FORMULATION AND EVALUATION OF GASTRORETENTIVE CLARITHROMYCIN FLOATING TABLETS

The objective of the present study is to optimize, formulate and evaluate the gastroretentive clarithromycin Floating tablets. Clarithromycin is a broad spectrum antibiotic. It has high absorption in the upper part of GIT, it has low oral bioavailability. The present investigation, it is aimed to develop GFDDS of Clarithromycin (effervescent floating tablets) with three different swellable polymers Hydroxy propyl methyl cellulose (HPMC K4M, HPMC K15M), Hydroxyl propyl cellulose (HPC), Hydroxyl ethyl cellulose (HEC) by wet granulation method. The prepared batches GFDDS of clarithromycin evaluated for Precompression Parameters and Post compression parameters like Weight variation, Hardness testing, Friability, Drug content uniformity, Floating lag time, Drug content release and In vitro drug release. Weight variation of floating tablets ranged from 0.875 ± 0.06 to 1.24 ± 0.002. The hardness lies between 4.24 ± 0.164 and 5.91 ± 0.109. The friability of all gastro retentive floating tablets of clarithromycin was found between 0.263 ± 0.002 and 508 ± 0.002. Drug content ranged between 96.92 ± 0.627 and 98.79 ± 0.242. The drug release was found to be better with 98% release in 12 hrs Thus the formulation prepared with HPMC K15M were found to be superior to the rest, among them FHM8was found to be as best formulation. Reasons for fluctuations of release depend on the selection of polymer.