Cortical circuit alterations precede motor impairments in Huntington’s disease mice

[1]  Michael J. Yetman,et al.  Intersectional Monosynaptic Tracing for Dissecting Subtype-Specific Organization of GABAergic Interneuron Inputs , 2018, Nature Neuroscience.

[2]  Jessica A. Cardin,et al.  Inhibitory Interneurons Regulate Temporal Precision and Correlations in Cortical Circuits , 2018, Trends in Neurosciences.

[3]  A. Stroh,et al.  Metformin reverses early cortical network dysfunction and behavior changes in Huntington’s disease , 2018, eLife.

[4]  M. L. Nielsen,et al.  Integrative Characterization of the R6/2 Mouse Model of Huntington's Disease Reveals Dysfunctional Astrocyte Metabolism. , 2018, Cell reports.

[5]  X. W. Yang,et al.  Molecular insights into cortico-striatal miscommunications in Huntington's disease , 2018, Current Opinion in Neurobiology.

[6]  É. Fino,et al.  Reconstituting Corticostriatal Network on-a-Chip Reveals the Contribution of the Presynaptic Compartment to Huntington's Disease. , 2018, Cell reports.

[7]  Martin H. Schaefer,et al.  Spatiotemporal Proteomic Profiling of Huntington’s Disease Inclusions Reveals Widespread Loss of Protein Function , 2017, Cell reports.

[8]  L. Raymond,et al.  An Automated Home-Cage System to Assess Learning and Performance of a Skilled Motor Task in a Mouse Model of Huntington’s Disease , 2017, eNeuro.

[9]  Amanda J. Kedaigle,et al.  Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice , 2017, Nature Neuroscience.

[10]  Arthur Konnerth,et al.  Impairments of neural circuit function in Alzheimer's disease , 2016, Philosophical Transactions of the Royal Society B: Biological Sciences.

[11]  R. Tremblay,et al.  GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits , 2016, Neuron.

[12]  Marco Y. Hein,et al.  The Perseus computational platform for comprehensive analysis of (prote)omics data , 2016, Nature Methods.

[13]  Tobias Bonhoeffer,et al.  Cell-specific restoration of stimulus preference after monocular deprivation in the visual cortex , 2016, Science.

[14]  Tobias Bonhoeffer,et al.  Selective Persistence of Sensorimotor Mismatch Signals in Visual Cortex of Behaving Alzheimer’s Disease Mice , 2016, Current Biology.

[15]  S. Humbert,et al.  The Biology of Huntingtin , 2016, Neuron.

[16]  Giovanni Coppola,et al.  Integrated genomics and proteomics to define huntingtin CAG length-dependent networks in HD Mice , 2016, Nature Neuroscience.

[17]  T. Cummins,et al.  Cortical inhibitory deficits in premanifest and early Huntington’s disease , 2016, Behavioural Brain Research.

[18]  Rafael Yuste,et al.  moco: Fast Motion Correction for Calcium Imaging , 2015, Front. Neuroinform..

[19]  George V. Rebec,et al.  Cortical Efferents Lacking Mutant huntingtin Improve Striatal Neuronal Activity and Behavior in a Conditional Mouse Model of Huntington's Disease , 2015, The Journal of Neuroscience.

[20]  R. Murmu,et al.  Altered Sensory Experience Exacerbates Stable Dendritic Spine and Synapse Loss in a Mouse Model of Huntington's Disease , 2015, The Journal of Neuroscience.

[21]  H. Yin,et al.  Huntingtin Is Required for Normal Excitatory Synapse Development in Cortical and Striatal Circuits , 2014, The Journal of Neuroscience.

[22]  Simon X. Chen,et al.  Emergence of reproducible spatiotemporal activity during motor learning , 2014, Nature.

[23]  Nan Wang,et al.  Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease , 2014, Nature Medicine.

[24]  C. Cepeda,et al.  Neuronal Targets of Mutant Huntingtin Genetic Reduction to Ameliorate Huntington’s Disease Pathogenesis in Mice , 2014, Nature medicine.

[25]  Jianfang Chen,et al.  Characterization of Striatal Neuronal Loss and Atrophy in the R6/2 Mouse Model of Huntington’s Disease , 2014, PLoS currents.

[26]  A. Holtmaat,et al.  Dendritic Spine Instability Leads to Progressive Neocortical Spine Loss in a Mouse Model of Huntington's Disease , 2013, The Journal of Neuroscience.

[27]  R. Morimoto,et al.  Huntington's disease: underlying molecular mechanisms and emerging concepts. , 2013, Trends in biochemical sciences.

[28]  Stefan R. Pulver,et al.  Ultra-sensitive fluorescent proteins for imaging neuronal activity , 2013, Nature.

[29]  M. Scanziani,et al.  Inhibition of Inhibition in Visual Cortex: The Logic of Connections Between Molecularly Distinct Interneurons , 2013, Nature Neuroscience.

[30]  George V. Rebec,et al.  Role of cerebral cortex in the neuropathology of Huntington's disease , 2013, Front. Neural Circuits.

[31]  Michael Z. Lin,et al.  Improving FRET dynamic range with bright green and red fluorescent proteins , 2012, Nature Methods.

[32]  Edward O. Mann,et al.  Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model , 2012, Cell.

[33]  James J. Pekar,et al.  Impaired cortico-striatal functional connectivity in prodromal Huntington's Disease , 2012, Neuroscience Letters.

[34]  C. Cepeda,et al.  A critical window of CAG repeat-length correlates with phenotype severity in the R6/2 mouse model of Huntington's disease. , 2012, Journal of neurophysiology.

[35]  L. Raymond,et al.  Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function , 2011, Neuroscience.

[36]  D. Geschwind,et al.  Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease , 2011, Neurobiology of Disease.

[37]  G. Rebec,et al.  Dysregulated Neuronal Activity Patterns Implicate Corticostriatal Circuit Dysfunction in Multiple Rodent Models of Huntington's Disease , 2011, Front. Syst. Neurosci..

[38]  Hans J. Johnson,et al.  Cerebral cortex structure in prodromal Huntington disease , 2010, Neurobiology of Disease.

[39]  D. Oorschot,et al.  Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington's disease. , 2010, Brain : a journal of neurology.

[40]  Susanne A Schneider,et al.  Abnormal motor cortex plasticity in premanifest and very early manifest Huntington disease , 2009, Journal of Neurology, Neurosurgery & Psychiatry.

[41]  Carlos Cepeda,et al.  Alterations in Cortical Excitation and Inhibition in Genetic Mouse Models of Huntington's Disease , 2009, The Journal of Neuroscience.

[42]  Alexander Münchau,et al.  Abnormal Motor Cortex Excitability in Preclinical and Very Early Huntington's Disease , 2009, Biological Psychiatry.

[43]  A. Morton,et al.  Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice , 2009, Neurobiology of Disease.

[44]  I. Módy,et al.  Progressive synaptic pathology of motor cortical neurons in a BAC transgenic mouse model of Huntington's disease , 2008, Neuroscience.

[45]  Scott J Barton,et al.  Altered Information Processing in the Prefrontal Cortex of Huntington's Disease Mouse Models , 2008, The Journal of Neuroscience.

[46]  Bruce Fischl,et al.  Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity. , 2008, Brain : a journal of neurology.

[47]  S. Hersch,et al.  Neuroprotective Effects of Synaptic Modulation in Huntington's Disease R6/2 Mice , 2007, The Journal of Neuroscience.

[48]  D. Tank,et al.  Imaging Large-Scale Neural Activity with Cellular Resolution in Awake, Mobile Mice , 2007, Neuron.

[49]  Patrik Brundin,et al.  Loss of SNAP‐25 and rabphilin 3a in sensory‐motor cortex in Huntington’s disease , 2007, Journal of neurochemistry.

[50]  S. Shipp Structure and function of the cerebral cortex , 2007, Current Biology.

[51]  C. Cepeda,et al.  Molecular Neurodegeneration Pathological Cell-cell Interactions Are Necessary for Striatal Pathogenesis in a Conditional Mouse Model of Huntington's Disease , 2022 .

[52]  Michelle K. Lupton,et al.  The Hdh Q150/Q150 knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes , 2007, Brain Research Bulletin.

[53]  S. Dunnett,et al.  The operant serial implicit learning task reveals early onset motor learning deficits in the HdhQ92 knock‐in mouse model of Huntington's disease , 2007, The European journal of neuroscience.

[54]  G. Rebec,et al.  Hyperactive striatal neurons in symptomatic Huntington R6/2 mice: Variations with behavioral state and repeated ascorbate treatment , 2006, Neuroscience.

[55]  B. Harper Huntington Disease , 2005, Journal of the Royal Society of Medicine.

[56]  B Fischl,et al.  Regional cortical thinning in preclinical Huntington disease and its relationship to cognition , 2005, Neurology.

[57]  I. Módy,et al.  Pathological Cell-Cell Interactions Elicited by a Neuropathogenic Form of Mutant Huntingtin Contribute to Cortical Pathogenesis in HD Mice , 2005, Neuron.

[58]  R. Mandel,et al.  Systemic mannitol-induced hyperosmolality amplifies rAAV2-mediated striatal transduction to a greater extent than local co-infusion. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

[59]  Sarah A. J. Reading,et al.  Functional brain changes in presymptomatic Huntington's disease , 2004, Annals of neurology.

[60]  Yun-Ping Deng,et al.  Cellular localization and development of neuronal intranuclear inclusions in striatal and cortical neurons in R6/2 transgenic mice , 2002, The Journal of comparative neurology.

[61]  M. Chesselet,et al.  Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice. , 2001, Journal of neurophysiology.

[62]  A. Morton,et al.  Abnormalities in the synaptic vesicle fusion machinery in Huntington’s disease , 2001, Brain Research Bulletin.

[63]  A. Morton,et al.  Progressive depletion of complexin II in a transgenic mouse model of Huntington's disease , 2001, Journal of neurochemistry.

[64]  S. W. Davies,et al.  Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[65]  Stephen B. Dunnett,et al.  Characterization of Progressive Motor Deficits in Mice Transgenic for the Human Huntington’s Disease Mutation , 1999, The Journal of Neuroscience.

[66]  Marian DiFiglia,et al.  Huntington Disease , 1998 .

[67]  S. W. Davies,et al.  Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice , 1996, Cell.

[68]  D. Brooks,et al.  Proton magnetic resonance spectroscopy in Huntington's disease: Evidence in favour of the glutamate excitotoxic theory? , 1996, Movement disorders : official journal of the Movement Disorder Society.

[69]  Manish S. Shah,et al.  A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes , 1993, Cell.

[70]  D. Salmon,et al.  Impaired learning of a motor skill in patients with Huntington's disease. , 1988, Behavioral neuroscience.

[71]  Eric H Kim,et al.  New Perspectives on the Neuropathology in Huntington's Disease in the Human Brain and its Relation to Symptom Variation. , 2012, Journal of Huntington's disease.

[72]  K. Svoboda,et al.  Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window , 2009, Nature Protocols.