Excess growth hormone suppresses DNA damage repair in epithelial cells.
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S. Melmed | V. Gorbunova | K. Wawrowsky | C. Bresee | Masaaki Yamamoto | H. Kameda | A. Ben-Shlomo | R. Barrett | J. Gleeson | V. Chesnokova | S. Zonis | Anat Ben-Shlomo
[1] S. Melmed,et al. Peptide Hormone Regulation of DNA Damage Responses. , 2020, Endocrine reviews.
[2] S. Melmed,et al. Growth hormone in the tumor microenvironment , 2019, Archives of endocrinology and metabolism.
[3] J. Kopchick,et al. The effects of growth hormone on therapy resistance in cancer , 2019, Cancer drug resistance.
[4] E. Davis,et al. Growth Hormone Upregulates Melanocyte-Inducing Transcription Factor Expression and Activity via JAK2-STAT5 and SRC Signaling in GH Receptor-Positive Human Melanoma , 2019, Cancers.
[5] S. Melmed,et al. Growth Hormone Induces Colon DNA Damage Independent of IGF-1. , 2019, Endocrinology.
[6] H. Sørensen,et al. Cancer Incidence in Patients With Acromegaly: A Cohort Study and Meta-Analysis of the Literature , 2018, The Journal of clinical endocrinology and metabolism.
[7] A. Bartke. Growth Hormone and Aging: Updated Review , 2018, The world journal of men's health.
[8] M. Murphy,et al. p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways , 2018, eLife.
[9] Arnaud J. Legrand,et al. Sp1 phosphorylation by ATM downregulates BER and promotes cell elimination in response to persistent DNA damage , 2017, Nucleic acids research.
[10] T. Graham,et al. An evolutionary perspective on field cancerization , 2017, Nature Reviews Cancer.
[11] T. Zhu,et al. Autocrine hGH stimulates oncogenicity, epithelial-mesenchymal transition and cancer stem cell-like behavior in human colorectal carcinoma , 2017, Oncotarget.
[12] J. Kopchick,et al. Growth Hormone and the Epithelial-to-Mesenchymal Transition , 2017, The Journal of clinical endocrinology and metabolism.
[13] S. Jackson,et al. ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response. , 2017, Molecular cell.
[14] Shiyong Wu,et al. Growth Hormone Receptor Knockdown Sensitizes Human Melanoma Cells to Chemotherapy by Attenuating Expression of ABC Drug Efflux Pumps , 2017, Hormones and Cancer.
[15] Shiyong Wu,et al. Targeting growth hormone receptor in human melanoma cells attenuates tumor progression and epithelial mesenchymal transition via suppression of multiple oncogenic pathways , 2017, Oncotarget.
[16] W. Fu,et al. Growth hormone is increased in the lungs and enhances experimental lung metastasis of melanoma in DJ-1 KO mice , 2016, BMC Cancer.
[17] Richard A. Miller,et al. mTOR regulates the expression of DNA damage response enzymes in long‐lived Snell dwarf, GHRKO, and PAPPA‐KO mice , 2016, Aging cell.
[18] D. Sinclair,et al. JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks , 2016, Cell reports.
[19] N. Barzilai,et al. The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research. , 2016, Cell metabolism.
[20] S. Yakar,et al. Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models. , 2016, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
[21] S. Melmed,et al. Growth hormone is permissive for neoplastic colon growth , 2016, Proceedings of the National Academy of Sciences.
[22] N. Corcoran,et al. Molecular Pathways: Targeting DNA Repair Pathway Defects Enriched in Metastasis , 2016, Clinical Cancer Research.
[23] M. Tabernero,et al. Growth Hormone Protects the Intestine Preserving Radiotherapy Efficacy on Tumors: A Short-Term Study , 2015, PloS one.
[24] P. Perros,et al. The role of colonoscopic screening in acromegaly revisited: review of current literature and practice guidelines , 2015, Pituitary.
[25] Claudia Giachino,et al. Histone variants as emerging regulators of embryonic stem cell identity , 2015, Epigenetics.
[26] M. Washburn,et al. TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin , 2015, Nature Communications.
[27] S. Melmed,et al. STAT3 upregulation in pituitary somatotroph adenomas induces growth hormone hypersecretion. , 2015, The Journal of clinical investigation.
[28] S. Lees-Miller,et al. The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis. , 2015, Progress in biophysics and molecular biology.
[29] C. Giachino,et al. Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions , 2015, Nucleic acids research.
[30] S. Targan,et al. Reliable Generation of Induced Pluripotent Stem Cells From Human Lymphoblastoid Cell Lines , 2014, Stem cells translational medicine.
[31] Y. Liu,et al. Human GH receptor-IGF-1 receptor interaction: implications for GH signaling. , 2014, Molecular endocrinology.
[32] V. Tillmann,et al. Translational Neuroendocrinology: Control of Human Growth , 2014, Journal of neuroendocrinology.
[33] D. Chia. Minireview: mechanisms of growth hormone-mediated gene regulation. , 2014, Molecular endocrinology.
[34] H. Lieberman,et al. DNA Damage Response Genes and the Development of Cancer Metastasis , 2014, Radiation research.
[35] C. Harris,et al. p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes. , 2013, The Journal of clinical investigation.
[36] V. Macaulay,et al. IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination , 2013, Oncogene.
[37] K. Ho,et al. Action of GH on skeletal muscle function: molecular and metabolic mechanisms. , 2013, Journal of molecular endocrinology.
[38] V. Anisimov,et al. The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer. , 2013, Critical reviews in oncology/hematology.
[39] R. Ramesh,et al. Mitogen-activated protein kinases and their role in radiation response. , 2013, Genes & cancer.
[40] S. Melmed,et al. Growth hormone is a cellular senescence target in pituitary and nonpituitary cells , 2013, Proceedings of the National Academy of Sciences.
[41] T. Zhu,et al. Growth hormone and cancer: an update on progress , 2013, Current opinion in endocrinology, diabetes, and obesity.
[42] J. Kopchick,et al. The GH/IGF-1 axis in ageing and longevity , 2013, Nature Reviews Endocrinology.
[43] A. Bartke,et al. Hepatocellular alterations and dysregulation of oncogenic pathways in the liver of transgenic mice overexpressing growth hormone , 2013, Cell cycle.
[44] Y. Shiloh,et al. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more , 2013, Nature Reviews Molecular Cell Biology.
[45] S. Melmed,et al. PTTG Acts As a STAT3 Target Gene for Colorectal Cancer Cell Growth and Motility , 2013, Oncogene.
[46] Bruce H Fireman,et al. Variation of adenoma prevalence by age, sex, race, and colon location in a large population: implications for screening and quality programs. , 2013, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
[47] M. Martinka,et al. Role of Tip60 in human melanoma cell migration, metastasis, and patient survival. , 2012, The Journal of investigative dermatology.
[48] T. Zhu,et al. Autocrine human GH promotes radioresistance in mammary and endometrial carcinoma cells. , 2012, Endocrine-related cancer.
[49] S. Boulton,et al. Playing the end game: DNA double-strand break repair pathway choice. , 2012, Molecular cell.
[50] S. Brewster,et al. Depletion of the type 1 IGF receptor delays repair of radiation-induced DNA double strand breaks. , 2012, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
[51] Hye Kyong Kweon,et al. Research Resource: Identification of Novel Growth Hormone-Regulated Phosphorylation Sites by Quantitative Phosphoproteomics , 2012, Molecular endocrinology.
[52] T. Tatlisumak,et al. Optimized Mouse Model for the Imaging of Tumor Metastasis upon Experimental Therapy , 2011, PloS one.
[53] S. Hatakeyama,et al. TRIM proteins and cancer , 2011, Nature Reviews Cancer.
[54] A. D. De Marzo,et al. Differential epithelium DNA damage response to ATM and DNA-PK pathway inhibition in human prostate tissue culture , 2011, Cell cycle.
[55] R. Shamir,et al. Transcriptional modulation induced by ionizing radiation: p53 remains a central player , 2011, Molecular oncology.
[56] T. Dörk,et al. ATM Protein-dependent Phosphorylation of Rad50 Protein Regulates DNA Repair and Cell Cycle Control* , 2011, The Journal of Biological Chemistry.
[57] Jun Cheng,et al. TRIM29 negatively regulates p53 via inhibition of Tip60. , 2011, Biochimica et biophysica acta.
[58] Federica Madia,et al. Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans , 2011, Science Translational Medicine.
[59] Karen H. Vousden,et al. p53 and its mutants in tumor cell migration and invasion , 2011, The Journal of cell biology.
[60] S. Elledge,et al. The DNA damage response: making it safe to play with knives. , 2010, Molecular cell.
[61] Andrei Seluanov,et al. Analysis of DNA double-strand break (DSB) repair in mammalian cells. , 2010, Journal of visualized experiments : JoVE.
[62] S. Melmed. Acromegaly pathogenesis and treatment. , 2009, The Journal of clinical investigation.
[63] J. Bartek,et al. The DNA-damage response in human biology and disease , 2009, Nature.
[64] A. Tyner,et al. Reduced susceptibility to azoxymethane-induced aberrant crypt foci formation and colon cancer in growth hormone deficient rats. , 2009, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
[65] H. Nemoto,et al. Down-regulation of Tip60 gene as a potential marker for the malignancy of colorectal cancer. , 2009, Anticancer research.
[66] Markus Löbrich,et al. ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2 , 2009, The EMBO journal.
[67] A. Bartke. Declining sperm counts and increases in testicular cancer: a legacy of the cold war? , 2009, Journal of andrology.
[68] A. Bartke. Growth hormone and aging: A challenging controversy , 2008, Clinical interventions in aging.
[69] L. Samson,et al. DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. , 2008, The Journal of clinical investigation.
[70] I. Olkin,et al. Systematic Review: The Effects of Growth Hormone on Athletic Performance , 2008, Annals of Internal Medicine.
[71] L. Donehower,et al. How does suppression of IGF-1 signaling by DNA damage affect aging and longevity? , 2008, Mechanisms of Ageing and Development.
[72] E. Arvat,et al. Growth hormone treatment in human ageing: benefits and risks , 2008, Hormones.
[73] G. Mazziotti,et al. Growth hormone, insulin-like growth factors, and the skeleton. , 2008, Endocrine reviews.
[74] T. Paull,et al. Activation and regulation of ATM kinase activity in response to DNA double-strand breaks , 2007, Oncogene.
[75] J. Bartek,et al. DNA damage signalling guards against activated oncogenes and tumour progression , 2007, Oncogene.
[76] Lewis A. Chodosh,et al. Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis , 2007, Nature Cell Biology.
[77] C. Carter-Su,et al. Recent advances in growth hormone signaling , 2007, Reviews in Endocrine and Metabolic Disorders.
[78] J. Iñiguez-Lluhí,et al. Multiple mechanisms of growth hormone-regulated gene transcription. , 2007, Molecular genetics and metabolism.
[79] Anne E Carpenter,et al. CellProfiler: image analysis software for identifying and quantifying cell phenotypes , 2006, Genome Biology.
[80] H. Werner,et al. The insulin-like growth factor-I receptor gene: a downstream target for oncogene and tumor suppressor action , 2006, Trends in Endocrinology & Metabolism.
[81] M. Vance,et al. Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline. , 2006, The Journal of clinical endocrinology and metabolism.
[82] Xiaofeng Jiang,et al. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[83] Carlo Rago,et al. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. , 2005, Cancer cell.
[84] F. Bogazzi,et al. Growth hormone inhibits apoptosis in human colonic cancer cell lines: antagonistic effects of peroxisome proliferator activated receptor-gamma ligands. , 2004, Endocrinology.
[85] M. T. Vallejo-Cremades,et al. Differential Action of Growth Hormone in Irradiated Tumoral and Nontumoral Intestinal Tissue , 2003, Digestive Diseases and Sciences.
[86] R. Bronson,et al. Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. , 2003, The journals of gerontology. Series A, Biological sciences and medical sciences.
[87] M. Kastan,et al. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation , 2003, Nature.
[88] J. Sorkin,et al. Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. , 2002 .
[89] R. Perona,et al. Growth hormone protects against radiotherapy-induced cell death. , 2002, European journal of endocrinology.
[90] E. C. Stevens,et al. Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly. , 2002, Endocrine reviews.
[91] T. Zhu,et al. Signal transduction via the growth hormone receptor. , 2001, Cellular signalling.
[92] G. Sonenshein,et al. Growth hormone prevents apoptosis through activation of nuclear factor-kappaB in interleukin-3-dependent Ba/F3 cell line. , 2000, Molecular endocrinology.
[93] D. Hanahan,et al. The Hallmarks of Cancer , 2000, Cell.
[94] S. Jackson,et al. The DNA-dependent protein kinase , 1999 .
[95] E. Rogakou,et al. DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139* , 1998, The Journal of Biological Chemistry.
[96] R. Zhou,et al. DNA damage induced by etoposide; a comparison of two different methods for determination of strand breaks in DNA. , 1996, Cancer letters.
[97] S. Velasco-Miguel,et al. Induction of the growth inhibitor IGF-binding protein 3 by p53 , 1995, Nature.
[98] H. Yamamoto,et al. Effects of aging and sex on plasma insulin-like growth factor I (IGF-I) levels in normal adults. , 1991, Acta endocrinologica.
[99] P. Sönksen,et al. The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. , 1989, The New England journal of medicine.
[100] M C Willingham,et al. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[101] J. Minna,et al. Positive correlation between histological tumor involvement and generation of tumor cell colonies in agarose in specimens taken directly from patients with small-cell carcinoma of the lung. , 1980, Cancer research.
[102] M. Waters,et al. Growth hormone and cell growth. , 2012, Endocrine development.
[103] Lye Mun Tho,et al. The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. , 2010, Advances in cancer research.
[104] M. Vance,et al. Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society Clinical Practice Guideline. , 2006, The Journal of clinical endocrinology and metabolism.
[105] Jiri Bartek,et al. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks , 2006, Nature Cell Biology.