论文信息 - The spread of neurodegenerative disease.

The spread of neurodegenerative disease.

Dementias such as Alzheimer's disease and frontotemporal dementia are thought to spread from one part of the brain to another. Two recent studies suggest that a protein-templating mechanism underlies the spread of disease in at least a subgroup of these dementias.

John Hardy | Tamas Revesz | J. Hardy | T. Révész | J. Hardy

[1] M. Jucker,et al. Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders , 2011, Annals of neurology.

[2] T. Crow,et al. Induction of beta (A4)-amyloid in primates by injection of Alzheimer's disease brain homogenate. Comparison with transmission of spongiform encephalopathy. , 1994, Molecular neurobiology.

[3] O. Lindvall,et al. Research in motion: the enigma of Parkinson's disease pathology spread , 2008, Nature Reviews Neuroscience.

[4] Menno P. Witter,et al. Trans-Synaptic Spread of Tau Pathology In Vivo , 2012, PloS one.

[5] Naruhiko Sahara,et al. Propagation of Tau Pathology in a Model of Early Alzheimer's Disease , 2012, Neuron.