The construction of UHV power grid has a substantial influence on the sustainable development of China's electric power industry and impetus to industrial upgrade of electro technical equipment manufacturing industry in China. The design, leading the whole UHV engineering construction, plays a very important role in both digestion and utilization of scientific achievements and guidance to the practical engineering implementation. This chapter deals with the issues that need to be particularly considered in such aspects as site selection, main electrical connection, model selection of distribution equipment and general layout.