Thermal sweat lactate in cystic fibrosis and in normal children

SummaryWe attempt to determine whether the decrease in Na+ reabsorption and the increase in K+ secretion in sweat of cystic fibrosis patients (CF) were associated with changes in glandular anaerobic metabolism evaluated by forehead sweat lactate excretion rate. 6 CF and 11 normal (C) children, 5 months to 14 years old, were exposed to external thermal load (45‡ C).The data showed that: 1) Na+, K+ and Cl− concentrations in CF are constant at any flow rate (QSW); 2) In both groups the excretion rates of Na+, K+ and Cl− increased linearly with QSW but the slopes in CF were significantly higher than in C (p<0.001); 3) Lactate excretion rate increased with x0051;SW as in CF and C with the same slope.We suggest that an increase in energy expenditure of Na+ − K+ exchange and an active secretion of K+ by the duct could explain the normal energy metabolism that we observed in CF sweat glands.

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