DendroPrime as an adhesion barrier on fracture fixation plates: an experimental study in rabbits

We tested the anti-adhesional effect of a new thiol-ene-based coating in a rabbit model. In 12 New Zealand white rabbits, the periosteum and cortex of the proximal phalanx of the second toe of both hind paws was scratched. Stainless steel plates were fixated with screws. One plate was coated with DendroPrime and the other left bare. The non-operated second toes of both hind paws of an additional four rabbits served as controls. Seven weeks after surgery, the soft tissue adhesion to the plates was evaluated macroscopically, and joint mobility was measured biomechanically. Toe joint mobility was about 20% greater and statistically significant in specimens with coated plates compared with the bare plates. Soft tissue overgrowth and, in some cases, synovitis or adhesions between the plate and the tendon were observed on all bare plates but not on any of the coated plates. We conclude that the thiol-ene-based coating can improve joint mobility by about 20%. This material has a potential to reduce adhesion around plates in fracture surgery.

[1]  Marianne Arner,et al.  High‐Performance Thiol–Ene Composites Unveil a New Era of Adhesives Suited for Bone Repair , 2018 .

[2]  M. Arner,et al.  Reoperations and postoperative complications after osteosynthesis of phalangeal fractures: a retrospective cohort study , 2017, Journal of plastic surgery and hand surgery.

[3]  P. Esenwein,et al.  Implantation of a denaturated cellulose adhesion barrier after plate osteosynthesis of finger proximal phalangeal fractures: results of a randomized controlled trial , 2016, The Journal of hand surgery, European volume.

[4]  D. Warwick,et al.  A multicentre, randomized, double-blind trial of the safety and efficacy of mannose-6-phosphate in patients having Zone II flexor tendon repairs , 2015, The Journal of hand surgery, European volume.

[5]  S. Omokawa,et al.  Predictors of Postoperative Finger Stiffness in Unstable Proximal Phalangeal Fractures , 2015, Plastic and Reconstructive Surgery, Global Open.

[6]  T. Franz,et al.  Plate fixation of extra-articular fractures of the proximal phalanx: do new implants cause less problems? , 2015, Archives of Orthopaedic and Trauma Surgery.

[7]  K. Olmarker,et al.  Effect of lactoferrin peptide (PXL01) on rabbit digit mobility after flexor tendon repair. , 2012, The Journal of hand surgery.

[8]  S. Polinder,et al.  Economic impact of hand and wrist injuries: health-care costs and productivity costs in a population-based study. , 2012, The Journal of bone and joint surgery. American volume.

[9]  J. Sproedt,et al.  Ergebnisse osteosynthetisch versorgter Grundphalanxfrakturen der Finger , 2012, Handchirurgie, Mikrochirurgie, Plastische Chirurgie.

[10]  C. Egloff,et al.  [Results after osteosynthesis of extraarticular proximal phalangeal fractures]. , 2012, Handchirurgie, Mikrochirurgie, Plastische Chirurgie.

[11]  K. Olmarker,et al.  A lactoferrin-derived peptide (PXL01) for the reduction of adhesion formation in flexor tendon surgery: an experimental study in rabbits , 2011, The Journal of hand surgery, European volume.

[12]  K. Olmarker,et al.  Model for assessment of mobility of toes and healing of tendons in rabbits , 2010, Journal of plastic surgery and hand surgery.

[13]  Jessica S Hayes,et al.  Surfaces to control tissue adhesion for osteosynthesis with metal implants: in vitro and in vivo studies to bring solutions to the patient , 2010, Expert review of medical devices.

[14]  B. Hanson,et al.  Surgeons' beliefs and perceptions about removal of orthopaedic implants , 2008, BMC musculoskeletal disorders.

[15]  L. Nagy,et al.  Complications after plate fixation of phalangeal fractures. , 2006, The Journal of trauma.

[16]  W. Obremskey,et al.  Hardware Removal: Indications and Expectations , 2006, The Journal of the American Academy of Orthopaedic Surgeons.

[17]  J. S. Watson,et al.  Efficacy of Adcon-T/N After Primary Flexor Tendon Repair in Zone II: A Controlled Clinical Trial , 2003, Journal of hand surgery.

[18]  P. Stern,et al.  Complications and range of motion following plate fixation of metacarpal and phalangeal fractures. , 1998, The Journal of hand surgery.

[19]  O. Böstman,et al.  Routine implant removal after fracture surgery: a potentially reducible consumer of hospital resources in trauma units. , 1996, The Journal of trauma.

[20]  L. Hagberg,et al.  Sodium hyaluronate as an adjunct in adhesion prevention after flexor tendon surgery in rabbits. , 1992, The Journal of hand surgery.