The role of prognostic biomarkers and their implications in early detection of preeclampsia: A systematic review

[1]  P. Velusamy,et al.  The Updated Review on Plant Peptides and Their Applications in Human Health , 2022, International Journal of Peptide Research and Therapeutics.

[2]  S. Gopinath,et al.  Volatile Organic Compounds as Potential Biomarkers for Noninvasive Disease Detection by Nanosensors: A Comprehensive Review , 2022, Critical reviews in analytical chemistry.

[3]  D. Jianu,et al.  MTHFR Gene Polymorphisms and Cardiovascular Risk Factors, Clinical-Imagistic Features and Outcome in Cerebral Venous Sinus Thrombosis , 2020, Brain sciences.

[4]  Yusuke Suzuki,et al.  Pathophysiological roles of ADMA-mediated endothelial injury in hypertensive disorders of pregnancy , 2020, Hypertension Research in Pregnancy.

[5]  L. Ginaldi,et al.  Hyperhomocysteinemia is Associated with Inflammation, Bone Resorption, Vitamin B12 and Folate Deficiency and MTHFR C677T Polymorphism in Postmenopausal Women with Decreased Bone Mineral Density , 2020, International journal of environmental research and public health.

[6]  I. Khodadadi,et al.  Evaluation of methylenetetrahydrofolate reductase (MTHFR) activity and the levels of homocysteine and malondialdehyde (MDA) in the serum of women with preeclampsia , 2020, Clinical and experimental hypertension.

[7]  A. Diniz,et al.  Analyzing Preeclampsia as the Tip of the Iceberg Represented by Women with Long-Term Cardiovascular Disease, Atherosclerosis, and Inflammation , 2020, Current Atherosclerosis Reports.

[8]  H. Shaikh,et al.  MTHFR and F5 genetic variations have association with preeclampsia in Pakistani patients: a case control study , 2019, BMC Medical Genetics.

[9]  Jie Lei,et al.  Early prediction of preeclampsia and small-for-gestational-age via multi-marker model in Chinese pregnancies: a prospective screening study , 2019, BMC Pregnancy and Childbirth.

[10]  R. Lakshmy,et al.  Differential global and MTHFR gene specific methylation patterns in preeclampsia and recurrent miscarriages: A case-control study from North India. , 2019, Gene.

[11]  Weronika Dymara-Konopka,et al.  The Role of Nitric Oxide, ADMA, and Homocysteine in The Etiopathogenesis of Preeclampsia—Review , 2019, International journal of molecular sciences.

[12]  G. Román,et al.  Epigenetic Factors in Late-Onset Alzheimer’s Disease: MTHFR and CTH Gene Polymorphisms, Metabolic Transsulfuration and Methylation Pathways, and B Vitamins , 2019, International journal of molecular sciences.

[13]  Y. Zhang,et al.  The association between maternal methylenetetrahydrofolate reductase C677T and A1298C polymorphism and birth defects and adverse pregnancy outcomes , 2018, Prenatal diagnosis.

[14]  I. Reiss,et al.  Human Placental Vascular Reactivity in Health and Disease: Implications for the Treatment of Pre-eclampsia. , 2019, Current pharmaceutical design.

[15]  D. Tsikas,et al.  Utility of homoarginine in the GC-MS quantification of asymmetric dimethylarginine (ADMA) in human serum proteins. , 2018, Analytical biochemistry.

[16]  A. Stupin,et al.  The Markers of Endothelial Activation , 2018, Endothelial Dysfunction - Old Concepts and New Challenges.

[17]  P. Varjú,et al.  Asymmetric dimethylarginine levels in preeclampsia - Systematic review and meta-analysis. , 2018, Placenta.

[18]  Xin Xu,et al.  Asymmetric dimethylarginine (ADMA) as an important risk factor for the increased cardiovascular diseases and heart failure in chronic kidney disease. , 2018, Nitric oxide : biology and chemistry.

[19]  R. Głowacki,et al.  Simultaneous determination of total homocysteine, cysteine, glutathione, and N-acetylcysteine in brain homogenates by HPLC. , 2018, Journal of separation science.

[20]  Y. Menezo,et al.  MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series , 2018, Journal of Assisted Reproduction and Genetics.

[21]  T. Wataganara,et al.  Prediction and prevention of pre‐eclampsia in Asian subpopulation , 2018, The journal of obstetrics and gynaecology research.

[22]  A. Gamian,et al.  Quantitative Analysis of l-Arginine, Dimethylated Arginine Derivatives, l-Citrulline, and Dimethylamine in Human Serum Using Liquid Chromatography–Mass Spectrometric Method , 2018, Chromatographia.

[23]  S. Brennecke,et al.  Accuracy of second trimester prediction of preterm preeclampsia by three different screening algorithms , 2018, The Australian & New Zealand journal of obstetrics & gynaecology.

[24]  K. Nakashima,et al.  HPLC Analysis of Homocysteine and Related Compounds , 2018, Non-Proteinogenic Amino Acids.

[25]  Hsiao-Ling Yang,et al.  Meta-Prediction of MTHFR Gene Polymorphisms and Air Pollution on the Risk of Hypertensive Disorders in Pregnancy Worldwide , 2018, International journal of environmental research and public health.

[26]  H. Jang,et al.  Asymmetric dimethylarginine (ADMA) is identified as a potential biomarker of insulin resistance in skeletal muscle , 2018, Scientific Reports.

[27]  C. Forrest,et al.  Pregnancy Characteristics and Women’s Cardiovascular Health -- Handbook of Life Course Health Development , 2018 .

[28]  S. N. Murthy,et al.  The metabolism and significance of homocysteine in nutrition and health , 2017, Nutrition & Metabolism.

[29]  M. Goumans,et al.  Preeclampsia and coronary plaque erosion: Manifestations of endothelial dysfunction resulting in cardiovascular events in women. , 2017, European journal of pharmacology.

[30]  P. Rinaldo,et al.  A Rapid Screening Method for the Measurement of Neonatal Total Homocysteine in Dried Blood Spots by Liquid Chromatography-Tandem Mass Spectrometry , 2017 .

[31]  G. Girardi Pravastatin to treat and prevent preeclampsia. Preclinical and clinical studies. , 2017, Journal of reproductive immunology.

[32]  D. Bartkevičienė,et al.  The importance of folate, vitamins B6 and B12 for the lowering of homocysteine concentrations for patients with recurrent pregnancy loss and MTHFR mutations. , 2017, Reproductive toxicology.

[33]  Lei Dong,et al.  Circulating asymmetric dimethylarginine and the risk of preeclampsia: a meta-analysis based on 1338 participants , 2017, Oncotarget.

[34]  F. Fan,et al.  Relationship between plasma homocysteine level and lipid profiles in a community-based Chinese population , 2017, Lipids in Health and Disease.

[35]  Xu Wang,et al.  Association between the MTHFR C677T polymorphism, blood folate and vitamin B12 deficiency, and elevated serum total homocysteine in healthy individuals in Yunnan Province, China , 2017, Journal of the Chinese Medical Association : JCMA.

[36]  H. McNulty,et al.  Riboflavin, MTHFR genotype and blood pressure: A personalized approach to prevention and treatment of hypertension. , 2017, Molecular aspects of medicine.

[37]  S. Oh,et al.  A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women , 2016, Nutrients.

[38]  E. Halasová,et al.  International Journal of Molecular Sciences the Molecular and Cellular Effect of Homocysteine Metabolism Imbalance on Human Health , 2022 .

[39]  Parvinder Kumar,et al.  Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G gene polymorphisms and associated risk of cardiovascular diseases: A study from Jammu region , 2016, Indian heart journal.

[40]  Y. Zheng,et al.  SAM/SAH Analogs as Versatile Tools for SAM-Dependent Methyltransferases. , 2016, ACS chemical biology.

[41]  Robert G. Wallace,et al.  Potential Diagnostic and Prognostic Biomarkers of Epigenetic Drift within the Cardiovascular Compartment , 2016, BioMed research international.

[42]  S. Deshpande,et al.  Association of maternal serum homocysteine level with severity of preeclampsia: a case control study - , 2016 .

[43]  P. Lucassen,et al.  Accurate measurement of the essential micronutrients methionine, homocysteine, vitamins B6, B12, B9 and their metabolites in plasma, brain and maternal milk of mice using LC/MS ion trap analysis. , 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[44]  E. Tsigas,et al.  Preeclampsia and future cardiovascular disease in women: How good are the data and how can we manage our patients? , 2015, Seminars in perinatology.

[45]  T. Duan,et al.  First-Trimester Maternal Serum Levels of sFLT1, PGF and ADMA Predict Preeclampsia , 2015, PloS one.

[46]  A. Göçmen,et al.  The evaluation of homocysteine level in patients with preeclampsia. , 2015, Ginekologia polska.

[47]  P. Ganguly,et al.  Role of homocysteine in the development of cardiovascular disease , 2015, Nutrition Journal.

[48]  E. Varga,et al.  Homocysteine and MTHFR Mutations. , 2005, Circulation.

[49]  S. Salimi,et al.  The early-onset preeclampsia is associated with MTHFR and FVL polymorphisms , 2015, Archives of Gynecology and Obstetrics.

[50]  Kunxian Yang,et al.  Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for preeclampsia: a meta-analysis , 2015, Journal of Assisted Reproduction and Genetics.

[51]  L. Botto,et al.  Prevalence of Variants in Methylenetetrahydrofolate Reductase and the Severity of Pulmonary Vascular Disease , 2015, Pediatric Cardiology.

[52]  S. Lentz,et al.  AGXT2: a promiscuous aminotransferase. , 2014, Trends in pharmacological sciences.

[53]  C. Prada,et al.  Endothelial dysfunction and preeclampsia: role of oxidative stress , 2014, Front. Physiol..

[54]  B. Schwartz New criteria for supplementation of selected micronutrients in the era of nutrigenetics and nutrigenomics , 2014, International journal of food sciences and nutrition.

[55]  J. Loscalzo,et al.  Epigenetic Modifications: Basic Mechanisms and Role in Cardiovascular Disease (2013 Grover Conference Series) , 2014, Pulmonary circulation.

[56]  A. Gugliandolo,et al.  Toxic Effects of Mildly Elevated Homocysteine Concentrations in Neuronal-Like Cells , 2014, Neurochemical Research.

[57]  M. Torloni,et al.  Aspirin plus calcium supplementation to prevent superimposed preeclampsia: a randomized trial , 2014, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[58]  N. Al-Jameil,et al.  A Brief Overview of Preeclampsia , 2013, Journal of clinical medicine research.

[59]  C. Gopu,et al.  Simultaneous determination of homocysteine and asymmetric dimethylarginine in human urine by liquid chromatography-tandem mass spectrometry. , 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[60]  H. McNulty,et al.  MTHFR 677TT genotype and disease risk: is there a modulating role for B-vitamins? , 2013, Proceedings of the Nutrition Society.

[61]  W. King,et al.  Effects of methionine synthase and methylenetetrahydrofolate reductase gene polymorphisms on markers of one-carbon metabolism , 2013, Genes & Nutrition.

[62]  M. Nematbakhsh,et al.  Serum Levels of Asymmetric Dimethylarginine, Vascular Endothelial Growth Factor, and Nitric Oxide Metabolite Levels in Preeclampsia Patients , 2013, ISRN obstetrics and gynecology.

[63]  K. Gomes,et al.  Assessment of L-arginine asymmetric 1 dimethyl (ADMA) in early-onset and late-onset (severe) preeclampsia. , 2013, Nitric oxide : biology and chemistry.

[64]  G. Rice,et al.  Levels of Key Enzymes of Methionine-Homocysteine Metabolism in Preeclampsia , 2013, BioMed research international.

[65]  H. Toda,et al.  Regulation of myometrial circulation and uterine vascular tone by constitutive nitric oxide. , 2013, European journal of pharmacology.

[66]  S. Yusuf,et al.  Measures of cardiovascular risk and subclinical atherosclerosis in a cohort of women with a remote history of preeclampsia. , 2013, Atherosclerosis.

[67]  S. Tyagi,et al.  Defective Homocysteine Metabolism: Potential Implications for Skeletal Muscle Malfunction , 2013, International journal of molecular sciences.

[68]  J. Fassett,et al.  Regulation of DDAH1 as a Potential Therapeutic Target for Treating Cardiovascular Diseases , 2013, Evidence-based complementary and alternative medicine : eCAM.

[69]  Xi-mei Wang,et al.  Methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and risk of preeclampsia: an updated meta-analysis based on 51 studies. , 2013, Archives of medical research.

[70]  V. Garovic,et al.  Preeclampsia and the Future Risk of Hypertension: The Pregnant Evidence , 2013, Current Hypertension Reports.

[71]  Z. Rahimi,et al.  MTHFR C677T and eNOS G894T variants in preeclamptic women: Contribution to lipid peroxidation and oxidative stress. , 2013, Clinical biochemistry.

[72]  Zhi-min He,et al.  Protection of DDAH2 Overexpression Against Homocysteine-Induced Impairments of DDAH/ADMA/NOS/NO Pathway in Endothelial Cells , 2012, Cellular Physiology and Biochemistry.

[73]  J. Frühauf,et al.  Vitamins E, A and B2 as Possible Risk Factors for Preeclampsia - under Consideration of the PROPER Study ("Prevention of Preeclampsia by High-Dose Riboflavin Supplementation"). , 2012, Geburtshilfe und Frauenheilkunde.

[74]  S. Paşa,et al.  The role of homocysteine, asymmetric dimethylarginine and nitric oxide in pre-eclampsia , 2012, Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology.

[75]  G. Koren,et al.  Homocysteine, folate and pregnancy outcomes , 2012, Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology.

[76]  B. Sibai,et al.  Maternal mortality from preeclampsia/eclampsia. , 2012, Seminars in perinatology.

[77]  C. Stefanadis,et al.  The role of nitric oxide on endothelial function. , 2012, Current vascular pharmacology.

[78]  A. Khosrowbeygi,et al.  Circulating levels of homocysteine in preeclamptic women. , 2011, Bangladesh Medical Research Council bulletin.

[79]  Byung Jin Kim,et al.  Associations of Plasma Homocysteine Levels with Arterial Stiffness in Prehypertensive Individuals , 2011, Clinical and experimental hypertension.

[80]  Yang Xia,et al.  Receptor-activating autoantibodies and disease: preeclampsia and beyond , 2011, Expert review of clinical immunology.

[81]  S. Monte Biochemical markers for prediction of preclampsia: review of the literature. , 2011, Journal of prenatal medicine.

[82]  Y. Tain,et al.  Asymmetric dimethylarginine: clinical applications in pediatric medicine. , 2011, Journal of the Formosan Medical Association = Taiwan yi zhi.

[83]  Dustin R. Bunch,et al.  A simple and fast liquid chromatography–tandem mass spectrometry method for measurement of underivatized l-arginine, symmetric dimethylarginine, and asymmetric dimethylarginine and establishment of the reference ranges , 2011, Analytical and Bioanalytical Chemistry.

[84]  M. Murphy,et al.  Homocysteine in pregnancy. , 2011, Advances in clinical chemistry.

[85]  G. Lip,et al.  Endothelial damage/dysfunction and hypertension in pregnancy. , 2011, Frontiers in bioscience.

[86]  J. Leiper,et al.  The biology and therapeutic potential of the DDAH/ADMA pathway. , 2010, Current pharmaceutical design.

[87]  A. Szuba,et al.  Effect of selected drugs on plasma asymmetric dimethylarginine (ADMA) levels. , 2010, Die Pharmazie.

[88]  Hong Wang,et al.  Regulation of homocysteine metabolism and methylation in human and mouse tissues , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[89]  B. Cohn,et al.  Preeclampsia and Cardiovascular Disease Death: Prospective Evidence From the Child Health and Development Studies Cohort , 2010, Hypertension.

[90]  M. Lever,et al.  The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. , 2010, Clinical biochemistry.

[91]  U. Förstermann Nitric oxide and oxidative stress in vascular disease , 2010, Pflügers Archiv - European Journal of Physiology.

[92]  R. Levine,et al.  Pathogenesis of preeclampsia. , 2010, Annual review of pathology.

[93]  S. Blackwell The biochemistry, measurement and current clinical significance of asymmetric dimethylarginine , 2010, Annals of clinical biochemistry.

[94]  T. Félix,et al.  Genetics of homocysteine metabolism and associated disorders. , 2010, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[95]  Wei Zhang,et al.  Association of homocysteine, asymmetric dimethylarginine, and nitric oxide with preeclampsia , 2010, Archives of Gynecology and Obstetrics.

[96]  L. Vatten,et al.  Hypertensive Disorders in Pregnancy and Subsequently Measured Cardiovascular Risk Factors , 2009, Obstetrics and gynecology.

[97]  K. Hecher,et al.  The Role of Nitric Oxide Synthase Inhibition by Asymmetric Dimethylarginine in the Pathophysiology of Preeclampsia , 2009, Gynecologic and Obstetric Investigation.

[98]  A. Franx,et al.  Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks' gestation (HYPITAT): a multicentre, open-label randomised controlled trial , 2009, The Lancet.

[99]  W. Holzgreve,et al.  Reproductive Biology and Endocrinology Open Access Potential Markers of Preeclampsia – a Review , 2022 .

[100]  M. Turiel,et al.  Asymmetric dimethylarginine (ADMA): an endogenous inhibitor of nitric oxide synthase and a novel cardiovascular risk molecule. , 2009, Medical science monitor : international medical journal of experimental and clinical research.

[101]  A. Mangoni,et al.  Dimethylarginine dimethylaminohydrolase regulation: a novel therapeutic target in cardiovascular disease , 2009, Expert opinion on drug metabolism & toxicology.

[102]  L. Myatt,et al.  Vascular biology of preeclampsia , 2009, Journal of thrombosis and haemostasis : JTH.

[103]  C. Hubel,et al.  The two stage model of preeclampsia: variations on the theme. , 2009, Placenta.

[104]  V. Roberts,et al.  Protein nitration in placenta - functional significance. , 2008, Placenta.

[105]  M. Fenech,et al.  One-carbon metabolism enzyme polymorphisms and uteroplacental insufficiency. , 2008, American journal of obstetrics and gynecology.

[106]  V. Garovic,et al.  Review: Preeclampsia and future cardiovascular risk: formal risk factor or failed stress test? , 2008, Therapeutic advances in cardiovascular disease.

[107]  P. Gambert,et al.  Impact of Asymmetric Dimethylarginine on Mortality After Acute Myocardial Infarction , 2008, Arteriosclerosis, thrombosis, and vascular biology.

[108]  Ted M. Lakowski,et al.  A Kinetic Study of Human Protein Arginine N-Methyltransferase 6 Reveals a Distributive Mechanism* , 2008, Journal of Biological Chemistry.

[109]  U. Lendeckel,et al.  Effect of Telmisartan on Nitric Oxide–Asymmetrical Dimethylarginine System: Role of Angiotensin II Type 1 Receptor and Peroxisome Proliferator Activated Receptor γ Signaling During Endothelial Aging , 2008, Hypertension.

[110]  S. Karumanchi,et al.  Molecular mechanisms of preeclampsia. , 2008, Microvascular research.

[111]  C. Stehouwer,et al.  Homocysteine and asymmetric dimethylarginine (ADMA): biochemically linked but differently related to vascular disease in chronic kidney disease , 2007, Clinical chemistry and laboratory medicine.

[112]  H. Safar,et al.  Homocysteine levels and peripheral arterial occlusive disease: a prospective cohort study and review of the literature. , 2007, The Journal of cardiovascular surgery.

[113]  Maristela L Onozato,et al.  Isoform-Specific Regulation by NG,NG-Dimethylarginine Dimethylaminohydrolase of Rat Serum Asymmetric Dimethylarginine and Vascular Endothelium-Derived Relaxing Factor/NO , 2007, Circulation research.

[114]  P. Ueland,et al.  Homocysteine, Cysteine, and Related Metabolites in Maternal and Fetal Plasma in Preeclampsia , 2007, Pediatric Research.

[115]  J. Horowitz,et al.  An overview of plasma concentrations of asymmetric dimethylarginine (ADMA) in health and disease and in clinical studies: methodological considerations. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[116]  T. Teerlink,et al.  HPLC analysis of ADMA and other methylated L-arginine analogs in biological fluids. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[117]  E. Schwedhelm,et al.  High-throughput liquid chromatographic-tandem mass spectrometric determination of arginine and dimethylated arginine derivatives in human and mouse plasma. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[118]  W. Holzgreve,et al.  Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia , 2007, Seminars in Immunopathology.

[119]  B. Huppertz The feto–maternal interface: setting the stage for potential immune interactions , 2007, Seminars in Immunopathology.

[120]  G. Ohel,et al.  Evidence of periopathogenic microorganisms in placentas of women with preeclampsia. , 2007, Journal of periodontology.

[121]  J. Cooke,et al.  Dimethylarginine dimethylaminohydrolase promotes endothelial repair after vascular injury. , 2007, Journal of the American College of Cardiology.

[122]  J. König,et al.  Plasma B vitamins and their relation to the severity of chronic heart failure. , 2007, The American journal of clinical nutrition.

[123]  A. Makedos,et al.  Homocysteine, folic acid and B12 serum levels in pregnancy complicated with preeclampsia , 2007, Archives of Gynecology and Obstetrics.

[124]  F. Paccaud,et al.  Homocysteine as a risk factor for cardiovascular disease: should we (still) worry about? , 2006, Swiss medical weekly.

[125]  M. Kimoto,et al.  Contribution of whole blood to the control of plasma asymmetrical dimethylarginine. , 2006, American journal of physiology. Heart and circulatory physiology.

[126]  M. Woodward,et al.  The association between homocysteine and myocardial infarction is independent of age, sex, blood pressure, cholesterol, smoking and markers of inflammation: the Glasgow Myocardial Infarction Study , 2006, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[127]  P. Ueland,et al.  Automated assay for the determination of methylmalonic acid, total homocysteine, and related amino acids in human serum or plasma by means of methylchloroformate derivatization and gas chromatography-mass spectrometry. , 2005, Clinical chemistry.

[128]  S. Hernández-Díaz,et al.  Methylenetetrahydrofolate Reductase Polymorphisms and the Risk of Gestational Hypertension , 2005, Epidemiology.

[129]  R. Rodrigo,et al.  Pathophysiological basis for the prophylaxis of preeclampsia through early supplementation with antioxidant vitamins. , 2005, Pharmacology & therapeutics.

[130]  E. Schwedhelm Quantification of ADMA: analytical approaches , 2005, Vascular medicine.

[131]  R. Laaksonen,et al.  DDAH gene and cardiovascular risk , 2005, Vascular medicine.

[132]  O. Braun,et al.  Searching for DDAH inhibitors: S-nitroso-L-homocysteine is a chemical lead. , 2005, Journal of the American Chemical Society.

[133]  H. Arnesen,et al.  Relationship between obesity, smoking, and the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine. , 2004, Metabolism: clinical and experimental.

[134]  H. Valantine,et al.  Cytomegalovirus Infection Impairs the Nitric Oxide Synthase Pathway: Role of Asymmetric Dimethylarginine in Transplant Arteriosclerosis , 2004, Circulation.

[135]  D. Chace,et al.  Use of tandem mass spectrometry for multianalyte screening of dried blood specimens from newborns. , 2003, Clinical chemistry.

[136]  W. Hague Homocysteine and pregnancy. , 2003, Best practice & research. Clinical obstetrics & gynaecology.

[137]  M. Vilaseca,et al.  Plasma total homocysteine in uncomplicated pregnancy and in preeclampsia. , 2003, European journal of obstetrics, gynecology, and reproductive biology.

[138]  J. Drai,et al.  Methods for homocysteine analysis and biological relevance of the results. , 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[139]  D. Charnock-Jones,et al.  Hypoxia-Reoxygenation: A Potent Inducer of Apoptotic Changes in the Human Placenta and Possible Etiological Factor in Preeclampsia , 2002, Circulation research.

[140]  J. Granger,et al.  Pathophysiology of Preeclampsia: Linking Placental Ischemia/Hypoxia with Microvascular Dysfunction , 2002, Microcirculation.

[141]  P. Tsao,et al.  Homocysteine Impairs the Nitric Oxide Synthase Pathway: Role of Asymmetric Dimethylarginine , 2001, Circulation.

[142]  E. Steegers,et al.  Hyperhomocysteinaemia: a risk factor for preeclampsia? , 2001, European journal of obstetrics, gynecology, and reproductive biology.

[143]  R. Rozen,et al.  Polymorphisms in the Methylenetetrahydrofolate Reductase Gene , 2001, American journal of pharmacogenomics : genomics-related research in drug development and clinical practice.

[144]  S. Daly,et al.  Elevated plasma homocysteine in early pregnancy: a risk factor for the development of severe preeclampsia. , 2001, American journal of obstetrics and gynecology.

[145]  D. Tsikas,et al.  LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases. , 2000, Circulation research.

[146]  H R Herschman,et al.  PRMT1 Is the Predominant Type I Protein Arginine Methyltransferase in Mammalian Cells* , 2000, The Journal of Biological Chemistry.

[147]  B. Yug,et al.  Hyperhomocysteinemia: an additional cardiovascular risk factor. , 1999, WMJ : official publication of the State Medical Society of Wisconsin.

[148]  M. Faas,et al.  Etiology and pathogenesis of preeclampsia: current concepts. , 1999, American journal of obstetrics and gynecology.

[149]  G. Hankey,et al.  Homocysteine and vascular disease , 1999, The Lancet.

[150]  P. Tsao,et al.  Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. , 1999, Circulation.

[151]  P. Tsao,et al.  Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia. , 1998, Circulation.

[152]  J. Stamler,et al.  Biological chemistry of thiols in the vasculature and in vascular-related disease. , 2009, Nutrition reviews.

[153]  R K Gordon,et al.  S‐Adenosylmetliionine and methylation , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[154]  E. Isotani,et al.  Accumulation of endogenous inhibitors for nitric oxide synthesis and decreased content of L‐arginine in regenerated endothelial cells , 1995, British journal of pharmacology.

[155]  L. Duley Maternal mortality associated with hypertensive disorders of pregnancy in Africa, Asia, Latin America and the Caribbean , 1992, British journal of obstetrics and gynaecology.

[156]  S. Moncada,et al.  Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure , 1992, The Lancet.

[157]  L. Chesley Diagnosis of preeclampsia. , 1985, Obstetrics and gynecology.

[158]  J. Mcdermott,et al.  Studies on the catabolism of Ng-methylarginine, Ng, Ng-dimethylarginine and Ng, Ng-dimethylarginine in the rabbit. , 1976, The Biochemical journal.

[159]  V. Herbert,et al.  Interrelations of vitamin B12 and folic acid metabolism: folic acid clearance studies. , 1962, The Journal of clinical investigation.