Tailoring the Electrochemical and Mechanical Properties of PEDOT:PSS Films for Bioelectronics

The effect of 3-glycidoxypropyltrimethoxysilane (GOPS) content in poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) dispersions on the properties of films spun cast from these formulations is investigated. It has been found out that the concentration of GOPS has a tremendous, yet gradual impact on the electrical, electrochemical, and mechanical properties of the PEDOT:PSS/GOPS films and that there is an optimum concentration which maximizes a particular feature of the film such as its water uptake or elasticity. The benefits of aqueous stability and mechanical strength with GOPS are to be compensated by an increase in the electrochemical impedance. GOPS aids obtaining excellent mechanical integrity in aqueous media with still highly conducting properties. Moreover, active devices like organic electrochemical transistors that contain 1 wt% GOPS, which is a concentration that leads to film with high electrical conductivity with sufficient mechanical stability and softness, exhibit steady performance over three weeks. These results suggest that variations in the concentration of such an additive like GOPS can enable a facile co-optimization of electrical and mechanical properties of a conducting polymer film for in vivo bioelectronics application.

[1]  Manfred Lindau,et al.  Direct Measurement of Ion Mobility in a Conducting Polymer , 2013, Advanced materials.

[2]  F. Gu,et al.  Improving biocompatibility by surface modification techniques on implantable bioelectronics. , 2013, Biosensors & bioelectronics.

[3]  Shiming Zhang,et al.  Solvent-induced changes in PEDOT:PSS films for organic electrochemical transistors , 2015 .

[4]  Christopher J. Tassone,et al.  Structural control of mixed ionic and electronic transport in conducting polymers , 2016, Nature Communications.

[5]  P. Leleux,et al.  Using white noise to gate organic transistors for dynamic monitoring of cultured cell layers , 2015, Scientific Reports.

[6]  Jonathan Rivnay,et al.  Organic electrochemical transistors for cell-based impedance sensing , 2015 .

[7]  T. Hua,et al.  Flexible Organic Electronics in Biology: Materials and Devices , 2015, Advanced materials.

[8]  G. Buzsáki,et al.  NeuroGrid: recording action potentials from the surface of the brain , 2014, Nature Neuroscience.

[9]  Magnus Berggren,et al.  Organic Bioelectronics: Bridging the Signaling Gap between Biology and Technology. , 2016, Chemical Reviews.

[10]  Hai Zhou,et al.  Electrospun PEDOT:PSS–PVA nanofiber based ultrahigh-strain sensors with controllable electrical conductivity , 2011 .

[11]  Christine E. Schmidt,et al.  Conducting polymers in biomedical engineering , 2007 .

[12]  Christophe Bernard,et al.  Controlling Epileptiform Activity with Organic Electronic Ion Pumps , 2015, Advanced materials.

[13]  I. N. Sneddon The relation between load and penetration in the axisymmetric boussinesq problem for a punch of arbitrary profile , 1965 .

[14]  H. Okuzaki,et al.  Spinning and Characterization of Conducting Microfibers , 2003 .

[15]  E. Southern,et al.  Oligonucleotide hybridizations on glass supports: a novel linker for oligonucleotide synthesis and hybridization properties of oligonucleotides synthesised in situ. , 1992, Nucleic acids research.

[16]  Jianyong Ouyang,et al.  Significant Conductivity Enhancement of Conductive Poly(3,4-ethylenedioxythiophene):Poly(styrenesulfonate) Films by Adding Anionic Surfactants into Polymer Solution , 2008 .

[17]  P. Leleux,et al.  Highly Conformable Conducting Polymer Electrodes for In Vivo Recordings , 2011, Advanced materials.

[18]  George G. Malliaras,et al.  The Rise of Organic Bioelectronics , 2014 .

[19]  V. Senez,et al.  Wettability of PEDOT:PSS films. , 2016, Soft matter.

[20]  G. Malliaras,et al.  Engineering hydrophilic conducting composites with enhanced ion mobility. , 2014, Physical chemistry chemical physics : PCCP.

[21]  Allen Kine,et al.  Impedance spectroscopy study of conducting polymer blends of PEDOT:PSS and PVA , 2015 .

[22]  George G. Malliaras,et al.  Interfacing Electronic and Ionic Charge Transport in Bioelectronics , 2016 .

[23]  Christophe Bernard,et al.  Localized Neuron Stimulation with Organic Electrochemical Transistors on Delaminating Depth Probes , 2015, Advanced materials.

[24]  Takao Ishida,et al.  Morphological Change and Mobility Enhancement in PEDOT:PSS by Adding Co‐solvents , 2013, Advanced materials.

[25]  Johannes C. Brendel,et al.  A High Transconductance Accumulation Mode Electrochemical Transistor , 2014, Advanced materials.

[26]  M. V. Voinova,et al.  Viscoelastic Acoustic Response of Layered Polymer Films at Fluid-Solid Interfaces: Continuum Mechanics Approach , 1998, cond-mat/9805266.

[27]  J. Reynolds,et al.  Crystallization Driven Formation of Conducting Polymer Networks in Polymer Blends , 2000 .

[28]  J. Dual,et al.  Mechanical characterization of PEDOT : PSS thin films , 2009 .

[29]  Agneta Richter-Dahlfors,et al.  Organic Bioelectronic Tools for Biomedical Applications , 2015 .

[30]  George G Malliaras,et al.  Organic bioelectronics: a new era for organic electronics. , 2013, Biochimica et biophysica acta.

[31]  April K. Y. Wong,et al.  Surface characterization of 3-glycidoxypropyltrimethoxysilane films on silicon-based substrates , 2005, Analytical and bioanalytical chemistry.

[32]  David C. Martin,et al.  Stiffness, strength and adhesion characterization of electrochemically deposited conjugated polymer films. , 2016, Acta biomaterialia.

[33]  Lawrence Kulinsky,et al.  Electrical conductivity of polymer blends of poly(3,4‐ethylenedioxythiophene): Poly(styrenesulfonate): N‐methyl‐2‐pyrrolidinone and polyvinyl alcohol , 2012 .

[34]  P. Leleux,et al.  In vivo recordings of brain activity using organic transistors , 2013, Nature Communications.

[35]  Euisik Yoon,et al.  Chronic In Vivo Evaluation of PEDOT/CNT for Stable Neural Recordings , 2016, IEEE Transactions on Biomedical Engineering.