Understanding Growth Hormone Secretion and Short Stature

Short stature is a clinical challenge in the daily practice of pediatric endocrinology, regarding the several technical, cultural and economic factors associated with its approach. This article intends to review the physiology of growth hormone secretion, the endocrine regulation of human growth and the clinical aspects of the diagnosis and treatment of short stature. It specifically analyses the treatment of short stature with growth hormone, along with its side effects, cost/benefit analysis and possible risks. A clinical case from a medical school is also described, intending a better understanding of this frequent ambulatory situation in endocrinology and pediatrics.

[1]  Carmen Fajardo-Montañana,et al.  Documento de consenso del área de conocimiento de Neuroendocrinología de la Sociedad Española de Endocrinología y Nutrición para el abordaje del hipopituitarismo durante la transición , 2014 .

[2]  P. Cohen,et al.  Dose-sparing and safety-enhancing effects of an IGF-I-based dosing regimen in short children treated with growth hormone in a 2-year randomized controlled trial: therapeutic and pharmacoeconomic considerations , 2014, Clinical endocrinology.

[3]  A. Stevens,et al.  Pharmacogenomics of insulin-like growth factor-I generation during GH treatment in children with GH deficiency or Turner syndrome , 2013, The Pharmacogenomics Journal.

[4]  C. Boguszewski,et al.  Reappraisal of serum insulin-like growth factor-I (IGF-1) measurement in the detection of isolated and combined growth hormone deficiency (GHD) during the transition period. , 2013, Arquivos brasileiros de endocrinologia e metabologia.

[5]  M. Polak,et al.  Monocentric study of 112 consecutive patients with childhood onset GH deficiency around and after transition. , 2013, European journal of endocrinology.

[6]  S. Hooper,et al.  The impact of short stature on health-related quality of life in children with chronic kidney disease. , 2013, The Journal of pediatrics.

[7]  C. Shin,et al.  Influence of Body Mass Index on the Growth Hormone Response to Provocative Testing in Short Children without Growth Hormone Deficiency , 2013, Journal of Korean medical science.

[8]  M. Butler,et al.  Growth hormone receptor (GHR) gene polymorphism and prader–willi syndrome , 2013, American journal of medical genetics. Part A.

[9]  L. Cuttler,et al.  Clinical practice. Short stature in childhood--challenges and choices. , 2013, The New England journal of medicine.

[10]  R. Schiffmann,et al.  4H syndrome with late-onset growth hormone deficiency caused by POLR3A mutations. , 2012, Archives of neurology.

[11]  J. Coste,et al.  Long-term mortality after recombinant growth hormone treatment for isolated growth hormone deficiency or childhood short stature: preliminary report of the French SAGhE study. , 2012, The Journal of clinical endocrinology and metabolism.

[12]  M. A. Gómez,et al.  [Budget impact of growth hormone treatment during the transition phase between childhood and adulthood]. , 2012, Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria.

[13]  P. Chanson,et al.  Growth hormone effects on cortical bone dimensions in young adults with childhood-onset growth hormone deficiency , 2011, Osteoporosis International.

[14]  J. Baron,et al.  Usefulness of magnetic resonance findings of the hypothalamic-pituitary region in the management of short children with growth hormone deficiency: evidence from a longitudinal study , 2011, Child's Nervous System.

[15]  David M. Evans,et al.  Adult height variants affect birth length and growth rate in children , 2011, Human molecular genetics.

[16]  A. Carrascosa,et al.  Estudios Españoles de Crecimiento 2010 , 2011 .

[17]  I. Robinson,et al.  Growth hormone (GH)-releasing hormone increases the expression of the dominant-negative GH isoform in cases of isolated GH deficiency due to GH splice-site mutations. , 2010, Endocrinology.

[18]  Mark I. McCarthy,et al.  Distinct variants at LIN28B influence growth in height from birth to adulthood. , 2010, American journal of human genetics.

[19]  N. Shaw,et al.  Childhood growth hormone deficiency, bone density, structures and fractures: scrutinizing the evidence , 2010, Clinical endocrinology.

[20]  J. Ehrich,et al.  Growth hormone treatment of renal growth failure during infancy and early childhood , 2009, Pediatric Nephrology.

[21]  P. Cohen,et al.  Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop. , 2008, The Journal of clinical endocrinology and metabolism.

[22]  M. Ranke,et al.  Effect of growth hormone (GH) treatment on the near-final height of 1258 patients with idiopathic GH deficiency: analysis of a large international database. , 2006, The Journal of clinical endocrinology and metabolism.

[23]  S. Radovick,et al.  Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee. , 2003, The Journal of pediatrics.

[24]  M. Tauber,et al.  Can some growth hormone (GH)-deficient children benefit from combined therapy with gonadotropin-releasing hormone analogs and GH? Results of a retrospective study. , 2003, The Journal of clinical endocrinology and metabolism.