Proactive and retroactive interference in young adults, healthy older adults, and older adults with amnestic mild cognitive impairment

Abstract This study investigated memory interference in amnestic mild cognitive impairment (aMCI) and normal aging. Participants were 27 young adults, 44 healthy older adults, and 15 older adults with aMCI. Memory interference was examined on the California Verbal Learning Test (CVLT) and on a modified AB-AC paradigm. Despite significant differences in memory performance on the CVLT, interference measures on this test did not distinguish individuals with aMCI and healthy older adults. The AB-AC task involved first learning a list (AB list) of 12 semantically related word pairs (e.g., knee-bone). Twenty minutes later, a second list (AC list) was learned in which the same stimulus words were paired with new response words (e.g., knee-bend). Both lists were repeated until 100% accurate recall was achieved. Finally, participants recalled the first (AB) list. Proactive interference (PI) was greater among older than younger adults, and greater still among individuals with aMCI, but the older and aMCI groups showed similar levels of retroactive interference. This study suggests that PI contributes to the memory deficits seen in aMCI and that tests sensitive to PI may assist in the early identification of aMCI. Memory interventions aimed at alleviating PI may improve memory functioning in individuals with aMCI. (JINS, 2009, 15, 83–93.)

[1]  J. Hodges,et al.  Semantic Knowledge in Mild Cognitive Impairment and Mild Alzheimer's Disease , 2006, Cortex.

[2]  K. Bayles,et al.  Performance of Alzheimer's disease patients in judging word relatedness , 1999, Journal of the International Neuropsychological Society.

[3]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[4]  Ranjan Duara,et al.  Vulnerability to Proactive Semantic Interference and Progression to Dementia among Older Adults with Mild Cognitive Impairment , 2007, Dementia and Geriatric Cognitive Disorders.

[5]  David A. Balota,et al.  Semantic priming effects, lexical repetition effects, and contextual disambiguation effects in healthy aged individuals and individuals with senile dementia of the Alzheimer type , 1991, Brain and Language.

[6]  L Hasher,et al.  Aging and suppression: memory for previously relevant information. , 1991, Psychology and aging.

[7]  K. Blennow,et al.  Imaging and CSF Studies in the Preclinical Diagnosis of Alzheimer's Disease , 2007, Annals of the New York Academy of Sciences.

[8]  M. Weiner,et al.  Patterns of Verbal Memory Performance in Mild Cognitive Impairment, Alzheimer Disease, and Normal Aging , 2006, Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology.

[9]  M. Lawton,et al.  Assessment of Older People: Self-Maintaining and Instrumental Activities of Daily Living , 1969 .

[10]  R. Petersen,et al.  Mild cognitive impairment , 2006, The Lancet.

[11]  E. Caine,et al.  Cued recall and release from proactive interference in Alzheimer's disease. , 1988, Journal of clinical and experimental neuropsychology.

[12]  Methodological control of semantic priming in Alzheimer's disease. , 1996 .

[13]  B. Ober,et al.  Methodological control of semantic priming in Alzheimer's disease. , 1996, Psychology and aging.

[14]  N Butters,et al.  Detection and staging of dementia in Alzheimer's disease. Use of the neuropsychological measures developed for the Consortium to Establish a Registry for Alzheimer's Disease. , 1992, Archives of neurology.

[15]  J M Watson,et al.  Cross-modal semantic and homograph priming in healthy young, healthy old, and in Alzheimer's disease individuals , 1999, Journal of the International Neuropsychological Society.

[16]  E. Tangalos,et al.  Mild Cognitive Impairment Clinical Characterization and Outcome , 1999 .

[17]  C. Jack,et al.  Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment , 2004, Journal of internal medicine.

[18]  R. Snaith,et al.  The Hospital Anxiety and Depression Scale , 1983 .

[19]  Howard J. Rosen,et al.  Multiple Cognitive Deficits in Amnestic Mild Cognitive Impairment , 2006, Dementia and Geriatric Cognitive Disorders.

[20]  S. Cappa,et al.  Release from proactive interference in early Alzheimer's disease , 1995, Neuropsychologia.

[21]  E. Tangalos,et al.  CME Practice parameter: , 2022 .

[22]  D. Balota,et al.  Exploring semantic memory by investigating buildup and release of proactive interference in healthy older adults and individuals with dementia of the Alzheimer type , 2003, Journal of the International Neuropsychological Society.

[23]  G. Huston.  The Hospital Anxiety and Depression Scale. , 1987, The Journal of rheumatology.

[24]  A. Gade,et al.  Semantic Memory Impairment in the Earliest Phases of Alzheimer’s Disease , 2005, Dementia and Geriatric Cognitive Disorders.

[25]  Arthur P. Shimamura,et al.  Memory interference effects and aging: Findings from a test of frontal lobe function. , 1994 .

[26]  J. Jonides,et al.  Brain mechanisms of proactive interference in working memory , 2006, Neuroscience.

[27]  Simon J Graham,et al.  Recollection- and familiarity-based memory in healthy aging and amnestic mild cognitive impairment. , 2008, Neuropsychology.

[28]  E. Kaplan,et al.  Error Analysis of the Nine-Word California Verbal Learning Test (CVLT-9) Among Older Adults With and Without Dementia , 2002, The Clinical neuropsychologist.

[29]  Larry L. Jacoby,et al.  Dissociating Automatic and Consciously Controlled Effects of Study/Test Compatibility , 1996 .

[30]  L. Cermak,et al.  Alcoholic Korsakoff's Syndrome: An Information-Processing Approach to Amnesia , 1980 .

[31]  Ranjan Duara,et al.  Semantic interference deficits and the detection of mild Alzheimer's disease and mild cognitive impairment without dementia , 2004, Journal of the International Neuropsychological Society.

[32]  R. Doody,et al.  The influence of handedness on the clinical presentation and neuropsychology of Alzheimer disease. , 1999, Archives of neurology.

[33]  M Moscovitch,et al.  Paired-associate learning in institutionalized and noninstitutionalized old people: an analysis of interference and context effects. , 1983, Journal of gerontology.

[34]  P. Remy,et al.  Executive Functions Deficit in Mild Cognitive Impairment , 2007, Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology.

[35]  J. Hodges,et al.  Naming of objects, faces and buildings in mild cognitive impairment , 2008, Cortex.

[36]  R. Petersen.  Mild cognitive impairment as a diagnostic entity , 2004, Journal of internal medicine.

[37]  F. Collette,et al.  Directed Forgetting and Aging: The Role of Retrieval Processes, Processing Speed, and Proactive Interference , 2008, Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition.

[38]  T. Salthouse,et al.  Task decomposition analysis of intertrial free recall performance on the Rey Auditory Verbal Learning Test in normal aging and Alzheimer's disease. , 1999, Journal of clinical and experimental neuropsychology.

[39]  M. Yamada,et al.  [Dementia rating scale]. , 1997, Nihon rinsho. Japanese journal of clinical medicine.

[40]  H. Chenery,et al.  Strategy-based semantic priming in Alzheimer's dementia , 2000 .

[41]  R. Petersen,et al.  Aging, Memory, and Mild Cognitive Impairment , 1997, International Psychogeriatrics.

[42]  J. J. Ryan,et al.  Wechsler Adult Intelligence Scale-III , 2001 .

[43]  M. Lawton,et al.  Assessment of older people: self-maintaining and instrumental activities of daily living. , 1969, The Gerontologist.

[44]  S. Corkin,et al.  Cognitive test performance in detecting, staging, and tracking Alzheimer's disease. , 1995, Archives of neurology.