Leader peptide and a membrane protein scaffold guide the biosynthesis of the tricyclic peptide microviridin.

[1]  R. Rink,et al.  Requirements of the Engineered Leader Peptide of Nisin for Inducing Modification, Export, and Cleavage , 2010, Applied and Environmental Microbiology.

[2]  Katherine H. Huang,et al.  Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria , 2010, Proceedings of the National Academy of Sciences.

[3]  E. Dittmann,et al.  Exploiting the Natural Diversity of Microviridin Gene Clusters for Discovery of Novel Tricyclic Depsipeptides , 2010, Applied and Environmental Microbiology.

[4]  A. J. Link,et al.  Much of the microcin J25 leader peptide is dispensable. , 2010, Journal of the American Chemical Society.

[5]  G. Sheldrick,et al.  Labyrinthopeptins: a new class of carbacyclic lantibiotics. , 2010, Angewandte Chemie.

[6]  W. A. van der Donk,et al.  Follow the leader: the use of leader peptides to guide natural product biosynthesis. , 2010, Nature chemical biology.

[7]  Matthew R. Levengood,et al.  In Vitro Mutasynthesis of Lantibiotic Analogues Containing Nonproteinogenic Amino Acids , 2009, Journal of the American Chemical Society.

[8]  T. Hemscheidt,et al.  Substrate specificity and scope of MvdD, a GRASP-like ligase from the microviridin biosynthetic gene cluster. , 2009, ACS chemical biology.

[9]  J. Walton,et al.  Processing of the Phalloidin Proprotein by Prolyl Oligopeptidase from the Mushroom Conocybe albipes* , 2009, The Journal of Biological Chemistry.

[10]  M. Donia,et al.  Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds. , 2009, Natural product reports.

[11]  B. Shen,et al.  Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. , 2009, Chemistry & biology.

[12]  T. Hemscheidt,et al.  Post‐translational Modification in Microviridin Biosynthesis , 2008, Chembiochem : a European journal of chemical biology.

[13]  E. Dittmann,et al.  Inside Cover: Ribosomal Synthesis of Tricyclic Depsipeptides in Bloom‐Forming Cyanobacteria (Angew. Chem. Int. Ed. 40/2008) , 2008 .

[14]  A. Driessen,et al.  Distinct Contributions of the Nisin Biosynthesis Enzymes NisB and NisC and Transporter NisT to Prenisin Production by Lactococcus lactis , 2008, Applied and Environmental Microbiology.

[15]  W. A. van der Donk,et al.  The importance of the leader sequence for directing lanthionine formation in lacticin 481. , 2008, Biochemistry.

[16]  J. Ravel,et al.  A global assembly line for cyanobactins. , 2008, Nature chemical biology.

[17]  O. Kuipers,et al.  NisC, the cyclase of the lantibiotic nisin, can catalyze cyclization of designed nonlantibiotic peptides. , 2007, Biochemistry.

[18]  S. Duquesne,et al.  Two enzymes catalyze the maturation of a lasso peptide in Escherichia coli. , 2007, Chemistry & biology.

[19]  O. Kuipers,et al.  Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin. , 2005, Biochemistry.

[20]  O. Kuipers,et al.  NisT, the Transporter of the Lantibiotic Nisin, Can Transport Fully Modified, Dehydrated, and Unmodified Prenisin and Fusions of the Leader Peptide with Non-lantibiotic Peptides* , 2004, Journal of Biological Chemistry.

[21]  W. M. Vos,et al.  Protein engineering of lantibiotics , 1996, Antonie van Leeuwenhoek.

[22]  J. Michiels,et al.  Processing and export of peptide pheromones and bacteriocins in Gram-negative bacteria. , 2001, Trends in microbiology.

[23]  N. Kelleher,et al.  Cofactor requirements and reconstitution of microcin B17 synthetase: a multienzyme complex that catalyzes the formation of oxazoles and thiazoles in the antibiotic microcin B17. , 1999, Biochemistry.

[24]  S. Mikkat,et al.  Isolation of salt-induced periplasmic proteins from Synechocystis sp. strain PCC 6803 , 1999, Archives of Microbiology.

[25]  R. Kolter,et al.  The leader peptide is essential for the post‐translational modification of the DNA‐gyrase inhibitor microcin B17 , 1997, Molecular microbiology.

[26]  K. Yamaguchi,et al.  Microviridins D-F, serine protease inhibitors from the cyanobacterium Oscillatoria agardhii (NIES-204)☆ , 1996 .

[27]  K. Kaya,et al.  Microviridin. A novel tricyclic depsipeptide from the toxic cyanobacterium Microcystis viridis , 1990 .

[28]  J. Gordon,et al.  Eukaryotic signal peptide structure/function relationships. Identification of conformational features which influence the site and efficiency of co-translational proteolytic processing by site-directed mutagenesis of human pre(delta pro)apolipoprotein A-II. , 1989, The Journal of biological chemistry.

[29]  C. Franche,et al.  [88] Tests on nif probes and DNA hybridizations , 1988 .

[30]  M. M. Bradford.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[31]  E. Southern.  Detection of specific sequences among DNA fragments separated by gel electrophoresis. , 1975, Journal of molecular biology.