Cortical circuit alterations precede motor impairments in Huntington’s disease mice
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M. Mann | T. Arzberger | R. Klein | Fabian Hosp | I. Dudanova | S. Liebscher | Elena Katharina Schulz-Trieglaff | Sara Gutiérrez-Ángel | Kerstin Voelkl | J. Bader | Johanna Burgold
[1] Michael J. Yetman,et al. Intersectional Monosynaptic Tracing for Dissecting Subtype-Specific Organization of GABAergic Interneuron Inputs , 2018, Nature Neuroscience.
[2] Jessica A. Cardin,et al. Inhibitory Interneurons Regulate Temporal Precision and Correlations in Cortical Circuits , 2018, Trends in Neurosciences.
[3] A. Stroh,et al. Metformin reverses early cortical network dysfunction and behavior changes in Huntington’s disease , 2018, eLife.
[4] M. L. Nielsen,et al. Integrative Characterization of the R6/2 Mouse Model of Huntington's Disease Reveals Dysfunctional Astrocyte Metabolism. , 2018, Cell reports.
[5] X. W. Yang,et al. Molecular insights into cortico-striatal miscommunications in Huntington's disease , 2018, Current Opinion in Neurobiology.
[6] É. Fino,et al. Reconstituting Corticostriatal Network on-a-Chip Reveals the Contribution of the Presynaptic Compartment to Huntington's Disease. , 2018, Cell reports.
[7] Martin H. Schaefer,et al. Spatiotemporal Proteomic Profiling of Huntington’s Disease Inclusions Reveals Widespread Loss of Protein Function , 2017, Cell reports.
[8] L. Raymond,et al. An Automated Home-Cage System to Assess Learning and Performance of a Skilled Motor Task in a Mouse Model of Huntington’s Disease , 2017, eNeuro.
[9] Amanda J. Kedaigle,et al. Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice , 2017, Nature Neuroscience.
[10] Arthur Konnerth,et al. Impairments of neural circuit function in Alzheimer's disease , 2016, Philosophical Transactions of the Royal Society B: Biological Sciences.
[11] R. Tremblay,et al. GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits , 2016, Neuron.
[12] Marco Y. Hein,et al. The Perseus computational platform for comprehensive analysis of (prote)omics data , 2016, Nature Methods.
[13] Tobias Bonhoeffer,et al. Cell-specific restoration of stimulus preference after monocular deprivation in the visual cortex , 2016, Science.
[14] Tobias Bonhoeffer,et al. Selective Persistence of Sensorimotor Mismatch Signals in Visual Cortex of Behaving Alzheimer’s Disease Mice , 2016, Current Biology.
[15] S. Humbert,et al. The Biology of Huntingtin , 2016, Neuron.
[16] Giovanni Coppola,et al. Integrated genomics and proteomics to define huntingtin CAG length-dependent networks in HD Mice , 2016, Nature Neuroscience.
[17] T. Cummins,et al. Cortical inhibitory deficits in premanifest and early Huntington’s disease , 2016, Behavioural Brain Research.
[18] Rafael Yuste,et al. moco: Fast Motion Correction for Calcium Imaging , 2015, Front. Neuroinform..
[19] George V. Rebec,et al. Cortical Efferents Lacking Mutant huntingtin Improve Striatal Neuronal Activity and Behavior in a Conditional Mouse Model of Huntington's Disease , 2015, The Journal of Neuroscience.
[20] R. Murmu,et al. Altered Sensory Experience Exacerbates Stable Dendritic Spine and Synapse Loss in a Mouse Model of Huntington's Disease , 2015, The Journal of Neuroscience.
[21] H. Yin,et al. Huntingtin Is Required for Normal Excitatory Synapse Development in Cortical and Striatal Circuits , 2014, The Journal of Neuroscience.
[22] Simon X. Chen,et al. Emergence of reproducible spatiotemporal activity during motor learning , 2014, Nature.
[23] Nan Wang,et al. Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease , 2014, Nature Medicine.
[24] C. Cepeda,et al. Neuronal Targets of Mutant Huntingtin Genetic Reduction to Ameliorate Huntington’s Disease Pathogenesis in Mice , 2014, Nature medicine.
[25] Jianfang Chen,et al. Characterization of Striatal Neuronal Loss and Atrophy in the R6/2 Mouse Model of Huntington’s Disease , 2014, PLoS currents.
[26] A. Holtmaat,et al. Dendritic Spine Instability Leads to Progressive Neocortical Spine Loss in a Mouse Model of Huntington's Disease , 2013, The Journal of Neuroscience.
[27] R. Morimoto,et al. Huntington's disease: underlying molecular mechanisms and emerging concepts. , 2013, Trends in biochemical sciences.
[28] Stefan R. Pulver,et al. Ultra-sensitive fluorescent proteins for imaging neuronal activity , 2013, Nature.
[29] M. Scanziani,et al. Inhibition of Inhibition in Visual Cortex: The Logic of Connections Between Molecularly Distinct Interneurons , 2013, Nature Neuroscience.
[30] George V. Rebec,et al. Role of cerebral cortex in the neuropathology of Huntington's disease , 2013, Front. Neural Circuits.
[31] Michael Z. Lin,et al. Improving FRET dynamic range with bright green and red fluorescent proteins , 2012, Nature Methods.
[32] Edward O. Mann,et al. Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model , 2012, Cell.
[33] James J. Pekar,et al. Impaired cortico-striatal functional connectivity in prodromal Huntington's Disease , 2012, Neuroscience Letters.
[34] C. Cepeda,et al. A critical window of CAG repeat-length correlates with phenotype severity in the R6/2 mouse model of Huntington's disease. , 2012, Journal of neurophysiology.
[35] L. Raymond,et al. Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function , 2011, Neuroscience.
[36] D. Geschwind,et al. Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease , 2011, Neurobiology of Disease.
[37] G. Rebec,et al. Dysregulated Neuronal Activity Patterns Implicate Corticostriatal Circuit Dysfunction in Multiple Rodent Models of Huntington's Disease , 2011, Front. Syst. Neurosci..
[38] Hans J. Johnson,et al. Cerebral cortex structure in prodromal Huntington disease , 2010, Neurobiology of Disease.
[39] D. Oorschot,et al. Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington's disease. , 2010, Brain : a journal of neurology.
[40] Susanne A Schneider,et al. Abnormal motor cortex plasticity in premanifest and very early manifest Huntington disease , 2009, Journal of Neurology, Neurosurgery & Psychiatry.
[41] Carlos Cepeda,et al. Alterations in Cortical Excitation and Inhibition in Genetic Mouse Models of Huntington's Disease , 2009, The Journal of Neuroscience.
[42] Alexander Münchau,et al. Abnormal Motor Cortex Excitability in Preclinical and Very Early Huntington's Disease , 2009, Biological Psychiatry.
[43] A. Morton,et al. Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice , 2009, Neurobiology of Disease.
[44] I. Módy,et al. Progressive synaptic pathology of motor cortical neurons in a BAC transgenic mouse model of Huntington's disease , 2008, Neuroscience.
[45] Scott J Barton,et al. Altered Information Processing in the Prefrontal Cortex of Huntington's Disease Mouse Models , 2008, The Journal of Neuroscience.
[46] Bruce Fischl,et al. Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity. , 2008, Brain : a journal of neurology.
[47] S. Hersch,et al. Neuroprotective Effects of Synaptic Modulation in Huntington's Disease R6/2 Mice , 2007, The Journal of Neuroscience.
[48] D. Tank,et al. Imaging Large-Scale Neural Activity with Cellular Resolution in Awake, Mobile Mice , 2007, Neuron.
[49] Patrik Brundin,et al. Loss of SNAP‐25 and rabphilin 3a in sensory‐motor cortex in Huntington’s disease , 2007, Journal of neurochemistry.
[50] S. Shipp. Structure and function of the cerebral cortex , 2007, Current Biology.
[51] C. Cepeda,et al. Molecular Neurodegeneration Pathological Cell-cell Interactions Are Necessary for Striatal Pathogenesis in a Conditional Mouse Model of Huntington's Disease , 2022 .
[52] Michelle K. Lupton,et al. The Hdh Q150/Q150 knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes , 2007, Brain Research Bulletin.
[53] S. Dunnett,et al. The operant serial implicit learning task reveals early onset motor learning deficits in the HdhQ92 knock‐in mouse model of Huntington's disease , 2007, The European journal of neuroscience.
[54] G. Rebec,et al. Hyperactive striatal neurons in symptomatic Huntington R6/2 mice: Variations with behavioral state and repeated ascorbate treatment , 2006, Neuroscience.
[55] B. Harper. Huntington Disease , 2005, Journal of the Royal Society of Medicine.
[56] B Fischl,et al. Regional cortical thinning in preclinical Huntington disease and its relationship to cognition , 2005, Neurology.
[57] I. Módy,et al. Pathological Cell-Cell Interactions Elicited by a Neuropathogenic Form of Mutant Huntingtin Contribute to Cortical Pathogenesis in HD Mice , 2005, Neuron.
[58] R. Mandel,et al. Systemic mannitol-induced hyperosmolality amplifies rAAV2-mediated striatal transduction to a greater extent than local co-infusion. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.
[59] Sarah A. J. Reading,et al. Functional brain changes in presymptomatic Huntington's disease , 2004, Annals of neurology.
[60] Yun-Ping Deng,et al. Cellular localization and development of neuronal intranuclear inclusions in striatal and cortical neurons in R6/2 transgenic mice , 2002, The Journal of comparative neurology.
[61] M. Chesselet,et al. Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice. , 2001, Journal of neurophysiology.
[62] A. Morton,et al. Abnormalities in the synaptic vesicle fusion machinery in Huntington’s disease , 2001, Brain Research Bulletin.
[63] A. Morton,et al. Progressive depletion of complexin II in a transgenic mouse model of Huntington's disease , 2001, Journal of neurochemistry.
[64] S. W. Davies,et al. Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[65] Stephen B. Dunnett,et al. Characterization of Progressive Motor Deficits in Mice Transgenic for the Human Huntington’s Disease Mutation , 1999, The Journal of Neuroscience.
[66] Marian DiFiglia,et al. Huntington Disease , 1998 .
[67] S. W. Davies,et al. Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice , 1996, Cell.
[68] D. Brooks,et al. Proton magnetic resonance spectroscopy in Huntington's disease: Evidence in favour of the glutamate excitotoxic theory? , 1996, Movement disorders : official journal of the Movement Disorder Society.
[69] Manish S. Shah,et al. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes , 1993, Cell.
[70] D. Salmon,et al. Impaired learning of a motor skill in patients with Huntington's disease. , 1988, Behavioral neuroscience.
[71] Eric H Kim,et al. New Perspectives on the Neuropathology in Huntington's Disease in the Human Brain and its Relation to Symptom Variation. , 2012, Journal of Huntington's disease.
[72] K. Svoboda,et al. Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window , 2009, Nature Protocols.