Horizontal polymerization of mixed trifunctional silanes on silica: a potential chromatographic stationary phase

A new design for surface bonding of monolayers, applicable to chromatogrphic stationary phases, is reported. This design is shown to combine the superior hydrolytic stability of self-assembled monolayers with the selectivity and reproducibility of monomeric stationary phases. While the new methodology is applicable to any type of functionality, it is demonstrated here for C 18 on a flat silica surface

[1]  L. White,et al.  Hydrophobicity effects in the condensation of water films on quartz , 1990 .

[2]  S. Granick,et al.  Formation and Characterization of a Highly Ordered and Well- Anchored Alkylsilane Monolayer on Mica by Self -Assembly , 1991 .

[3]  J. Dorsey,et al.  Retention mechanisms in reversed-phase liquid chromatography. Stationary-phase bonding density and partitioning. , 1989, Analytical chemistry.

[4]  M. Novotny,et al.  Electrophoretic separations of proteins in capillaries with hydrolytically stable surface structures. , 1990, Analytical chemistry.

[5]  W. Cooper,et al.  Analysis of thermally and chemically modified silica gels by heterogeneous gas-solid chromatography and infrared spectroscopy , 1989 .

[6]  R. Maoz,et al.  On the formation and structure of self-assembling monolayers. I. A comparative atr-wettability study of Langmuir—Blodgett and adsorbed films on flat substrates and glass microbeads , 1984 .

[7]  M. Wirth,et al.  Effect of wetting on the reorientation of acridine orange at the interface of water and a hydrophobic surface , 1992 .

[8]  C. McMartin,et al.  Use of octadecasilyl-silica for the extraction and purification of peptides in biological samples. Application to the identification of circulating metabolites of corticotropin-(1-24)-tetracosapeptide and somatostatin in vivo. , 1977, The Biochemical journal.

[9]  R. Maoz,et al.  Penetration-controlled reactions in organized monolayer assemblies. 1. Aqueous permanganate interaction with monolayer and multilayer films of long-chain surfactants , 1987 .

[10]  S. Wise,et al.  Synthesis and characterization of polymeric C18 stationary phases for liquid chromatography , 1984 .

[11]  George M. Whitesides,et al.  The structure of self-assembled monolayers of alkylsiloxanes on silicon: a comparison of results from ellipsometry and low-angle x-ray reflectivity , 1989 .