphenol in Mice Liver , 2018, International journal of environmental research and public health.

[4]  Y. Assaraf,et al.  Modulating ROS to overcome multidrug resistance in cancer. , 2018, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

[5]  Yankai Xia,et al.  Obesity aggravates toxic effect of BPA on spermatogenesis. , 2017, Environment international.

[6]  A. Denicola,et al.  N-acetylcysteine improves the quality of red blood cells stored for transfusion. , 2017, Archives of biochemistry and biophysics.

[7]  M. Diaz-Meco,et al.  Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy. , 2017, Molecular cell.

[8]  F. Slack,et al.  MUC1-C Inhibition Leads to Decrease in PD-L1 Levels Via up-Regulation of Micro RNAs , 2016 .

[9]  J. Chipuk,et al.  Physiological and Pharmacological Control of BAK, BAX, and Beyond. , 2016, Trends in cell biology.

[10]  C. Croce,et al.  Finally, An Apoptosis-Targeting Therapeutic for Cancer. , 2016, Cancer research.

[11]  Roy A Jensen,et al.  Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy. , 2016, Seminars in cancer biology.

[12]  M. Haigis,et al.  Mitochondria and Cancer , 2016, Cell.

[13]  Yankai Xia,et al.  Metabolomics profiles delineate uridine deficiency contributes to mitochondria-mediated apoptosis induced by celastrol in human acute promyelocytic leukemia cells , 2016, Oncotarget.

[14]  Qun Zhao,et al.  Celastrol Induces Cell Apoptosis and Inhibits the Expression of the AML1-ETO/C-KIT Oncoprotein in t(8;21) Leukemia , 2016, Molecules.

[15]  K. D. Saha,et al.  Heat Killed Attenuated Leishmania Induces Apoptosis of HepG2 Cells Through ROS Mediated p53 Dependent Mitochondrial Pathway , 2016, Cellular Physiology and Biochemistry.

[16]  A. Coulibaly,et al.  Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction. , 2016, Blood.

[17]  S. Tait,et al.  Mitochondria and the hallmarks of cancer , 2016, The FEBS journal.

[18]  D. Green,et al.  Cell Death Signaling. , 2015, Cold Spring Harbor perspectives in biology.

[19]  T. Horvath,et al.  Mitochondrial ROS Signaling in Organismal Homeostasis , 2015, Cell.

[20]  M. Nassiri,et al.  Acute Promyelocytic Leukemia: A Review and Discussion of Variant Translocations. , 2015, Archives of pathology & laboratory medicine.

[21]  M. Dai,et al.  Celastrol induces apoptosis of human osteosarcoma cells via the mitochondrial apoptotic pathway , 2015, Oncology reports.

[22]  Ralph Mazitschek,et al.  Treatment of Obesity with Celastrol , 2015, Cell.

[23]  Jiong Hu,et al.  Mutations of Epigenetic Modifier Genes as a Poor Prognostic Factor in Acute Promyelocytic Leukemia Under Treatment With All-Trans Retinoic Acid and Arsenic Trioxide , 2015, EBioMedicine.

[24]  S. Fulda.  Targeting apoptosis for anticancer therapy. , 2015, Seminars in cancer biology.

[25]  Zhaoming Ye,et al.  Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study , 2015, Cell Death and Disease.

[26]  Seamus J. Martin,et al.  Parkin sensitizes toward apoptosis induced by mitochondrial depolarization through promoting degradation of Mcl-1. , 2014, Cell reports.

[27]  Limin Li,et al.  Arsenic trioxide and mannitol for the treatment of acute promyelocytic leukemia relapse in the central nervous system. , 2014, Blood.

[28]  Jiang Li,et al.  Targeting Apoptosis Pathways in Cancer and Perspectives with Natural Compounds from Mother Nature , 2014, Cancer Prevention Research.

[29]  Hui Zhou,et al.  Inhibition of miR-17 and miR-20a by oridonin triggers apoptosis and reverses chemoresistance by derepressing BIM-S. , 2014, Cancer research.

[30]  G. Uzan,et al.  Celastrol Inhibits Lung Infiltration in Differential Syndrome Animal Models by Reducing TNF-α and ICAM-1 Levels while Preserving Differentiation in ATRA-Induced Acute Promyelocytic Leukemia Cells , 2014, PloS one.

[31]  R. Gabdoulline,et al.  ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis , 2014, Cell Death and Differentiation.

[32]  Fatima Al-Shahrour,et al.  Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. , 2013, Nature chemical biology.

[33]  D. Newmeyer,et al.  The rheostat in the membrane: BCL-2 family proteins and apoptosis , 2013, Cell Death and Differentiation.

[34]  A. Jemal,et al.  Outcome of older patients with acute myeloid leukemia , 2013, Cancer.

[35]  A. Gross,et al.  A ROS rheostat for cell fate regulation. , 2013, Trends in cell biology.

[36]  J. Hyun,et al.  The critical role of catalase in prooxidant and antioxidant function of p53 , 2012, Cell Death and Differentiation.

[37]  G. Avvisati.  Coagulopathy in APL: a step forward? , 2012, Blood.

[38]  S. Grant,et al.  Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process. , 2012, Blood.

[39]  X. Cui.  Reactive oxygen species: the achilles' heel of cancer cells? , 2012, Antioxidants & redox signaling.

[40]  Huanjie Shao,et al.  PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60. , 2010, Leukemia research.

[41]  M. Surette,et al.  Cysteine biosynthesis, oxidative stress and antibiotic resistance in Salmonella typhimurium. , 2010, Research in microbiology.

[42]  Evan W. Miller,et al.  An Integrated Imaging Approach to the Study of Oxidative Stress Generation by Mitochondrial Dysfunction in Living Cells , 2010, Environmental health perspectives.

[43]  H. Dombret,et al.  Very long-term outcome of acute promyelocytic leukemia after treatment with all-trans retinoic acid and chemotherapy: the European APL Group experience. , 2009, Blood.

[44]  H. Koeffler,et al.  Blockade of mTOR signaling potentiates the ability of histone deacetylase inhibitor to induce growth arrest and differentiation of acute myelogenous leukemia cells , 2008, Leukemia.

[45]  I. Wilson,et al.  Evaluation of the repeatability of ultra-performance liquid chromatography-TOF-MS for global metabolic profiling of human urine samples. , 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[46]  Monica L Guzman,et al.  Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data. , 2008, Blood.

[47]  Di Chen,et al.  Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. , 2006, Cancer research.

[48]  W. Ludwig,et al.  Stress-induced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species. , 2005, Blood.

[49]  P. Dekhuijzen.  Antioxidant properties of N‐acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease , 2004, European Respiratory Journal.

[50]  N. Sakato,et al.  Apoptosis Induction in HL-60 Cells and Inhibition of Topoisomerase II by Triterpene Celastrol , 2003, Bioscience, biotechnology, and biochemistry.

[51]  Ki-Hwan Lee,et al.  Differential gene expression in retinoic acid-induced differentiation of acute promyelocytic leukemia cells, NB4 and HL-60 cells. , 2002, Biochemical and biophysical research communications.

[52]  Xin Lu,et al.  Live or let die: the cell's response to p53 , 2002, Nature Reviews Cancer.

[53]  T. Fan,et al.  Bcl-2 family proteins and apoptosis. , 2002, Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica.

[54]  D. Hanahan,et al.  The Hallmarks of Cancer , 2000, Cell.

[55]  K. Robertson,et al.  Retinoic acid-resistant HL-60R cells harbor a point mutation in the retinoic acid receptor ligand-binding domain that confers dominant negative activity. , 1992, Blood.

[56]  S. Collins,et al.  Characterization of the continuous, differentiating myeloid cell line (HL-60) from a patient with acute promyelocytic leukemia , 1979 .

[57]  V. Costa,et al.  The Multifaceted Role of Annexin A1 in Viral Infections , 2023, Cells.

[58]  Ma Bao-gen.  Effects of tripterine on proliferation and apoptosis of acute myeloid leukemia primary cells , 2011 .

[59]  N. Turner,et al.  (cid:1) 2 (VIII) Collagen Substrata Enhance Endothelial Cell Retention Under Acute Shear Stress Flow via an (cid:1) 2 (cid:2) 1 Integrin–Dependent Mechanism An In Vitro and In Vivo Study , 2006 .

[60]  S. Collins,et al.  Characterization of the continuous, differentiating myeloid cell line (HL-60) from a patient with acute promyelocytic leukemia. , 1979, Blood.