Study of a high-resolution, 3D positioning cadmium zinc telluride detector for PET

This paper investigates the performance of 1 mm resolution cadmium zinc telluride (CZT) detectors for positron emission tomography (PET) capable of positioning the 3D coordinates of individual 511 keV photon interactions. The detectors comprise 40 mm × 40 mm × 5 mm monolithic CZT crystals that employ a novel cross-strip readout with interspersed steering electrodes to obtain high spatial and energy resolution. The study found a single anode FWHM energy resolution of 3.06 ± 0.39% at 511 keV throughout most of the detector volume. Improved resolution is expected with properly shielded front-end electronics. Measurements made using a collimated beam established the efficacy of the steering electrodes in facilitating enhanced charge collection across anodes, as well as a spatial resolution of 0.44 ± 0.07 mm in the direction orthogonal to the electrode planes. Finally, measurements based on coincidence electronic collimation yielded a point spread function with 0.78 ± 0.10 mm FWHM, demonstrating 1 mm spatial resolution capability transverse to the anodes-as expected from the 1 mm anode pitch. These findings indicate that the CZT-based detector concept has excellent performance and shows great promise for a high-resolution PET system.

[1]  S. Ramo Currents Induced by Electron Motion , 1939, Proceedings of the IRE.

[2]  S. Sinha,et al.  CdTe Strip Detector Characterization for High Resolution Small Animal PET , 2008, IEEE Transactions on Nuclear Science.

[3]  Michael R. Pelling,et al.  CZT detectors with 3D readout for gamma-ray spectroscopy and imaging , 2003, SPIE Optics + Photonics.

[4]  Guillem Pratx,et al.  Bayesian reconstruction of photon interaction sequences for high-resolution PET detectors , 2009, Physics in medicine and biology.

[5]  Craig S. Levin,et al.  New Imaging Technologies to Enhance the Molecular Sensitivity of Positron Emission Tomography , 2008, Proceedings of the IEEE.

[6]  H. B. Barber,et al.  Signals induced in semiconductor gamma-ray imaging detectors , 1999 .

[7]  C. Levin,et al.  Effects of system geometry and other physical factors on photon sensitivity of high-resolution positron emission tomography , 2007, Physics in medicine and biology.

[8]  B. Sundal,et al.  Study of cadmium zinc telluride (CZT) radiation detector modules under moderate and long-term variations of temperature and humidity , 2007, 2007 IEEE Nuclear Science Symposium Conference Record.

[9]  Dominique Sappey-Marinier,et al.  Raytest ClearPET™, a new generation small animal PET scanner , 2007 .

[10]  P. Luke Electrode configuration and energy resolution in gamma-ray detectors , 1996 .

[11]  Magdalena Rafecas,et al.  Performance evaluation of MADPET-II, a small animal dual layer LSO-APD PET scanner with individual detector read out and depth of interaction information , 2007 .

[12]  Eric C. Bellm,et al.  Cathode depth sensing in CZT detectors , 2004, SPIE Optics + Photonics.

[13]  H. B. Barber,et al.  Charge transport in arrays of semiconductor gamma-ray detectors. , 1995, Physical review letters.

[14]  R. James,et al.  Time of flight experimental studies of CdZnTe radiation detectors , 2000 .

[15]  R. Fontaine,et al.  Performance evaluation of the LabPET™ APD-based digital PET scanner , 2009, 2007 IEEE Nuclear Science Symposium Conference Record.

[16]  R. F. Brown,et al.  PERFORMANCE EVALUATION , 2019, ISO 22301:2019 and business continuity management – Understand how to plan, implement and enhance a business continuity management system (BCMS).

[17]  Guillem Pratx,et al.  Effects of multiple-interaction photon events in a high-resolution PET system that uses 3-D positioning detectors. , 2010, Medical physics.

[18]  Feng Zhang,et al.  Feasibility study of using two 3-D position sensitive CZT detectors for small animal PET , 2005, IEEE Nuclear Science Symposium Conference Record, 2005.

[19]  P. Vaska,et al.  Studies of CZT for PET applications , 2005, IEEE Nuclear Science Symposium Conference Record, 2005.

[20]  C. Levin,et al.  Methods to extract more light from minute scintillation crystals used in an ultra-high resolution positron emission tomography detector , 2004 .

[21]  R. Leahy,et al.  Optimization and performance evaluation of the microPET II scanner for in vivo small-animal imaging , 2004, Physics in medicine and biology.

[22]  John Missimer,et al.  Performance evaluation of the 16-module quad-HIDAC small animal PET camera. , 2004, Physics in medicine and biology.

[23]  D. Wehe,et al.  A modeling method to calibrate the interaction depth in 3-D position sensitive CdZnTe gamma-ray spectrometers , 1999 .

[24]  C. Levin,et al.  Charge collection studies of a high resolution CZT-based detector for PET , 2008, 2008 IEEE Nuclear Science Symposium Conference Record.

[25]  C. Levin,et al.  Effects of multiple-interaction photon events in a high-resolution PET system that uses 3-D positioning detectors. , 2010, Medical physics.

[26]  Paul L. Hink,et al.  Model calculations of the response of CZT strip detectors , 1999, Optics & Photonics.

[27]  Craig S Levin,et al.  Impact of high energy resolution detectors on the performance of a PET system dedicated to breast cancer imaging. , 2006, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[28]  S.S. Junnarkar,et al.  Initial performance of the RatCAP, a PET camera for conscious rat brain imaging , 2005, IEEE Nuclear Science Symposium Conference Record, 2005.