The NF-κB transcription factor RelA is required for the tolerogenic function of Foxp3(+) regulatory T cells.

[1]  Hongbo Hu,et al.  Survival and maintenance of regulatory T cells require the kinase TAK1 , 2015, Cellular and Molecular Immunology.

[2]  Ye Zheng,et al.  Regulatory T cell identity: formation and maintenance. , 2015, Trends in immunology.

[3]  Matthew E. Ritchie,et al.  limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.

[4]  Jinfang Zhu,et al.  Dynamic expression of T-bet and GATA3 by regulatory T cells maintains immune tolerance , 2014, Nature Immunology.

[5]  E. Shevach,et al.  TCR signaling fuels Treg cell suppressor function , 2014, Nature Immunology.

[6]  A. Rudensky,et al.  Continuous requirement for the T cell receptor for regulatory T cell function , 2014, Nature Immunology.

[7]  Deepali V. Sawant,et al.  Once a Treg, always a Treg? , 2014, Immunological reviews.

[8]  Adrian Liston,et al.  Homeostatic control of regulatory T cell diversity , 2014, Nature Reviews Immunology.

[9]  M. Okada,et al.  Regulation of regulatory T cells: epigenetics and plasticity. , 2014, Advances in immunology.

[10]  R. Morita,et al.  TRAF6 Is Essential for Maintenance of Regulatory T Cells That Suppress Th2 Type Autoimmunity , 2013, PloS one.

[11]  Ming O. Li,et al.  Transcriptional control of regulatory T cell development and function , 2013, Trends in Immunology.

[12]  S. Nutt,et al.  Differentiation and function of Foxp3(+) effector regulatory T cells. , 2013, Trends in immunology.

[13]  L. Turka,et al.  An obligate cell-intrinsic function for CD28 in Tregs. , 2013, The Journal of clinical investigation.

[14]  S. Gerondakis,et al.  NF-κB control of T cell development , 2013, Nature Immunology.

[15]  K. Nakai,et al.  T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. , 2012, Immunity.

[16]  C. Auffray,et al.  IL-2 and IL-7 Determine the Homeostatic Balance between the Regulatory and Conventional CD4+ T Cell Compartments during Peripheral T Cell Reconstitution , 2012, The Journal of Immunology.

[17]  Shane J. Neph,et al.  Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification , 2012, Cell.

[18]  G. Hansen,et al.  ICOS Mediates the Generation and Function of CD4+CD25+Foxp3+ Regulatory T Cells Conveying Respiratory Tolerance , 2012, The Journal of Immunology.

[19]  S. Akira,et al.  Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells , 2012, Nature Immunology.

[20]  P. Krammer,et al.  Molecular Mechanisms of Treg-Mediated T Cell Suppression , 2012, Front. Immun..

[21]  Keji Zhao,et al.  GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice. , 2011, The Journal of clinical investigation.

[22]  R. Nurieva,et al.  Follicular regulatory T (Tfr) cells with dual Foxp3 and Bcl6 expression suppress germinal center reactions , 2011, Nature medicine.

[23]  S. Ghosh,et al.  Cell-Intrinsic NF-κB Activation Is Critical for the Development of Natural Regulatory T Cells in Mice , 2011, PloS one.

[24]  W. Shi,et al.  The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells , 2011, Nature Immunology.

[25]  T. Kuhlmann,et al.  Reduced Treg frequency in LFA‐1‐deficient mice allows enhanced T effector differentiation and pathology in EAE , 2010, European journal of immunology.

[26]  S. Gerondakis,et al.  Roles of the NF-kappaB pathway in lymphocyte development and function. , 2010, Cold Spring Harbor perspectives in biology.

[27]  Xiaoxiao Wan,et al.  FoxP3+RORγt+ T Helper Intermediates Display Suppressive Function against Autoimmune Diabetes , 2010, The Journal of Immunology.

[28]  C. Benoist,et al.  Genomic definition of multiple ex vivo regulatory T cell subphenotypes , 2010, Proceedings of the National Academy of Sciences.

[29]  A. Scheffold,et al.  Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus , 2009, Proceedings of the National Academy of Sciences.

[30]  M. F. Shannon,et al.  c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells , 2009, The Journal of experimental medicine.

[31]  S. Ghosh,et al.  Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. , 2009, Immunity.

[32]  M. Greene,et al.  Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome. , 2009, Immunity.

[33]  S. Sakaguchi,et al.  Regulatory T cells: how do they suppress immune responses? , 2009, International immunology.

[34]  Daniel J. Campbell,et al.  T-bet controls regulatory T cell homeostasis and function during type-1 inflammation , 2009, Nature Immunology.

[35]  A. Rudensky,et al.  Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses , 2009, Nature.

[36]  J. Kern,et al.  The T‐cell receptor repertoire of regulatory T cells , 2008, Immunology.

[37]  N. Rose,et al.  Sex differences in autoimmune disease from a pathological perspective. , 2008, The American journal of pathology.

[38]  T. Nomura,et al.  Regulatory T Cells and Immune Tolerance , 2008, Cell.

[39]  E. Chi,et al.  Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. , 2008, Immunity.

[40]  T. Hanke,et al.  Characterization of mouse CD4 T cell subsets defined by expression of KLRG1 , 2007, European journal of immunology.

[41]  Christophe Benoist,et al.  Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. , 2007, Immunity.

[42]  D. Saur,et al.  Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis. , 2007, The Journal of clinical investigation.

[43]  S. Hori,et al.  Full restoration of peripheral Foxp3+ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras , 2007, Proceedings of the National Academy of Sciences.

[44]  A. Rudensky,et al.  Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3 , 2007, Nature Immunology.

[45]  Vincent C. Manganiello,et al.  Foxp3-dependent programme of regulatory T-cell differentiation , 2007, Nature.

[46]  C. Loddenkemper,et al.  Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease , 2007, The Journal of experimental medicine.

[47]  Y. Wan,et al.  Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[48]  A. Rudensky,et al.  Regulatory T cell lineage specification by the forkhead transcription factor foxp3. , 2005, Immunity.

[49]  M. Schmitz,et al.  Transient and Selective NF-κB p65 Serine 536 Phosphorylation Induced by T Cell Costimulation Is Mediated by IκB Kinase β and Controls the Kinetics of p65 Nuclear Import 1 , 2004, The Journal of Immunology.

[50]  J. Buer,et al.  Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells , 2004, The Journal of experimental medicine.

[51]  M. Schmitz,et al.  Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import. , 2004, Journal of immunology.

[52]  A. Rudensky,et al.  Foxp3 programs the development and function of CD4+CD25+ regulatory T cells , 2003, Nature Immunology.

[53]  Terence P. Speed,et al.  A comparison of normalization methods for high density oligonucleotide array data based on variance and bias , 2003, Bioinform..

[54]  T. Nomura,et al.  Control of Regulatory T Cell Development by the Transcription Factor Foxp3 , 2002 .

[55]  D. Galas,et al.  Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse , 2001, Nature Genetics.

[56]  S. Gerondakis,et al.  Rel Induces Interferon Regulatory Factor 4 (IRF-4) Expression in Lymphocytes , 2000, The Journal of experimental medicine.

[57]  D. Baltimore,et al.  Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. , 1995, Nature.

[58]  S. Gerondakis,et al.  The subunit composition of NF-kappa B complexes changes during B-cell development. , 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[59]  S. Gerondakis,et al.  rel/NF-kappa B nuclear complexes that bind kB sites in the murine c-rel promoter are required for constitutive c-rel transcription in B-cells. , 1993, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[60]  V. Godfrey,et al.  Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[61]  V. Godfrey,et al.  X-linked lymphoreticular disease in the scurfy (sf) mutant mouse. , 1991, The American journal of pathology.

[62]  D. Mason,et al.  OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset [published erratum appears in J Exp Med 1991 Apr 1;173(4):1037] , 1990, The Journal of experimental medicine.