Prevention of immunoglobulin production by allotypedependent T cells

Adoptive lymphocyte transfers between Iga, Igb and Igd allotype‐congenic mouse strains revealed host barriers against the production of certain donor allotypes. First, as recipients of Igb cells, Iga and Igd mice permitted the production of donor Ig‐4b but not that of Ig‐lb. The apparent mediators of this Ig‐lb barrier were T cells specific for Ig‐lb determinants on B cells. Additional cell transfers showed Iga mice to have a second barrier against allotype production by Igd donor cells. Reciprocal cell transfers showed Igb and Igd mice to have comparatively weak barriers against Iga‐producing cells.

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